Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05482126Recruiting
Studying brain sensing in advanced Parkinson’s during deep brain stimulation
This study looks at how the brain “filters” sensory information in people with advanced Parkinson’s disease, using brain imaging and deep brain stimulation (DBS) that you may already be getting as routine care. The goal is to better understand what drives Parkinson’s symptoms and how DBS might affect the brain.
Birmingham, AlabamaAges 18–89 - NCT05482906Recruiting
Smartphone and MRI study for people with multiple sclerosis
This study looks at how information from a brain/spinal MRI and a smartphone relates to walking and daily function in people with multiple sclerosis (MS). It may help researchers understand what signals predict changes over time.
Nantes, Loire-AtlantiqueAges 18 years+ - NCT05483816Recruiting
Sensory stimulation trial for nerve pain in people with neuropathy
This study tests a multi-sensory (multiple-sense) stimulation approach to see if it can help people with nerve-related pain in the legs/feet. You must be able to safely take part in MRI-related sessions and answer questions about pain and health history.
Zurich, Canton of ZurichAges 18–80 - NCT05484245Recruiting
Ultrasound-guided surgery for certain brain mass lesions
This trial looks at using real-time ultrasound to help surgeons remove or treat certain brain growths and bleeding areas. It may help by making the procedure more precise for newly diagnosed cases in the upper part of the brain.
MoscowAges 18–100 - NCT05484557Recruiting
Apixaban vs enoxaparin to prevent blood clots after spinal cord injury
This trial studies whether apixaban works as well as enoxaparin to prevent dangerous blood clots after spinal cord injury. If you qualify, you would take one of these medicines to lower clot risk during the recovery period.
RaananaAges 18 years+ - NCT05484349RecruitingPhase 3
Tizanidine to prevent frequent migraine attacks
This Phase 3 trial tests tizanidine to help prevent migraine attacks. If you have frequent migraine with or without aura, it compares tizanidine against placebo while tracking your headaches in diaries.
Luzhou, SichuanAges 18–65 - NCT05484570Recruiting
Study of how rare DNA repair disorders affect the body over time
This natural history study follows people with specific DNA repair disorders to better understand symptoms and how they change over time. It may help researchers plan future treatments by mapping what complications to expect and when.
Minneapolis, MinnesotaAges 6 months+ - NCT05485649Recruiting
Pregnant people with epilepsy followed at a Toronto clinic
This study follows pregnant people who have epilepsy who were seen at a specific Toronto epilepsy clinic over a set time period. It aims to learn about health outcomes during pregnancy, which may help improve care and planning for future patients.
Toronto, OntarioAges Any age - NCT05486637RecruitingEarly Phase 1
Hearing aid and implant study using voice emotion prompts
This early-phase study checks how well people understand emotions in voices when they have a cochlear implant (or normal hearing). It may help improve communication training and support for patients and families.
Tempe, ArizonaAges 6–80 - NCT05527080Recruiting
Study brain and movement development in healthy infants
This study looks at how infants’ movement (motility) and early thinking (cognition) develop over time. It may help researchers better understand normal development in healthy babies.
HelsinkiAges 5 months–2.2 years - NCT05487053Recruiting
Nerve block type test after knee replacement
This study compares two pain-control methods for the leg after a total knee replacement: a single injection versus a continuous nerve-block catheter. It aims to see which option helps people recover and do rehab better.
MoscowAges 18 years+ - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT05487989Recruiting
Visual pathway study for recent optic neuritis
This study looks at how the eye-to-brain visual pathways work in people who have had optic neuritis symptoms for less than 4 weeks. It may help researchers better understand neuro-inflammatory (nerve inflammation) disorders and improve future care.
LilleAges 18–65 - NCT05489549Recruiting
Study of heart amyloid risk in people with TTR gene variants
This study looks at people who carry certain TTR gene variants, which can cause a specific type of heart amyloid buildup. It also includes people with symptoms, to understand how the condition develops and how it may be monitored.
New York, New YorkAges 30–80 - NCT05489575Recruiting
CPAP machine for high blood pressure when lying down at night
This study tests whether using a CPAP breathing machine at night can lower high blood pressure that happens while you sleep. It targets people with nervous-system problems that affect blood pressure changes when standing.
Nashville, TennesseeAges 40–80 - NCT05490134RecruitingEarly Phase 1
Testing naloxone for brain effects in healthy adults
This early study tests a medicine called naloxone, given by the study, to see how it affects the brain and safety in people who are otherwise well. It may help researchers understand naloxone’s potential role in brain-related conditions.
Charleston, South CarolinaAges 18–65 - NCT05491031Recruiting
MRI scan study to predict disability changes in MS
This study uses MRI scans to predict how quickly disability may worsen in people with multiple sclerosis (MS). It may help doctors spot people at higher risk of progression earlier.
PoitiersAges 18 years+ - NCT05491434Recruiting
Study of muscle loss in colon cancer patients
This trial looks at muscle loss (called sarcopenia) in people with colon cancer to test an intervention that may help strength or recovery. If you’re age 70 or older and meet the cancer and health requirements, you may be able to take part.
L'Hospitalet de Llobregat, BarcelonaAges 70 years+ - NCT05491525RecruitingPhase 2/Phase 3
Vibegron for children with nerve bladder using intermittent catheter
This study tests how well and how safely vibegron works long-term in children (ages 2 to under 18) with a nerve-related bladder condition, who regularly use intermittent catheterization. It also tracks how the body processes the medicine and whether it helps bladder control over time.
Little Rock, ArkansasAges 2–17 - NCT05492188Recruiting
Testing training and skin reflex changes for nerve pain after SCI
This study looks at how a training program affects skin reflexes and nerve pain in people with spinal cord injury (SCI). It may help researchers find better ways to manage nerve pain by changing how the body responds to touch and training.
Charleston, South CarolinaAges 18 years+ - NCT05492513Recruiting
Constraint therapy for adults with mild arm weakness after stroke
This study tests a therapy that focuses on using your weaker arm more after a stroke by “constraining” the better arm during training. It may help improve how you move and use your hand and wrist in daily life if you still have mild movement and can participate in clinic sessions.
Birmingham, AlabamaAges 18 years+ - NCT05493514Recruiting
Robotic training program for walking and balance
This trial studies whether a robotic training system (called G-EO) can help people with neurological conditions improve walking and balance. It may help by testing which factors predict who benefits most, and it requires regular training sessions.
MilanAges 18 years+ - NCT05493722RecruitingEarly Phase 1
Adjusting deep brain stimulator settings for hard-to-control seizures
This early-phase study tests whether changing your deep brain stimulator settings can improve seizure control in people whose epilepsy is not helped by usual treatments. It is mainly for patients who already have the stimulator placed.
Minneapolis, MinnesotaAges 18 years+ - NCT05493605Recruiting
MRI study of heart involvement in Wilson disease
This study looks at whether Wilson disease affects the heart, using MRI scans (and possibly contrast dye). Your results may help doctors better understand cardiac (heart) involvement and how it progresses in Wilson disease.
ParisAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.