Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05880043RecruitingPhase 1/Phase 2
IV NK cell treatment for advanced cancers that returned
This Phase 1/2 study tests an intravenous (IV) immune-cell therapy made from donors (allogeneic NK cells) to treat advanced solid tumors, relapsed/refractory non-Hodgkin lymphoma, or multiple myeloma. It may help by targeting cancer cells more directly, but early-phase trials mainly focus on safety and finding the right dosing.
SeoulAges 19 years+ - NCT05880056RecruitingPhase 4
Dissolving bisoprolol film for newly diagnosed high blood pressure
This trial tests a dissolving form of bisoprolol (a blood-pressure medicine) in people in Egypt with newly diagnosed mild to moderate high blood pressure. It aims to see how well this specific dose form controls blood pressure and fits everyday use.
Al FayyumAges 21–65 - NCT05880641Recruiting
Shockwave balloon treatment for very hard, blocked iliac arteries
This trial tests a device called Shockwave M5+/L6 intravascular lithotripsy to help deliver stent grafts when the iliac (pelvic) arteries are extremely calcified and hard to access. It may help people who are being evaluated for endovascular (through-the-blood-vessel) treatment but whose anatomy makes standard access difficult.
Ancona, AnconaAges 18 years+ - NCT05880680Recruiting
SEAL device registry for certain brain aneurysms treated through blood vessels
This study follows people who have a brain aneurysm that can be treated using the SEAL device placed from inside a blood vessel. It aims to track how well the treatment works and how safely it can be used in real-world care.
Itagüi, MedellínAges 18–80 - NCT05881447Recruiting
Study kidney disease patterns in people in Tanzania
This study looks at how common chronic kidney disease is, how it develops over time, and what risk factors are linked to it. It may help improve how kidney disease is recognized and managed in your community.
Bagamoyo, Coast RegionAges 18–99 - NCT05883072Recruiting
Using AI to support care for people with diabetes in Pakistan
This study tests whether AI-generated support can be helpful for adults living with diabetes. You may be asked to participate if you live in Pakistan and can legally consent.
Karachi, SindhAges 18–100 - NCT05881798Recruiting
Vena cava filter data study for specific filter type
This study checks outcomes and safety using real-world health data from people who received a specific type of vena cava filter. It may help improve future care by understanding how these devices perform after placement.
Los Angeles, CaliforniaAges 18 years+ - NCT05883878Recruiting
Personalized plan to prevent heart disease in high-risk adults
This trial looks at an individualized prevention approach for people who are at higher risk of heart and blood vessel problems. It aims to help lower future cardiovascular risk before heart disease develops.
Roma, ItaliaAges 40–69 - NCT05884008Recruiting
Using CT heart scans and AI to study plaque function
This study looks at people who had a heart attack and had a special CT scan (CT angiography) before or during the years leading up to it. Researchers will use the scan and computer analysis (AI) to better understand heart plaque and how it may relate to heart attacks.
Cangzhou, HebeiAges 18–80 - NCT05884762Recruiting
Brain training rehab for arm recovery after a recent stroke
This trial tests an upper-limb (arm/hand) rehabilitation program guided by brain activity signals, started soon after a stroke. It may help people with early incomplete arm recovery improve hand and arm function.
RennesAges 18–80 - NCT05884840Recruiting
Cardiovascular risk screening for people without heart disease
This trial tests a new way to check cardiovascular (heart and blood vessel) risk during a routine primary care visit. If your risk score is high enough, it may help your care team better target prevention early.
BarcelonaAges 50–74 - NCT05884892Recruiting
Join a heart condition registry for hypertrophic cardiomyopathy
This program builds a registry of people diagnosed with hypertrophic cardiomyopathy and their family members. By collecting health information over time, researchers hope to better understand the condition and improve care.
AswānAges Any age - NCT05885295Recruiting
Testing thinking and memory after stroke using cognitive exams
This study looks at how thinking and memory change after a stroke using short cognitive tests. It may help researchers better understand which brain changes affect thinking, and how to measure them accurately.
LondonAges 18 years+ - NCT05885412RecruitingPhase 1
Study drug for heart rhythm problems in PKP2 heart disease
This Phase 1 trial tests RP-A601 (a gene-delivery type treatment) to see if it can reduce dangerous heart rhythm problems in people with PKP2-related arrhythmogenic cardiomyopathy (ACM). Because it’s an early safety/dose study, the main goal is to check safety and how the body responds.
La Jolla, CaliforniaAges 18 years+ - NCT05885932Recruiting
Stent treatment versus medicines for blocked neck artery
This study compares a drug-coated stent placed in a neck (vertebral) artery versus best medical treatment with medicines and risk-factor control. It aims to reduce problems caused by a badly narrowed artery after recent stroke-like symptoms.
BeijingAges 18 years+ - NCT05886517Recruiting
Transcatheter aortic valve in patients too high-risk for surgery
This trial looks at placing a new aortic valve through the groin (transfemoral) without needing on-site heart surgery for people who are considered very high risk for standard open-heart valve surgery. It aims to measure early outcomes to see how safe and effective this approach is for frail or complex patients.
Acquaviva delle Fonti, BariAges 75–120 - NCT05887167RecruitingPhase 1
Test safety of making CAR T cells from your own blood
This Phase 1 study looks at whether it is safe and practical to collect your own stem cells and use them to support CAR T-cell therapy for certain blood cancers that have come back or did not respond. It aims to find the best way to combine these steps, which may help some people receive CAR T treatment.
Los Angeles, CaliforniaAges 18–85 - NCT05888467Recruiting
Exercise study for women at risk of pregnancy heart problems
This study looks at how physical activity affects the heart and blood-vessel health “profile” in women who have risk factors for a pregnancy condition (called GHD, related to preeclampsia risk). It may help researchers find safer or more helpful activity guidance before pregnancy.
Diepenbeek, LimburgAges 18–50 - NCT05887440Recruiting
Isokinetic strength training for knee control after stroke
This trial studies whether a special strength-training program that uses an “isokinetic” machine can improve walking and knee control in people after stroke. It is for people who have noticeable knee movement during walking and can safely take part in rehab.
RennesAges 18–75 - NCT05888688Recruiting
Studying muscle loss in people with heart failure or diabetes
This study looks at sarcopenia, which is age-related loss of muscle, in people with certain types of heart failure or in people with stable type 2 diabetes but no symptoms. The goal is to better understand muscle changes and what might help people stay stronger.
Leicester, LeicestershireAges 18 years+ - NCT05890664RecruitingPhase 3
Colchicine after shock treatment to stop atrial fibrillation
This trial tests whether colchicine given after cardioversion (a procedure that restores normal rhythm) helps keep the heart in normal rhythm afterward. It may help some people have fewer early returns of atrial fibrillation.
Bruderholz, Basel-LandschaftAges 18 years+ - NCT05891145Recruiting
Remimazolam to prevent irregular heartbeat after heart surgery
This trial tests whether a medication called remimazolam can help prevent atrial fibrillation—a common, irregular heart rhythm that can happen after surgery. It focuses on people having a specific planned type of heart bypass surgery and checks if the study medication reduces postoperative rhythm problems.
Yangzhou, JiangsuAges 50–70 - NCT05891509Recruiting
DTI-guided minimally invasive surgery for deep brain bleeding
This trial studies whether a special scan-guided, minimally invasive procedure can safely remove bleeding in the basal ganglia (deep in the brain) soon after it happens. It may help patients recover better by targeting the bleeding while protecting important brain pathways.
Ganzhou, JiangxiAges 18–80 - NCT05892042Recruiting
Anticoagulant treatment for a heart clot after a heart attack
This trial studies whether a specific blood thinner can better treat a left-side heart clot found soon after a heart attack. It may help prevent the clot from getting worse or causing complications.
Changchun, JilinAges 18–80
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.