Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT07268495Recruiting
Lidocaine spray to reduce pain after fibroid surgery
This trial tests if spraying lidocaine (a numbing medicine) inside the belly along with lidocaine given through an IV can lower pain after surgery to remove uterine fibroids. It may help you have less pain and recover more comfortably.
Yinchuan, NingxiaAges 18–65 - NCT07269561Recruiting
Headache registry and long-term follow-up study
This trial is a registry study that tracks people with various headache disorders over time. It aims to learn more about how headaches affect patients and to improve future care.
Wuhan, HubeiAges 6–70 - NCT07269925Recruiting
How different electrical frequencies affect muscle strength and pain
This study tests whether changing the electrical frequency during a type of nerve stimulation (percutaneous neuromodulation) can improve muscle strength and reduce pain sensitivity in people with a hidden muscle knot (trigger point) in the shoulder blade area.
Krakow, PolandAges 18–65 - NCT07270406Recruiting
Healthy habits for better sleep in people with HIV and pain
This study tests a healthy behaviors program to help prevent insomnia in people with HIV who also have ongoing pain. If you have trouble sleeping and chronic pain, this program may help improve your sleep and well-being.
St Louis, MissouriAges 25–65 - NCT07270588Recruiting
MobACT: Online support for chronic pain
This trial tests an internet-based program to help people manage chronic pain. You participate from home using a computer or tablet.
BolognaAges 18 years+ - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90 - NCT07272473Recruiting
Neck therapy for dizziness and balance in Meniere's disease
This study tests if gentle neck therapy (called cervical mobilization) can help reduce dizziness, improve balance, and help your body feel its position better. If you have Meniere’s disease and ongoing dizziness or imbalance, this treatment might add to your care routine.
Afyonkarahisar, AfyonkarahisarAges 18–60 - NCT07274215Recruiting
Nerve block injection for pain and nausea after sleeve gastrectomy
This study tests a special numbing injection (called a paragastric block) to see if it reduces pain and nausea after sleeve gastrectomy surgery. If you are having this weight-loss surgery, the injection might help you feel better and recover more comfortably.
IstanbulAges 18–65 - NCT07275164Recruiting
High-intensity interval exercise for shoulder pain
This trial tests if high-intensity interval training (short bursts of intense exercise) can help people with long-term shoulder pain caused by rotator cuff problems or frozen shoulder.
WilrijkAges 18 years+ - NCT07275762RecruitingPhase 2
Y-4 for postherpes nerve pain
This trial tests a new drug called Y-4 for people with lingering nerve pain after shingles (postherpetic neuralgia). If you have had pain for more than a month after your rash healed, this study may help find a new treatment option.
Nanjing, JiangsuAges 18 years+ - NCT07276542RecruitingPhase 2/Phase 3
Ketamine for phantom limb pain: a six-month outpatient study
This study tests whether ketamine, given as an outpatient treatment, can reduce phantom limb pain over six months. You would come to a clinic for multiple ketamine sessions, with at least a week between each session, and be followed for a year.
Sacramento, CaliforniaAges 18–65 - NCT07278050Recruiting
Comparing two nerve blocks for shoulder surgery
This trial compares two types of nerve blocks (interscalene and serratus posterior superior intercostal plane block) for pain relief during shoulder surgery. If you are having arthroscopic shoulder surgery under general anesthesia, you may be able to join.
Istanbul, BagcilarAges 18–75 - NCT07280338Recruiting
Emotional intelligence and chronic face pain study
This study looks at how emotional intelligence (understanding and managing emotions) relates to chronic pain in the face or jaw. If you have temporomandibular dysfunction (TMD) or have no chronic pain, you may be able to join and help researchers learn more.
BrestAges 18 years+ - NCT07280416Recruiting
Sleep changes in first year after cancer diagnosis
This study follows people who are newly diagnosed with cancer to see how their sleep changes during the first year. It looks at whether treatments like chemo or immunotherapy affect insomnia.
Le Puy-en-VelayAges 18–80 - NCT07281651Recruiting
Understanding pain sensitivity in knee pain and fibromyalgia
This study looks at how the brain and nerves process pain in people with knee pain or fibromyalgia. It compares them to pain-free people to understand differences in muscle signals.
Derby, DerbyshireAges 40 years+ - NCT07282392Recruiting
Emotional awareness therapy for lupus and fibromyalgia pain
This study tests if a therapy called Emotional Awareness and Expression Therapy (EAET) can help people with lupus and fibromyalgia or chronic widespread pain feel better by addressing emotional factors that may worsen their pain. You would attend sessions to learn how to understand and express your emotions in healthy ways.
Salt Lake City, UtahAges 18–65 - NCT07285083Recruiting
Pain relief after abdominal surgery: comparing two numbing medicines
This study compares two numbing medicines (bupivacaine alone vs. bupivacaine plus dexmedetomidine) to see which provides better pain relief after abdominal surgery. If you are having a planned abdominal operation, this trial may help improve your recovery comfort.
Rahim Yar Khan, Punjab ProvinceAges 21–45 - NCT07287501Recruiting
Pain education and exercise for older adults with chronic pain
This trial is for older adults (65+). It combines pain science education with exercise to help manage chronic pain. You'll learn about how pain works and practice exercises designed to reduce pain and improve movement.
Salamanca, SalamancaAges 65 years+ - NCT07287709Recruiting
Laser vs. standard treatment for painful adult molars
This study tests if using a laser is better than the usual method for treating painful, inflamed teeth that still have a live nerve. The goal is to save the tooth and reduce pain without removing the nerve entirely.
AlexandriaAges 16–50 - NCT07288021RecruitingPhase 4
Topical anesthesia for balloon catheter insertion
This trial tests whether applying a numbing cream to the cervix before inserting a balloon catheter makes the procedure less painful for women being induced into labor. If you are scheduled for labor induction with a balloon, this study may help reduce your discomfort.
HaifaAges 18 years+ - NCT07289893Recruiting
Kettlebell training for shoulder pain in athletes
This trial tests whether kettlebell training can help people with long-lasting shoulder pain caused by rotator cuff tendon problems or small tears. You would do kettlebell exercises and see if your pain and strength improve.
AnkaraAges 18–35 - NCT07290205RecruitingEarly Phase 1
Remimazolam brain imaging study
This study uses brain scans to see how a new sedative called remimazolam affects the brain in healthy adults. It will help researchers understand the drug's effects and ensure it's safe.
Pittsburgh, PennsylvaniaAges 18–59 - NCT07290361Recruiting
Physical therapy for spine pain in primary care
This trial tests a program that connects people with spine pain (neck or back pain) from their primary care clinic to a physical therapist. The goal is to see if this approach helps patients get more timely and effective care.
San Diego, CaliforniaAges 18 years+ - NCT07290660Recruiting
Motor imagery and exercise for shoulder pain
This study tests whether combining mental movement training with targeted exercises can reduce shoulder pain caused by impingement syndrome. It aims to improve your shoulder function without surgery.
IstanbulAges 25–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.