Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06795386Recruiting
Widespread pain after rapid weight loss in Black and Hispanic adults
This study looks at whether rapid weight loss from bariatric surgery leads to long-term widespread pain in Black and Hispanic adults. The goal is to understand how weight loss affects pain and find better ways to help people manage it.
New York, New YorkAges 18–75 - NCT05150795RecruitingEarly Phase 1
Testing pregabalin before surgery versus fentanyl during surgery
This trial compares two medicines used around the time of surgery—pregabalin given by mouth before surgery versus fentanyl given during surgery—to see which better controls pain after the operation. You might join if you’re a generally healthy surgical patient and aren’t using certain related medicines.
CairoAges 21–45 - NCT06148818Recruiting
Neck exercises for jaw pain relief
This study tests whether special neck exercises can help reduce jaw pain in people who have both jaw (TMJ) problems and neck pain. If you have had jaw pain for at least 3 months and also have achy neck pain, you may be able to join.
TrabzonAges 18–55 - NCT06534372Recruiting
Factors affecting chronic pain after open-heart surgery
This study looks at factors that may lead to long-term pain after open-heart surgery. It follows patients who have coronary bypass or valve surgery to understand what might cause ongoing pain.
Ankara, AnkaraAges 18–80 - NCT07445386Recruiting
Nerve block for upper abdominal cancer pain
This trial compares two types of nerve blocks to treat severe pain from upper abdominal cancers like stomach, pancreas, or liver cancer. It may be an option if your pain hasn't been controlled with standard treatments.
AnkaraAges 18 years+ - NCT07448285RecruitingPhase 3
Platelet-rich plasma injection for chronic shoulder pain
This trial tests whether injecting platelet-rich plasma (a concentration of your own blood cells that may help healing) can reduce chronic shoulder pain. It's for people whose pain hasn't improved with standard painkillers and who have a specific shoulder tendon condition.
Barakaldo, BizkaiaAges 35–75 - NCT07452120Recruiting
Comparing two nerve blocks for pain after hip surgery
This trial studies two different nerve block methods to see which provides better pain relief after hip replacement surgery. If you are having hip surgery and want to help find the best way to manage pain, this study may be for you.
Sivas, SivasAges 18 years+ - NCT07453641Recruiting
White Noise for Calm Infants During Needle Procedures
This study tests if playing white noise helps calm babies aged 1-3 months during common needle procedures like blood draws or IV placement, by reducing crying time. It offers a simple, drug-free way to ease discomfort.
IstanbulAges 1 month–3 months - NCT04646707Recruiting
Nerve block to reduce opioid use after neck spine surgery
This trial tests whether a targeted back/neck numbing injection (an erector spinae block) can help reduce the amount of opioid pain medicine needed after posterior cervical spine surgery. It also aims to support an “enhanced recovery” pathway so patients may recover more comfortably and potentially faster.
Toronto, OntarioAges 18–80 - NCT07448246Recruiting
Rhomboid block for pain after breast implant surgery
This trial tests if a specific nerve block (rhomboid intercostal block) can reduce pain after breast implant surgery. If you are having bilateral breast implants and are in good general health, you may be eligible.
Aydin, EfelerAges 18–65 - NCT07447830Recruiting
Virtual reality for pain relief during wound care
This study tests if using a virtual reality headset during wound care can reduce pain for people with pressure ulcers in long-term care. It aims to find a more comfortable way to manage wound treatment.
Montreal, QuebecAges Any age - NCT07453524Recruiting
Understanding what matters to people with chronic pain
This study asks people with chronic pain about their preferences and experiences. Your answers will help doctors understand what matters most to patients like you.
BrusselsAges 18 years+ - NCT07447219Recruiting
Ergonomics program for dental workers
This study tests an ergonomics program designed to reduce muscle and bone pain in dental healthcare workers. If you are a practicing dental professional, this program may help you prevent work-related injuries.
Serdang, SelangorAges 25–65 - NCT07453485Recruiting
Electrical stimulation for Achilles tendon pain and function
This study tests if a brief session of neuromuscular electrical stimulation can reduce pain and improve function in people with Achilles tendon problems, such as midportion or insertional pain, or a healed rupture that happened at least 3 months ago.
Brasília, Federal DistrictAges 18–60 - NCT07450781Enrolling by invitation
How saline temperature and local anesthetics affect shoulder pain after gallbladder surgery
This trial tests whether warming the saline used during surgery or adding a numbing medicine can reduce shoulder pain after laparoscopic gallbladder removal. It also checks how these affect inflammation markers in the blood.
AlexandriaAges 18–65 - NCT07449078Recruiting
Cognitive functional therapy for chronic ankle sprain
This trial tests a type of talk therapy that teaches you new ways to move and think about your ankle. It may help people who have ongoing pain or instability from an old sprain.
Istanbul, AtaşehirAges 18–65 - NCT07452614Recruiting
Predicting pulp treatment success with metabolic markers
This trial tests if a metabolic biomarker can predict how well a vital pulp treatment works for tooth pain caused by deep cavities. It aims to help patients keep their natural teeth instead of needing root canals.
BaghdadAges 16–50 - NCT07451769Recruiting
Testing a new drug target for migraine relief
This trial tests a substance that activates adrenomedullin receptors, which may be a new way to treat migraines. It may help people who have migraines without aura and aren't on preventive migraine medications.
Glostrup MunicipalityAges 18–65 - NCT07444957Recruiting
Safety of a drug-coated balloon for heart artery blockages
This study tests a special balloon coated with a drug called sirolimus to open blocked heart arteries. It may be an option for people with coronary artery disease who need a less invasive treatment.
Vigo, PontevedraAges 18 years+ - NCT07452627Recruiting
Comparing Nerve Blocks for Sternotomy Pain
This study compares three different injection techniques (nerve blocks) to reduce pain after heart surgery that cuts through the breastbone. The goal is to find the best way to control pain with fewer side effects.
Bursa, NilüferAges 18–80 - NCT07446868Recruiting
Comparing two nerve blocks for pain after mastectomy
This trial compares two nerve-block techniques (SPSIP and ESPB) to see which one provides better pain relief after breast cancer surgery. The goal is to reduce pain and improve recovery after a modified radical mastectomy.
Cairo, Cairo GovernorateAges 18–65 - NCT07444697Recruiting
Erections after heart stent in men with and without heart attack
This study looks at how having a stent placed affects men's ability to have erections. It compares men who had a heart attack with those who had stable chest pain. If you take part, you will fill out short questionnaires about your sexual function and recovery for 6 months.
KirikkaleAges 30–75 - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT07447856RecruitingPhase 1
Herbal plasters for pain relief while using opioids
This trial tests a topical herbal plaster to see if it can help reduce pain in people with cancer who are already taking opioids. The plaster is placed on the most painful area and may allow you to use less opioid medication.
Basking Ridge, New JerseyAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.