Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT05708430RecruitingPhase 2
Test stem-cell mixture injection for painful thumb arthritis
This Phase 2 study tests how safe an injection made from your own body fat cells (stroma vascular fraction) is in people with painful arthritis at the base of the thumb. It also looks at whether pain and hand function improve after the injection.
AmiensAges 18 years+ - NCT07147049RecruitingPhase 2
Testing a new painkiller for moderate to severe pain after surgery
This trial tests a new tablet called HL-1186 for people with moderate to severe pain after certain surgeries. It aims to see if the drug is safe and works well for pain control.
Chengdu, SichuanAges 18–75 - NCT06193057Recruiting
Custom vs standard total ankle replacement trial
This study compares a custom-made artificial ankle joint to a standard one for people with arthritis in one ankle. If you are a candidate for a first-time ankle replacement, this trial could help find out which type of implant works best.
Bologna, BOAges 40–75 - NCT05710627Recruiting
Testing TENEX for hip pain from greater trochanteric pain syndrome
This trial studies whether TENEX (a minimally invasive procedure) can reduce hip pain caused by greater trochanteric pain syndrome (GTPS). It is for people who have tried non-surgical treatments for at least 6 months without enough relief, and who have confirmed GTPS on imaging (MRI or CT).
The Bronx, New YorkAges 30–90 - NCT07553611Recruiting
Regional anesthesia and shoulder surgery recovery outcomes
This study compares different numbing techniques used during shoulder arthroscopy (a minimally invasive shoulder surgery) to see which one helps patients recover better, use less pain medication, and experience fewer complications like temporary paralysis of the breathing muscle under the rib cage.
Antalya, MuratpaşaAges 18–65 - NCT07311369RecruitingPhase 2
Testing a new pain tablet after abdominal surgery
This trial tests a new pain tablet (HL-1186) for people having abdominal surgery. It aims to see if the tablet is safe and works well to manage pain after the operation.
Changsha, HunanAges 18–75 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT06696430Recruiting
Nudging to use TENS for pain after surgery
This trial tests whether a simple reminder (nudging) can encourage staff and patients to use a device called TENS, which uses mild electrical pulses to help reduce pain after urological surgery.
Gothenburg, VGRAges 18 years+ - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT07177820Recruiting
Virtual group acupuncture for chemo-related nerve pain
This study tests if virtual group acupuncture can help reduce nerve pain and numbness caused by chemotherapy (called CIPN). It is for people who finished taxane-based chemo for early-stage breast cancer and still have symptoms.
Charlestown, MassachusettsAges 18–80 - NCT07496034RecruitingPhase 3
Gou-Teng-San for frequent migraines
This study tests a Chinese herbal formula called Gou-Teng-San (GTS) for preventing episodic migraines. It is for adults who have frequent migraines but have not tried many prevention medicines.
Taichung, SouthAges 18–70 - NCT07374952RecruitingPhase 4
Finding the smallest effective dose for a clavicle nerve block
This study tests how much numbing medicine is needed to block nerves below the collarbone during shoulder surgery. It aims to find the smallest effective dose to reduce side effects.
Montreal, QuebecAges 18–70 - NCT07307495Recruiting
Pain relief after back surgery and its effect on recovery
This study tests a new painkiller, oliceridine fumarate, given through a pump after lumbar spine surgery. The goal is to see if it helps the bowels and stomach recover faster compared to standard pain relief.
Xi'an, ShaanxiAges 18–75 - NCT07132762Recruiting
Shock wave therapy for chronic low back pain
This study tests whether adding a special sound wave therapy (called ESWT) to standard care (like exercise and education) can reduce pain and improve daily function in people with long-term low back pain. It is designed for people whose back pain does not have a specific known cause.
DenizliAges 18–65 - NCT07525895Enrolling by invitation
Nerve Stretching for Lower Leg Pain Relief
This study tests whether gentle stretching exercises targeting the sciatic nerve (a major nerve in your leg) can help reduce leg pain and improve how your body perceives pain. Researchers will compare this treatment to standard care to see if it works.
Istanbul, AtaşehirAges 18–30 - NCT07542470Enrolling by invitationPhase 4
Cold and compression therapy after spinal surgery
This study compares a new cold and compression device (NICE1) to standard care after spinal surgery to see if it reduces pain and swelling. If you're having spine surgery, this trial tests whether keeping the area cold and compressed helps you recover better.
Sarasota, FloridaAges 18 years+ - NCT06065449RecruitingPhase 3
Comparing two radiation therapies for painful bone metastases
This trial compares two types of radiation therapy to relieve pain from cancer that has spread to the bones. It aims to see whether a more targeted, high-dose approach (SBRT) works better than standard palliative radiation.
Houston, TexasAges 18 years+ - NCT07063602Recruiting
Comparing nerve block methods for pain after lung surgery
This study compares two ways of giving a paravertebral nerve block (an injection near the spine to numb the chest) to control pain after a type of lung surgery called VATS. It aims to find the best approach for reducing pain and the need for stronger pain medicines.
Montreal, QuebecAges 18 years+ - NCT05955768Enrolling by invitation
Lidocaine in a cervical dilator to reduce removal pain
This study tests whether putting lidocaine (a numbing medicine) into a disposable cervical dilator can reduce pain during uterine device removal done with local anesthesia. If you’re eligible, your experience of pain is measured so researchers can compare comfort between study procedures.
Hangzhou, ZhejiangAges 18–65 - NCT07662668Recruiting
NSAID effect on periostin in back pain patients
This trial tests how a common anti-inflammatory drug (NSAID) affects a protein called periostin, which may be linked to spine problems. It could help people with herniated discs or spinal stenosis.
DaeguAges 20–80 - NCT07542808RecruitingPhase 2/Phase 3
Stem cell treatment vs. hyaluronic acid for knee arthritis
This study tests whether an injection of stem cells (special cells that can help repair tissue) works better than a standard hyaluronic acid injection for knee osteoarthritis pain. Both treatments are injected into the knee to reduce pain and improve function.
Abu DhabiAges 18 years+ - NCT07650526Recruiting
Brain Stimulation for Nerve Pain Relief
This study tests two types of magnetic brain stimulation (aiTBS and rTMS) to treat long-lasting nerve pain. Researchers want to see which approach works better and develop a way to predict who will benefit most.
Boulogne-Billancourt, Île-de-France RegionAges 18–80 - NCT07458282Recruiting
Testing a long-lasting numbing medicine for pain after laparoscopic surgery
This trial is testing if a special numbing medicine called liposomal bupivacaine, given as a nerve block during surgery, can help reduce pain after laparoscopic procedures like gallbladder removal or hernia repair. It might help you feel better with less need for strong painkillers.
Beijing, Beijing MunicipalityAges 18–64 - NCT07573969RecruitingPhase 3
Pain Relief Medicines Added to Spinal Injection for Back Surgery
This trial tests whether adding one of two different medicines (dexmedetomidine or ketamine) to a numbing injection in the lower spine improves pain relief after back surgery. You would receive the injection while asleep during surgery to help manage pain afterward.
CairoAges 21–60
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.