Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,753 recruiting studies in this area right now.
By phase
- Not applicable3,099
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University30
- Mayo Clinic27
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York81
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,752 total
- NCT06119698Recruiting
Improving Health for Older Adults With Pain Through Engagement
This study tests a program to help older adults with long-lasting bone, joint, or muscle pain become more active. Participants wear a smartwatch and get support to manage their pain and improve their health.
Boston, MassachusettsAges 55 years+ - NCT06123286RecruitingEarly Phase 1
Tart cherry and omega-3s for joint pain from hormone therapy
This study tests whether taking tart cherry and omega-3 supplements can help reduce joint pain and stiffness caused by aromatase inhibitors (a common breast cancer treatment). If you have bothersome joint pain while on this hormone therapy, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT06128772Recruiting
Acupuncture study for chronic pain
This study tests if battlefield acupuncture, a specific type of ear acupuncture using tiny needles or tacks, can help veterans with chronic pain. It may be a good option if you have a history of substance use disorder and are interested in a non-drug approach to pain relief over 16 weeks.
Bedford, MassachusettsAges 18 years+ - NCT06129890Recruiting
Brain stimulation for nerve pain and depression
This trial tests whether a noninvasive brain stimulation technique (rTMS) can help people with long-term nerve pain who also have depression. It aims to see if this treatment can reduce pain and improve mood.
Saint-EtienneAges 18–85 - NCT06131658Recruiting
Functional training for iliotibial band syndrome in runners
This trial tests whether functional motor control exercises can reduce pain and improve flexibility and leg function in runners with IT band syndrome. It may help you run without pain on the outside of your knee.
Faisalābad, Punjab ProvinceAges 19–40 - NCT06134154Recruiting
Carbon dioxide gas for children's endoscopy
This study tests if carbon dioxide gas is safe and works well for children getting an endoscopy. An endoscopy is a procedure where a doctor uses a thin tube to look inside the body.
Birmingham, AlabamaAges 6 months–18 years - NCT06134791Recruiting
Comparing neck test results in cervicogenic headache patients
This study compares people with cervicogenic headache (headache from neck problems) to see if a simple neck test can tell them apart. It aims to help doctors diagnose this type of headache better.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06136676Recruiting
Comparing spiritual and secular meditation in healthy adults
This study looks at how two kinds of meditation—spiritual (Christian or Muslim) and secular (non-religious)—affect your mind, body, emotions, and social life. If you are a healthy Christian or Muslim adult who prays weekly, this could help researchers understand which type of meditation may work best for people like you.
Calicut, KeralaAges 18–60 - NCT06139510Recruiting
Understanding Pain in Sickle Cell Disease
This study looks at what causes pain in people with sickle cell disease. They hope to learn more about pain patterns to better help patients manage it.
Durham, North CarolinaAges 15–40 - NCT06141187Recruiting
Vertebroplasty vs. sham for spine fractures due to osteoporosis
This trial tests if a procedure called vertebroplasty (injecting bone cement into a fractured spine bone) relieves pain better than a sham (fake) procedure. It is for people with painful spine fractures caused by osteoporosis (weak bones) that started within the last three months.
Middelfart, FynAges 50 years+ - NCT06141720Recruiting
Mindfulness for endometriosis surgery
This trial tests if a mindfulness program can help people preparing for endometriosis surgery. It may reduce stress and improve recovery.
Hershey, PennsylvaniaAges 18 years+ - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT06146894Recruiting
Comparing filling methods for tooth pain after root canal
This study compares different ways to fill a tooth's root canals after cleaning them. It looks at which method causes the least pain after a single visit root canal treatment.
Kafr ash Shaykh, Kafr El-ShaikhAges 18–60 - NCT06148818Recruiting
Neck exercises for jaw pain relief
This study tests whether special neck exercises can help reduce jaw pain in people who have both jaw (TMJ) problems and neck pain. If you have had jaw pain for at least 3 months and also have achy neck pain, you may be able to join.
TrabzonAges 18–55 - NCT06149819Recruiting
Chest pain nurse track for emergency care
This trial is testing a nurse-led care pathway for people who come to the emergency room with chest pain that is not caused by an injury. The goal is to see if this approach can improve care and speed up the process.
Grenoble, GrenobleAges 18 years+ - NCT06153199Recruiting
Managing low back pain in nursery and landscape workers
This study tests a self-management program to help people who work in nurseries or landscaping manage their low back pain. It aims to give you practical tools to reduce pain and stay active at work.
Gainesville, FloridaAges 18 years+ - NCT06153303Recruiting
Online therapy for endometriosis and chronic pain
This trial tests if an internet-based program based on acceptance and commitment therapy (ACT) can help people with endometriosis and chronic pain. It aims to improve daily functioning and quality of life.
Lund, Skåne CountyAges 18–65 - NCT06153589Recruiting
Music therapy for leg ulcer pain relief
This trial tests whether listening to music during wound cleaning can reduce pain for people with leg ulcers caused by vein or artery problems. It aims to make the procedure more comfortable.
Fort-de-FranceAges 18 years+ - NCT06155916Recruiting
Sleep and nerve pain: a pregabalin study
This study tests whether a nerve pain medication (pregabalin) helps people with long-term nerve pain sleep better. It involves brain scans to see how the medication affects the brain.
Helsinki, HUSAges 18–75 - NCT06157866Recruiting
Cognitive training with acupuncture for fibromyalgia pain
This study tests whether a type of mental training (cognitive training) can help your brain respond better to acupuncture for fibromyalgia pain. You would receive acupuncture while doing a thinking task, and the study will use brain scans to see how your brain changes.
Charlestown, MassachusettsAges 18–65 - NCT06158620RecruitingPhase 1/Phase 2
Nasal spray for pain after ureter stent placement
This trial tests whether a nasal spray form of the painkiller ketorolac can safely reduce pain from a ureteral stent after stone surgery. If you are having a ureteroscopy with stent placement, this might help you manage discomfort without stronger medications.
Dallas, TexasAges 18 years+ - NCT06160323Recruiting
Pain block for inoperable pancreatic cancer
This trial tests whether an early nerve block during endoscopy can better control pain from pancreatic cancer compared to waiting and using standard treatments.
Hong Kong, Hong KongAges 18 years+ - NCT06160778RecruitingPhase 3
Comparing two pain medicines for kids with belly pain
This study compares two common pain relievers—ketorolac and morphine—given through an IV to children with acute abdominal pain. It aims to find which works better and has fewer side effects for this condition.
Calgary, AlbertaAges 6–17
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,753 recruiting pain medicine studies from the U.S. registry right now, out of 6,795 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.