Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT06477965Recruiting
Registry for artery embolization to treat chronic pain
This is a registry study that gathers information from people who have had an artery embolization procedure to treat long-term pain from conditions such as arthritis. The goal is to track outcomes and better understand the procedure's effectiveness.
Cary, North CarolinaAges 18 years+ - NCT06646172Recruiting
Long-acting pain medicine during heart surgery
This trial tests a long-acting numbing medicine (liposomal bupivacaine) compared to standard local anesthetic during heart surgery through the breastbone. It aims to provide better pain control with fewer side effects.
Wuhan, HubeiAges 18–90 - NCT06075602Recruiting
Complex and calcified coronary artery disease: a registry study
This study watches how people with complex or calcified heart artery disease are treated (with stents or bypass surgery) and how they do over time. It aims to learn which treatments work best for tough blockages.
Lucerne, Canton of LucerneAges 18 years+ - NCT06661642Recruiting
Predicting pain after planned surgery
This study looks at whether we can predict how much pain you will feel after surgery. It aims to help doctors better manage pain after your operation.
AalborgAges 18 years+ - NCT04988685Recruiting
Heart artery balloon treatment registry study for adults
This study follows adults with blocked heart arteries who are treated using a special type of balloon (drug-coated balloon) during a procedure. It aims to track real-world outcomes to better understand how well this treatment works for people with new blockages or previously treated vessel narrowing.
Lucerne, Canton of LucerneAges 18 years+ - NCT06663644Recruiting
Muscle energy technique for short-term low back pain
This study will test whether a gentle hands-on technique called muscle energy can help relieve short-term lower back pain caused by poor posture. If you are an adult between 18 and 40 with new back pain and no other major health issues, this trial may be a good fit.
Gilgit, Gilgit-BaltistanAges 18–40 - NCT06215989Recruiting
Low-dose colchicine for acute coronary syndrome
This trial tests whether a low dose of the anti-inflammatory drug colchicine can help people who have recently had a heart attack or unstable angina. It aims to see if colchicine reduces the risk of future heart problems.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07675304RecruitingEarly Phase 1
Mesotherapy for chronic low back pain study
This trial tests whether injecting a natural substance (collagen) into the lower back can safely reduce chronic pain. It may help people with pain that hasn't spread to the legs.
WarsawAges 18–65 - NCT07674836Recruiting
Comparing two nerve blocks for chronic pain after breast surgery
This study tests two types of nerve blocks (SPSIP and ESP blocks) to see which one works better for long-term pain after a single-sided breast surgery like mastectomy. It aims to find a safer, more effective way to manage chronic pain after surgery.
İzmit, KocaeliAges 18–65 - NCT07679074Recruiting
Samphire guided care program for women's mood and brain fog
This 12-week program tests a mobile app and gentle brain stimulation device designed to help women manage mood and thinking problems linked to their menstrual cycle, perimenopause, or menopause. It aims to improve day-to-day well-being, work productivity, and overall quality of life.
San Francisco, CaliforniaAges 18–65 - NCT06668415Recruiting
Spencer technique after hydrodilation for frozen shoulder
This trial tests if adding a gentle hands-on treatment (Spencer technique) to the standard fluid injection procedure (hydrodilation) helps people with frozen shoulder move more easily and feel better. If you have been diagnosed with unilateral frozen shoulder and have already had the hydrodilation procedure, you may qualify.
Rawalpindi, Punjab ProvinceAges 40–65 - NCT07672808Recruiting
Pain relief after hip replacement without opioids
This study tests a combination of non-opioid pain medicines to reduce the need for opioids after hip replacement surgery. It aims to help patients manage pain with fewer risks of addiction and side effects.
Detroit, MichiganAges 18 years+ - NCT07671950Recruiting
Deep brain stimulation for neuropathic dental pain
This trial studies whether deep brain stimulation (DBS) can help people with a type of nerve-related tooth pain called atypical odontalgia. It is for those who have not found relief from standard treatments like medications or injections.
Vancouver, British ColumbiaAges 19–80 - NCT07672145Recruiting
Gallbladder removal: belly button vs. upper belly cut
This trial compares two ways to remove the gallbladder during laparoscopic surgery: through the belly button or through a cut just below the breastbone. It aims to find which method causes less pain and recovers faster.
Lahore, Punjab ProvinceAges 18–60 - NCT07674407Recruiting
Fear of movement and physical function in back pain
This study looks at how fear of movement relates to physical function in people with long-term low back pain from a herniated disc. It may help understand how to improve daily activities.
IstanbulAges 18–65 - NCT07677969Recruiting
Arm loss, balance, pain, and daily life study
This study looks at how the percentage of arm loss affects balance, neck and back pain, daily activities, and reaction time in people with one arm amputated who use a myoelectric or bionic hand. It may help understand how to improve care and rehabilitation.
AnkaraAges 18–65 - NCT07677631Recruiting
Emotional allodynia in fibromyalgia: a questionnaire study
This study compares how people with fibromyalgia and those with other long-term pain conditions experience emotional pain (like feeling hurt by emotions). You will fill out a questionnaire about emotional sensitivity. The goal is to see if emotional allodynia (pain from emotions) is more common in fibromyalgia.
BariAges 18 years+ - NCT07676942Recruiting
Pain relief options after urethral surgery
This study compares two medications given during surgery to see which one better manages pain after urethral reconstruction. It aims to improve recovery and comfort after the procedure.
WarsawAges 18 years+ - NCT07672015RecruitingPhase 4
Testing a new pain drug in surgery patients at risk for opioid dependence
This trial tests a new painkiller called suzetrigine for post-surgery pain. It's designed for people whose medical records suggest they may have a higher chance of needing strong painkillers (opioids) long after surgery. We want to see if suzetrigine works better at preventing that.
La Jolla, CaliforniaAges 18 years+ - NCT07679295Enrolling by invitation
Port needle change: pain, anxiety, and satisfaction
This trial tests if using a stress ball during port needle changes can help reduce pain and anxiety in cancer patients. It aims to improve comfort and patient satisfaction.
SanliurfaAges 18 years+ - NCT07672093Recruiting
Dry needling for forearm muscle knots
This study tests whether inserting a thin needle (dry needling) into a tight muscle knot in your forearm can help release it without causing pain. It's for healthy adults who have a non-painful knot in their dominant arm.
Reus, TarragonaAges 18–40 - NCT07675616Recruiting
Comparing two drugs for numbing the eye before tear-duct surgery
This trial tests whether adding dexmedetomidine or magnesium sulfate to lidocaine makes numbing the eye more effective for tear-duct surgery. The goal is to find which combination provides better pain control during surgery.
CairoAges 18 years+ - NCT07672418Recruiting
Pain relief after tonsil surgery: ibuprofen vs. ketorolac
This study compares two common pain relievers (ketorolac and ibuprofen) given after tonsil/adenoid surgery in teenagers. It aims to see which works better while keeping side effects low.
Houston, TexasAges 13–18
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.