Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,968 recruiting studies in this area right now.
By phase
- Not applicable7,950
- Phase 2484
- Phase 4479
- Phase 3447
- Phase 1361
- Phase 1/Phase 2161
- Phase 2/Phase 386
Top conditions
- Stroke839
- Heart Failure566
- Hypertension399
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma334
- Atrial Fibrillation269
- Ischemic Stroke201
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke137
- Myocardial Infarction102
- Pulmonary Hypertension100
- Congenital Heart Disease85
- Stroke, Ischemic85
- Acute Coronary Syndrome82
- Peripheral Arterial Disease82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris92
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama196
- Massachusetts183
- Arizona174
- New York161
- Florida145
- Maryland120
- Illinois119
- Minnesota119
- Texas118
Recruiting studies9,965 total
- NCT06280820Enrolling by invitation
A study of heart failure patterns (MAP-HEART)
This study looks at different types of heart failure to understand them better. You may join if you have active heart failure (with symptoms like shortness of breath or swelling) and are willing to participate in research activities.
Baltimore, MarylandAges 18–100 - NCT06555952Recruiting
Grape seed extract for blood pressure and heart health
This trial tests whether a grape seed extract can help lower blood pressure in people with mildly high blood pressure and slightly elevated blood sugar. It's designed for adults aged 40-60 who are not on blood pressure or diabetes medications.
Chicago, IllinoisAges 40–60 - NCT06909565RecruitingPhase 4
Inclisiran to prevent heart and leg events after artery procedure
This study tests whether a twice-yearly injection called inclisiran can prevent heart attacks, strokes, or leg complications in people who recently had a procedure to open a blocked artery. You may be eligible if you had a heart or leg artery procedure within the last two weeks.
Alexander City, AlabamaAges 18 years+ - NCT06373289Recruiting
Blood pressure in lung arteries and oxygen levels in preemies
This study tests whether changing oxygen targets in preterm infants with high blood pressure in the lungs (pulmonary hypertension) helps their heart and lungs work better. It may help doctors find the best oxygen levels for these babies.
Birmingham, AlabamaAges 1 month–5 months - NCT00315380Recruiting
Study following people with eosinophilic granulomatosis with polyangiitis
This study looks at the health course of people who have eosinophilic granulomatosis with polyangiitis, a rare inflammatory condition. Your participation may help researchers better understand how the illness changes over time.
San Diego, CaliforniaAges Any age - NCT06375044RecruitingPhase 1
Study of SIM0500 for relapsed or refractory multiple myeloma
This trial tests a new medication, SIM0500, for people whose multiple myeloma has returned or stopped responding to other treatments. It aims to see if the drug is safe and effective for those who have tried all standard options.
Phoenix, ArizonaAges 18 years+ - NCT07589634RecruitingPhase 2
Tocilizumab to prevent side effects from ramantamig in multiple myeloma
This study tests whether a drug called tocilizumab can prevent serious side effects (cytokine release syndrome) when combined with a new cancer drug called ramantamig. You'll be eligible if you have multiple myeloma that has come back or stopped responding to prior treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT07367100Recruiting
Testing a new clot-removal catheter for stroke
This study tests a special catheter (a thin tube) designed to remove blood clots from large arteries in the brain during a stroke. The goal is to see if it is safe and effective at restoring blood flow.
EdegemAges 18–90 - NCT07294807Recruiting
Salt substitute trial to prevent high blood pressure in pregnancy
This trial tests whether switching to a low-sodium salt substitute can help prevent high blood pressure disorders (like preeclampsia) during pregnancy. It is for pregnant people who are at increased risk and eat most meals at home.
Bishan, Chongqing MunicipalityAges 18 years+ - NCT07114718Recruiting
Stent for babies with heart defect needing extra blood flow
This trial tests a special stent for babies with a heart defect that needs a temporary blood vessel to stay open. The stent is placed to help blood flow to the lungs until the baby can have a more permanent surgery.
Los Angeles, CaliforniaAges 1 minute–6 months - NCT07575269Recruiting
New ablation treatment for irregular heartbeat
This trial tests a new tool called FARAFLEX that uses pulsed electrical energy to treat atrial fibrillation (an irregular heart rhythm). The goal is to see if this method can safely stop AF symptoms in people whose medications haven't worked.
Jonesboro, ArkansasAges 18 years+ - NCT07429214Recruiting
Study of a new catheter for atrial fibrillation ablation
This trial tests a new catheter system to treat atrial fibrillation (AF) by creating small scars in the heart to block faulty signals. It may help people with symptoms that continue despite medication and who are scheduled for a standard ablation procedure.
AalstAges 18–75 - NCT07613099RecruitingPhase 3
Testing a new PET scan to detect lung and heart scarring
This study tests a new imaging scan (called 18F-FAPI PET/CT) that may help detect scarring in the lungs, heart, or blood vessels. If you have a heart, lung, or blood vessel condition that could cause scarring, this scan might show damage earlier and help doctors plan better treatment.
Bethesda, MarylandAges 18–100 - NCT06615973Recruiting
Stroke recovery and social factors study
This study looks at how social factors (like where you live or your income) might affect thinking and memory after a stroke. If you had a stroke before and joined a related study, you may be able to join this one.
Bethesda, MarylandAges 18–99 - NCT05610787Enrolling by invitation
Testing a device that helps move an EXCOR pediatric heart pump
This trial studies an “active driving” system that controls the EXCOR pediatric heart pump. It’s meant for children who need a heart pump as a bridge to heart transplantation, to help the pump work more safely and effectively.
Los Angeles, CaliforniaAges Up to 21 years - NCT07527299Recruiting
Varipulse catheter study for persistent atrial fibrillation
This study tests a new catheter to treat persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year). It aims to isolate the pulmonary veins and superior vena cava to restore normal rhythm. Some participants may also receive a left atrial appendage occlusion device if needed.
Tucson, ArizonaAges 18–80 - NCT07428564Recruiting
VARIPULSE catheter and TRUPULSE generator for persistent atrial fibrillation
This study tests a new catheter and generator system to treat persistent atrial fibrillation (an irregular heartbeat that lasts more than a week). It may help people whose symptoms haven't been controlled by medication and who need a procedure called ablation to fix the heart's electrical signals.
AalstAges 18–75 - NCT07400042Recruiting
Peripheral vein pressure test for heart failure patients
This study tests if measuring pressure from a vein in the arm can help guide treatment for people hospitalized with worsening heart failure. It aims to understand if this simple procedure could replace or reduce the need for more invasive monitoring.
Milwaukee, WisconsinAges 18 years+ - NCT06904066RecruitingPhase 1
Custom T cells for blood cancers with specific mutations
This trial tests a personalized treatment where your immune cells are collected, modified to recognize unique cancer markers (neoantigens) from TP53 or RAS mutations, and returned to fight blood cancers like AML, MDS, or multiple myeloma.
Bethesda, MarylandAges 18–120 - NCT07405164RecruitingPhase 3
Long-term extension study for people taking belzutifan
This study is for people who are already taking belzutifan in a related trial (LITESPARK-043) and want to continue treatment for advanced solid tumors or von Hippel-Lindau-related conditions. It tests the safety and effects of long-term use.
Boston, MassachusettsAges 18 years+ - NCT06714097Recruiting
Digital twin technology for stroke and related conditions
This trial tests a digital twin system to help prevent a second stroke or brain bleed in people with stroke, Moyamoya disease, or cerebral amyloid angiopathy. The system uses your medical data to create a virtual copy of you, which doctors can use to plan your care.
Milan, MichiganAges 18 years+ - NCT07569640RecruitingPhase 3
Heart failure combination pill study
This study tests a single pill that combines several heart failure medicines to see if it helps people with a weakened heart pump feel better and stay out of the hospital. It is being done in Sri Lanka and may offer a simpler way to take multiple medications.
Kandy, Central ProvinceAges 18 years+ - NCT07258511RecruitingPhase 3
Comparing a new drug to Teclistamab for advanced multiple myeloma
This study tests a new experimental drug (JNJ-79635322) compared to another targeted immunotherapy (Teclistamab) for people with multiple myeloma that has returned or not responded after several prior treatments.
Phoenix, ArizonaAges 18 years+ - NCT06940752Enrolling by invitation
A new way to treat stubborn heart rhythm problems
This study tests a special navigation technique to improve the success of repeat catheter ablation for ventricular arrhythmias, helping patients who haven't been helped by prior procedures or medications.
Atlanta, GeorgiaAges 21–100
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,968 recruiting cardiology studies from the U.S. registry right now, out of 15,149 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Mental health
- Digestive system
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- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
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- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.