Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06590116Recruiting
Spinal manipulation for chronic low back pain
This study looks at how people feel about spinal manipulation therapy for long-term low back pain. It's for adults who have had pain in their lower back for more than three months and want to share their views on this type of treatment.
Gainesville, FloridaAges 18–70 - NCT06592378Recruiting
Managing pain after a broken bone with a smartphone app
This trial tests whether a smartphone app can help patients manage opioid pain medication safely after being discharged from the emergency room with a broken bone. If you have a simple fracture and plan to take opioids for pain, the app may help you track your use and recovery.
Providence, Rhode IslandAges 6 years+ - NCT06594796Recruiting
Lifestyle program for back pain and weight
This trial tests a combined exercise and lifestyle program for people with long-lasting low back pain who are overweight or have obesity. The program is delivered by physical therapists and aims to improve physical function and reduce pain.
AmsterdamAges 18 years+ - NCT06595329RecruitingPhase 1
Pain relief after kidney cancer surgery: epidural vs spinal opioids
This trial compares two ways to manage pain after open kidney cancer surgery: an epidural (a thin tube placed near your spine) versus a single spinal injection of opioids. Both aim to control pain, but the study wants to see which method works better, with fewer side effects.
SplitAges 18 years+ - NCT06600178RecruitingPhase 1
Heart medication for women with chest pain and small vessel disease
This trial tests a diabetes medication called SGLT2 inhibitors to see if it can improve blood flow to the heart and reduce chest pain in women who have small vessel heart disease (microvascular dysfunction) but not blocked large arteries. Participants will take the medication and be monitored for symptom relief and heart function improvements.
Charlottesville, VirginiaAges 18 years+ - NCT06600230Recruiting
Pelvic floor training for period pain relief
This study tests whether exercises that strengthen the pelvic floor muscles can reduce period pain (dysmenorrhea). It may help if you have regular cycles and no other gynecological conditions.
IstanbulAges 18–35 - NCT07690449Recruiting
CT signs of nerve irritation in sciatica
This study looks at three specific signs on a CT scan that may show nerve-root irritation in people with sciatica. It only includes patients who are already scheduled for a CT-guided nerve injection to treat their pain.
Nice, Alpes MaritimesAges 18 years+ - NCT06351046Recruiting
Preventing chronic pain from getting worse
This trial tests a virtual reality program to see if it can help prevent long-term pain from becoming more severe. You may be eligible if you have had pain for at least 3 months and rate your average pain as moderate or higher.
Copenhagen, København Ø.Ages 18 years+ - NCT06349772RecruitingEarly Phase 1
Pain relief after robotic sleeve gastrectomy: Zynrelef vs Exparel
This trial compares two long-acting pain medicines, Zynrelef and Exparel, to see which works better for pain control after robotic sleeve gastrectomy. The goal is to improve recovery and reduce the need for stronger painkillers.
Lubbock, TexasAges 18–65 - NCT07689214Recruiting
Normast for diabetic nerve pain in adults
This study tests an oral medication called Normast to see if it helps adults with diabetic polyneuropathy, a type of nerve damage from diabetes. The trial aims to find out if the drug can reduce symptoms and improve quality of life.
Rome, ItalyAges 18–80 - NCT07689461Recruiting
Virtual reality for pain after hip replacement
This trial tests if using virtual reality can help reduce pain after hip replacement surgery. It may be a good option if you are having a hip replacement and have moderate to severe pain.
MalatyaAges 18–99 - NCT06361472Recruiting
Personalized physical therapy for chronic neck pain
This study tests a standard physical therapy program for neck pain, with added focus on factors like your personal situation and beliefs, to see if it helps more than therapy alone. It is for Spanish-speaking adults who have had moderate neck pain for over a month without serious underlying causes.
Ciudad Autónoma de Buenos Aires, Buenos AiresAges 18 years+ - NCT06915909Recruiting
Robotic prostate surgery with low pressure gas for less pain
This trial tests whether using lower gas pressure during robotic prostate surgery can reduce pain after the operation. It aims to help men recover more comfortably.
Stevenage, HertfordshireAges 18–75 - NCT07091682Recruiting
A trial of a dissolvable heart stent for long blockages
This trial tests a new type of stent made from magnesium that slowly dissolves over time. It is for people who have a long blockage in a heart artery that has not been treated before and may be a good option for those who are stable and have not had a recent heart attack.
ErfurtAges 18–80 - NCT07605546Recruiting
Radiation Therapy for Cancer Pain Relief
This trial tests whether a focused radiation treatment called SRS (stereotactic radiosurgery) can help relieve severe cancer pain that hasn't improved with strong pain medications. You would receive a one-time radiation procedure aimed at pain-causing areas in your brain.
Los Angeles, CaliforniaAges 18 years+ - NCT07235098Recruiting
Music therapy for lung cancer surgery patients
This trial tests whether listening to music in the hospital can help reduce distress and pain after surgery for lung cancer. If you are having a minimally invasive surgery (keyhole surgery) to remove part of your lung, you may be able to join.
Bellinzona, Canton TicinoAges 18 years+ - NCT07443930Recruiting
Musicians' Health Education Study
This study looks at how well health education programs work for musicians. You can take part simply by filling out a questionnaire.
GöttingenAges Any age - NCT06600919Recruiting
Music therapy app for anxiety before ENT surgery
This study tests whether listening to calming music through a phone app before ENT surgery can help prevent anxiety. It is for adults who are scheduled for ear, nose, or throat surgery.
Saint-DenisAges 18 years+ - NCT06601218RecruitingPhase 1
Daily oral cannabis for cancer patients with solid tumors
This trial tests whether taking a daily oral cannabis (marijuana) dose is safe for people with advanced solid tumors (cancer that has spread). It's looking for people who are already on a stable cancer treatment and want to see if adding cannabis affects their symptoms or how they feel.
Lexington, KentuckyAges 18 years+ - NCT06601634Recruiting
Neck pain improvement after cervical spine surgery
This study looks at what factors help predict better neck pain after a specific type of neck surgery called ACDF. If you have a degenerative neck condition and are scheduled for this surgery, the results could help doctors understand what leads to the best pain relief.
Krakow, Lesser Poland VoivodeshipAges 18–65 - NCT06602271RecruitingPhase 3
Study of PF614 for Pain After Tummy Tuck Surgery
This study tests a new painkiller called PF614 for pain after tummy tuck surgery. It compares the study drug to a placebo (a pill with no medicine) to see how well it works and how safe it is.
Atlanta, GeorgiaAges 18–75 - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT06606821RecruitingPhase 4
Tirzepatide for heart health in people with overweight or obesity
This trial tests the weight‑loss medication tirzepatide (Mounjaro) in people who are overweight or have obesity and have stable coronary artery disease. The goal is to see if tirzepatide can reduce dangerous fatty plaque in heart arteries.
CopenhagenAges 18 years+ - NCT06609772Recruiting
Pain education for liver donors after surgery
This trial tests an individualised pain education program to see if it can reduce chronic pain and improve quality of life for living liver donors after their surgery.
Malatya, BattalgaziAges Any age
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.