Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,968 recruiting studies in this area right now.
By phase
- Not applicable7,950
- Phase 2484
- Phase 4479
- Phase 3447
- Phase 1361
- Phase 1/Phase 2161
- Phase 2/Phase 386
Top conditions
- Stroke839
- Heart Failure566
- Hypertension399
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma334
- Atrial Fibrillation269
- Ischemic Stroke201
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke137
- Myocardial Infarction102
- Pulmonary Hypertension100
- Congenital Heart Disease85
- Stroke, Ischemic85
- Acute Coronary Syndrome82
- Peripheral Arterial Disease82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris92
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama196
- Massachusetts183
- Arizona174
- New York161
- Florida145
- Maryland120
- Illinois119
- Minnesota119
- Texas118
Recruiting studies9,965 total
- NCT06600191Recruiting
New mitral valve study for leak repair
This trial tests a new device called the Capstan system to fix a leaky mitral valve (mitral regurgitation) without open-heart surgery. It may help people whose valve leak is moderate to severe and still have symptoms despite medicines.
MelbourneAges 18 years+ - NCT07518186RecruitingPhase 3
Comparing Two New Myeloma Treatments: JNJ-79635322 vs Teclistamab
This study compares two new antibody-based drugs (JNJ-79635322 and teclistamab) to see which works better for multiple myeloma that has come back or stopped responding to prior treatment. Both drugs are designed to help your immune system fight myeloma cells.
Birmingham, AlabamaAges 18 years+ - NCT05879757RecruitingTeam says not enrolling
Real-world HyQvia use for adults with myeloma and weak immunity
This study looks at how HyQvia (an immune-boosting medicine given under the skin) is used in real life for adults with multiple myeloma and secondary immune problems. It may help doctors understand what works best and how patients do when HyQvia is used routinely.
CórdobaAges 18 years+ - NCT05301140RecruitingTeam says not enrolling
Registry study for paired VNS after stroke
This study follows people who already have the Vivistim device implanted after an ischemic stroke affecting arm or hand function. It may help researchers better understand how paired nerve stimulation therapy works in real-world care.
Orlando, FloridaAges 22 years+ - NCT05183152RecruitingTeam says not enrolling
Non-invasive brain signal control for assistive devices
This study tests an assistive device that you control using signals from the brain and muscles without surgery. It may help people with movement problems communicate or operate devices using gentle, non-invasive sensing.
Austin, TexasAges 18–80 - NCT07789535Recruiting
Sleep study for people with high blood pressure and poor sleep
This study looks at how improving sleep might affect blood vessel health in people with high blood pressure who don't sleep well. You might join if you have high blood pressure and poor sleep quality.
Guimarães, Braga DistrictAges 18–70 - NCT06959524Recruiting
Drug-coated balloon for new coronary blockages
This trial is testing a special balloon coated with medication to treat newly formed blockages in the heart's arteries. The medication may help keep the artery open after the balloon opens it during a standard procedure.
Jonesboro, ArkansasAges 18 years+ - NCT07220005Recruiting
Ultrasound brain stimulation for arm weakness after stroke
This study tests a new non-invasive therapy using low-intensity focused ultrasound to stimulate the brain area affected by a stroke, which may help improve arm weakness in people who have had a stroke more than 6 months ago.
Durham, North CarolinaAges 21 years+ - NCT07791017Recruiting
Ultrasound for detecting baker's cysts in suspected deep vein thrombosis
This study tests whether a focused ultrasound of the back of the knee can accurately detect Baker's cysts (a benign fluid-filled sac) in people who have symptoms that might suggest a blood clot. It aims to improve diagnosis and avoid unnecessary treatments.
AarhusAges 18 years+ - NCT07791069Enrolling by invitation
Study of a device to manage blood flow in the lungs for heart disease in young children
This study looks at how well a new device works to control blood flow to the lungs in children with heart problems. It reviews medical records of children who had this device placed in their lung arteries.
Le Plessis-RobinsonAges Up to 3 years - NCT06335082Enrolling by invitation
Study of Farapulse ablation for atrial fibrillation
This registry is collecting information to see how well the Farapulse PFA system works and how safe it is for treating atrial fibrillation (AF), a common heart rhythm problem. If you are scheduled to have an ablation for AF with this system, this study will follow your progress.
Birmingham, AlabamaAges 18 years+ - NCT07592273RecruitingPhase 2/Phase 3
Gene therapy for diabetic eye disease without macular swelling
This trial tests a gene therapy injection into the eye to treat diabetic retinopathy (eye damage from diabetes) before it progresses. The goal is to slow or prevent vision loss and potentially delay the need for laser treatment or other injections.
Phoenix, ArizonaAges 18 years+ - NCT07681596RecruitingPhase 1/Phase 2
Study of a new drug for relapsed or refractory multiple myeloma
This trial tests an experimental drug for multiple myeloma that has come back or not responded to at least three previous treatments. It aims to see if the drug can help people whose cancer has progressed despite prior therapies including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody.
Duarte, CaliforniaAges 18 years+ - NCT06843356Recruiting
Endovascular treatment for worsening mild stroke with basilar artery blockage
This trial tests a procedure to open a blocked artery in the back of the brain (basilar artery) for people who had a mild stroke that later got worse. If you are eligible, you may receive this treatment up to 24 hours after your symptoms worsen.
Wuhu, AnhuiAges 18 years+ - NCT07671677Recruiting
BodyGuardian monitoring after AF ablation
This study tests using a portable heart monitor called BodyGuardian to check for atrial fibrillation returning after a procedure called ablation. It may help your doctor find irregular heartbeats early.
Delray Beach, FloridaAges 18 years+ - NCT07560956Enrolling by invitation
Quality of Life in Adults With Untreated Fabry Disease
This study looks at how Fabry disease affects daily life in adults who haven't started treatment yet. Researchers want to understand your experiences and challenges to improve care for people with this rare genetic condition.
GothenburgAges 18 years+ - NCT07785492Recruiting
AI-assisted care for acute ischemic stroke
This trial tests whether an artificial intelligence system can help doctors make better treatment decisions for people who have had an acute ischemic stroke within the last 24 hours. The goal is to see if this AI support improves outcomes compared to standard care.
Changsha, HunanAges 18 years+ - NCT07585968Recruiting
New Catheter Treatment for Dangerous Heart Rhythms
This trial tests a new catheter-based procedure to treat life-threatening irregular heartbeats (ventricular tachycardia) that keep coming back despite medication. If you've had a heart attack and your implanted defibrillator hasn't fully controlled these arrhythmias, this procedure might help prevent future episodes.
Columbus, OhioAges 18–85 - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Fairhope, AlabamaAges 40–85 - NCT06321575Recruiting
New device for clearing leg artery blockages
This trial tests a new device called the Golazo® Atherectomy System that removes plaque from leg arteries to improve blood flow. It may help people with leg pain when walking or small wounds caused by blocked arteries.
Scottsdale, ArizonaAges 18 years+ - NCT02089607Recruiting
Fenestrated or branched stent for large aortic tears or bulges
This study tests a special type of stent-graft (a tube with branch openings) to treat large or rapidly growing aneurysms and certain aortic dissections in the chest/abdomen or aortic arch. It aims to prevent the aneurysm from rupturing and to safely restore blood flow to key branch arteries.
Rochester, MinnesotaAges 18 years+ - NCT07242391Recruiting
Menopausal hormone therapy and heart function study
This study looks at how menopausal hormone therapy might affect the heart's pumping ability. It may help women who are naturally entering menopause understand if hormone therapy can protect their heart health.
Rochester, MinnesotaAges 45–60 - NCT06782230Recruiting
A biobank for rare disease samples and data
This study creates a collection of biological samples and health information from people with rare diseases and their family members. It aims to build a shared resource that can help future research on rare conditions.
San Donato Milanese, MilanAges Any age - NCT07691502Recruiting
Using CT scans before angioplasty to plan treatment
This trial tests if using a special heart CT scan (CCTA with FFRCT) before a planned angioplasty can help doctors better plan where to place stents. You may be eligible if you have a narrowing in one or two heart arteries that haven't been treated before.
Minneapolis, MinnesotaAges 22 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,968 recruiting cardiology studies from the U.S. registry right now, out of 15,149 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.