Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05624125Recruiting
Beetroot juice study for circulation problems in leg arteries
This trial tests whether drinking beetroot juice can improve how well people with peripheral artery disease (PAD) can function and walk. It’s looking at circulation-related measurements in the legs and how you do on walking tests.
Chicago, IllinoisAges 50 years+ - NCT05624905Recruiting
Heart procedure registry for people getting angiography and stents
This study is a real-world registry that collects information from people who have a heart artery test (coronary angiography) and may also get a stent procedure (percutaneous coronary intervention). It may help doctors improve how these procedures are done by tracking outcomes and care.
SeoulAges 19 years+ - NCT05625438Recruiting
Home video therapy for early arm recovery after stroke
This study tests a home-based (telerehabilitation) program to help people practice arm movement after a recent stroke (or certain brain injuries). It may help improve arm function when started soon after symptoms begin.
Fullerton, CaliforniaAges 18 years+ - NCT05626296Recruiting
Blood-sample study of stroke patterns using multiple tests
This study looks at blood and lab “molecular” patterns in people who have had an ischemic stroke (a blocked blood vessel). It aims to understand differences between people labeled as having “phlegm-heat syndrome” versus not, which may help future stroke care. You may be eligible if your stroke was recent and confirmed by MRI.
Beijing, Beijing MunicipalityAges 50–80 - NCT05626894RecruitingPhase 2
Wrist sensor app to help use the weaker arm at home
This Phase 2 study tests a new wrist sensor system that tracks arm movement and gives feedback using a phone or tablet. It aims to improve daily use of the weaker (hemiparetic) arm in people with a prior stroke.
Boston, MassachusettsAges 18–85 - NCT05627375RecruitingPhase 3
Blood thinner options for clot patients already on antiplatelets
This Phase 3 trial compares the best “blood thinner” approach for people who have a new clot in the leg (DVT) or lung (PE) and who already take antiplatelet medicines for heart or blood-vessel prevention. It aims to find an antithrombotic plan that lowers clot risk while managing bleeding risk.
AmiensAges 18 years+ - NCT05627440Recruiting
Protein diet program to improve muscle strength in heart failure
This trial tests whether adding dietary protein can help skeletal muscles recover and function better in people living with heart failure. It may help with strength, muscle wasting, and overall ability to do daily activities.
Boston, MassachusettsAges 18–100 - NCT05628324Recruiting
Game-based training using muscle signals after stroke
This trial tests whether an EMG-controlled computer game can help retrain how your arm muscles activate after stroke. It may help improve upper-limb movement by practicing with real-time muscle feedback.
Charleston, South CarolinaAges 18 years+ - NCT05629000Recruiting
Study of treatment planning after carotid artery narrowing
This study looks at an approach to better plan treatment for people with significant narrowing of the carotid artery (the main artery to the brain). It may help doctors choose safer, more effective care after surgery.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05629104Recruiting
Predicting long-term outcomes after aortic valve procedure
This study follows people who have aortic valve treatment to better predict how they will do in the long term. It may help doctors understand what outcomes to expect after the procedure and improve future care.
UppsalaAges 18 years+ - NCT05628948Recruiting
Donate blood for a heart and metabolism research biobank
This study builds a “biobank,” which is a collection of blood and related samples, to support future research on heart and metabolic (sugar/body-fat) conditions. It may help researchers better understand these diseases and improve future prevention and treatments.
Cleveland, OhioAges 18 years+ - NCT05629559RecruitingPhase 1/Phase 2
Study drug 4D-310 for Fabry disease with heart problems
This Phase 1/2 study tests how safe and potentially effective 4D-310 is for adults with Fabry disease who have heart involvement. It may help people who can’t tolerate standard treatments like enzyme replacement therapy (ERT) or migalastat, or who still have disease progression.
MelbourneAges 18–65 - NCT05630586RecruitingPhase 2
Semaglutide shot for early stroke recovery
This Phase 2 study tests whether a semaglutide injection given under the skin soon after an acute ischemic stroke can improve recovery. It may help reduce disability, especially if treatment starts within about 4.5 hours of symptom onset.
AarhusAges 18 years+ - NCT05631730RecruitingPhase 3
Flecainide plus metoprolol vs metoprolol alone for rhythm control
This trial studies whether adding flecainide to metoprolol can better reduce dangerous heart rhythm problems in people with mitral valve prolapse. It also checks safety and side effects compared with metoprolol alone.
OsloAges 18 years+ - NCT05632432Recruiting
Heart tissue grafts to help the heart after surgery
This trial tests whether transplanting tiny heart “micrografts” from the left heart chamber area can improve heart function after cardiac surgery. It is meant for people with weakened heart pumping and heart failure symptoms despite medicine.
Helsinki, UusimaaAges 18–75 - NCT05633303Recruiting
Personalized ablation plan for persistent atrial fibrillation
This trial looks at whether tailoring an ablation procedure to you can work better for people with persistent atrial fibrillation. It’s for patients getting their first left atrial ablation and who have had AF for less than 24 months.
LondonAges 18 years+ - NCT05633810RecruitingPhase 3
Testing colchicine plus coated aspirin to prevent heart events
This Phase 3 study tests whether colchicine and a special type of aspirin can lower the risk of future heart attacks, strokes, or other major heart problems in people with type 2 diabetes who have not had a prior heart event. It aims to reduce cardiovascular risk using medicines that may calm inflammation and protect blood vessels.
Bentley, Western AustraliaAges 55–80 - NCT05635227Recruiting
Medications during heart surgery to help control breathing and circulation
This study looks at whether giving dexamethasone and olanzapine during certain heart surgeries can improve how blood flow and ventilation (breathing support) are managed. It’s meant to see if these medicines help the body handle heart-lung bypass more safely.
CopenhagenAges 18 years+ - NCT05636748Recruiting
Study how blood clots affect stroke, using special scans
This study looks at how blood clots form and contribute to an acute ischemic (clot-related) stroke. It uses PET-CT scanning to better understand the process and may help improve how future stroke treatments are targeted.
EdinburghAges 18 years+ - NCT05636397Recruiting
Oral L-citrulline for fragile preterm babies with lung or bowel disease
This trial studies whether an oral medicine called L-citrulline (L-cit) is safe and how it works in very preterm infants. It includes two groups: babies with chronic lung disease (with or without high blood pressure in the lungs) and babies recovering from severe bowel infection (NEC).
Toronto, OntarioAges 1 month–6 months - NCT05636787RecruitingPhase 2
Treosulfan chemo for myeloma before stem cell transplant
This trial tests whether the chemotherapy medicine treosulfan (Trecondi® Ideogen) works well and is safe for people with myeloma who are moving on to high-dose chemotherapy plus their own stem cell transplant. It may help strengthen the transplant “conditioning” treatment before the transplant.
BernAges 18–75 - NCT05637814Recruiting
Screening for critical heart defects with extra blood flow checks
This trial tests if adding blood flow measurements to standard pulse oximeter screening better detects critical congenital heart disease in fetuses and newborns. It may help identify babies who need early heart care.
Davis, CaliforniaAges birth–3 weeks - NCT05638503Recruiting
Study of heart changes in people with hypertension
This study looks at new ways to measure heart structure and heart pumping function in people with high blood pressure. The results may help doctors better understand heart changes over time and improve care.
Jinan, ShandongAges 30–75 - NCT05638269Recruiting
Study of gut bacteria in people with serious long-term illness
This study looks at the types of gut bacteria in people living in certain parts of China who have serious long-term (chronic) illnesses. The goal is to better understand how gut bacteria differ and may help doctors in the future tailor care.
Chaoyang, Beijing MunicipalityAges 18–75
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.