Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05767242Recruiting
Early brain tests in babies at language risk
This study looks for early brain signals that may predict future language difficulties in very young children. It compares babies with a family history of language problems to babies without, using safe testing to see what markers show up early.
Bosisio Parini, LCAges 6 months–8 years - NCT05767476Recruiting
Testing cooling treatment after lack of oxygen at birth
This trial studies outcomes in newborns who had breathing problems from low oxygen before or during birth and were treated with a cooling therapy (therapeutic hypothermia). It may help doctors understand which babies benefit most and what recovery looks like over time.
RomeAges 10 minutes–6 hours - NCT05768048Recruiting
Study tracks SMA patients with specific gene changes
This study follows people with spinal muscular atrophy (SMA) who have a particular genetic change in the SMN1 gene. It compares long-term outcomes for those who do and do not receive disease-modifying treatments, to better understand what helps over time.
GenovaAges Any age - NCT05768139RecruitingPhase 1/Phase 2
Testing a new targeted drug for advanced solid tumors with PI3Kα mutation
This trial tests tersolisib, a new targeted medicine, in adults with advanced or hard-to-remove solid cancers. It focuses on tumors that have a specific genetic change (PI3Kα mutation) to see how well the treatment works and what side effects it causes.
Los Angeles, CaliforniaAges 18 years+ - NCT05768490RecruitingPhase 3
Radiation plus targeted pills for EGFR lung cancer brain spots
This Phase 3 study tests whether giving brain radiation early or later, along with almonertinib (a targeted pill), works better for people with EGFR-mutated non-small cell lung cancer that has a small number of brain metastases. It aims to control brain disease while checking safety and effectiveness in a carefully selected group.
Guangdong, GuangzhouAges 18–75 - NCT05769699Recruiting
Blood test study for Parkinson’s stages
This study measures blood biomarkers (measurable substances in blood) in people with Parkinson’s at different stages. It may help doctors understand how Parkinson’s changes over time and could guide future testing or treatments.
RomaAges 18–80 - NCT05770544RecruitingPhase 2/Phase 3
Entrectinib for ROS1 fusion cancers with matching gene test
This trial studies entrectinib, a targeted pill, in people whose cancer has a specific gene change called ROS1 fusion. It may help by shrinking tumors that depend on this ROS1 gene switch, and the study requires starting with a new tissue sample and treatment monitoring.
BelfastAges Any age - NCT05772611Recruiting
Study of immune responses in brain autoimmune and nerve syndromes
This study looks at how the immune system works in certain neurological conditions, including autoimmune encephalitis and related nerve disorders. Researchers may use blood and/or spinal fluid samples, especially when antibodies are present or can’t be found, to better understand what’s driving the illness.
LyonAges 18 years+ - NCT05772637Recruiting
Testing bladder feeling in people with multiple sclerosis
This study checks how your bladder “sensation” works using bladder testing (including urodynamic testing) to better understand MS-related bladder problems. It may help researchers match bladder symptoms to what’s happening inside the bladder.
Paris, Choisir Une RégionAges 18–99 - NCT05773443Recruiting
Digital program plus an oral drug for Lewy body dementia
This study tests an eHealth program together with a patient-and-caregiver support program, along with a medicine called ambroxol. It aims to see whether this combined approach is safe and helpful for people with dementia with Lewy bodies (or early memory changes from it).
Haugesund, RogalandAges 50–85 - NCT05773482Recruiting
Breathing and attention training for fibromyalgia pain
This study tests whether breathing and attention exercises can change how your body controls pain in people with fibromyalgia. It may help you learn non-medication ways to influence pain signals and improve comfort.
Gainesville, FloridaAges 18–70 - NCT05773872Recruiting
Testing social understanding in narcolepsy and hypersomnia
This study compares “social cognition” (how people recognize and understand others’ thoughts and feelings) in adults with narcolepsy or idiopathic hypersomnia. It may help researchers better understand how these conditions can affect everyday social interactions.
AmiensAges 18 years+ - NCT05773885Recruiting
Telerehab sessions for people with Parkinson’s disease
This study tests whether rehab delivered through the internet (“telerehabilitation”) can help people with Parkinson’s disease. You may be able to do therapy from home, while the team monitors your function during the study.
Cassino, FrosinoneAges 30–80 - NCT05774288Recruiting
Testing a device to close a heart opening called PFO
This trial studies whether a Cera™ device is safe and effective for closing a patent foramen ovale (PFO), a small hole in the heart. It is for adults whose PFO is linked to certain types of stroke or ongoing clot-related events.
Beijing, Beijing MunicipalityAges 18–60 - NCT05775627Recruiting
Study how sleep affects metabolism in healthy adults
This trial studies how changes in sleep and the body’s daily rhythm may affect metabolism (how your body handles energy and sugar). It is for generally healthy, medication-free young adults who follow a controlled diet and sleep schedule.
Portland, OregonAges 18–40 - NCT05775367Recruiting
Cochlear implants for young children with one-sided deafness
This study checks whether cochlear implants help young children (ages about 7 months to under 3 years) who have very severe hearing loss in one ear. It also compares them with similar children who do not get implants, to understand what outcomes to expect.
Durham, North CarolinaAges 7 months–5.9 years - NCT05775458Recruiting
Study of treatments for aggressive brain tumor cell damage
This study looks at glioblastoma (GBM), a very aggressive brain tumor, and how “brain cell overload” (glutamate excitotoxicity) may affect tumor growth. It focuses on adults who are planned for complete tumor removal, followed by standard radiation and chemotherapy.
Milan, MilanAges 18 years+ - NCT05775523Recruiting
Safety follow-up study for children using lonapegsomatropin
This study tracks the safety of lonapegsomatropin in children being treated for growth hormone deficiency (GHD). It’s meant to check for side effects and make sure the medicine continues to be safe in real-world use.
Phoenix, ArizonaAges 1–18 - NCT05776030Recruiting
Test of different-speed ergonomic wheelchairs for daily users
This study tests a wheelchair design that can better match how you move and sit while using a manual wheelchair every day. You may be able to try different wheelchair setups if you meet the safety, seating, and body-size requirements.
Minneapolis, MinnesotaAges 18 years+ - NCT05776511Recruiting
Eye Movement Test for White Matter Brain Changes
This study tests whether a special eye-tracking camera can help diagnose the cause of white matter hypersignals—unusual bright spots seen on brain MRI. Researchers want to see if eye movements can reveal clues about what's causing these brain changes.
NiceAges 18 years+ - NCT05776641Recruiting
Light and sound training to help prevent Alzheimer’s memory loss
This study tests whether regular “gamma” light and sound stimulation can delay or prevent Alzheimer’s disease-related memory decline in people who are currently not showing dementia but are at higher risk. It uses brain testing (MRI and PET) and memory/language tests over about 13 months.
Boston, MassachusettsAges 55–90 - NCT05776810Recruiting
Check why fainting happens using tilt tests or heart tracing
This study looks at people who have had repeated fainting spells and still don’t know the cause. It tests whether different types of heart monitoring (like tilt testing or an ECG/heart tracing) can better explain what’s triggering syncope and guide prevention.
Calgary, AlbertaAges 50–110 - NCT05778188RecruitingPhase 2
RLS-0071 for newborns with moderate or severe HIE
This trial studies whether RLS-0071 is safe and can help some newborns with moderate or severe hypoxic-ischemic encephalopathy (HIE), a brain injury caused by low oxygen around birth. Babies in the study also receive standard whole-body cooling (therapeutic hypothermia), and the researchers will watch for side effects and early signs of benefit.
Little Rock, ArkansasAges Up to 10 hours - NCT05777889Recruiting
Infrared imaging for nerve-stimulation pain in one leg
This study uses infrared images to help evaluate spinal cord stimulation for complex regional pain syndrome (CRPS) when it affects one leg. It aims to see whether the imaging approach matches pain and treatment needs in people whose pain hasn’t improved with standard care.
New York, New YorkAges 18–85
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.