Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,982 recruiting studies in this area right now.
By phase
- Not applicable7,962
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke844
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California465
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas118
Recruiting studies9,979 total
- NCT07321899Recruiting
Study of a new tricuspid valve replacement device for severe leakage
This trial tests a new device called the Medtronic Intrepid TTVR system to replace the tricuspid valve in people with severe tricuspid regurgitation (leaky valve). It aims to see if the device can safely and effectively fix the leak and improve symptoms.
Phoenix, ArizonaAges 18 years+ - NCT07067658Recruiting
Monitoring leg swelling in heart failure to reduce hospital stays
This trial tests a new home monitoring device for people with heart failure and leg swelling. The device helps track fluid changes early, so you may be able to avoid hospital stays.
Aylesbury, BuckinghamshireAges 18 years+ - NCT07482943RecruitingPhase 4
Dapagliflozin for heart function after Fontan procedure
This trial tests whether dapagliflozin, a diabetes drug that also helps the heart, can improve exercise ability and heart function in people who have had the Fontan procedure for a single ventricle heart defect.
Hong KongAges 12 years+ - NCT07168161RecruitingPhase 3
BDB-001 for ANCA vasculitis (GPA/MPA) trial
This trial tests a new drug called BDB-001 for people with a type of blood vessel inflammation (ANCA vasculitis, specifically GPA or MPA). It aims to see if adding BDB-001 to standard treatment can help control the disease better.
Beijing, Beijing MunicipalityAges 18–75 - NCT07701369Recruiting
AI-assisted heart ultrasound for older adults with heart failure
This trial tests whether artificial intelligence can help interpret heart ultrasounds in older patients with acute heart failure. It aims to make echocardiograms more accurate and easier to obtain in geriatric care.
ParisAges 75 years+ - NCT07728643Recruiting
Blood vessel particles in children with new high blood pressure
This study looks at tiny particles in the blood (called extracellular vesicles) that may signal early blood vessel changes in children with new high blood pressure. If your child is between 6 and 17, has just been diagnosed with high blood pressure and hasn't started treatment, and is otherwise healthy, this trial may help doctors better understand how high blood pressure affects kids.
OsijekAges 6–17 - NCT07722637Recruiting
Cardiac rehab's effect on cell health in heart disease
This study looks at whether a heart rehab program can affect a type of cell damage (ferroptosis) in people who recently had heart artery disease. It could help show why rehab is good for recovery.
Kayseri, KayseriAges 18–75 - NCT07728630Recruiting
Blood Vessel Health in Newly Diagnosed Hypertension
This study looks at tiny particles from blood vessel cells to understand early changes in people with newly diagnosed high blood pressure. It compares people with normal blood pressure and those with high blood pressure who have never been treated.
OsijekAges 18 years+ - NCT06081348RecruitingPhase 2
Sertraline vs. placebo for anxiety in kids with developmental disorders
This trial compares sertraline (a common antidepressant) to a placebo (a pill with no medicine) to see which better reduces anxiety in children and teens who also have a neurodevelopmental disorder like autism, ADHD, or Tourette's. The goal is to help you and your child understand if this treatment might offer relief from anxiety.
Calgary, AlbertaAges 8–17 - NCT07728656Recruiting
Trial on blood vessel markers in pregnancy with high blood pressure
This study looks at tiny particles released from blood vessels in pregnant women with high blood pressure. The goal is to find better ways to detect and manage conditions like preeclampsia.
OsijekAges 18 years+ - NCT07729449Recruiting
Predicting headache after cesarean using ultrasound and oxygen monitoring
This trial measures how well two monitoring tools (optic nerve ultrasound and brain oxygen levels) can predict headache after a planned cesarean. It may help find better ways to prevent post-dural puncture headache.
Ordu, AltinorduAges 18–40 - NCT07728539Recruiting
Comparing a faster ablation method for atrial fibrillation
This study compares a newer, faster type of ablation (high-power short-duration) with the standard approach for treating atrial fibrillation. The goal is to see which method is safer and more effective at restoring a normal heart rhythm.
MoscowAges 18–70 - NCT07107022Recruiting
Study of Penumbra System for acute ischemic stroke
This study is collecting information on how well the Penumbra System works and how safe it is when used to remove blood clots in people having a certain type of stroke. It is for patients who are eligible for mechanical thrombectomy (a procedure to remove the clot) using this device as the first treatment.
Nedlands, Western AustraliaAges 18–80 - NCT06999122Recruiting
Testing a new helmet-style brain scanner for stroke bleeding
This trial tests a new type of brain scanner (similar to a helmet) that looks for bleeding in the brain without radiation. It is for people who have had stroke-like symptoms in the last 24 hours and have not yet received treatment.
Los Angeles, CaliforniaAges 22 years+ - NCT05611307Recruiting
Heart Health in Testicular Cancer Survivors
This study looks at heart health in men who have survived testicular cancer. It compares those who had different treatments (surgery, chemotherapy, or chemotherapy plus a stem cell transplant) to see if there are hidden signs of heart or blood vessel problems.
Indianapolis, IndianaAges 18–99 - NCT06657976RecruitingPhase 2
Beetroot juice and exercise for PAD
This study tests whether beetroot juice, which contains natural nitrates that help blood vessels relax, combined with exercise, can improve walking ability in people with peripheral artery disease (PAD). You might be able to join if you have PAD, can walk without a walker, and are willing to avoid beet products for a while.
Chicago, IllinoisAges 50 years+ - NCT07089121RecruitingPhase 1/Phase 2
Descartes-08 for young people with autoimmune diseases
This trial tests a new therapy called Descartes-08 for children, teens, and young adults with autoimmune conditions like lupus, myasthenia gravis, or dermatomyositis. It aims to see if it can help control moderate disease that hasn't responded well enough to other treatments.
Washington D.C., District of ColumbiaAges 12 years+ - NCT06773780Recruiting
Comparing two pain blocks for TAVI heart valve replacement
This study compares two types of ultrasound-guided nerve blocks (pain shots) given before a TAVI procedure to see which one provides better pain relief after surgery. If you are scheduled for a TAVI and meet the health criteria, you may be able to participate.
IstanbulAges 18–85 - NCT06849076Recruiting
Ankle joint motion and body awareness after stroke
This study tests if a hands-on ankle treatment can improve your sense of where your ankle is in space (proprioception) after a stroke. It looks at how well you can feel and control your ankle movement.
Bolu, MerkezAges 45–75 - NCT07078383Recruiting
Study of the Rapidlink device for aorta repair
This trial tests a device called Rapidlink that helps repair blood vessels branching off the aorta during open heart surgery. It may be an option if you need open surgery to fix your thoracic aorta.
Los Angeles, CaliforniaAges 18 years+ - NCT07473700RecruitingPhase 2
Study of TX000045 for lung scarring and high blood pressure in the lungs
This trial tests a new medicine called TX000045 for people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs (pulmonary hypertension). It aims to see if the drug can help improve breathing and daily function.
Phoenix, ArizonaAges 18–80 - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT07551141Recruiting
Vibration to Help Stroke Recovery: Balance and Walking
This study tests whether vibrations applied to the bottom of your feet can help improve walking and balance after stroke. You'll receive plantar vibration therapy (gentle vibrations under your feet) while performing walking and balance exercises to see if it helps your recovery.
Bolu, MerkezAges 18–75 - NCT06453187Enrolling by invitation
Testing wound dressings for diabetic and vein ulcers
This study tests whether special wound dressings (called CAMPs) can help heal diabetic foot ulcers and venous leg ulcers faster. If you have a hard-to-heal sore on your foot or leg, this trial may be an option.
Los Angeles, CaliforniaAges 18–80
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,982 recruiting cardiology studies from the U.S. registry right now, out of 15,268 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.