Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT06426316Recruiting
Immune cells and migraines study
This study looks at how certain immune cells and inflammatory chemicals relate to migraines. If you have migraines or an autoimmune condition (like lupus, rheumatoid arthritis, or Crohn's disease), you may be able to participate. The goal is to understand what causes migraines.
Clermont-Ferrand, AURAAges 18–50 - NCT06438471RecruitingPhase 1
Study of a new drug for nerve pain after spinal cord injury
This trial tests an experimental pill for people with spinal cord injury who have long-term nerve pain. It aims to see if the drug can reduce pain and be safe.
Augusta, GeorgiaAges 18 years+ - NCT06423300Recruiting
Testing a new implant for kneecap cartilage damage
This trial tests a new implant called the Patellar LIFT System to treat pain caused by cartilage damage behind the kneecap. It is for people who have tried other treatments like physical therapy but still have significant knee pain.
La Mesa, CaliforniaAges 22–65 - NCT06359652Recruiting
Get Fit for Function: Exercise before lung surgery
This study tests a program to help you get stronger before lung surgery. It may improve your recovery after the operation.
Chicago, IllinoisAges 18 years+ - NCT06419439RecruitingPhase 2
Ketamine for Veterans with Chronic Back Pain and Depression
This study tests whether ketamine, combined with talk therapy, can help veterans with both chronic low back pain and depression. The goal is to reduce pain and improve mood.
Ann Arbor, MichiganAges 18 years+ - NCT06415591Recruiting
Nerve stimulation for fibromyalgia in veterans
This trial tests whether a mild ear nerve stimulation device can reduce pain for veterans with fibromyalgia. It also looks at how the brain changes with treatment using MRI scans for some participants.
Decatur, GeorgiaAges 18 years+ - NCT06414473RecruitingPhase 1/Phase 2
CBD for knee osteoarthritis pain
This study tests whether a CBD (cannabidiol) product can help reduce pain and improve daily life for people with knee osteoarthritis. If you have moderate to severe knee pain and haven't used cannabis recently, you may be able to join.
Gainesville, FloridaAges 40–75 - NCT06401317RecruitingPhase 2
Steroid vs saline injections for thumb arthritis pain
This study compares two types of injections for thumb arthritis pain: a steroid (cortisone) and salt water (saline). We want to see if the steroid provides better pain relief than the salt water.
Montreal, QuebecAges 18 years+ - NCT06411197Recruiting
Walking and muscle pain in healthy adults
This study looks at how people walk and how muscles in the legs may feel sore. It is for healthy adults to understand normal movement patterns.
Aalborg, North DenmarkAges 18–45 - NCT06409156Recruiting
Comparing two nerve blocks for upper abdominal surgery pain
This trial tests two different types of nerve blocks to see which one provides better pain relief after upper belly surgery. If you are having open surgery on your stomach, liver, pancreas, or spleen, this study may help reduce your need for strong opioids.
Cleveland, OhioAges 18 years+ - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06407115Enrolling by invitation
Pain care support for rural patients
This study tests a nurse-led program to help people living in rural areas manage chronic pain. You'll work with a care manager who can support your pain treatment goals.
Winston-Salem, North CarolinaAges 18 years+ - NCT06418958Recruiting
Heat from dental light on healthy teeth
This trial measures how much the temperature rises inside a healthy tooth when a dental curing light is used. It helps dentists understand if certain light wavelengths could be safer for teeth.
Gainesville, FloridaAges 21–35 - NCT06406010RecruitingPhase 4
Nerve block for pain after hip surgery
This trial tests whether a specific nerve block can reduce pain after a hip socket surgery. The results could help improve recovery and reduce the need for strong painkillers.
CopenhagenAges 18 years+ - NCT06409832Recruiting
Study of rimegepant for migraine prevention
This study tests a medicine called rimegepant to see if it helps prevent migraines. If you have migraine at least 4 days per month, this might be for you.
Florence, FlorenceAges 18 years+ - NCT06411054Recruiting
Acupuncture with electrical stimulation for pain during miscarriage procedure
This study tests whether adding a type of acupuncture (Acu-TENS) to standard care can reduce pain during a procedure to remove pregnancy tissue after a first-trimester miscarriage. If you are eligible, you may receive either acupuncture with a mild electrical current or a placebo device during the procedure.
Hong KongAges 18 years+ - NCT06409442Recruiting
Support and vibration for shoulder impingement
This study tests two non-invasive treatments—corrective external support (like special tape) and regional vibration—for people with subacromial impingement syndrome, a common cause of shoulder pain. It aims to see if these treatments can reduce pain and improve shoulder function.
Izmir, BalçovaAges 18 years+ - NCT06402409Recruiting
Studying multiple health conditions in spinal pain patients
This study looks at people who have neck or back pain along with other health conditions. It aims to understand how these conditions together affect your health and well-being.
AalborgAges 18 years+ - NCT06420336Recruiting
Pain relief after cleft palate surgery
This study compares two ways to manage pain after cleft palate repair surgery that uses a bone graft from the hip. The goal is to see which method provides better pain control for children and teens.
Charleston, South CarolinaAges 6–18 - NCT06420141Recruiting
Nerve pain after ankle fracture surgery
This study looks at why some people develop nerve pain (neuropathic pain) after breaking their ankle and having surgery. If you have an ankle fracture that needs surgery, you may be able to join and help researchers understand this type of pain better.
Indianapolis, IndianaAges 18–85 - NCT06404983Recruiting
Opioid-free anesthesia for breast cancer surgery
This study tests whether breast cancer surgery can be done safely without using opioid pain medicines during anesthesia. The goal is to see if avoiding opioids leads to fewer side effects and a smoother recovery.
Ioannina, EpirusAges 18–99 - NCT05766059Recruiting
Noninvasive brain stimulation to aid stroke or phantom limb pain rehab
This trial tests new, noninvasive brain stimulation techniques to help recovery after stroke weakness or after arm amputation with phantom limb pain. If you fit the type and timing of your condition, the study may help improve pain or hand/arm function without surgery.
Milan, LombardyAges 18–85 - NCT06388590Recruiting
Acupuncture for chronic pelvic pain
This trial tests whether acupuncture can help relieve long-term pelvic pain. It is for women who are part of the military community and have not had endometriosis found during a laparoscopy.
Nellis Air Force Base, NevadaAges 21–65 - NCT06384846Recruiting
AI predicts heart attacks using white blood cells
This study tests whether an artificial intelligence tool can accurately predict a heart attack (acute coronary syndrome) by looking at the properties of your white blood cells. If successful, it could help doctors diagnose heart attacks faster from a simple blood sample.
Graz, Styria / SteiermarkAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.