Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,578 recruiting studies in this area right now.
By phase
- Not applicable2,954
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,578 total
- NCT06994546Recruiting
ArtiBest injection for knee osteoarthritis pain
This trial tests a new hyaluronic acid injection called ArtiBest for people with mild to moderate knee osteoarthritis who haven't gotten enough relief from other treatments like physical therapy or pain pills. It aims to see if the injection can reduce knee pain and improve function.
Kaohsiung CityAges 35–85 - NCT05266040RecruitingPhase 2
Valacyclovir to reduce pain from infected tooth abscess
This Phase 2 study tests whether valacyclovir, an antiviral medicine, can help reduce moderate-to-severe pain from an acute infected tooth abscess. Participants also receive standard dental treatment, and the study looks at whether the added medicine helps with pain.
San Francisco, CaliforniaAges 18–80 - NCT06466330Recruiting
Knee embolization for post-replacement pain
This trial tests a non-surgical treatment called microparticle geniculate artery embolization for people with persistent knee pain after a total knee replacement. It aims to reduce pain by blocking tiny blood vessels that may be causing inflammation.
CréteilAges 40–80 - NCT06996691Recruiting
Comparing two nerve blocks for lung surgery pain
This study compares two types of nerve blocks to see which one better controls pain after lung surgery. It may help find a better way to manage pain with fewer side effects.
CairoAges 18–70 - NCT06754657RecruitingPhase 4
Comparing pain blocks for rotator cuff surgery recovery
This trial tests two ways of numbing the shoulder during rotator cuff surgery to see which leads to better recovery after outpatient surgery. It compares a single injection with a continuous pump that delivers numbing medicine for a longer time.
SantiagoAges 18–75 - NCT06838572Recruiting
Cooling the wrist to reduce pain from arterial line placement
This study tests whether cooling the skin on your wrist before a routine arterial line placement (a small tube in your wrist artery) can reduce the pain of the procedure. If you are having surgery and need an arterial line, this might help make the experience more comfortable.
Chongqing, Chongqing MunicipalityAges Any age - NCT06766994Recruiting
Pain relief methods after hysterectomy: a recovery comparison
This study compares two different ways to manage pain after abdominal hysterectomy surgery. The goal is to see which method helps you recover better and feel more comfortable.
Erzurum, YakutiyeAges 18–65 - NCT07015411Recruiting
Neuro supplements for migraine prevention
This trial tests whether a combination of vitamins and supplements can help prevent migraines. It's for adults who have migraines often (at least 6 days per month) and want to try a non-drug option.
MechelenAges 18–75 - NCT07020000Recruiting
Lumbar fusion with EARP nerve cuff electrode
This trial uses a medical device called the EARP Interbody System with a nerve cuff electrode during lower back fusion surgery. It collects real-world data to confirm the device is safe and works well for people having fusion between the second and fifth lumbar vertebrae.
Jacksonville, FloridaAges 22–80 - NCT06984276Recruiting
Nerve blocks for pain relief in children having heart surgery
This study compares two different ultrasound-guided numbing injections (pectoral nerve block vs. transverse thoracic plane block) to see which provides better pain control for children aged 6 months to 7 years undergoing heart surgery through a chest incision with a heart-lung machine.
CairoAges 6 months–7 years - NCT06996340Recruiting
White noise during IVF treatment for women with infertility
This study tests whether listening to white noise can help reduce stress in women undergoing in vitro fertilization (IVF) for the first time. It may help you feel more relaxed during treatment.
Samsun, AtakumAges 18–35 - NCT06993922Recruiting
Scalp block with added sedative for brain surgery pain
This study tests adding a sedative (dexmedetomidine) to the usual numbing medicine (bupivacaine) for a scalp block before brain surgery. The goal is to see if this combination reduces pain after surgery better than the numbing medicine alone.
CairoAges 18–65 - NCT07023497Recruiting
Finding the best dose of spinal morphine for C-section pain relief
This study tests different doses of morphine given through a spinal injection during a planned C-section to find the best balance of pain relief and side effects. It may help women have better pain control after surgery.
Ioannina, EpirusAges 18–50 - NCT07021586Recruiting
Tongue pressure in adults with chronic neck pain
This study looks at how tongue pressure might be related to chronic neck pain in people aged 50 to 65. If you have ongoing neck pain, it could help researchers understand how your muscles work.
TaipeiAges 50–65 - NCT07018375RecruitingPhase 4
Oliceridine for pain after lung surgery
This study tests a new pain medication called oliceridine given through an IV after lung surgery to see if it helps reduce long-term pain. Participation may help improve pain management after surgery.
Baoding, HebeiAges 18–75 - NCT07016581Enrolling by invitation
Best length for a spinal cord stimulation test
This study is testing how long a spinal cord stimulation trial should last to best diagnose whether it will help your chronic pain. It compares different trial lengths to see which one gives the most accurate result.
Baltimore, MarylandAges 18 years+ - NCT07022106Recruiting
Comparing physiotherapy techniques for period pain
This study compares different physical therapy techniques to help reduce period pain. It is for people with painful periods (dysmenorrhea) who do not have other gynecological conditions.
Istanbul, BeykozAges 18–30 - NCT07016672Recruiting
PRP vs. hyaluronic acid for advanced knee arthritis
This study compares two treatments—platelet-rich plasma (PRP) and hyaluronic acid (a lubricating injection)—for people with severe knee arthritis seen on MRI. The goal is to see which better reduces pain.
Toulon, VarAges 18 years+ - NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT07017660Recruiting
Virtual reality for comfort during cystoscopy
This trial tests if using virtual reality (VR) during a cystoscopy (a procedure to look inside the bladder) can help reduce pain or anxiety. If you are having a rigid cystoscopy for the first time under local anesthesia, you may be able to participate.
AnkaraAges 18–70 - NCT07022821RecruitingPhase 4
Comparing two pain medicines after planned C-section
This study tests two medications, dexmedetomidine and ketamine, to see which one works better for pain after a planned C-section. If you're having a scheduled C-section and are generally healthy, this trial could help find better pain relief options.
Lahore, Punjab ProvinceAges 18–50 - NCT07019818RecruitingPhase 4
Esmolol vs. sufentanil for recovery after gallbladder surgery
This trial tests two different medicines given during gallbladder surgery to see which one helps you recover better. One medicine (esmolol) controls heart rate, while the other (sufentanil) is a strong painkiller. The goal is to find out which approach leads to a smoother recovery after your surgery.
Brive-la-Gaillarde, FranceAges 18 years+ - NCT07021287Recruiting
Cold therapy after knee replacement surgery
This study compares different cold therapy programs to see which works best for pain and swelling after total knee replacement. Everyone in the study receives cold therapy, and the researchers will track recovery outcomes.
Yiwu, ZhejiangAges 18 years+ - NCT07023692Enrolling by invitation
Using visual and sound tricks to ease pain and worry during a bone marrow test
This trial tests whether watching a video or listening to sounds can help reduce pain and anxiety during a bone marrow aspiration or biopsy. It's for adults who are either healthy volunteers or patients without a blood cancer diagnosis, and who need this test at the clinic in Lund, Sweden.
Lund, Skåne CountyAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,578 recruiting pain medicine studies from the U.S. registry right now, out of 6,493 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.