Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,981 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2482
- Phase 4481
- Phase 3449
- Phase 1361
- Phase 1/Phase 2164
- Phase 2/Phase 387
Top conditions
- Stroke841
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke201
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke138
- Myocardial Infarction100
- Pulmonary Hypertension100
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas117
Recruiting studies9,978 total
- NCT06552052Recruiting
Natural history study of genetic blood vessel disease
This study tracks the health of people with a confirmed ACTA2 gene change over time to better understand the disease. It may help researchers learn how to improve care for this condition.
Boston, MassachusettsAges 4 weeks+ - NCT06550479Recruiting
Comparing three types of arm fistulas for dialysis
This trial compares three types of surgical connections (fistulas) between an artery and a vein in the arm, used for dialysis. It looks at which type works best for people with advanced kidney disease who need a new access point for dialysis.
WroclawAges 18 years+ - NCT06544915Recruiting
Synbiotic vs. probiotic for heart and gut health
This study tests whether a synbiotic (a combination of probiotics and prebiotics) is better than a probiotic alone or a placebo for improving gut health and heart health. If you are a healthy adult who hasn't taken antibiotics recently and has few heart disease risk factors, you may be able to join.
Saratoga Springs, New YorkAges 18–60 - NCT06309550Recruiting
Testing for heart failure with preserved ejection fraction
This trial uses special tests to see if you have a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It's for people who feel short of breath but haven't been diagnosed with this condition yet.
MilanAges Any age - NCT06539208RecruitingPhase 1/Phase 2
Study of YOLT-201 for transthyretin amyloidosis with nerve or heart damage
This trial tests an experimental gene-editing medicine called YOLT-201 for people with a type of amyloidosis that damages nerves or the heart. It aims to see if one or two doses can safely stop the disease from getting worse.
Beijing, Beijing MunicipalityAges 18–80 - NCT05997693RecruitingPhase 3
One month of blood thinners after heart bypass surgery
This trial tests whether taking just one month of two blood thinners after coronary artery bypass graft (CABG) surgery is safe and as effective as the standard longer course. It focuses on people having their first bypass surgery who receive at least one vein graft from the leg.
Englewood, New JerseyAges 18 years+ - NCT06533787Recruiting
Heart ultrasound in sick newborns in the NICU
This study tests how using a heart ultrasound (echocardiography) can help doctors better manage care for very sick newborns in the NICU. It may help guide treatment for babies who are unstable, regardless of their weight or how early they were born.
SohagAges 2 hours–4 weeks - NCT06529055Enrolling by invitation
Caffeine and nicotine pouch effects on exercise and brain function
This trial tests how caffeine and nicotine pouches affect your body during exercise, including heart function, thinking, and behavior. It looks at short bursts of high-intensity activity in healthy men who already exercise regularly.
Hattiesburg, MississippiAges 21–40 - NCT07053618Recruiting
Heart pump support for high-risk heart procedures
This trial tests a temporary heart pump to support patients with weak hearts (ejection fraction 35% or less) who need a high-risk stent procedure instead of bypass surgery. The pump may help keep blood flowing during the procedure.
Beijing, Beijing MunicipalityAges 18–90 - NCT06521047Recruiting
Long-term follow-up for EXCELLENT trial participants
This study looks at the long-term health of people who took part in the EXCELLENT trial. If you finished that trial within the last 10 years, you may be able to join this study to help researchers understand how participants are doing over time.
Mulhouse, FranceAges 18 years+ - NCT06520891Recruiting
Statin with SGLT2i for ischemic heart disease
This study tests if taking a statin along with an SGLT2 inhibitor (a diabetes drug that also helps the heart) works better for people with heart disease caused by blocked arteries. The goal is to improve heart function with this combination therapy.
Al Fayyum, Faiyum GovernorateAges 50–80 - NCT06980688Recruiting
Propofol dosing for safer blood pressure during surgery
This trial tests a new way of giving the anesthetic propofol to keep your blood pressure more stable during surgery. It may help reduce side effects like dizziness or fainting after the procedure.
BadenAges 55 years+ - NCT06517537Recruiting
Modified aortic root enlargement for small aortic valves
This trial tests a modified surgical technique for replacing a narrowed aortic valve in people whose valve opening is unusually small. The goal is to help the new valve fit better and work well.
Beijing, Beijing MunicipalityAges 50–70 - NCT06512571Recruiting
Heart changes in Fabry disease: an observational study
This study looks at people with Fabry disease, a genetic condition that can cause the heart muscle to thicken. Researchers want to understand how the heart's blood vessels change over time, which may help improve care for Fabry disease.
BeijingAges 18 years+ - NCT06515795Recruiting
Simple exercises to lower blood pressure in resistant hypertension
This study tests two simple, low-effort exercises (like squeezing a ball or holding a gentle pose) to see if they can help lower blood pressure for people whose high blood pressure doesn’t respond well to medication. The goal is to offer a safe, easy way to improve heart health.
AveiroAges 40–75 - NCT07495813RecruitingPhase 1
Study of RO7763505 in healthy people and stable heart disease
This study tests an experimental drug (RO7763505) in healthy people and people with stable heart disease. It aims to see how safe the drug is and how it works in the body.
GroningenAges 18–75 - NCT06506422RecruitingPhase 2/Phase 3
How empagliflozin may help aging arteries
This study tests if a diabetes medication, empagliflozin, can reduce age-related stiffening of arteries in people without diabetes. If you are between 60 and 80 and have stiff arteries, this trial could help improve your vascular health.
Columbia, MissouriAges 60–80 - NCT06503341Recruiting
Preventive cardiology patient registry
This study is a registry that collects information from people who visit preventive cardiology clinics. It helps doctors learn more about heart disease prevention and how to better care for patients.
Karachi, SindhAges 18–90 - NCT06905405Recruiting
Imaging for early heart failure with stiff heart muscle (HFpEF)
This study uses advanced imaging to find early signs of a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may help if you have shortness of breath and a slightly enlarged heart chamber but don't yet have a clear heart failure diagnosis.
Sheffield, South YorkshireAges 18 years+ - NCT02898181Recruiting
Ear cartilage stimulation for sudden heart failure worsening
This trial tests whether a gentle stimulation near your ear (on the tragus, a small ear area) can help people whose heart failure has recently gotten worse while in the hospital. If it works, it may improve symptoms and recovery during this acute phase.
Oklahoma City, OklahomaAges 18–80 - NCT07206472Recruiting
Study of bempedoic acid for high cholesterol
This study observes patients with high cholesterol or mixed lipid disorders who are taking bempedoic acid, alone or with ezetimibe, to see how it works in real life. It aims to gather information that may help doctors better manage cholesterol.
Belo HorizonteAges 18 years+ - NCT06258447Recruiting
CardiAMP bone marrow cell therapy for heart failure
This trial tests a new treatment using your own bone marrow cells to help your heart pump better. It's for people with heart failure after a heart attack whose heart function is moderately reduced.
Clearwater, FloridaAges 21–90 - NCT06107907Recruiting
Oxygen flow and pressure in heart failure patients
This study tests a new way to measure pressure in your lungs while you receive high-flow oxygen therapy. It may help doctors better understand how to use this treatment in people with heart failure who need extra breathing support.
TaipeiAges 18 years+ - NCT06492746Recruiting
Blood pressure monitoring during heart surgery
This trial tests a new method to monitor blood pressure during heart surgery that uses a heart-lung machine. It is for people at higher risk for stroke or other brain blood vessel issues.
Evanston, IllinoisAges 45 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,981 recruiting cardiology studies from the U.S. registry right now, out of 15,236 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.