Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT07671950Recruiting
Deep brain stimulation for neuropathic dental pain
This trial studies whether deep brain stimulation (DBS) can help people with a type of nerve-related tooth pain called atypical odontalgia. It is for those who have not found relief from standard treatments like medications or injections.
Vancouver, British ColumbiaAges 19–80 - NCT07676422Recruiting
Stress ball use during mouth care
This study tests if squeezing a stress ball during mouth care can help reduce discomfort or stress. You may be able to join if you can follow instructions and don't have any hand or movement issues.
VanAges 18 years+ - NCT07676942Recruiting
Pain relief options after urethral surgery
This study compares two medications given during surgery to see which one better manages pain after urethral reconstruction. It aims to improve recovery and comfort after the procedure.
WarsawAges 18 years+ - NCT07672808Recruiting
Pain relief after hip replacement without opioids
This study tests a combination of non-opioid pain medicines to reduce the need for opioids after hip replacement surgery. It aims to help patients manage pain with fewer risks of addiction and side effects.
Detroit, MichiganAges 18 years+ - NCT06656299Recruiting
Nerve block for gallbladder removal surgery
This study tests a nerve block called EOIB to see if it helps reduce pain after gallbladder removal surgery. If you are having planned gallbladder surgery, this might be a good option for you.
IstanbulAges 18–65 - NCT06672354Recruiting
Virtual reality vs. exercises for balance in older adults
This trial tests whether a fun virtual reality game (like a video game you do standing up) can improve balance and walking better than a set of simple exercises. It is for older adults who can still walk on their own but want to stay steady on their feet.
IslamabadAges 55 years+ - NCT06562816RecruitingPhase 4
Comparing two pain relievers after root canal treatment
This study tests two different pain medicines (trypsin-chymotrypsin and naproxen sodium) to see which one works better for pain after a root canal. It may help you if you need a root canal and are generally healthy.
Karachi, SindhAges 18–45 - NCT06671860Recruiting
Exercises and hands-on therapy for neck pain
This study tests whether combining eye exercises with hands-on therapy helps people with non-specific neck pain (pain not caused by a known injury or disease). It may help improve how your neck moves and reduce discomfort.
IstanbulAges 18–65 - NCT06671743RecruitingPhase 3
Medication before root canal to reduce pain
This study tests whether taking a medication before a root canal can reduce pain afterward. It is for people who need a root canal on a lower back tooth that has a painful, inflamed nerve but no infection at the root tip.
AjmanAges 20–50 - NCT06671132RecruitingPhase 2
Computer training for pain relief using smell exercises
This trial tests a computer program that uses smell training to help people with chronic low back pain. It aims to reduce pain by retraining brain connections.
Washington D.C., District of ColumbiaAges 18–85 - NCT07666646Recruiting
Nerve block comparison for lung function after gallbladder surgery
This trial compares two types of nerve blocks to see which one better preserves lung function after laparoscopic gallbladder removal. It may help patients recover breathing ability more quickly after surgery.
Kayseri, KocasinanAges 18–70 - NCT07668648Recruiting
Two nerve blocks for shoulder surgery pain relief
This study compares two types of nerve blocks to reduce pain after shoulder surgery. One block is placed near the neck (interscalene) and the other is placed further away (serratus posterior superior intercostal plane block). The goal is to see which works better and has fewer side effects.
Bursa, NilüferAges 18–75 - NCT06675877Recruiting
Virtual reality for kids with kidney disease on dialysis
This study tests whether virtual reality (VR) can help reduce anxiety and depression in children with end-stage kidney disease who are on hemodialysis through an arteriovenous fistula. It may offer a fun, drug-free way to feel better during treatment.
TantaAges 8–18 - NCT06674707Recruiting
Agility training with foot exercises for kneecap pain
This trial tests whether adding foot exercises to agility training can better relieve long-lasting knee pain (patellofemoral pain syndrome) in adults ages 20 to 40. Eligible participants will have had pain behind the kneecap for over 6 months.
Lahore, Punjab ProvinceAges 20–40 - NCT07669961Recruiting
Distraction cards vs toy squeezing for kids getting shots
This trial compares using distraction cards or a squeezable toy to help children aged 4–7 feel less pain and fear during a routine vaccination shot.
Mersin, ProvinceAges 4–7 - NCT07665463Recruiting
Recovery after surgery with or without opioids
This study compares recovery quality after major urological surgery using either opioid-free or opioid-based general anesthesia. It aims to see if avoiding opioids can improve how patients feel after surgery.
Krakow, Lesser Poland VoivodeshipAges 18–75 - NCT07665593Recruiting
AI breathing training after open heart surgery
This trial tests if an AI-assisted breathing exercise device can reduce pain, fatigue, and improve breathing in patients recovering from open heart surgery.
Kocaeli, İzmitAges 18 years+ - NCT07665762RecruitingPhase 3
Numbing medicine for arm surgery pain prevention
This trial compares two additives to standard numbing medicine given before wrist fracture surgery to see which better prevents severe pain. You may qualify if you have risk factors for hard-to-control pain after surgery.
Hong KongAges 18–90 - NCT07663604Enrolling by invitation
Pain experience in fibromyalgia
This study looks at how women with fibromyalgia experience pain. It aims to better understand their pain to help improve care.
Denizli, ŞirnakAges 18 years+ - NCT07668206Recruiting
Talking therapy for thoracic outlet syndrome pain
This study tests if talking with a counselor (motivational interviewing) can help people with long-term pain from thoracic outlet syndrome feel better. It is for adults who have not had surgery recently.
AnkaraAges 18–65 - NCT07665086Enrolling by invitation
Isometric exercise for rheumatoid arthritis
This study tests whether simple isometric (holding still) exercises can help people with rheumatoid arthritis. The goal is to see if these exercises improve hand function and quality of life.
DenizliAges 18–65 - NCT07664904Recruiting
Periostin protein levels and quality of life in back pain patients
This study looks at how a protein called periostin relates to back function and quality of life in people with disc herniations or spinal stenosis. You'll fill out two questionnaires and have your periostin measured from a blood draw or MRI.
Daegu, DaeguAges 20–80 - NCT06673953Recruiting
Breathing training for heart surgery recovery with neck posture problems
This trial tests whether a breathing exercise device can improve heart and lung function in men who had heart bypass surgery at least 3 months ago and also have neck pain from poor posture. It may help you breathe better and feel stronger after surgery.
Giza, Giza GovernorateAges 45–55 - NCT06662617Recruiting
Numbing injections for pain after gallbladder surgery
This study tests whether two different numbing injections (M-TAPA and TAPB) placed before surgery can reduce pain after keyhole gallbladder removal, compared to standard care. If you qualify, the injections may help you feel less discomfort after the operation.
SivasAges 18–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.