Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05321875RecruitingPhase 3
Candesartan to prevent heart failure in certain gene carriers
This trial tests whether candesartan (a blood-pressure medicine) can delay or prevent heart muscle weakening in people who carry a disease-causing dilated cardiomyopathy gene variant but still have fairly strong heart pumping. Participants are randomly assigned to candesartan or a placebo to see which one keeps the heart healthier over time.
Majadahonda, MadridAges 18–64 - NCT05322824Recruiting
Study for adults with narrowed brain or neck arteries
This study enrolls people age 40 or older who have at least 50% narrowing in one brain or neck (carotid) artery. It collects clinical information to better understand this condition and how patients are doing over time.
Hangzhou, ZhejiangAges 40 years+ - NCT05323487RecruitingPhase 1
Study why water pills (diuretics) stop working in heart failure
This Phase 1 study looks at why “water pills” sometimes stop relieving fluid overload in people with heart failure. It may help researchers understand the causes of diuretic resistance and improve future treatment for fluid management.
New Haven, ConnecticutAges 18 years+ - NCT05323916Recruiting
Intensive rehab program after a first stroke
This trial tests whether an intensive, day-long rehabilitation program can improve recovery after a first ischemic stroke. It focuses on people with mild to moderate disability who can safely handle several hours of therapy each day.
PragueAges 18–85 - NCT05325034Recruiting
Lipid-lowering plan after heart attack in adults
This study tests a cholesterol-lowering treatment plan for adults admitted for a Type 1 heart attack. It may help your care team choose guideline-based cholesterol goals and treatments after the event.
Wollongong, New South WalesAges 18 years+ - NCT05326828Recruiting
Implant monitor to find hidden atrial fibrillation after heart injury
This study tests whether an implantable heart rhythm monitor can detect atrial fibrillation (an irregular heartbeat) in people who had a type of heart attack with non-obstructed arteries. The goal is to find a possible reason for the event so doctors can treat it appropriately.
BernAges 18–85 - NCT05326308Recruiting
Zanubrutinib treatment in several blood cancers
This non-interventional study looks at outcomes for people with certain slow-growing blood cancers who are treated with zanubrutinib, with specific add-on use of obinutuzumab for follicular lymphoma. It may help doctors understand how this treatment is working in real-world care across several cancer types.
SalzburgAges 18 years+ - NCT05326932Recruiting
Extended-Time Thrombectomy for Large-Artery Stroke
This trial studies whether a mechanical procedure to remove a blocked artery can help people with an ischemic stroke caused by a large artery blockage, even when treatment starts 24–72 hours after symptoms began. It also checks that only patients with “salvageable” brain tissue on CT scans are treated.
ShanghaiAges 18 years+ - NCT05327062Recruiting
Noninvasive mapping to guide a heart resynchronization device
This trial tests a noninvasive way to map your heart’s wiring and veins to help guide placement of a heart resynchronization therapy (CRT) device. If you have certain abnormal heart rhythm and weak heart pumping, it may help doctors place the therapy more accurately and safely.
Chicago, IllinoisAges 18 years+ - NCT05327933Recruiting
Preventing chronic bleeding from the brain’s covering after surgery
This trial looks at whether a procedure called middle meningeal artery embolization can help stop chronic subdural hematoma (slow bleeding/collection under the brain covering) from coming back after your first surgery. It studies an added endovascular treatment right after your operation to reduce recurrence.
Berlin, State of BerlinAges 18 years+ - NCT05329285Recruiting
Compare bypass or stent for heart weakness from blocked arteries
This study compares two ways to improve blood flow in people with weakened heart pumping (ischemic cardiomyopathy): bypass surgery (CABG) versus stent treatment (PCI). It aims to see which approach works better when the heart still has enough at-risk muscle and when best medical therapy is already started.
GothenburgAges 18 years+ - NCT05329714Recruiting
Deep testing registry for people with pulmonary hypertension
This trial is a global registry that collects detailed health information (“deep phenotyping”) from people diagnosed with pulmonary hypertension. It helps researchers better understand the condition and how people differ, which can guide better future treatments.
Giessen, HesseAges Any age - NCT05332262Recruiting
Study to predict heart damage risk during planned angioplasty
This trial focuses on people with stable coronary artery disease who are scheduled for planned angioplasty (PCI). It looks for a “precision medicine” approach to identify who may be at risk for a small heart injury around the procedure, so doctors can better prevent it.
Jacksonville, FloridaAges 18 years+ - NCT05332457Recruiting
Beta-blocker effects on heart rate and exercise capacity in atrial fibrillation
This study looks at how taking a beta-blocker affects your resting heart rate during activity and how fit your heart and lungs are during an exercise test. It may help clarify whether the way the medication controls heart rate is linked to better exercise tolerance in people with persistent atrial fibrillation.
TaipeiAges 20 years+ - NCT05332691Recruiting
Beating-heart septal myectomy for thick-heart blockage
This trial studies surgery that removes part of the thick heart muscle while the heart is still beating to relieve a blockage that makes blood leaving the heart harder. It may help people with hypertrophic obstructive cardiomyopathy whose symptoms persist despite medication.
Wuhan, HubeiAges 8 years+ - NCT05332756Recruiting
Long-term follow-up of moyamoya care and family health
This trial follows people with moyamoya disease who are treated with medication only, and it also looks at first-degree relatives. The goal is to understand long-term outcomes and whether careful conservative care is beneficial over time.
Beijing, Beijing MunicipalityAges 2–60 - NCT05333666Recruiting
Checking how blood NOAC levels relate to outcomes
This study looks at whether the amount of a blood thinner (NOAC) in your bloodstream is linked to health outcomes. It may help doctors better understand how to monitor and use these medicines safely.
Taipei, Please SelectAges 20 years+ - NCT05334615Recruiting
Study of blood clot problems after COVID or flu
This study looks at blood clot–related complications after COVID-19 (and in some cases flu) in adults admitted to the hospital. It may help doctors better understand and manage these complications.
Iowa City, IowaAges 18–99 - NCT05336383RecruitingPhase 2
Radiation after prior CAR T for relapsed multiple myeloma
This trial tests giving “salvage” radiation (radiation meant to control remaining cancer) after you’ve already had BCMA CAR-T therapy for multiple myeloma. It’s for people whose PET or other scan still shows active myeloma at least 30 days after CAR-T, and who have a spot that radiation can target.
Houston, TexasAges 18 years+ - NCT05337319Recruiting
Registry for people in the hospital with coronary artery disease
This study keeps a careful record of what care people with coronary artery disease receive while they are hospitalized. It may help doctors improve future treatment by showing what is happening in real-world practice.
BeijingAges 18 years+ - NCT05336877Recruiting
Using Medicare data to study pacemaker care after implant
This study looks at Medicare claims to understand how well different pacemakers work in real-world care after they are implanted. You may be included if you are a Medicare patient who received an Aveir VR leadless pacemaker or a single-chamber ventricular pacemaker after the study began.
Sylmar, CaliforniaAges 18 years+ - NCT05337241Recruiting
Saline enhanced needle ablation for stubborn heart rhythm
This trial studies a special “needle” ablation method (with saline) to treat a dangerous, repeat heart rhythm problem called monomorphic ventricular tachycardia (VT). It’s for adults whose VT keeps coming back despite prior treatments and who may not benefit from another standard ablation.
Birmingham, AlabamaAges 18 years+ - NCT05339061Recruiting
Modified stent graft for complex abdominal aortic aneurysms
This study tests a specially customized endovascular (through blood vessels) repair for certain large or fast-growing aneurysms near the kidney area or chest-to-abdomen area. It may help people who are higher risk for open surgery and whose anatomy fits the device.
San Diego, CaliforniaAges 18 years+ - NCT05339529Recruiting
Thymosin A1 to help protect organs after emergency aortic surgery
This study looks at whether thymosin A1 can reduce immune-related problems and organ injury after emergency surgery for an acute aortic condition. If you qualify, you may receive thymosin A1 as part of the treatment plan to see if it improves recovery.
Bengbu, AnhuiAges 18–90
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.