Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad27
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06650631Recruiting
Heat treatment for knee pain from arthritis
This study tests if a heat treatment device can help reduce knee pain caused by arthritis. It involves people with moderate pain who can walk without help and have a recent knee X-ray.
Gravesano, SwitzerlandAges 19–69 - NCT06651775Recruiting
High-Intensity Laser Therapy for Chronic Leg Pain from Herniated Disc
This study tests whether a type of high-intensity laser therapy (HILT) can help relieve leg pain caused by a herniated disc in the lower back. It is for people who have not had recent back treatments or surgery.
Ankara, CankayaAges 18–65 - NCT06652581Recruiting
Testing a nerve block for gallbladder surgery pain
This study tests a special nerve block called M-TAPA to see if it helps control pain during and after gallbladder removal surgery. It might offer better pain relief with fewer side effects.
Denpasar, BaliAges 18–65 - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT06653803Recruiting
Nerve blocks for pain after chest wall surgery
This trial compares two types of nerve blocks (rhomboid intercostal and retrolaminar) to see which provides better pain relief after a type of chest surgery called thoracoscopic sympathectomy. If you are having this surgery, you may be eligible to join.
Damanhūr, El-BeheiraAges 18–60 - NCT06655337Recruiting
Testing a smartphone app for managing hospital discharge
This study tests whether a smartphone app called Medidux helps you manage your symptoms and discharge from the hospital if you came in with coughing, back pain, or belly discomfort. You'll use the app to report how you're feeling, and the care team can check in with you after you leave.
Horgen, Canton of ZurichAges 18 years+ - NCT06655506Recruiting
Enhanced Recovery for Gynecologic Cancer Surgery
This trial studies whether an enhanced recovery after surgery (ERAS) program improves outcomes for people with gynecologic cancer. It aims to help you recover faster and with fewer complications.
Athens, AthensAges 25–85 - NCT06655675Recruiting
Blood flow changes after epidural pain relief in labor
This study looks at how a type of labor pain relief (combined spinal-epidural) affects blood flow in the mother and baby's main arteries. It may help doctors understand if this common pain relief method is safe for all labors.
Toronto, OntarioAges 18–50 - NCT06655844Recruiting
Sana Device for chronic pain from Lyme disease
This study tests the Sana device—a special light and sound tool—to see if it can help reduce chronic nerve pain in people with Post-Treatment Lyme Disease Syndrome. You may be able to join if you have ongoing nerve pain after Lyme treatment and meet a few basic health and medication rules.
New York, New YorkAges 18 years+ - NCT06656156Recruiting
Stretching technique for chronic low back pain relief
This trial tests a physical therapy stretching method called PNF on the hip and hamstring muscles to see if it reduces chronic low back pain. It may help if you have had non-specific low back pain for over 3 months with tightness in your hips or legs.
Karachi, SindhAges 15–40 - NCT06656299Recruiting
Nerve block for gallbladder removal surgery
This study tests a nerve block called EOIB to see if it helps reduce pain after gallbladder removal surgery. If you are having planned gallbladder surgery, this might be a good option for you.
IstanbulAges 18–65 - NCT06657326Recruiting
New stent for high bleeding risk patients
This trial tests a new type of stent (BioFreedom Ultra) compared to a standard one (BioFreedom) in people who have a high risk of bleeding. Both stents release medicine to keep arteries open, and the study checks if the newer stent works better with a shorter course of blood thinners.
Johor Bahru, JohorAges 18 years+ - NCT06658249Recruiting
Core exercises vs foot-ankle strength for knee arthritis
This study compares core strengthening exercises with foot-ankle exercises to see which helps more with knee osteoarthritis symptoms like pain and walking difficulty. It might help you move better and climb stairs more easily.
Lahore, Punjab ProvinceAges 40–65 - NCT06658327Recruiting
Stretching for knee arthritis in postmenopausal women
This study compares two types of stretching to see which better reduces pain and improves movement in postmenopausal women with knee osteoarthritis. It may help you find a simple, drug-free way to manage your symptoms.
Lahore, Punjab ProvinceAges 50–65 - NCT06659991RecruitingEarly Phase 1
Pain and daily tasks in jaw joint disorder
This study tests how pain from a jaw joint disorder (TMD) affects your ability to do daily tasks. You'll track your pain and activities on your smartphone to help researchers understand the link.
Minneapolis, MinnesotaAges 21–65 - NCT06660186Recruiting
Sternal plating for high-risk heart surgery patients
This study looks at whether using special metal plates to close the breastbone after heart surgery can help people at higher risk for slow healing. It may be an option if you have multiple risk factors like diabetes, heavy smoking related lung disease, or obesity.
Cleveland, OhioAges 18–89 - NCT06660901Recruiting
Study on cannabis use and vomiting in emergency rooms
This study looks at patients who come to the ER with belly pain or vomiting and uses cannabis, to better understand a condition called cannabinoid hyperemesis syndrome (severe nausea and vomiting caused by long-term cannabis use). If you're eligible, you'll answer a few questions to help doctors learn more.
AngersAges 18–65 - NCT06661642Recruiting
Predicting pain after planned surgery
This study looks at whether we can predict how much pain you will feel after surgery. It aims to help doctors better manage pain after your operation.
AalborgAges 18 years+ - NCT06661681Recruiting
Cognitive functional therapy for chronic shoulder pain
This study tests a new type of therapy called Cognitive Functional Therapy (CFT) for people with ongoing shoulder pain. It focuses on how you move and think about your pain, and aims to help you manage better without surgery or injections.
João Pessoa, ParaíbaAges 18–60 - NCT06662617Recruiting
Numbing injections for pain after gallbladder surgery
This study tests whether two different numbing injections (M-TAPA and TAPB) placed before surgery can reduce pain after keyhole gallbladder removal, compared to standard care. If you qualify, the injections may help you feel less discomfort after the operation.
SivasAges 18–80 - NCT06663956RecruitingPhase 3
Web app for cancer pain management study
This trial tests whether a special website or app can help people with cancer do a better job managing their pain. If you have moderate or severe cancer pain that needs morphine and you can use a simple app to track your symptoms, this may help you feel better.
Chengdu, SichuanAges Any age - NCT06664203Recruiting
Nerve block for arm surgery pain relief
This trial tests a special type of nerve block (called variable volume truncal block) for pain relief during arm, elbow, forearm, hand, or wrist surgery. It may help reduce pain and the need for strong pain medicines.
IstanbulAges 18–65 - NCT06665438RecruitingPhase 3
Pain relief after knee arthroscopy: numbing injection with added medication
This trial tests whether adding dexmedetomidine to a numbing injection (bupivacaine) inside the knee joint provides better pain relief after arthroscopic ACL reconstruction. It aims to help patients recover more comfortably after surgery.
AsyutAges 18–65 - NCT06666621RecruitingPhase 4
Naloxone injection for low back pain
This trial tests whether naloxone, a drug that blocks opioid effects, can change how your body responds to pain injections in the lower back. It may help find new ways to treat low back pain that hasn't improved with physical therapy or oral medications.
Nashville, TennesseeAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,811 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.