Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT06998446Recruiting
Sodium in the skin and eczema study
This study looks at sodium levels in the skin of older adults with eczema. It uses an MRI scan to measure sodium and may help us understand how sodium affects eczema severity.
San Francisco, CaliforniaAges 50 years+ - NCT06922851Recruiting
Protein filter therapy for dilated cardiomyopathy
This trial tests a protein filtering treatment (immunoadsorption) for people with dilated cardiomyopathy who have a specific antibody linked to heart damage. It aims to see if removing these antibodies can improve heart function.
Wuhan, HubeiAges 18–75 - NCT06988605Recruiting
Nemolizumab for teens and adults with moderate-to-severe eczema
This study looks at how well nemolizumab works in everyday practice for people with moderate-to-severe atopic dermatitis (eczema). It helps researchers understand the real-world benefits and safety of this treatment.
Birmingham, AlabamaAges 12 years+ - NCT06985225Recruiting
Study of mucus plugs and lung function in mucus-related lung disease
This study looks at how mucus plugs affect air flow in the lungs. It may help find new ways to treat people with lung conditions like cystic fibrosis, severe asthma, COPD, or bronchiectasis.
Kansas City, KansasAges 18–65 - NCT06984679Recruiting
Physical function study for kids with cystic fibrosis
This trial compares physical abilities between children with cystic fibrosis and healthy children. It aims to find differences that could lead to better care and therapies.
IzmirAges 6–18 - NCT06992076Recruiting
Hemophilia patients' experience with marstacimab treatment
This registry study follows people with hemophilia A or B who are taking marstacimab as their regular preventive treatment. It aims to understand how the medicine works in real life and how patients feel during treatment.
Xiamen, FujianAges 12 years+ - NCT06989593Recruiting
Storytelling study for parents of children with urogenital conditions
This study tests whether guided journaling (writing or dictating stories) can help parents cope and connect. It involves a 5-week journaling activity and one follow-up interview.
Boston, MassachusettsAges 18 years+ - NCT06989814Recruiting
Liquid biopsy test for Lynch syndrome cancer patients
This trial tests a simple blood test to measure tumor DNA in people with Lynch syndrome who have been newly diagnosed with cancer but haven't started treatment yet. It aims to see if this test can help monitor the cancer.
Leiden, South HollandAges 18 years+ - NCT05522374Recruiting
Study registry for people with suspected or confirmed NBIA
This trial is a research registry that collects information from people who have suspected or confirmed NBIA (a rare inherited brain movement/nerve condition). It helps researchers learn more about the condition and how it affects people, which may support future studies.
OttawaAges Any age - NCT05651347RecruitingPhase 3
Melatonin in pregnancy to protect babies with slow growth
This trial studies whether taking melatonin during pregnancy can help protect the baby’s brain and organs in cases of poor fetal growth. It focuses on pregnancies at a specific gestational age with signs that the placenta may not be working well.
Camperdown, New South WalesAges 18 years+ - NCT06974877RecruitingPhase 1
PET/CT Imaging for Amyloid in CAPS on Anakinra
This trial uses a special PET/CT scan to see if a radioactive tracer can measure changes in amyloid buildup in people with CAPS who have developed a skin reaction to anakinra. It may help doctors understand how the disease is affecting your organs.
Bethesda, MarylandAges 18–120 - NCT06975189RecruitingPhase 2
Reducing radiation in preterm baby lung scans
This trial tests whether using ultrasound instead of X-rays for lung imaging can safely reduce radiation exposure in very premature babies. If your baby needs lung imaging, they may be able to join.
Melbourne, VictoriaAges Up to 1 day - NCT06982352RecruitingPhase 1
Testing safety of LPX-TI641 for eczema and psoriasis
This study tests a new drug called LPX-TI641 to see if it's safe and how it works in people with atopic dermatitis (eczema) or psoriasis. If you have moderate-to-severe symptoms that haven't been helped by standard creams, you might be able to join.
Fargo, North DakotaAges 18 years+ - NCT06975618RecruitingPhase 1/Phase 2
Study of CYH33 for PIK3CA-related overgrowth and vascular malformations
This trial tests a new drug called CYH33 for people with conditions caused by a specific gene mutation (PIK3CA) that leads to abnormal tissue growth or blood vessel problems. It aims to see if the drug is safe and can help shrink or control these growths.
Beijing, Beijing MunicipalityAges Any age - NCT06979024Enrolling by invitation
Observational study of myotonic dystrophy type 1
This study follows people with myotonic dystrophy type 1 over time to learn more about the condition. It is for people of any age who have genetic confirmation of DM1, whether or not they have symptoms.
Fuzhou, FujianAges Any age - NCT06972719Recruiting
Hormone therapy after ovary removal for BRCA mutation carriers
This study looks at giving hormone therapy after ovary and fallopian tube removal in women with a BRCA mutation. The goal is to help manage menopause symptoms while you are still premenopausal.
Chapel Hill, North CarolinaAges 19–50 - NCT06264570Recruiting
Personalized supplements for high homocysteine and cholesterol
This study tests a personalized approach based on your genes to choose the right natural supplements for people with high homocysteine and high LDL cholesterol. It aims to help lower these levels safely.
Novosibirsk, Novosibisk RegionAges 18–80 - NCT06971731RecruitingPhase 3
JNT-517 pill for adults with PKU
This trial tests a new pill called JNT-517 to see if it can lower high blood phenylalanine (Phe) levels in people with PKU. You may be a good fit if you have PKU, are at least 18, and can stick to a steady diet.
Los Angeles, CaliforniaAges 18 years+ - NCT06970106RecruitingPhase 1/Phase 2
Study of PYC-001 eye injections for people with a type of inherited optic nerve disease
This trial tests a new medicine called PYC-001, given as an injection into the eye, for people with a specific genetic form of vision loss called autosomal dominant optic atrophy (ADOA). It aims to see if the treatment is safe and could help protect or improve vision.
Sydney, New South WalesAges 18 years+ - NCT06966167Recruiting
Laser vs. standard cataract surgery in Fuchs' dystrophy
This study compares two types of cataract surgery in people with Fuchs' dystrophy: one using a laser and the standard method. It looks at which approach gives better results for the cornea and vision.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT06969586Enrolling by invitation
Eye drops study for Fuchs corneal disease and glaucoma
This study tests whether special eye drops (Rho-kinase inhibitors) can improve the health of the cornea in people who have both Fuchs endothelial corneal dystrophy and glaucoma. The drops may help reduce corneal swelling and preserve your vision.
Zagreb, CroatiaAges 40–90 - NCT06970028Recruiting
Sensation study in ADPKD patients
This study looks at how people with ADPKD (a kidney condition that causes cysts) sense touch and temperature on their skin. It will compare their results with those of healthy volunteers to better understand the condition and help future treatments.
LeuvenAges 12 years+ - NCT06971146Recruiting
Nurse-led telehealth for gout management
This trial tests whether nurse-led telehealth visits can help people with gout maintain healthy urate levels. If you have gout and are already on medication like allopurinol, this study may offer a convenient way to manage your condition from home.
AarhusAges 18 years+ - NCT06966375Recruiting
Worldwide yearly screening for repaired hypospadias
This study will test a yearly screening program for males who have had surgery to fix hypospadias (a birth defect where the urine opening is on the underside of the penis). It aims to understand how screening can help monitor long-term health.
Madison, WisconsinAges 5–65
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.