Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05375617Recruiting
Study for newly diagnosed childhood cancers in Europe
This study follows children and teens with newly diagnosed certain leukemia (ALL) and certain favorable brain tumors to learn best care and outcomes. It may help your team compare standard treatments and monitor health over time.
New York, New YorkAges 3–21 - NCT05375513Recruiting
Home exercise and brain-health support for mild memory trouble
This study tests a program you do at home (with online coaching) to help people with mild memory problems (“mild cognitive impairment”) improve thinking and brain health. It also focuses on lowering extra risk factors (like low activity, poor sleep, diet, or heart/metabolic risks).
Edmonton, AlbertaAges 60–85 - NCT05375968RecruitingPhase 2
Test blood-flow changes in POTS after meals
This Phase 2 study looks at how blood pools in the belly veins when you stand or eat, in people with POTS (postural tachycardia syndrome). The goal is to understand what’s driving symptoms like feeling nearly faint and whether this helps guide better care.
Nashville, TennesseeAges 18–50 - NCT05378035Recruiting
DOAC interruption study for Chinese people with atrial fibrillation
This trial studies how safely and effectively to pause a blood thinner (a DOAC) for about 48 hours before an elective procedure in people with atrial fibrillation. It may help confirm the best way to reduce bleeding risk without raising stroke risk.
Hong KongAges 18–80 - NCT05378490Recruiting
Study of stroke types and thrombolysis treatment
This study includes people who have had certain kinds of sudden brain blood-flow problems (like an ischemic stroke, bleeding in the brain, or a brief warning episode) or conditions that look similar. It looks at how treatment such as clot-busting medicine (thrombolysis) fits for these situations.
LørenskogAges 18 years+ - NCT05378633Recruiting
CyberKnife treatment for multiple brain metastases
This trial looks at how well (and how much) CyberKnife radiation works for people with multiple brain metastases. It may help your care team understand the best way to treat several brain spots safely.
HeidelbergAges 18 years+ - NCT05378555RecruitingPhase 3
Oral ketamine for sickle cell pain crises
This trial tests whether taking ketamine by mouth can help treat “vaso-occlusive” pain episodes that may require hospital admission. If it works, it could offer an easier way to manage severe pain during sickle cell crises.
Boston, MassachusettsAges 12–24 - NCT05379855Recruiting
Eye drops for eye alignment and double-vision control in children
This study tests eye drops to improve how a child’s eyes line up and how well they can use both eyes together. It may help children with certain types of outward eye drifting (intermittent exotropia/exophoria).
ShanghaiAges 5–14 - NCT05380050Recruiting
Telehealth vs in-person skills training for brain injury and PTSD
This study compares a combined skills program delivered by video/phone (telehealth) versus meeting in person. It aims to improve attention and coping skills for veterans who have both mild brain injury and PTSD.
Gainesville, FloridaAges 30–55 - NCT05382754Recruiting
Home sleep testing for children being checked for sleep apnea
This trial tests whether home sleep testing can help diagnose sleep apnea in children. It is for kids who are already being referred for an in-lab sleep study at CHOP.
Philadelphia, PennsylvaniaAges 5–12 - NCT05380856Recruiting
Sacral nerve stimulation for bladder, bowel, and sexual symptoms
This trial studies whether sacral neuromodulation (a device that sends mild nerve signals) can improve bladder, bowel, and sexual symptoms caused by nerve problems. It is for people whose current bladder treatments have not worked well enough.
Odense, FynAges 18–80 - NCT05383742RecruitingPhase 2
Compare 6- vs 9-month treatment for tuberculous meningitis
This Phase 2 study tests whether a shorter, stronger 6-month set of medicines works as well as the usual 9-month regimen for tuberculous meningitis (TB infection in the covering of the brain/spinal cord). The goal is to improve outcomes while reducing treatment time and exposure.
Porto AlegreAges 15 years+ - NCT05385315Recruiting
Blood test study to help detect Parkinson’s disease early
This study looks for a new blood marker that could help doctors detect Parkinson’s disease earlier. Depending on your diagnosis and treatment status, your blood may be compared with other people’s to see how well the test works.
GrenobleAges 18 years+ - NCT05386108RecruitingPhase 1/Phase 2
Test abemaciclib plus elacestrant for breast cancer brain spread
This trial studies whether the combination of abemaciclib and elacestrant can slow or shrink ER-positive, HER2-negative breast cancer that has spread to the brain. It is designed for people whose cancer has progressed despite prior hormone (endocrine) treatment.
Fullerton, CaliforniaAges 18 years+ - NCT05386394RecruitingPhase 2
Brain stimulation to help primary progressive aphasia speech
This trial tests a non-painful brain stimulation method to improve language and speech problems caused by primary progressive aphasia. It may help some people communicate more clearly by targeting specific brain regions.
Baltimore, MarylandAges 50–90 - NCT05387954RecruitingPhase 3
PFO closure or blood thinners after stroke in ages 60–80
This trial studies the best way to prevent another stroke after a recent stroke in people ages 60 to 80 who have a “PFO” heart connection. It compares closing the PFO vs taking mouth blood-thinners or antiplatelet medicine, based on what your doctors determine is safest for you.
AmiensAges 60–80 - NCT05388331Recruiting
Study of silent brain lesions seen on MRI
This study follows people who have silent white-matter spots on brain MRI that may be related to nerve insulation problems (demyelination). It aims to better understand what these findings mean and whether they point to a specific condition.
NiceAges Any age - NCT05389878Recruiting
Stroke patient registry for people within 6 months of stroke
This trial sets up a registry (a secure database) to better track and understand adults who have had an ischemic or hemorrhagic stroke within the last 6 months. Being listed may help researchers learn what care works best for different types and stages of stroke.
FlorenceAges 18 years+ - NCT05390268Recruiting
Mobile app behavioral therapy for youth with tic disorders
This trial tests whether a mobile app can help children and teens reduce tic symptoms using behavioral treatment strategies. It may help if your tics are affecting your daily life and you have not had very recent tic-specific behavioral training.
Aarhus N, RisskovAges 9–17 - NCT05390918Recruiting
Trial for teen sleep and suicidal thoughts risk
This study aims to see if treating insomnia (sleep problems) can lower overall risk related to suicidal behavior in teens. You may be eligible if you’ve had both recent sleep issues and recent suicidal thoughts, with some important safety exclusions.
Columbus, OhioAges 11–18 - NCT05393492Recruiting
Emotion and behavior skills after a brain injury
This study tests a structured program to help people after a brain injury manage emotions and challenging behaviors, and to reduce distress for them and their families. If you (or your family member) can participate safely and understand the activities in French, you may be invited to join a group and assessments.
Illkirch-GraffenstadenAges 18 years+ - NCT05393518Recruiting
Study linking brain signals to anxiety in people with epilepsy
This study looks at how brain electrical signals relate to anxiety symptoms in people with drug-resistant epilepsy. It compares people who do (or do not) meet criteria for generalized anxiety disorder, to better understand anxiety in this setting.
BordeauxAges 18–65 - NCT05393830Recruiting
Study tests how sleep loss affects emotion control
This study looks at how losing sleep changes a person’s ability to manage emotions. You may need to do brain scans (fMRI), and you would be asked to avoid alcohol and recreational drugs during the study.
Boston, MassachusettsAges 18–40 - NCT05394506Recruiting
Study of factors that affect muscle laminopathy with LMNA changes
This study looks at what influences the course of a muscle disease caused by an LMNA genetic change (a type of laminopathy). It may help researchers better understand the disease and how it affects muscle and sometimes breathing or heart function.
Bron, Auvergne-Rhône-AlpesAges 2 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.