Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05903001Recruiting
Breathing muscle testing to help track lung disease
This study checks whether measurements of your breathing muscle (the diaphragm) can act as a useful “biomarker” to track lung disease. You might be asked to do breathing tests and follow study instructions, and your results may help researchers better monitor COPD, asthma, fibrosis, or pulmonary hypertension.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT05903170Recruiting
Shock energy study for heart rhythm conversion in atrial fibrillation
This trial tests whether using a specific “shock energy” during electrical cardioversion works safely and effectively for people with persistent atrial fibrillation. You might be eligible if your cardioversion is planned (not an emergency) and your doctors determine you can safely take blood thinners.
Wellington, Wellington RegionAges 18 years+ - NCT05903235Recruiting
VR and mirror therapy for arm recovery after stroke
This trial tests a mix of virtual reality (VR) and mirror therapy to help improve arm movement after a stroke. You may be asked to use the technology and give feedback, and the study may compare it with other care approaches to see if it helps more.
Taoyuan CityAges 20–80 - NCT05903560Recruiting
Arm versus leg access for clot removal in basilar stroke
This trial compares doing a clot-removal procedure through the arm artery versus the leg artery for an emergency stroke caused by a blocked basilar artery. It aims to see which access route is safer and more effective for restoring blood flow when time is critical.
Nanjing, JiangsuAges 18 years+ - NCT05903898Recruiting
AI to improve stroke care after hospital admission
This trial uses artificial intelligence (computer tools that help analyze information) to improve stroke care for people admitted quickly after symptoms start. It may help hospitals make faster or better care decisions, based on patient details and follow-up results.
TromsøAges 18 years+ - NCT05904301Recruiting
Registry for autoimmune and autoinflammatory disease patients
This study builds a nationwide list (registry) of people with certain autoimmune or inflammation-related illnesses. It helps researchers understand these diseases better over time, which can guide future care.
YerevanAges Any age - NCT05906056Recruiting
CPM therapy vs bone overgrowth in hip or knee
This study compares continuous passive motion (a machine that gently moves a joint without you moving it) versus the body’s tendency to form extra bone called heterotopic ossification. It aims to see whether CPM can affect how and how much bone overgrowth develops after neurologic injuries like stroke, brain injury, or spinal cord injury.
Ioannina, EpirusAges 15–70 - NCT05907005Recruiting
Text-message mental health support for stroke family caregivers
This study tests whether instant-message support can reduce stress and depression symptoms for family caregivers of people having their first stroke. It may help you cope better while your loved one is in the hospital and during early recovery.
Hong KongAges 18 years+ - NCT05906810Recruiting
Treating gum inflammation around implants to improve blood vessel function
This study looks at whether non-surgical gum treatment around dental implants can improve early problems in blood vessel function. It includes people with implant gum disease, and also compares them with healthy people who do not have gum disease.
CataniaAges Any age - NCT05907031Recruiting
Brain stimulation to improve language after left-stroke aphasia
This trial studies a specific brain-stimulation method to help improve speech and language problems (aphasia) after an ischemic stroke. You may qualify if your stroke affected the left side of the brain and your language testing shows moderate language difficulty.
Fuzhou, FujianAges 35–75 - NCT05907694Recruiting
Treatment of stroke from PFO, with or without closure
This study looks at whether treating a history of “cryptogenic” stroke (stroke with no clear cause) using a patent foramen ovale (PFO) closure, plus medical therapy, is better than medical therapy alone. It focuses on people over 60 with a heart shunt seen on an ultrasound of the heart.
Québec, QuebecAges 18 years+ - NCT05908331Recruiting
Balloon treatment test for narrowed stents in heart arteries
This trial tests whether a special drug-coated balloon (“MagicTouch”) can treat re-narrowing inside a previously placed stent. It may help patients whose stent has become blocked again, by improving blood flow and reducing repeat narrowing.
Birmingham, AlabamaAges 18–110 - NCT05908214Recruiting
Electrical stimulation for leg stiffness and overactive nerves
This study tests a treatment using high-frequency electrical stimulation to reduce overactive nerve signals that can cause stiff legs, poor ankle control, cramps, or restless legs. It may help improve movement and comfort during walking or at night, depending on the condition.
LausanneAges 18 years+ - NCT05908409RecruitingPhase 1/Phase 2
Testing an investigational drug for blood cancers that came back
This Phase 1/2 trial tests IDP-121 in people with certain blood cancers that have returned or did not respond to available treatments. The goal is to find a safe dose and see whether the treatment can help control the cancer.
Santander, CantabriaAges 18 years+ - NCT05908955Recruiting
Atrial fibrillation ablation with extra vein targeting
This trial studies a modified ablation procedure that targets the superior vena cava in addition to the pulmonary veins to help stop episodes of paroxysmal (coming and going) atrial fibrillation. It may help people whose symptoms continue despite antiarrhythmic medicines.
Beijing, Beijing MunicipalityAges 40–75 - NCT05913804RecruitingPhase 1
Study of YTS104 cell therapy for hard-to-treat myeloma
This Phase 1 study tests an injected cell therapy (YTS104) for people with multiple myeloma that has come back or did not respond after several prior treatments. The goal is to see whether the treatment is safe and may help control the disease.
TianjinAges 18–75 - NCT05913622Recruiting
Testing heart pump unloading during VA ECMO in adults
This study will look at whether “left ventricular unloading” (using a device like IABP or Impella) helps people who are in cardiogenic shock while on VA ECMO. It compares outcomes for people who get unloading versus those who stay on VA ECMO alone.
BrugesAges 18 years+ - NCT05914038Recruiting
Personalized brain stimulation to improve arm recovery after stroke
This trial studies whether personalized rTMS (a noninvasive brain stimulation) can help improve arm and hand strength after a recent stroke. It may help people who still have weaker upper-limb movement within the first few months after stroke.
Taipei County, TaipeiAges 20 years+ - NCT05913908Recruiting
Valve procedure study for severe tricuspid leakage
This trial tests how well a new catheter-based valve system works for people with severe (or worse) tricuspid valve leaking who still have symptoms despite medicines. It aims to improve outcomes by treating the leaking valve without open-heart surgery, if your heart structure and overall health fit the study.
Phoenix, ArizonaAges 18 years+ - NCT05914662RecruitingPhase 2
Zanubrutinib plus BR for newly diagnosed symptomatic WM
This Phase 2 trial studies zanubrutinib combined with BR (bendamustine and rituximab) in adults newly diagnosed with Waldenström macroglobulinemia (WM) who have symptoms. It may help shrink the abnormal disease and improve symptoms like high blood stickiness, nerve problems, anemia, and other lymphoma-related issues.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT05914779Recruiting
Early antibiotics after out-of-hospital cardiac arrest
This study looks at whether starting antibiotics soon after an out-of-hospital cardiac arrest helps patients who are unlikely to have an infection. Antibiotics may prevent or treat infection-related complications, but only if certain infection and health conditions are met.
Doha, Baladiyat ad DawhahAges 18 years+ - NCT05916287Recruiting
STANISLAS cohort follow-up visit for heart and kidney health
This study is a follow-up visit for people who joined the STANISLAS family health cohort. Researchers look at how genes and environment may affect heart and kidney (kidneys) health over time.
Vandœuvre-lès-Nancy, LorraineAges Any age - NCT05916469Recruiting
Hormone treatment for heavy periods in teens and young adults
This trial studies how a progestin hormone—given as an IUD or tablets—can help reduce heavy menstrual bleeding in people with certain bleeding-related conditions. It may help you by testing whether the treatment works and is practical for your situation.
Palo Alto, CaliforniaAges 10–24 - NCT05916950Recruiting
Study of a new treatment for blocked leg arteries
This trial studies a device-based treatment approach for people with blocked (narrowed or fully blocked) arteries in the thigh or behind the knee that reduce blood flow to the leg. It may help improve blood flow and walking ability, but you must meet specific artery and imaging requirements.
St. Helena, CaliforniaAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.