Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07092982Recruiting
Comparing two numbing methods for knee replacement surgery
This study compares two different numbing techniques to see which provides better pain control during and after total knee replacement. It may help find a way to reduce pain and improve recovery.
IstanbulAges 18–75 - NCT07091123RecruitingPhase 4
Comparing two treatments for chronic back pain after surgery
This study compares two treatments for long-term back pain after surgery: a spinal cord stimulator (a device that sends mild electrical pulses to your spine) and a pump that delivers pain medicine directly to your spinal fluid. It will look at which treatment you prefer and how well it works over time.
Cleveland, OhioAges 30 years+ - NCT06824935Enrolling by invitation
Cataract surgery anesthesia needs study
This study looks at how much anesthesia is needed during outpatient cataract surgery. It may help find the right approach for your comfort and safety.
IstanbulAges 18 years+ - NCT07067710Recruiting
Imagery and movement study for breast cancer survivors
This study tests if visualizing and watching movements can help improve strength, motion, pain, and fear of movement in women who finished breast cancer treatment. It focuses on those with arm issues like pain, limited movement, or lymphedema.
Pamplona, NavarreAges 18 years+ - NCT07066709RecruitingPhase 2
Hip pain study after hip surgery
This study tests if a second hip surgery can help people who still have pain at least 6 months after their first hip surgery. It may help you if you have ongoing hip pain and haven't needed strong pain pills.
Madison, WisconsinAges 18–45 - NCT07063979Recruiting
Using a nerve-stimulation band to reduce nausea after weight-loss surgery
This trial tests if adding a small nerve-stimulation device (Reliefband) to standard recovery care can help prevent nausea and vomiting in the first 24 hours after robotic sleeve gastrectomy. If you are having this surgery and match the criteria, you may be able to join.
Plainsboro, New JerseyAges 18–75 - NCT07056166Recruiting
Ultrasound to predict epidural difficulty in labor
This study uses ultrasound to see if doctors can predict how easy or hard it will be to place an epidural for labor pain relief. It may help identify women who might need extra care during the procedure.
PaduaAges 18 years+ - NCT06860867Recruiting
Nucleus replacement for single-level discogenic low back pain
This trial tests a new device called PerQdisc for people with chronic low back pain from a single damaged disc in the lower spine. The goal is to see if the device can safely replace the inner gel of the disc without major surgery.
Glendale, ArizonaAges 22–70 - NCT04242589RecruitingPhase 2
Radiation plus bone cement for painful spinal metastasis pain
This trial tests adding a bone-cement procedure (vertebroplasty) along with radiation to reduce pain from cancer that has spread to the spine. It is for adults with painful metastatic (spread) tumors in the middle or lower spine, without current spinal cord pressure.
Edmonton, AlbertaAges 18 years+ - NCT07040267Recruiting
Does phone use change thumb strength and feeling?
This study looks at how smartphone use affects the strength and feeling in your thumb. If you are a young university student who uses a smartphone daily, you may help researchers understand if heavy phone use changes your thumb muscles or senses.
Istanbul, ÜsküdarAges 18–30 - NCT07215780Recruiting
Sitz baths after pelvic organ prolapse surgery
This study compares sitz baths to regular care after surgery for pelvic organ prolapse. It aims to see if sitz baths can help reduce pain and improve recovery. If you are having prolapse repair surgery, you may be able to join.
Bridgeport, ConnecticutAges 18 years+ - NCT05817591Recruiting
Testing how high-dose capsaicin affects nerve pain
This study looks at what “response profiles” different people have after treatment with high-concentration capsaicin for nerve-related pain. It may help doctors predict who benefits from capsaicin by measuring changes in symptoms and nerve sensitivity.
AnnecyAges 18 years+ - NCT07035015Recruiting
Virtual reality vs mannequin for learning a hip nerve block
This study compares learning a specific nerve block (for the hip/upper thigh) using a self-guided virtual reality headset versus a traditional mannequin. It is for doctors and trainees at The Ottawa Hospital who want to improve their ultrasound skills for this procedure.
Ottawa, OntarioAges Any age - NCT07222462Recruiting
Radiofrequency ablation for chronic low back pain
This study tests if radiofrequency ablation, a procedure that uses heat to block pain signals from the facet joints in your spine, can help people with long-term low back pain that hasn't improved with other treatments like physical therapy.
Atlanta, GeorgiaAges 18 years+ - NCT06863324Recruiting
Impact of radiation sensitivity on late side effects of facial pain radiosurgery
This study looks at whether how sensitive people are to radiation affects late side effects after radiosurgery for trigeminal neuralgia. It may help doctors better predict and prevent long-term problems.
Nice, Alpes-maritimesAges 18 years+ - NCT07027644Recruiting
Combined therapy for chronic neck pain relief
This trial tests whether combining a muscle-relaxation technique with cupping therapy is more effective than either alone for treating chronic neck pain caused by muscle knots in the upper trapezius. Participants must have had these knots for more than 6 months.
GizaAges 18–40 - NCT07024095Recruiting
Breathing muscle training after back surgery for osteoporosis
This study tests whether a simple breathing-muscle training program can help people recover better after vertebroplasty surgery for a broken back caused by osteoporosis. It aims to improve your breathing strength and overall function.
Kayseri, KocasinanAges 50 years+ - NCT06857331Recruiting
Numbing block for pain after liver transplant
This trial tests a special numbing injection (erector spinae plane block) to help control pain after liver transplant surgery. It may be a good option if you have severe liver disease and need a transplant.
KyivAges Any age - NCT07617545Recruiting
Nerve blocks for pain relief in kids' upper belly surgery
This trial compares two types of numbing injections (nerve blocks) given during surgery to help reduce pain afterward in children having upper abdominal surgery. The goal is to find which method works better to keep kids more comfortable after their operation.
AlexandriaAges 6–12 - NCT07297784Enrolling by invitation
Screen time and pain after tonsil removal in children
This study looks at whether children who use a lot of screens (like tablets, phones, or TV) feel more or less pain after tonsil surgery. It could help parents understand how media use affects recovery.
Tokat Province, Tokat ProvinceAges 4–11 - NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT07620782Recruiting
Study of two anesthesia drugs used together during surgery
This study tests how two common anesthesia medications—remimazolam (a sedative) and sevoflurane (an inhaled gas)—work together in your body during planned surgery. Understanding this combination may help doctors use safer anesthesia doses in the future.
YangsanAges 20–80 - NCT07217626RecruitingPhase 4
Nerve blocks before leg fracture surgery in older adults
This trial tests whether giving a nerve block (medicine to numb the leg) before surgery helps older adults recover better from a broken leg bone. If you are 50 or older and need surgery for a specific type of leg fracture, you may be eligible.
Baltimore, MarylandAges 50 years+ - NCT05577962RecruitingPhase 4
Recovery quality after thyroid surgery with and without opioids
This study compares two types of anesthesia for thyroid surgery: one with opioids (strong painkillers) and one without. The goal is to see which approach helps patients recover better right after surgery, with fewer side effects.
Beijing, Beijing MunicipalityAges 18–99
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.