Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2284
- Phase 1235
- Phase 3216
- Phase 1/Phase 2203
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome55
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California341
- Maryland161
- Alabama131
- Massachusetts116
- New York84
- Arizona78
- Texas72
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06342752Recruiting
Breath test for early lung disease in premature babies
This trial studies a breath test to predict lung disease in very premature babies. It could help doctors start treatment earlier to prevent serious breathing problems.
Edegem, AntwerpAges birth–3 days - NCT06345976Recruiting
How albinism affects daily vision and activities
This study is for adults with any type of albinism. It looks at how albinism affects your everyday vision and activities through a simple questionnaire.
ParisAges 18 years+ - NCT06346418Recruiting
Maternal genes and Beckwith-Wiedemann syndrome risk study
This study looks at how a mother's genes and chemical changes to DNA (called epimutations) may increase the risk of having a child with Beckwith-Wiedemann syndrome or affect a woman's ability to get pregnant and carry a baby to term. It aims to find genetic clues that could help explain these reproductive challenges.
MilanAges 18 years+ - NCT06347276Recruiting
PFO closure and brain microemboli study
This trial looks at whether closing a small hole in the heart (PFO) can reduce tiny clots traveling to the brain. It includes people who have had a stroke or migraine, and also those without symptoms but with high-risk features.
Beijing, Beijing MunicipalityAges 18–65 - NCT06349473RecruitingPhase 1
Study of SR604 in healthy people and those with bleeding disorders
This study tests a new drug called SR604 to see if it is safe and how it works in the body. It is for healthy men and for people with hemophilia A, hemophilia B, or factor VII deficiency who have frequent bleeding or are on preventive treatment.
Glendale, CaliforniaAges 18–60 - NCT06352216Recruiting
Joint inflammation in hemophilia A patients
This study looks at how many adults with moderate or severe hemophilia A have inflammation in their joints (synovitis). It aims to better understand joint health in people with hemophilia A, including those with inhibitors or joint replacements.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06353620Recruiting
Brain connections study for certain epilepsies and genetic syndromes
This study uses MRI and a special EEG to understand brain connections in people with specific types of epilepsy or genetic conditions like Angelman syndrome and Dup15q. It may help find better ways to treat these conditions.
Conegliano, TrevisoAges 6–75 - NCT06356246Recruiting
Oral health survey for adults with cystic fibrosis
This study uses an online survey to learn about the oral health of adults with cystic fibrosis. Your answers can help doctors understand and improve dental care for people like you.
Ivry-sur-Seine, Île-de-France RegionAges 18 years+ - NCT06356727Recruiting
Blood vessel health test for heart recovery
This study checks if tiny blood vessel problems in the heart affect how well the heart muscle recovers after being weak. It uses special imaging during a routine heart catheterization to look at these small vessels.
FerraraAges 18–85 - NCT06358638RecruitingPhase 2
Sickle cell transplant using a gentler approach for patients with donor antibodies
This trial is testing a new, gentler type of bone marrow transplant for children and young adults with sickle cell disease who have a healthy sibling donor with a mismatched blood type or who have antibodies against their donor's red blood cells. The goal is to replace the faulty bone marrow with healthy donor cells, with fewer side effects than traditional transplants.
Washington D.C., District of ColumbiaAges 2–25 - NCT06359795Recruiting
PET Scan for Thyroid Eye Disease Activity
This study uses a special PET/CT scan (with a tracer called 18F-AlF-FAPI) to see how active your thyroid eye disease is. It may help doctors better understand and manage the condition.
Beijing, Beijing MunicipalityAges 18–80 - NCT06360406Recruiting
Real-world study of Koselugo (selumetinib) in South Korea
This study looks at how patients with certain conditions are doing while taking Koselugo (selumetinib) in real life. It's a way to gather information about the treatment's effectiveness and safety outside of a controlled clinical trial.
BusanAges 3–99 - NCT06360913Recruiting
Blood and urine test for rare metabolic diseases
This study uses a simple blood spot and urine test to look for chemical signs of rare metabolic diseases. It aims to improve early detection and understanding of these conditions across all ages, including healthy individuals.
BrusselsAges 1 day–99 years - NCT06362473Recruiting
Italian Genetic Record for Lipid Disorders
This study creates a registry of people with inherited lipid disorders to better understand and track these conditions. It does not test a new treatment but helps researchers learn more about your condition.
Sesto San Giovanni, MilanoAges Any age - NCT06362629Recruiting
Smartphone App for Managing Eczema
This trial tests a smartphone app designed to help people manage their atopic dermatitis (eczema). If you or your child has eczema and can use a smartphone, this app may help track symptoms and provide advice.
Chengdu, SichuanAges 1–75 - NCT06363357Recruiting
Shoulder brace study for arm weakness from nerve or muscle diseases
This study tests a fabric shoulder brace that moves like a muscle. It may help people with nerve or muscle diseases improve arm movements like reaching and lifting.
Seoul, Jongno-guAges 10 years+ - NCT06364176RecruitingPhase 2
Adding losartan to improve Trikafta response in CF
This study tests whether adding the blood pressure medication losartan can help the standard CF drug Trikafta work better by reducing inflammation. It's for people with CF who still have high sweat chloride levels despite taking Trikafta.
Kansas City, KansasAges 12 years+ - NCT06364449Recruiting
Study on choices for first-time dialysis access
This study looks at how doctors decide which type of hemodialysis access (fistula or graft) to create for patients who need it for the first time. It gathers information from multiple hospitals to help improve future decision-making.
TaipeiAges 18–100 - NCT06364774RecruitingPhase 1/Phase 2
Gene therapy for transfusion-dependent beta thalassemia
This gene therapy trial uses a modified virus to deliver a healthy gene into your own stem cells. The goal is to help your body make normal red blood cells so you may need fewer or no transfusions.
Philadelphia, PennsylvaniaAges 18–40 - NCT06365788RecruitingPhase 2
Bicalutamide and Abemaciclib for AR-positive Triple-negative Breast Cancer
This trial tests a combination of two oral drugs—bicalutamide and abemaciclib—for people with a specific type of advanced triple-negative breast cancer that grows in response to androgen hormones (AR-positive). The goal is to see if this treatment can shrink tumors or slow disease progression.
AntwerpAges 18 years+ - NCT06366815Recruiting
A study of Duchenne muscular dystrophy in boys who no longer walk
This study is for boys with Duchenne muscular dystrophy who can no longer walk. It aims to describe how the condition changes over time once walking is lost, without testing any new treatments.
Bosisio Parini, LcAges 8–35 - NCT06367192Recruiting
School Readiness Program for Preschoolers with Sickle Cell
This study tests a program to help preschoolers with sickle cell disease get ready for school. It looks at whether a special learning program can help with skills like paying attention and getting along with others.
Memphis, TennesseeAges 3.5 years–6.5 years - NCT06370962Recruiting
Sleep study for children with cystic fibrosis on Kaftrio-Kalydeco
This study looks at sleep and daily activity rhythms in children with cystic fibrosis who are taking a medication called Kaftrio-Kalydeco. It aims to understand if the medication affects sleep patterns and how to improve them.
BronAges 2–17 - NCT06371937Recruiting
Heart and blood vessel disease biobank study
This study creates a collection of skin cells (turned into stem cells in a lab) from people with various heart and blood vessel conditions. It aims to find new ways to understand and treat these diseases.
London, OntarioAges 18–80
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,764 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.