Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06613178RecruitingPhase 4
IV acetaminophen for heart surgery recovery
This trial tests if giving acetaminophen (Tylenol) through a vein after heart surgery can help patients recover better. You may be a good fit if you are having planned heart surgery that is not an emergency.
Vancouver, British ColumbiaAges 18 years+ - NCT06613594Recruiting
Gentle Shoulder Stretches for Frozen Shoulder Treatment
This study compares two types of gentle shoulder stretching techniques (Kaltenborn Translatoric Glides vs. Traction Mobilization) to see which one helps reduce pain and improve movement in people with frozen shoulder. It is for adults aged 40–65 who have had chronic shoulder pain for more than 3 months.
Rawalpindi, Punjab ProvinceAges 40–65 - NCT06616324Recruiting
Virtual reality to reduce pain during kidney stone treatment
This study tests whether using a virtual reality (VR) headset during a kidney stone treatment called ESWL can help reduce pain and anxiety. If you're scheduled for ESWL at a hospital in Region Zealand, you may be able to use VR to distract yourself during the procedure.
RoskildeAges 18 years+ - NCT06617832Recruiting
Evaluating migraine treatment designs
This trial is testing new ways to treat migraine attacks. It is for adults in Denmark who have migraine on a few days each month and have used triptan rescue medicines.
Aarhus CAges 18–65 - NCT06619197Recruiting
Reflexology in Sickle Cell Disease Study
This study tests if foot reflexology, a gentle pressure technique on your feet, can help relieve pain from a sickle cell crisis while in the hospital. It is only for children and teens under 18.
BronAges Up to 18 years - NCT06621914Recruiting
Blood flow restriction training for military with leg injuries
This trial tests a low-weight exercise program using a special cuff on the leg (blood flow restriction) to see if it helps military personnel recover from leg injuries faster. It could be an option if pain is stopping you from doing normal rehab.
Loughborough, LeicestershireAges 18–55 - NCT06622369Recruiting
Virtual reality for less fear and pain during circumcision
This trial tests if watching virtual reality during circumcision can help children feel less fear, pain, and anxiety. It may be a good option if your child has not had surgery before, does not have ongoing pain, and does not wear eyeglasses.
IzmirAges 7–12 - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+ - NCT06626958Recruiting
Stress ball for pain and comfort during labor
This trial tests if squeezing a stress ball during active labor can reduce pain and increase comfort for women having a vaginal birth. It may offer a simple, drug-free way to manage labor pain.
Muş, MerkezAges 18–40 - NCT06628921Recruiting
Eptinezumab for treating a migraine attack right now
This trial tests if eptinezumab can stop a migraine attack that is already happening. It may help people who get migraines often and are already part of the TACHIS study.
RomaAges 18 years+ - NCT06632535Recruiting
Group visits and chiropractic care for older adults with chronic spine pain
This study tests whether group medical visits combined with chiropractic care can help older adults with chronic neck or back pain. If you join, you'll receive chiropractic treatments and attend group visits to learn pain management strategies.
Boston, MassachusettsAges 65 years+ - NCT06637111Recruiting
Ultrasound-guided hysteroscopy for difficult cases
This study tests if using ultrasound during an office hysteroscopy helps women who previously couldn't have the procedure due to a narrow cervix. It aims to make the exam safer and more successful.
CairoAges 18–65 - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99 - NCT06638515Recruiting
Walking and breathing exercise for pain relief
This study tests whether a specific breathing exercise (walking while breathing at a low lung volume) can reduce pain sensitivity. It's looking for healthy people who have no ongoing medical conditions or pain.
MadridAges 18–65 - NCT06638528Recruiting
Can Walking and Breath-Holding Reduce Pain Sensitivity?
This study tests a special breathing technique called 'walking apnea' (holding your breath while walking) to see if it can reduce pain sensitivity. Healthy volunteers will do this exercise, and researchers will measure how it affects your pain perception.
MadridAges 18–65 - NCT06638645Recruiting
Hospital stay after keyhole lung surgery
This study looks at how long people stay in the hospital after keyhole surgery to remove a part of the lung. It aims to find out what affects recovery time.
BrugesAges 18 years+ - NCT06639009Recruiting
Laser treatment for better mouth opening in oral fibrosis
This study tests if a special laser therapy (photobiomodulation) helps people with oral submucous fibrosis open their mouths wider. It's for people who haven't had other treatments for this condition in the last three months.
New Delhi, National Capital Territory of DelhiAges 18–99 - NCT06639438Recruiting
Sensory outcomes in people who use opioids
This study looks at how opioids affect the senses in people having planned surgery. Researchers want to compare patients who use opioids (for pain or addiction) with those who don't, to see if there are differences in sensation.
Boston, MassachusettsAges 18 years+ - NCT06639984RecruitingPhase 2
Psyllium for kids with IBS
This study tests if psyllium, a fiber supplement, helps reduce belly pain and other symptoms in children with irritable bowel syndrome (IBS). It may be an option if standard treatments haven't worked well.
Durham, North CarolinaAges 12–17 - NCT06640231Recruiting
Sealer activation for reducing pain after root canal
This trial tests if activating a sealer inside a tooth after root canal can reduce pain in the days after treatment. It may help people with a painful lower molar that still has a live nerve.
Cairo, New CairoAges 18–40 - NCT06642311Recruiting
Bladder filling for pain relief during hysteroscopy
This trial tests if filling the bladder with fluid can reduce pain during a minor procedure to look inside the uterus, for women whose uterus is tilted forward.
CairoAges 18–60 - NCT06644261RecruitingPhase 4
Comparing two methods of nerve block for pelvic pain
This study compares two ways to give a pudendal nerve block—one through the vagina, one through the buttock with X-ray guidance—to see which works better for women with pudendal neuralgia (nerve pain in the pelvic area). It may help find a more effective and comfortable treatment option.
Louisville, KentuckyAges 18 years+ - NCT06644807Recruiting
Neuromodulation for phantom limb pain after amputation
This trial tests a new approach to suppress phantom limb pain using neuromodulation methods. It may help people who have had a limb amputated and continue to experience persistent pain.
Moscow, MoscowAges 18–65 - NCT06647615Recruiting
Virtual reality for stomach pain in Crohn's disease
This study tests if using a virtual reality (VR) program can help reduce stomach pain in people with Crohn's disease that is not currently active. You will try the VR experience and report how your pain changes.
Jacksonville, FloridaAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.