Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT07202416Recruiting
Pain relief after c-section: nerve block vs spinal morphine
This study compares two ways to manage pain after a planned cesarean section: a nerve block near the spine (ESPB) versus morphine injected into the spinal fluid. The goal is to find which method helps mothers recover more comfortably.
Cesena, ForlìAges 18–45 - NCT07203859Recruiting
Nerve block for pain after kidney stone surgery
This study tests a nerve block (called Quadro Iliac Plane Block) given during kidney stone surgery to see if it helps control pain after the procedure. If you are having this type of surgery and are generally healthy, you may be able to join.
Sivas, SivasAges 18–65 - NCT07205614Recruiting
Good Pain Consultation for Endometriosis
This trial tests a new way to manage pain from endometriosis. It's a 'good pain consultation' designed to help women who have endometriosis and speak Norwegian.
Kristiansand, AgderAges 16–50 - NCT07205991Recruiting
Ways to stick with a back-pain mobile app
This trial tests strategies to help people with chronic low back pain use a mobile health app consistently. If you have ongoing back pain and participated in the NOTUS trial, this study might show you better ways to stay engaged with the app.
Sydney, New South WalesAges 18 years+ - NCT07207174Recruiting
Mindfulness vs CBT for chronic pain relief
This study compares two non-drug treatments—mindfulness training and cognitive-behavioral therapy—to see which helps adults with chronic pain better. Both aim to reduce pain and improve quality of life.
Tallahassee, FloridaAges 18 years+ - NCT07208357Recruiting
Pregabalin with toludesvenlafaxine for fibromyalgia pain
This study tests a combination of two medications (pregabalin and toludesvenlafaxine) to see if it is safe and effective for people with fibromyalgia whose pain has not improved with non-drug treatments and who have not yet tried standard medications for this condition.
BeijingAges 18 years+ - NCT07208799RecruitingPhase 2
Steroid comparison for jaw fracture recovery
This trial compares two steroid medicines (dexamethasone and methylprednisolone) to see which one better reduces swelling, pain, and other symptoms after surgery for a broken lower jaw near the chin. It could help you recover faster and with less discomfort.
Multan, Punjab ProvinceAges 18–40 - NCT07209345Recruiting
Scalp pain relief after brain surgery
This trial tests whether numbing the scalp before brain surgery can reduce pain afterward. You would receive a painkiller injection in your scalp before your surgery begins.
BeijingAges 18–64 - NCT07209566Recruiting
Muscles, nerves, and period pain in women
This study looks at how your muscles and nervous system relate to period pain. It compares women with and without painful periods to understand why some have more pain.
Azusa, CaliforniaAges 18–35 - NCT07210164Recruiting
Pre-surgery wellness program for gynecologic cancer surgery
This trial tests whether a pre-surgery wellness program (pre-habilitation) within an enhanced recovery protocol helps women recover better after surgery for endometrial, ovarian, or cervical cancer. It is designed for women who are having open abdominal surgery (laparotomy).
ThessalonikiAges 18–85 - NCT07210203Recruiting
Nerve gliding for pain, balance, and quality of life in diabetic nerve damage
This study tests whether adding nerve gliding exercises (neural mobilization) to usual care can reduce pain, improve balance, and enhance quality of life for people with diabetic peripheral neuropathy. It may help if you have mild to moderate nerve pain and are between 50 and 75 years old.
IslamabadAges 50–75 - NCT07211256Recruiting
Home brain stimulation for chronic pain
This trial tests if a gentle, home-use electrical brain stimulation device (tDCS) can help people with long-lasting pain that hasn't responded well to other treatments. If you have had pain for at least 6 months and a previous brain stimulation helped only briefly, this study may offer a new option.
Boulogne-Billancourt, Hauts de SeineAges 18–80 - NCT07212829Recruiting
Brain stimulation during exercise for chronic pain
This trial tests whether adding gentle brain stimulation (tDCS) to exercise can help people with chronic widespread pain (like fibromyalgia). It aims to see if this combination reduces pain better than exercise alone.
JetteAges 18–70 - NCT07214844Recruiting
Freezing vs. heating nerves for chronic low back pain
This study compares two procedures to treat long-term low back pain from the small joints in your spine. One uses extreme cold, the other uses heat to stop pain signals. It may help if you have had at least three months of back pain and other treatments haven't worked.
The Bronx, New YorkAges 18 years+ - NCT07217821Recruiting
Music and imagery for chronic pain
This study tests a step-by-step approach using music and guided imagery to help people with long-term muscle or joint pain. It's done from home using a device, so you don't need to travel.
Indianapolis, IndianaAges 18 years+ - NCT07218289Recruiting
Green light therapy for recovery after surgery
This study tests if exposing patients to green light after laparoscopic or robotic surgery can help reduce pain and improve recovery. You may be eligible if you are staying in the hospital for at least two days after your surgery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07222072RecruitingPhase 4
Methadone to reduce opioid use after spine surgery
This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
Cleveland, OhioAges 18–72 - NCT07222696Recruiting
Health coaching for rheumatoid arthritis to improve mental wellbeing
This study tests if working with a health coach (a trained peer) can help people with rheumatoid arthritis feel better emotionally, especially if they are dealing with depression or anxiety. You would meet with a coach remotely using your phone or computer.
New York, New YorkAges 18 years+ - NCT07224945Recruiting
Emergency room physical therapy for low back pain
This study tests whether physical therapy in the emergency room can help people with new or recent low back pain. If you have back pain that started in the last month, you may be able to join.
Chicago, IllinoisAges 18 years+ - NCT07225049Recruiting
Integrated treatment for PTSD and chronic pain
This study tests a combined therapy for people who have both PTSD and chronic pain. It aims to see if treating both conditions together is more helpful than treating them separately.
New York, New YorkAges 18 years+ - NCT07226076RecruitingPhase 3
Methadone for knee replacement pain and less opioids
This trial tests if adding methadone during knee replacement surgery can better control pain after the operation and reduce the need for opioid painkillers. It may help you recover with less discomfort and fewer side effects from strong pain medicines.
Charleston, South CarolinaAges 18–75 - NCT07226700RecruitingPhase 3
Suzetrigine for pain after hip replacement surgery
This study tests an investigational pain medicine called suzetrigine to see how well it controls pain after total hip replacement surgery. It is for adults 18–80 who are having a first-time hip replacement and can receive spinal anesthesia.
New York, New YorkAges 18–80 - NCT07227064RecruitingPhase 3
Methadone for pain relief after hip replacement surgery
This study tests whether a single dose of methadone given during hip replacement surgery can better control pain and reduce the need for other opioid painkillers afterward. It may help you recover with less pain and fewer side effects.
Charleston, South CarolinaAges 18–75 - NCT07228377Recruiting
Virtual reality for cancer pain and opioid use
This study tests if using virtual reality can help manage chronic cancer pain and reduce the amount of opioid pain medicine needed. You would use a VR headset at home and report how you feel.
Washington D.C., District of ColumbiaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.