Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 11,941 recruiting studies in this area right now.
By phase
- Not applicable9,343
- Phase 2764
- Phase 1557
- Phase 3513
- Phase 4339
- Phase 1/Phase 2300
- Phase 2/Phase 3125
Top conditions
- Stroke796
- Parkinson Disease395
- Alzheimer Disease338
- Multiple Sclerosis329
- Dementia226
- Epilepsy193
- Ischemic Stroke190
- Insomnia159
- Traumatic Brain Injury151
- Obstructive Sleep Apnea142
- Spinal Cord Injuries142
- Acute Ischemic Stroke139
- Sarcopenia135
- Mild Cognitive Impairment127
- Cerebral Palsy119
- Pain Management114
- Migraine107
- Fibromyalgia104
Leading sponsors
- Beijing Tiantan Hospital124
- Assistance Publique - Hôpitaux de Paris109
- Riphah International University105
- Mayo Clinic98
- VA Office of Research and Development92
- Xuanwu Hospital, Beijing89
- Hospices Civils de Lyon77
- Johns Hopkins University69
- University of Minnesota63
- Washington University School of Medicine63
Where studies are running
- California659
- Massachusetts305
- New York294
- Florida271
- Texas266
- Maryland248
- Alabama207
- Arizona207
- Illinois181
- Pennsylvania176
Recruiting studies11,941 total
- NCT06598202RecruitingPhase 1/Phase 2
Nasal Drop Therapy for ALS
This trial tests a nasal drop made from tiny cell particles (extracellular vesicles) for ALS. The goal is to see if it's safe and if it can slow down the disease. It may be an option if your ALS is in the early to moderate stage.
Beijing, Beijing MunicipalityAges 18–80 - NCT06653946RecruitingPhase 4
Predicting bleeding after stroke treatment in patients with atrial fibrillation
This trial looks at why some patients with a first-time stroke caused by atrial fibrillation experience bleeding in the brain after receiving clot-busting medication. It aims to find factors that predict this bleeding, which could help doctors choose safer treatments in the future.
Kafr ash ShaykhAges 18–75 - NCT06663111Recruiting
Rituximab and Ocrelizumab levels in Multiple Sclerosis
This trial looks at two medicines, rituximab and ocrelizumab, in the blood of people with multiple sclerosis. It only includes people who are already in another study called OVERLORD-MS and can give blood samples on a schedule.
Bergen, VestlandAges 18–60 - NCT02114450Recruiting
Training with a leg exoskeleton after stroke
This trial tests a “human–machine” leg exoskeleton system to help people with stroke improve standing and walking during rehab. You may be able to participate if you have certain levels of disability and spasticity, can safely stand and walk with help, and don’t have skin, joint, or medical issues that would make training unsafe.
Houston, TexasAges 18–75 - NCT04671381Recruiting
More affordable adult hearing care for eligible Alabama residents
This study aims to improve access and affordability of hearing healthcare for adults who have mild to moderate hearing loss. If you live in parts of South or West Central Alabama and meet the age and health requirements, your care may be coordinated through the program being tested.
Tuscaloosa, AlabamaAges 40 years+ - NCT04561557RecruitingEarly Phase 1
Cell therapy for relapsing nervous system autoimmune diseases
This early-phase trial tests CT103A “CAR-T” cell therapy to treat certain relapsing or treatment-resistant autoimmune diseases that affect the nervous system. It aims to see whether the cells are safe and may help reduce disease activity when standard treatments haven’t controlled symptoms.
Wuhan, HubeiAges 18–75 - NCT06665867Recruiting
Video Follow-Up for Kids With Stomach Pain
This trial tests whether video consultations (video calls) are a good option for follow-up appointments in children with functional abdominal pain disorders. It aims to make check-ups easier for families.
AmsterdamAges 4–17 - NCT06662461Recruiting
Nerve block for stubborn migraines: Stellate vs occipital
This trial tests which nerve block works better for stubborn migraines: one on the stellate ganglion (a cluster of nerves in the neck) or the greater occipital nerve (at the back of the head). They will also check how these blocks affect a chemical linked to migraine pain. If you have chronic migraines that haven't improved with multiple treatments, you may be eligible.
CairoAges 18 years+ - NCT07678086Recruiting
Breathing tube pressure and sore throat in children's appendix surgery
This trial tests whether carefully managing the pressure in the breathing tube during surgery can help prevent a sore throat in children after they have their appendix removed by keyhole surgery. It may help your child have a more comfortable recovery.
Ankara, YenimahalleAges 6–18 - NCT04604444Recruiting
Rehab program to improve speech brain plasticity after stroke
This study looks at how intensive therapy can change the brain’s ability to relearn speech after a stroke that caused language or speech planning problems. You may be a good candidate if your stroke-related aphasia or apraxia was diagnosed by a speech specialist about 7 months ago.
UppsalaAges 18–75 - NCT07679906Recruiting
Nationwide digital study for Alzheimer’s prevention and trial readiness
This study uses a saliva sample and online tools to see if you have a genetic risk factor for Alzheimer’s. It aims to build a large group of people who may be at higher risk, so they can be invited to future prevention trials.
HuningueAges 45 years+ - NCT07674667RecruitingPhase 1/Phase 2
Testing a treatment to restore UNC13A function in ALS
This trial tests a new treatment aimed at restoring the function of a gene called UNC13A in people with ALS. It involves multiple clinic visits, MRI scans, and spinal taps to see if the treatment is safe and may slow the disease.
Lübeck, Schleswig-HolsteinAges 18–75 - NCT07672756RecruitingPhase 1
Testing PL54 injection for adults with PKU
This study tests a new injection called PL54 to see if it is safe and tolerable for adults with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine. It is designed for people with high blood phenylalanine levels and may offer a new treatment option.
Hefei, AnhuiAges 18–55 - NCT07675070Recruiting
Temozolomide (Amitzo) for grade III or IV brain tumors
This trial studies a new form of the chemotherapy drug temozolomide (called Amitzo) in people with aggressive brain tumors (grade III or IV gliomas). It aims to see if the drug is safe and effective, and is for patients who need treatment for a new diagnosis or for tumors that have come back after standard care.
TehranAges 18–80 - NCT07677137Recruiting
Study of a new nerve stimulation device for chronic cluster headache prevention
This study is testing a new device that uses mild electrical stimulation near the back of the head to prevent cluster headaches. It is for people with chronic cluster headaches that are hard to treat with standard medicines.
Sint-NiklaasAges 22–70 - NCT07673107RecruitingPhase 2
Botulinum toxin injection for essential tremor of hands and arms
This trial tests an investigational botulinum toxin injection (AGN-151607-DP) to reduce shaking in the hands and arms caused by essential tremor. It is for adults who have been diagnosed with this condition and who do not have certain nerve or muscle disorders.
Fresno, CaliforniaAges 18–85 - NCT07675109Recruiting
Extended therapy for restless legs syndrome
This study tests a device that delivers nerve stimulation to help with restless legs syndrome (RLS). It aims to see if using the device for a longer period each night can reduce RLS symptoms and improve sleep.
Pleasanton, CaliforniaAges 21 years+ - NCT07675135RecruitingPhase 3
Testing a new narcolepsy drug for excessive daytime sleepiness
This study tests a new medicine, HBS-301, for people with narcolepsy type 1 or type 2 who still have excessive daytime sleepiness. If you take other medications for sleepiness or mood, they must be stable for at least 3 months, and you cannot take some as-needed sleepiness medicines.
Birmingham, AlabamaAges 18 years+ - NCT07673744RecruitingPhase 2
Maintenance treatment for myasthenia gravis after efgartigimod
This trial tests whether a follow-up treatment with ublituximab (given as an infusion) can help myasthenia gravis patients who first received efgartigimod. The goal is to see if it provides lasting control of MG symptoms.
Colorado Springs, ColoradoAges 18 years+ - NCT07676110Recruiting
Music and nature visuals for emotional well-being
This study tests if listening to enhanced music and watching natural visuals can improve your emotional health. You'll use your own headphones and a smartphone or tablet to take part.
Fort Collins, ColoradoAges 13 years+ - NCT07673809RecruitingPhase 1/Phase 2
Gene therapy trial for Duchenne muscular dystrophy in young boys
This trial tests a gene therapy called GNR-097 for boys with Duchenne muscular dystrophy (DMD). The therapy aims to help improve muscle function, and the study will check how safe and effective it is.
MinskAges 4–9 - NCT06610578Recruiting
Screening for brain artery blockage using eye exams
This trial tests if a simple eye exam can help screen for blocked brain arteries. It may help find people at risk earlier without invasive tests.
Beijing, None SelectedAges 18 years+ - NCT06649968Recruiting
Testing a smart glove for hand recovery after stroke
This trial tests a high-tech glove that helps track and improve hand and arm movement after a stroke. It may be an option for people who had a stroke 1 to 6 months ago and have mild to moderate arm weakness.
AcerenzaAges 18 years+ - NCT06664697Recruiting
Study of the IotaSOFT Insertion System for cochlear implants
This trial tests a new robotic system that helps doctors insert cochlear implant electrodes more gently. It may lead to safer surgery and better hearing outcomes for people with severe hearing loss.
Indianapolis, IndianaAges 12 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 11,941 recruiting neurology studies from the U.S. registry right now, out of 18,432 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.