Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable2,677
- Phase 2277
- Phase 1238
- Phase 3210
- Phase 1/Phase 2208
- Phase 497
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease134
- Atopic Dermatitis125
- Congenital Heart Disease84
- Cystic Fibrosis76
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy37
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)28
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
- Massachusetts General Hospital22
Where studies are running
- California325
- Maryland161
- Alabama133
- Massachusetts107
- Arizona86
- New York85
- Texas70
- Minnesota68
- Pennsylvania62
- Florida59
Recruiting studies3,756 total
- NCT07702149Recruiting
Diet for Behcet's disease patients with ringing in the ears
This trial tests whether a special diet can help ringing in the ears (tinnitus) in people with Behcet's disease who also have obesity. The goal is to see if dietary changes reduce tinnitus symptoms.
Giza, DokkiAges 40–55 - NCT07700459Recruiting
Exercise prehabilitation for congenital heart surgery
This study tests whether a supervised exercise program before heart surgery can help adults with congenital heart disease recover better. You would join an exercise class 2–3 times a week for several weeks leading up to your operation.
LiverpoolAges 18 years+ - NCT07699510Recruiting
Learning about TNPO2 gene disorders
This study aims to learn more about health problems caused by changes in the TNPO2 gene. It is a natural history study that will collect information to help understand and care for people with these rare genetic conditions.
Berlin, State of BerlinAges Any age - NCT07698743Recruiting
Eating disorders in phenylketonuria patients study
This study looks at eating habits and disorders in people with phenylketonuria (PKU) who are treated at a specific hospital in Nancy, France. Participating involves sharing information, which may help doctors better understand eating challenges in PKU.
NancyAges Any age - NCT07701759Recruiting
Oxygen levels during eye injections for premature babies
This study looks at how often low oxygen levels happen in premature babies when they get eye injections for a serious eye condition. The goal is to understand the risks and make the procedure safer.
BuraidahAges Any age - NCT07703020Enrolling by invitation
Obesity in PKU patients
This study looks at how common obesity is in adults with PKU and what factors may contribute to it.
Lausanne, Canton of VaudAges 18 years+ - NCT07702448Recruiting
Jaw surgery and its effect on mood and looks
This study looks at how jaw surgery affects your mood and how you feel about your appearance. You will answer questions one week before surgery and again 6 months after, and you need to use social media as part of the research.
Kirikkale, KırıkkaleAges 18–40 - NCT07702123Recruiting
Physical activity study for women with Behcet's and metabolic syndrome
This study tests if a physical activity program helps women who have both Behcet's disease and metabolic syndrome. It aims to improve their health and well-being.
Giza, DokkiAges 40–50 - NCT07701694Recruiting
Driving study for people with urea cycle disorders
This study evaluates how people with urea cycle disorders perform during a driving task. It may help researchers understand if the condition affects driving ability.
Memphis, TennesseeAges 16–40 - NCT07699666Recruiting
Cord clamping timing for preterm babies
This study compares waiting a bit before clamping the umbilical cord versus clamping it right away for babies born between 32 and 37 weeks of pregnancy. It helps determine which approach may be better for preterm infants.
Tunis, Tunis GovernorateAges birth+ - NCT06650683Recruiting
Nursing support for parents of babies with Hirschsprung disease
This trial is for parents of babies with Hirschsprung disease who need daily nursing care before surgery. It studies whether extra nursing support can help reduce parents' stress while taking care of their baby at home.
MarseilleAges Any age - NCT06053671Recruiting
Understanding genetics in focal epilepsy brain tissue
This study is looking at brain tissue from people with a specific type of epilepsy (Focal Cortical Dysplasia Type II). The goal is to understand what causes the seizures and how they develop, which may help improve future treatments.
LondonAges Any age - NCT07695701RecruitingPhase 4
Heart imaging study for a new ATTR-CM treatment
This trial uses heart scans to see how the drug acoramidis affects heart structure and function in people with a specific type of heart disease called ATTR cardiomyopathy. It may help doctors understand if the treatment is working.
St Louis, MissouriAges 18–80 - NCT07694440RecruitingPhase 2
Study of an experimental pill for adults with PKU
This trial tests an experimental medication taken as a pill to see if it can help people with PKU manage their condition. The study will check if the pill is safe and how it affects blood phenylalanine levels.
Oakland, CaliforniaAges 18–75 - NCT07695597RecruitingPhase 2
Study of SYH2070 for people with high cholesterol and triglycerides
This trial tests an investigational injection called SYH2070 to lower cholesterol and triglycerides in people who are already on a stable statin therapy. It may be a new option for those with mixed hyperlipidemia who need additional lipid control.
Hangzhou, ZhejiangAges 18 years+ - NCT04464655Recruiting
10-minute heart MRI protocol for people with heart conditions
This study uses a short, 10-minute heart MRI to check how well it works for people who need a clinically indicated heart scan. It may help streamline heart MRI testing, making exams faster while still providing useful heart information.
Montreal, QuebecAges 18 years+ - NCT07690111Recruiting
Study for people with TRPM3 gene changes
This is a global registry study for people who have a change (variant) in the TRPM3 gene. Researchers hope to learn more about the condition and how it affects patients.
Berlin, State of BerlinAges Any age - NCT07692061Enrolling by invitation
Speech therapy study for Cantonese-speaking kids with cleft palate
This study tests a new speech therapy program for children and teens (ages 4–17) who had cleft palate repair before age 2 and have certain speech sound errors. It aims to improve their speech clarity and communication.
Shatin, New TerritoriesAges 4–17 - NCT07692256RecruitingPhase 2
Empagliflozin for heart failure in children
This trial tests if empagliflozin, a diabetes medicine that also helps the heart, can improve symptoms in children with heart failure. It may help kids with severe symptoms or high levels of a heart stress marker called BNP.
Cairo, Cairo GovernorateAges 1 month–18 years - NCT07695610Recruiting
Studying unknown movement disorders in children in Vietnam
This trial is for children in Vietnam who have a movement disorder with an unknown cause. Researchers want to learn more by doing genetic testing, which might help find better treatments or answers for families.
Ho Chi Minh City, Ho Chi Minh CityAges Up to 18 years - NCT07692958Recruiting
Thinking skills training for children with heart defects
This trial tests a program to help children born with heart problems improve their thinking and planning skills (called 'executive function'), which may be affected by their heart condition or surgery. It is for children aged 9 to 13 who had heart surgery before age 1 and show some difficulties with these skills.
Zurich, Canton of ZurichAges 9–13 - NCT07689331Recruiting
Hungarian national amyloidosis study
This study creates a registry for people diagnosed with systemic amyloidosis in Hungary. It helps doctors better understand the condition by collecting medical history and tracking outcomes over time.
BalatonfüredAges 18 years+ - NCT07690930Enrolling by invitation
Hat glasses for eye protection during jaundice light therapy
This trial tests a special hat-like glasses to protect babies' eyes during phototherapy (light treatment for jaundice). It is for healthy full-term newborns who are in a regular hospital room.
KaramanAges birth–4 weeks - NCT07692217Recruiting
Joint health study for severe hemophilia A patients on new therapies
This study checks joint health and bleeding risk in people with severe hemophilia A who are taking newer factor VIII treatments or emicizumab. It uses ultrasound and blood tests to see how well these therapies protect joints.
Dallas, TexasAges 6 months+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting medical genetics studies from the U.S. registry right now, out of 5,439 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.