Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT06287970Recruiting
Testing a nerve stimulation device for chronic pelvic pain
This trial tests if a non-invasive nerve stimulation device (TaVNS) can reduce pain, urinary symptoms, and mood issues in men with moderate to severe chronic pelvic pain syndrome (CP/CPPS). It may offer a new drug-free option for symptom relief.
Beijing, Beijing MunicipalityAges 18–50 - NCT06285162Recruiting
Nerve health monitor during ICU dialysis
This trial uses a special monitor (called ANI) to check how well your nervous system is working while you are on continuous kidney dialysis in the ICU. It may help doctors better understand your body's response to fluid removal.
BronAges 18 years+ - NCT06287515RecruitingPhase 1
Radiation to the pituitary gland for cancer pain
This study tests a focused radiation treatment on a small gland in the brain to see if it can relieve cancer-related pain that hasn't been controlled by standard treatments like painkillers or other therapies. It may help patients whose pain limits their daily life.
Houston, TexasAges 18 years+ - NCT06290063RecruitingPhase 2
CBD for older adults who use cannabis
This study tests whether a pure CBD product (Epidiolex) can help older adults who use cannabis occasionally. It looks at how CBD affects people who already take medications for pain, sleep, or mood issues.
Boulder, ColoradoAges 60 years+ - NCT05666921Recruiting
Study thoughts and relationships in teens with body-pain symptoms
This trial studies how emotions and attachment (how people relate to others) may affect teens who have long-lasting body symptoms without an organic cause. It may help explain why symptoms happen and how support strategies could improve quality of life.
Florence, FirenzeAges 11–17 - NCT03415828Recruiting
Testing ethanol gel versus steroid gel for low back disc pain
This study compares two gels put on or into the painful disc area: an ethanol gel versus a steroid gel. It is for adults with long-lasting low back disc pain that did not improve with usual non-surgical care.
BordeauxAges 18 years+ - NCT06262126Recruiting
Virtual reality for non-cardiac chest pain
This study tests whether virtual reality can help people who have chest pain that is not caused by the heart. You will use a VR headset to see if it reduces your symptoms.
Jacksonville, FloridaAges 18 years+ - NCT06263907Recruiting
Nerve block to prevent depression after mastectomy
This study tests whether a nerve block near the neck (stellate ganglion block) can help prevent depression after mastectomy for breast cancer. It is for women who are generally healthy and have no history of mood disorders.
Al MansurahAges 21–65 - NCT06268704RecruitingPhase 4
Comparing two types of steroid injections for sacroiliac joint pain
This study compares two types of steroid medication used in injections for sacroiliac joint pain. It aims to see if one type works better than the other, helping patients with low back or buttocks pain find relief.
Albuquerque, New MexicoAges 18–99 - NCT06271707RecruitingPhase 4
Nerve block for surgery pain relief
This trial tests a nerve block (stellate ganglion block) to see if it helps reduce pain after surgery to remove part or all of the lung or esophagus. It may be an option for adults aged 18-85 having these procedures.
Minneapolis, MinnesotaAges 18–85 - NCT06271265RecruitingPhase 1
Testing EXPAREL for pain after heart surgery in children
This study tests a long-acting pain medicine (EXPAREL) given during heart surgery to see how it works in young children. The goal is to help control pain after surgery with fewer side effects.
Indianapolis, IndianaAges birth–6 years - NCT05840302Recruiting
Pain education program to increase activity in chronic low back pain
This trial studies whether teaching “pain neuroscience” (how pain works in the body and brain) helps people with long-term low back pain move more. It compares an education program as part of a multidisciplinary rehab to usual care during your planned hospital stay.
Lamalou-les-BainsAges 18 years+ - NCT06248216Recruiting
Virtual reality therapy for cancer treatment side effects
This study tests whether virtual reality (VR) can help ease common cancer-treatment side effects like pain, anxiety, sleep trouble, fatigue, or numbness. You may be able to join if you finished your main cancer treatment at least 3 months ago and have one of these symptoms.
Baltimore, MarylandAges 18–88 - NCT06246929Recruiting
Healthy aging for Black adults with chronic pain and memory concerns
This study tests a program to help Black adults aged 50+ manage chronic pain and early memory changes. It compares two approaches to see which works better for improving daily life and thinking skills.
Boston, MassachusettsAges 50 years+ - NCT06232304Recruiting
Program for young people with childhood lupus
This study tests a program to help teenagers and young adults with childhood-onset lupus manage symptoms like fatigue, sadness, or pain. It aims to improve daily life and well-being.
Birmingham, AlabamaAges 12–22 - NCT06252259Enrolling by invitation
How well does Choose to Move work for older adults?
This trial looks at how well a program called Choose to Move is working for older adults. Researchers want to hear from program staff, coaches, and participants (aged 50+) to see if the program is easy to use and helpful.
Vancouver, British ColumbiaAges 50 years+ - NCT06239974Recruiting
Vericiguat for chest pain from small vessel heart disease
This study tests whether a medication called vericiguat can improve chest pain caused by problems in the tiny blood vessels of the heart (not by large blockages). You may be a candidate if you have stable chest pain, are 40–75, and have had tests showing your heart's small vessels aren't working well.
Hong KongAges 40–75 - NCT06244732Recruiting
Pain control after open aneurysm surgery
This study tests two different ways to manage pain after open surgery for an abdominal aortic aneurysm. It compares a standard pain control method to another approach that may reduce the need for strong painkillers.
San Donato Milanese, MilanAges 18 years+ - NCT06250491Recruiting
Deep rTMS for Nerve Pain or Fibromyalgia
This study is testing a special type of brain stimulation (deep rTMS) for people with long-term nerve pain or fibromyalgia. The goal is to see if it can help reduce pain that hasn't gotten better with usual treatments.
Boulogne-BillancourtAges 18–80 - NCT06223503Recruiting
Pain support service study for veterans after surgery
This study tests a telehealth pain support program for veterans having orthopedic surgery. It aims to help manage pain after surgery and reduce the need for long-term opioid use.
Salt Lake City, UtahAges 18 years+ - NCT04658628Recruiting
Brain scan study to learn who responds to spinal cord stimulation
This trial uses brain imaging to understand which people with long-lasting low back pain are more likely to benefit from spinal cord stimulation (SCS). If you’re being considered for an SCS trial, the scans may help researchers predict response and improve future care.
Los Angeles, CaliforniaAges 21 years+ - NCT06228755Enrolling by invitation
Study on group integrative care for chronic pain
This study looks at how well group medical visits that combine different treatments (like mind-body approaches) work for people with chronic pain. It aims to make these visits more available and helpful.
Chapel Hill, North CarolinaAges 18 years+ - NCT06206486Recruiting
Gut germs and pain after kidney transplant
This study looks at whether the germs in your gut (microbiome) and certain chemicals in your blood affect pain after a kidney transplant. By joining, you may help doctors better understand and manage pain for future kidney transplant patients.
Chicago, IllinoisAges 18 years+ - NCT06209645Recruiting
Personalized brain stimulation for stubborn nerve pain relief
This study tests a non-invasive, personalized brain stimulation technique to reduce nerve pain that has not responded to standard treatments. It may be a good option if you have had nerve pain for over a year and have already tried other pain medications without enough relief.
BronAges 18–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.