Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05891886RecruitingEarly Phase 1
Testing supplemental oxygen for early blood clot in the lungs
This early-phase trial studies whether giving extra oxygen can help people with a recently diagnosed lung blood clot (pulmonary embolism). It mainly looks at people who have early symptoms and signs that the right side of the heart is under strain.
Boston, MassachusettsAges 18 years+ - NCT05892393RecruitingPhase 1
Scan test to find CD46-positive multiple myeloma lesions
This Phase 1 study tests a new special scan marker (a radioactive imaging agent) to see whether it can detect certain multiple myeloma spots in the body. If it works, it may help doctors better locate disease using a PET-style scan.
San Francisco, CaliforniaAges 18 years+ - NCT05892510RecruitingPhase 2/Phase 3
Tenecteplase after clot removal for no-reflow stroke
This trial tests whether giving tenecteplase directly into the brain artery after a thrombectomy can improve outcomes when blood flow doesn’t fully return (“no-reflow”) in an emergency stroke. It may help some people by reducing ongoing clot-related blockage after the main clot is removed.
Gold Coast, QueenslandAges 18 years+ - NCT05892965Recruiting
Instant-message online therapy for early post-stroke depression
This study tests whether brief online cognitive behavioral therapy (CBT) delivered through instant messages can reduce depression symptoms after a stroke. It may help if your depression started after your stroke and you have mild to moderately severe symptoms.
Hong KongAges 18 years+ - NCT05893407Recruiting
Ultrasound test of brain blood flow in ICU injury
This trial tests whether a contrast-enhanced ultrasound can measure blood flow in the brain of people admitted to the ICU for a sudden brain injury. It may help doctors better assess brain damage and guide care using a bedside imaging method.
ParisAges 18 years+ - NCT05893459Recruiting
Friend and family study for teens 13–17
This study looks at how a teen’s best friend and caregiver influence stress and coping. It enrolls teens who have either experienced maltreatment or not, to better understand what supports might help.
Columbia, South CarolinaAges 13–17 - NCT05894863Recruiting
Smart stent for severe leg artery blockages
This trial studies a new “smart” stent placed in the thigh-to-knee artery to treat significant blockages. It may help improve blood flow to the foot, and you would be followed closely to see how well the stent works over time.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05895487Recruiting
UniLine heart valve replacement study for aortic or mitral disease
This trial studies how well a specific bioprosthetic heart valve (“UniLine”) works after surgery, including safety and how long it lasts. You may be able to join if you are an adult getting a first-time mitral or aortic valve replacement with this exact valve.
KemerovoAges 18 years+ - NCT05895838RecruitingPhase 3
Trial for medicines after out-of-hospital cardiac arrest
This Phase 3 trial studies treatments given after a person survives an out-of-hospital cardiac arrest to improve recovery and survival. It is for patients who stay unconscious for a short time after circulation returns, and who meet safety conditions.
Copenhagen, Capital Region of DenmarkAges 18 years+ - NCT05896228RecruitingPhase 2
Combination therapy for relapsed multiple myeloma to target MRD
This Phase 2 trial tests iberdomide plus daratumumab, carfilzomib, and dexamethasone in people whose multiple myeloma has come back or not responded. The goal is to increase how often patients reach “MRD-negative” status, meaning very small amounts of cancer cells are not detectable, which may help improve outcomes.
Miami, FloridaAges 18–75 - NCT05896397Recruiting
Collecting European data for Cook aortic medical devices
This study collects information from routine care about patients who receive a Cook CMD. It may help improve how these devices are used and tracked over time by using medical record data.
Aarhus, DenmarkAges Any age - NCT05896579Recruiting
Study heart function during rest and exercise in COPD
This study measures how well the right side of your heart works when you are resting and when you exercise, in people with chronic obstructive pulmonary disease (COPD). It may help researchers better understand COPD-related heart strain and guide future care.
Aurora, ColoradoAges 40 years+ - NCT05897333Recruiting
Registry study for isolated coronary artery dilation
This is a “registry” study that collects health information about people who have isolated coronary artery ectasia (an abnormal dilation of a heart artery). It may help doctors better understand what to expect and how these conditions relate to symptoms like chest pain or heart attacks.
AnkaraAges 18–90 - NCT05896592Recruiting
Ablation versus changing pacing settings for slow heartbeats
This study compares a procedure called cardioneuroablation with staying on permanent pacing in people who have symptoms from a slow heart rate. It aims to see which approach works better and is safer for reducing symptoms related to sinus node or heart conduction problems.
Radom, Masovian VoivodeshipAges 18–65 - NCT05896826Recruiting
Magnetocardiography to better spot heart attack patients
This study tests whether magnetocardiography—a scan that measures heart signals using magnets—can more accurately identify myocardial infarction (heart attack). It may help doctors detect heart attacks faster and more accurately using safer, non-invasive testing.
Jinan, ShandongAges 18–79 - NCT05897632Recruiting
Rapid chest-pain evaluation for moderate-risk adults
This trial tests a faster “ambulatory rapid evaluation” approach for adults who come in with chest pain that could be heart-related, but is not clearly an emergency. It may help doctors quickly sort who is safe to send home and who needs urgent heart testing, using specific ECG and blood test results.
Detroit, MichiganAges 21 years+ - NCT05897645Recruiting
MRI study of artery plaque after recent stroke
This trial uses special brain MRI to look closely at plaque in certain brain arteries after an ischemic stroke (when a blood vessel is blocked). It may help researchers better understand which plaques are most dangerous soon after stroke.
ShenyangAges 40 years+ - NCT05898542Recruiting
Nature-based therapy for stroke recovery in rehab wards
This trial studies whether nature-based activities (like time outdoors or nature-focused programs) can improve recovery after a stroke. It’s aimed at people who are currently in a stroke rehabilitation setting soon after their stroke.
LahtiAges 18 years+ - NCT05899582Recruiting
Heart-bypass–like brain surgery for artery blockage patients
This trial studies whether a special bypass surgery can improve symptoms in people with a long-term (chronic) blockage of the middle brain artery. It aims to improve brain blood flow and reduce future stroke risk in the right patients.
BeijingAges 18–65 - NCT05900414Recruiting
Help choosing blood thinners to prevent stroke in AF
This trial tests a web-based decision aid that helps people with atrial fibrillation (AF) decide about stroke-prevention treatment, such as blood thinners. It may help you feel more confident and make safer choices by showing options at the right time after diagnosis.
Calgary, AlbertaAges 18 years+ - NCT05901259Recruiting
Tracking routine outcomes using a mobility suit database
This trial sets up a database to follow routine health and mobility outcomes over time. You may be included if you have certain neurological conditions and can safely use the EXOPULSE suit.
Bergshamra, Stockholm CountyAges 2 years+ - NCT05901675Recruiting
Weight loss and exercise after stroke in walking recovery
This trial studies whether a weight-loss plan combined with exercise can improve walking and leg movement after stroke. It may help if you have ongoing leg weakness but can still walk without devices for testing.
Charleston, South CarolinaAges 35–85 - NCT05902195Recruiting
Improve work ability for young adults after stroke
This study aims to help young adults who have had a stroke improve their ability to work. It may help people get back to work and manage daily function after stroke.
Hong KongAges 18 years+ - NCT05902910Recruiting
Robot therapy to improve arm movement after long-term stroke
This trial tests whether a therapy robot (the Luna EMG rehabilitation robot) can improve arm movement and be acceptable to use for people with chronic stroke. It focuses on helping the arm recover function over time and seeing how well patients tolerate the approach.
BrestAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.