Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT06473597RecruitingPhase 4
Comparing Nurtec and Maxalt for migraine in the ER
This trial tests two fast-dissolving migraine medicines, Nurtec ODT and Maxalt MLT-ODT, in adults coming to the emergency room with a migraine. The goal is to see which one works better and faster for pain relief.
Brooklyn, New YorkAges 18–65 - NCT06470503Enrolling by invitation
Exercise after radiation for bone metastases
This study tests whether a supervised exercise program helps people with cancer that spread to their bones feel stronger and move better after radiation treatment. It is designed for people who can walk independently and have stable bones.
Toronto, OntarioAges 18 years+ - NCT06442514Recruiting
Pain and Smoking Study: Phone Support for Veterans
This study tests a phone-based program to help Veterans with chronic pain quit smoking. If you're a VA patient who uses tobacco and has ongoing pain, you may be able to join and get support from home.
West Haven, ConnecticutAges 18 years+ - NCT06450444Recruiting
Neuromodulation implant for chronic or frequent migraine
This trial tests a new implantable device that uses mild electrical pulses to prevent migraines. It is for people who have tried at least three migraine prevention medicines without success and still have frequent migraines.
Broadmeadow, New South WalesAges 18–84 - NCT06443164Enrolling by invitation
Chronic Pain Treatment Before Gender-Affirming Surgery
This study tests a one-session pain management class called Empowered Relief for people with chronic pain who are planning gender-affirming surgery. The goal is to see if learning these skills before surgery helps with pain afterward.
Portland, OregonAges 18–100 - NCT06453447Recruiting
Prednisone to prevent CRPS after wrist fracture surgery
This trial tests whether a short course of the steroid prednisone can prevent or reduce complex regional pain syndrome (CRPS) after wrist surgery. It is for people who had a broken wrist fixed with a plate and screws and have a higher chance of developing CRPS.
Vancouver, British ColumbiaAges 19 years+ - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT06452407Recruiting
App for managing endometriosis symptoms and treatment
This trial tests a new app called elleFA to help track endometriosis symptoms and treatment. If you are being treated for endometriosis at the McGill University Health Centre, the app may make it easier to manage your care from home.
Montreal, QuebecAges 18 years+ - NCT06446596Recruiting
Phone-based exercise coach vs. standard home exercises for low back pain
This study compares doing exercises at home with a video coach on your phone versus doing standard exercises you get from a doctor. The goal is to see if the video program helps people with low back pain more than regular home exercises.
Valencia, Select OneAges 18–65 - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT06443281Recruiting
Understanding pain after spinal cord injury or nerve damage
This study is looking at how people with spinal cord injuries or peripheral neuropathy (nerve damage outside the spine) experience pain. The goal is to better understand the different types of pain, which could help doctors create more personalized treatments in the future.
Zurich, Canton of ZurichAges 18–80 - NCT06454669RecruitingPhase 2
Dronabinol added to opioids for chronic low back pain
This trial tests whether adding dronabinol (a prescription medication derived from cannabis) to your current opioid pain treatment can help reduce chronic low back pain more effectively. It is for people who have had persistent low back pain for at least 3 months and are already on a stable opioid regimen.
Houston, TexasAges 18–64 - NCT05865327Recruiting
Nerve freezing for rib-fracture pain using ultrasound guidance
This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.
Toronto, OntarioAges 18–100 - NCT05677412Recruiting
Studying sleep, stress, and pain in teens with ongoing pain
This study looks at how sleep and stress relate to pain that keeps coming back in teens. It may help researchers understand what could improve comfort and daily functioning when pain lasts more than three months.
HelsinkiAges 15–17 - NCT04893954Recruiting
Study of spine changes after weight loss from bariatric surgery
This study looks at how rapid weight loss after bariatric surgery may affect your spine over the following year or more. It may help doctors better predict who gets spine-related problems or improvements after surgery.
ParisAges 18 years+ - NCT06427356Recruiting
Team care for veterans with chronic pain at Salem VA
This study tests a team-based approach to help veterans with long-lasting pain. It looks at whether working with a group of specialists (like doctors, nurses, and mental health providers) can improve pain and daily life. It is for veterans already receiving care at the Salem VA who are part of the PREVAIL program.
Salem, VirginiaAges 18 years+ - NCT06368492Recruiting
Psilocybin for fibromyalgia pain
This trial tests whether psilocybin, a substance found in certain mushrooms, can help reduce pain in people with fibromyalgia. You would receive the drug and be monitored closely to see if it improves your pain levels.
Maastricht, LimburgAges 18–65 - NCT06381921Recruiting
IBS pain measurement study
This study tests a new way to measure belly pain in people with IBS using special sensors. It may help doctors better understand and treat your pain.
Storrs, ConnecticutAges 18–50 - NCT06424041Enrolling by invitationPhase 2
Fecal transplant for fibromyalgia pain relief
This study tests whether transferring healthy gut bacteria from a donor can reduce pain in women with fibromyalgia. You would first take antibiotics and laxatives to prepare your gut, then receive the transplant through a colonoscopy.
Haifa, NorthAges 18–75 - NCT06432452Enrolling by invitationPhase 2/Phase 3
Testing a new drug for coronary artery spasm
This trial tests a drug that blocks certain receptors to see if it reduces chest pain caused by coronary artery spasm. If you have frequent angina despite current treatments, this study may offer a new option.
Eindhoven, North BrabantAges 18 years+ - NCT06426316Recruiting
Immune cells and migraines study
This study looks at how certain immune cells and inflammatory chemicals relate to migraines. If you have migraines or an autoimmune condition (like lupus, rheumatoid arthritis, or Crohn's disease), you may be able to participate. The goal is to understand what causes migraines.
Clermont-Ferrand, AURAAges 18–50 - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT06434233RecruitingPhase 4
Opioid use after fallopian tube removal surgery
This study looks at how much opioid pain medicine people need after having their fallopian tubes removed through small incisions (laparoscopic or robotic salpingectomy). It aims to see if the usual pain medicine can be reduced to decrease opioid use.
Baltimore, MarylandAges 18 years+ - NCT06425016Recruiting
Robot-assisted vs. traditional sleeve gastrectomy
This study compares two types of weight-loss surgery: one done with the help of a robot and the other done by hand (laparoscopic). Both are types of sleeve gastrectomy, where the stomach is reduced in size. If you qualify for sleeve gastrectomy, this trial may help doctors learn which method works better.
Cleveland, OhioAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.