Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT06459635Recruiting
Migraine attack prediction study using smartphone tracking
This study uses a smartphone app or device to track your body signals and predict when a migraine attack is about to start. It is designed for people with frequent (10–14 days per month) migraines.
Madrid, MadridAges 18–65 - NCT06459648Recruiting
Can anti-CGRP antibodies prevent chronic migraine?
This study tests a new treatment (anti-CGRP antibodies) to prevent migraine attacks from becoming chronic. It looks at whether we can predict who will respond best, aiming to find better long-term control for people with frequent or chronic migraine.
Zaragoza, AragonAges 18–65 - NCT07576582Recruiting
Mud therapy for jaw joint pain
This trial tests whether a special mud treatment (peloid therapy) can reduce jaw joint pain and improve function in people with temporomandibular joint disorder. It is a non-drug approach that may help those who have had jaw pain for at least 4 weeks.
Uşak, MerkezAges 18–65 - NCT07680998Recruiting
Pain monitor device for recovery after day surgery
This trial tests a device that monitors pain and recovery after outpatient surgery. It may help manage pain more safely and improve your comfort after you go home.
Nîmes, GardAges 18 years+ - NCT05787470Recruiting
How hormone levels affect pain signals
This study looks at how hormone treatment and hormone levels may change how the body produces pain signals. It may help researchers better understand pain differences between people with different hormone levels and treatment histories.
Birmingham, AlabamaAges 18–65 - NCT07164677Recruiting
Nerve block for pain after open-heart surgery
This study tests a nerve block (an injection near the back muscles) to see if it helps control pain after open-heart surgery. It might be a good option if you are having planned heart surgery through a cut in the middle of your chest.
SamsunAges 18–80 - NCT06398990Recruiting
Cognitive exercise therapy vs. yoga for teen period pain
This study compares two non-drug treatments—a cognitive exercise therapy approach and yoga—to see which helps reduce pain and improve quality of life in teenagers with period pain. If you are between 10 and 19, have moderate to severe menstrual cramps, and have never given birth, you may be eligible.
Istanbul, AtaşehirAges 10–19 - NCT07681687Recruiting
Neck muscle control therapy for long-term neck pain
This study tests two different physical therapy techniques—one focusing on how your brain controls neck movement, and another that releases muscle tension—to see which works better for long-term neck pain. If you have chronic neck pain and limited movement, you may be able to join.
IslamabadAges 18–35 - NCT07241949Recruiting
Nerve block for gallbladder surgery pain relief
This study tests a nerve block called the external oblique intercostal block to reduce pain after laparoscopic gallbladder removal. If you are having this surgery, the block may help you need less pain medication and feel more comfortable after the procedure.
AdanaAges 18–65 - NCT07251387Recruiting
How muscles work together during pain and when expecting pain
This study looks at how your muscles coordinate when you're in pain or just expecting it. Healthy volunteers will be asked to walk or run while researchers measure muscle activity and test a cream's effect.
SherbrookeAges 18–35 - NCT07253025Recruiting
Comparing Two Root Canal Fillings for Pain Relief
This study compares two types of root canal filling materials—a resin-based sealer and a bioceramic sealer—to see which one causes less pain after the procedure. If you have a tooth with a painful, infected nerve (irreversible pulpitis), this trial may help determine which filler offers better comfort.
Peshawar, Khyber Pakhtoon Khawa(KPK)aAges 17–70 - NCT07256145Recruiting
Ultrasound-guided nerve block for post-shingles pain
This study compares a new ultrasound-guided nerve block (erector spinae plane block) with standard care to help manage stubborn nerve pain after shingles. It might be an option if usual medications havent helped your pain.
Alexandria, AleexandriaAges 20–70 - NCT07257744Recruiting
Pain management after open heart surgery: comparing three methods
This trial compares three ways to manage pain after open heart surgery to see which best prevents long-term chronic pain. It may help you decide with your doctor which pain control option is right for you.
Trabzon, TrabzonAges 18–85 - NCT07257770Recruiting
Gel for breast pain after surgery
This trial tests a soothing gel you apply to your breast to see if it relieves pain after surgery. It might help if you still feel discomfort around your surgical wound.
RomaAges 18–70 - NCT07260669RecruitingPhase 2
Vipoglanstat for endometriosis-related pelvic pain
This study tests an investigational drug called Vipoglanstat for women with endometriosis-related pelvic pain that happens even when they are not on their period. The goal is to see if it can reduce pain and improve quality of life.
BlagoevgradAges 18–44 - NCT07262632Recruiting
Cancer pain and AI assessment study
This study builds a database of videos and voice recordings from people with cancer, both with and without pain. The goal is to train artificial intelligence (AI) to automatically recognize pain, which could help doctors better manage it in the future.
Rotterdam, South HollandAges 18 years+ - NCT07262944Recruiting
Pain block study for ear surgery with rib cartilage
This study tests a pain-blocking injection during ear surgery to see if it helps reduce pain after the operation. It is for teenagers having ear reconstruction with rib cartilage at a specific hospital.
SeoulAges 13–18 - NCT07264270RecruitingPhase 1
A new injection for long-term sciatica pain
This trial tests a new medicine called C-1101, given as a shot into the spine, to see if it safely reduces pain from chronic sciatica. It is for people who have not gotten enough relief from standard treatments.
Broadmeadow, New South WalesAges 18–65 - NCT07264699Recruiting
Guided nerve block for hernia repair pain control
This trial tests whether a visually guided nerve block (TAP block) during laparoscopic hernia repair reduces pain and improves recovery. If you are having planned hernia surgery, this study may help you experience less pain after the procedure.
Olsztyn, Warmisko-mazurskieAges 18–80 - NCT07265557Recruiting
Comparing two pain plans after orthopedic surgery
This trial compares two different pain medication plans after major orthopedic surgery. It aims to find which plan helps you recover with less pain and fewer side effects.
Boston, MassachusettsAges 18 years+ - NCT07265960Recruiting
Virtual reality and stress ball for kidney stone procedure
This study tests if using a virtual reality headset or squeezing a stress ball can help reduce fear, pain, and anxiety during a procedure called ureteroscopy (a scope to treat kidney stones). It aims to make the experience more comfortable for you.
Mersin, TarsusAges 18 years+ - NCT07266103Recruiting
Personalized brain stimulation for chronic pain study
This study tests whether personalized sessions of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can help reduce chronic pain. It aims to understand how this treatment works and how it might be tailored to individuals.
GistrupAges 18–80 - NCT07266987Recruiting
Multisensory methods for comfort during thyroid biopsy
This study tests whether adding multisensory methods (like calming sounds or visuals) during a thyroid biopsy can make the procedure more comfortable for patients. It involves watching a short video before the biopsy and answering questions about your comfort level.
Muş, CenterAges 18–90 - NCT07267819Recruiting
Xeomin for migraines after a brain injury or health incident
This trial looks at whether Xeomin (a shot that relaxes muscles) helps prevent migraines in people who have had a traumatic brain injury or an unexplained health event, such as a blast or sudden illness. It is for U.S. government employees and their families who have already tried Xeomin at a U.S. military or medical facility.
Bethesda, MarylandAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.