Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,406 recruiting studies in this area right now.
By phase
- Not applicable9,740
- Phase 2783
- Phase 1576
- Phase 3534
- Phase 4342
- Phase 1/Phase 2307
- Phase 2/Phase 3124
Top conditions
- Stroke841
- Parkinson Disease427
- Alzheimer Disease342
- Multiple Sclerosis341
- Dementia227
- Ischemic Stroke201
- Epilepsy197
- Obstructive Sleep Apnea156
- Insomnia154
- Spinal Cord Injuries153
- Traumatic Brain Injury150
- Sarcopenia149
- Acute Ischemic Stroke138
- Cerebral Palsy131
- Mild Cognitive Impairment130
- Migraine113
- Pain Management113
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing93
- VA Office of Research and Development92
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California681
- Massachusetts299
- New York292
- Florida275
- Texas265
- Maryland246
- Arizona212
- Alabama210
- Illinois188
- Pennsylvania177
Recruiting studies12,404 total
- NCT07681336Recruiting
Ear nerve stimulation for chronic low back pain
This trial tests if stimulating the vagus nerve through the ear can reduce chronic low back pain in people who haven't gotten enough relief from painkillers. It aims to see if this non-invasive treatment can help manage pain without medication.
Ghent, Oost-VlaanderenAges 30–60 - NCT06846177Recruiting
Training programs for fatigue after stroke
This study compares two types of training—graded activity and task-oriented training—to see which one helps reduce fatigue after a stroke. If you are between 40 and 60 years old, had a stroke over 4 months ago, and often feel very tired, you may be able to join.
Mansehra, KPKAges 40–60 - NCT07457125RecruitingPhase 1/Phase 2
Exosome therapy for mild to moderate Alzheimer's disease
This trial tests a new drug made from stem cell exosomes (CB-Exo-A600) to see if it can help people with mild to moderate Alzheimer's disease. It aims to slow down symptoms and improve quality of life.
BeijingAges 50 years+ - NCT07321353Recruiting
Survivors Journey+: Support for brain tumor survivors
This study looks at how to support children and teens who have finished treatment for a brain tumor. It may help families find ways to cope and thrive after cancer therapy.
Cincinnati, OhioAges 15–25 - NCT06254755Enrolling by invitation
Comparing two clot removal methods for severe stroke
This trial compares two methods of removing blood clots from large arteries in the brain during a stroke: suction alone versus a combination of suction and a stent-like device. It aims to see which technique works better to restore blood flow and improve outcomes for people with severe acute strokes.
Goyang-si, Gyeonggi-doAges 18–120 - NCT06816797Recruiting
Testing a program for older adults worried about memory
This trial tests a program called Cog-Fun Aging to help older adults who notice memory changes and feel concerned. The study looks at whether the program can improve daily function and well-being.
JerusalemAges 60 years+ - NCT06821178Recruiting
My life and my experiences study for teens
This study looks at the life experiences of teenagers ages 12 to 18, comparing those who have had contact with social services or dependency court with those who have always lived with a parent. It helps researchers understand how different backgrounds affect well-being.
Irvine, CaliforniaAges 12–18 - NCT06821256Recruiting
Testing brain stimulation for multiple system atrophy
This trial tests if a gentle electrical current applied to the scalp can help people with a specific type of multiple system atrophy (the cerebellar variant) improve walking and other symptoms. The goal is to see if this non-invasive treatment is safe and effective.
Salerno, SaAges 40–90 - NCT07287878Recruiting
Brain stimulation to improve social reward in depression
This trial tests a new type of brain stimulation called temporal interference stimulation to see if it can improve how people with depression experience social rewards. You may be eligible if you have depression with certain features like increased appetite, weight gain, or feeling very sensitive to rejection, and you are between 16 and 60 years old.
Shanghai, ChinaAges 16–65 - NCT05390983Recruiting
Compare surgery vs balloon/stent for re-narrowed neck artery
This trial compares two treatments for a carotid artery that has narrowed again after a prior stent: surgery (endarterectomy) versus repeat balloon treatment with or without stenting. It may help find which approach works better to prevent further narrowing and complications.
Ostrava, Moravian-Silesian RegionAges 18–80 - NCT06239818Recruiting
Light therapy for concussion recovery in teens
This trial tests whether a special light therapy (photobiomodulation) can help teenagers recover faster from a sports-related concussion. If you qualify, you will receive the light treatment in addition to your usual care, and researchers will track your symptoms and thinking skills over time.
Houston, TexasAges 13–18 - NCT05625594RecruitingPhase 1
Test brain-directed CAR T cells for CNS lymphoma
This Phase 1 study tests a new type of immune therapy (CAR T cells) placed directly into the fluid around the brain to treat central nervous system (CNS) lymphoma. It mainly looks at safety and how well the treatment can control the lymphoma when other CNS treatments have not worked.
Duarte, CaliforniaAges 18 years+ - NCT05651802Recruiting
Brain MRI follow-up with or without preventive scans in SCLC
This study tests whether adding a preventive brain procedure (PCI) to standard follow-up brain MRIs helps people with limited-stage small-cell lung cancer stay disease-free longer. It compares “MRI only” versus “MRI plus PCI” after the cancer has fully responded to initial treatment.
Guangzhou, GuangdongAges 18 years+ - NCT06813300Recruiting
Brain signals during deep brain stimulation for thinking or moving tasks
This study looks at how brain signals change during deep brain stimulation (DBS) when you are thinking or moving. It aims to find better ways to see if DBS is working by recording your brain's electrical activity.
GrenobleAges 18 years+ - NCT06628193Enrolling by invitation
Ultrasound effects on human memory study
This study uses low-intensity focused ultrasound to see how it affects memory. It may help researchers understand how to improve memory or treat conditions that affect it.
Roanoke, VirginiaAges 18–65 - NCT06685510Enrolling by invitation
Deep brain stimulation outcomes and electrode position in Parkinson's
This study looks at how the placement of electrodes during deep brain stimulation (DBS) for Parkinson's disease affects recovery and motor symptoms right after surgery. It could help doctors improve DBS outcomes for people with Parkinson's.
Nanchang, JiangxiAges 18–75 - NCT04656431RecruitingPhase 1
Hyperpolarized imaging for CNS lymphoma
This trial tests a new type of imaging scan to see if it can better detect and monitor brain lymphoma. It may help doctors tailor treatment by seeing how the cancer responds early on.
San Francisco, CaliforniaAges 18 years+ - NCT06132737RecruitingPhase 1/Phase 2
Targeted radiation therapy for brain lymphoma
This trial tests a new targeted radiation therapy for lymphoma that has spread to the brain or spinal cord and has not responded to other treatments. The treatment uses a radioactive molecule (yttrium-90) attached to a substance that homes in on a specific marker (CXCR4) on the lymphoma cells, aiming to destroy them while limiting damage to healthy tissue.
Munich, BavariaAges 18–120 - NCT06782802Recruiting
Study on early diagnosis of a brain structure closure in pregnancy
This study looks at what it means when a small fluid-filled space in the baby's brain closes earlier than usual during pregnancy. Researchers want to understand if this finding can predict the baby's future health and development.
Bologna, BolognaAges 4 weeks–44 years - NCT07558616Recruiting
Brain Stimulation for Sleep Problems in Nerve Disorders
This study tests a non-invasive brain stimulation technique called Hi-tACS to improve sleep in people with specific nerve/immune diseases (like MS or NMOSD) or chronic insomnia who have not responded to sleep medications. The goal is to help you fall asleep and stay asleep, and feel less tired during the day.
Beijing, Beijing MunicipalityAges 18–65 - NCT06771323RecruitingPhase 2
Adding valbenazine to botox for neck muscle spasms
This study tests if adding a daily pill (valbenazine) to regular botox injections can better reduce neck muscle spasms. It helps people whose botox works but may not be enough.
Richmond, VirginiaAges 18–75 - NCT06758115Recruiting
Brain and Muscle Study for Teens with Scoliosis
This study looks at how the brain and muscles work together in teens with spinal curves (scoliosis). It uses skin sensors and brain wave tests to understand muscle control, which may help improve treatments.
HangzhouAges 10–18 - NCT05077735RecruitingPhase 2
Split-course radiation for diffuse midline glioma
This trial tests a new way of giving radiation therapy for a type of brain tumor called diffuse midline glioma. It aims to see if splitting the radiation into smaller courses can help while reducing side effects.
Phoenix, ArizonaAges 1 year+ - NCT06625060RecruitingPhase 2
Study of IPN10200 for preventing migraine in adults
This trial tests a new medicine called IPN10200 to see if it can prevent episodic or chronic migraine. It is for adults who have had migraine for at least a year and have tried at least one preventive treatment before.
Birmingham, AlabamaAges 18–80
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,406 recruiting neurology studies from the U.S. registry right now, out of 19,323 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.