Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT07113405Recruiting
Tea extract and knee strength after downhill jogging
This study tests whether taking a tea extract can help your knee muscles recover faster after a downhill jog. It compares the tea to a placebo to see if it reduces muscle soreness or weakness.
Fribourg, Canton of FribourgAges 18–40 - NCT05640232RecruitingPhase 3
Test medicine CDE100 for severe menstrual cramp pain
This Phase 3 study tests whether CDE100 can reduce menstrual cramp pain in people with primary dysmenorrhea (cramps that are not caused by another medical condition). It also checks how safe the treatment is and how it’s tolerated over time.
Hortolândia, São PauloAges 16–35 - NCT06369870RecruitingPhase 4
Nerve block for pain after minimally invasive aortic valve surgery
This trial tests a nerve block (injection of numbing medicine near the chest wall) to control pain after aortic valve replacement through a small right-sided chest incision. It may help reduce pain and the need for strong painkillers after surgery.
Ghent, East-FlandersAges 18 years+ - NCT06722742RecruitingPhase 3
Preventing shivering after spinal anesthesia for cesarean
This trial tests whether two common medicines, tramadol and ketamine, given through an IV, can prevent shivering that sometimes happens after spinal anesthesia for cesarean section. You may be able to join if you are having a planned cesarean and are generally healthy.
Karachi, SindhAges 18–40 - NCT06723730Recruiting
Mobilization and core strength for rotator cuff pain
This trial tests if adding a specific type of shoulder movement therapy and upper body core exercises can reduce pain and improve function in people with rotator cuff-related shoulder pain. It may help you if you have had shoulder pain for more than 6 weeks and it started after an injury.
Rawalpindi, Punjab ProvinceAges 18–65 - NCT07533786RecruitingPhase 2
New Pain Medicine After Abdominal Surgery
This study tests a new medication called HSK55718 to treat pain after abdominal surgery. If you're having moderate to severe pain within 4 hours of surgery, this trial may help you get relief and contribute to finding better pain treatments.
Changsha, HunanAges 18 years+ - NCT06724679Recruiting
Virtual reality for chronic back pain treatment
This trial tests if using a virtual reality (VR) headset can help people with long-term lower back pain during a spine rehabilitation program. It will see if VR is a practical and helpful addition to the program.
AngersAges 18–65 - NCT07559890Recruiting
Nerve ablation for low back pain with Modic changes
This study tests a procedure that uses heat to stop a nerve in the lower back from sending pain signals. It may help people with long-term central low back pain who have not gotten better with other treatments and have Modic changes on MRI.
PragueAges 18 years+ - NCT07484698Recruiting
Myofascial release with FIFA 11+ for hamstring health
This study tests whether adding a gentle muscle release technique to a proven warm-up program (FIFA 11+) can improve hamstring flexibility and lower your risk of injury. It's for male football players who can commit to a 6-week program.
Chakdara, KPKAges 16–30 - NCT05122078Recruiting
Test pain treatment guided by a heart-based index after bowel surgery
This trial studies whether using a monitor-based pain number (called the ANI) to guide pain medicine can improve bowel function after laparoscopic surgery for colorectal cancer. It may help reduce constipation or slow gut recovery by matching pain treatment to your body’s signals.
SeoulAges 19 years+ - NCT07593313Recruiting
Treatment for pain after stroke using spinal stimulation
This trial tests a treatment called spinal cord stimulation for people who develop chronic pain after a stroke. The pain is caused by the stroke itself and doesn't respond well to regular pain medicines. The treatment uses a small device to send mild electrical signals to your spinal cord to reduce pain.
Nanchong, SichuanAges 18 years+ - NCT07586462Recruiting
Deep Nerve Block for Abdominal Surgery Pain Relief
This trial tests a nerve block—a targeted numbing injection near abdominal muscles—to help reduce pain after abdominal surgery. Researchers want to see if this technique works well alongside standard anesthesia to help you recover more comfortably.
CrotoneAges Any age - NCT05111925Recruiting
Testing after-injury and after-recovery readiness for full duty
This study looks at how well service members are able to return to full physical duty after a low-back or leg injury (or to see readiness in those without an injury). It may help improve return-to-duty planning by measuring changes before and after recovery.
Bethesda, MarylandAges 18–44 - NCT06113185Recruiting
Pain Scale Study for Low Back Pain
This study tests a pain scale for people with long-term low back pain. It is a questionnaire study, not a treatment trial, so you will fill out forms about your pain.
Istanbul, None SelectedAges 18–55 - NCT07094178Recruiting
Steroid vs PRP shots for shoulder tendon pain
This trial compares two treatments for shoulder tendinopathy: a corticosteroid shot or a platelet-rich plasma (PRP) injection. It aims to find which one works better to relieve pain and improve function.
TunisAges 18 years+ - NCT07154056Recruiting
Spinal cord stimulation for stubborn nerve pain
This trial tests a new type of spinal cord stimulation for people with long-term nerve pain that hasn't improved with other treatments. The goal is to see if this special stimulation pattern can reduce pain better than standard care.
Poitiers, FranceAges 18–80 - NCT06386406Recruiting
A pre-made shoe insert for treating heel pain
This study tests a specially designed shoe insole for people with long-term heel pain from plantar fasciitis that hasn't gotten better with other treatments. It aims to see if the insole can help reduce pain and improve walking comfort.
LuganoAges 18–70 - NCT06739148Recruiting
Laser therapy for muscle training in healthy adults
This study tests if adding low-level laser therapy to muscle training with electrical stimulation and blood flow restriction can make your workouts more effective. It is for healthy adults aged 20-40.
TainanAges 20–40 - NCT05831345RecruitingPhase 3
Methadone during surgery to prevent post-surgery pain
This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
BrusselsAges 18–80 - NCT06651788Recruiting
Does ethyl chloride spray reduce injection pain?
This trial tests if spraying a numbing cold spray on the skin before a first-time steroid injection can reduce pain. It is for adults getting their first corticosteroid injection in an arm or leg.
Chicago, IllinoisAges 18 years+ - NCT07543796RecruitingPhase 2
Pain Relief After Hip Replacement Surgery
This study tests whether a new pain medication called TRD205 works well and is safe for people recovering from hip replacement surgery. If it works, it could offer better pain control after your operation.
Guangzhou, GuangdongAges 18–80 - NCT07548567Recruiting
Nerve Block to Reduce Pain During Below-Knee Fracture Surgery
This study tests a nerve-blocking injection (numbing medicine around the femoral artery nerve in your groin area) to help reduce pain and blood pressure changes during below-knee fracture surgery when a tourniquet (pressure cuff) is used. The goal is to see if this approach makes surgery more comfortable and safer.
AthensAges 18 years+ - NCT06966518Recruiting
Ketamine and magnesium for pain control after nose surgery
This study tests whether giving a combination of two medicines (ketamine and magnesium sulfate) during nose surgery can help reduce pain after the operation. It may be a good option for healthy adults having rhinoplasty and looking for better pain control.
CairoAges 18–65 - NCT07591207Recruiting
Pain relief patch after laparoscopic abdominal surgery
This trial tests whether a pain-relief patch (loxoprofen) works well and safely to reduce pain after common laparoscopic surgeries like gallbladder, appendix, or hernia repair. If it works, it could offer patients a non-invasive way to manage post-surgery pain.
Beijing, Beijing MunicipalityAges 18–64
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.