Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,982 recruiting studies in this area right now.
By phase
- Not applicable7,962
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke844
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California465
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas118
Recruiting studies9,979 total
- NCT04029363Recruiting
Transcatheter mitral valve procedure for high-surgery-risk patients
This trial studies a newer, catheter-based mitral valve treatment in people with moderate-severe to severe mitral valve leaking who are at high risk for open-heart surgery. It may help improve symptoms and heart function without traditional surgery, but you must meet key heart, anatomy, and safety requirements.
Darlinghurst, New South WalesAges 18 years+ - NCT04033614Recruiting
Device to help close an open abdomen between surgeries
This study looks at a device (“Fasciotens”) used to help manage an open abdomen and support closure during planned or necessary return surgeries. It aims to see how safely and effectively the device works in people who need a temporary open belly treatment.
Aachen, North Rhine-WestphaliaAges 18 years+ - NCT04036357Recruiting
Study of liver fat disease with heart and metabolism problems
This study looks at people with fatty liver disease and common health issues like obesity, diabetes, high blood pressure, or abnormal cholesterol. It may help researchers understand how liver fat and heart/metabolism problems relate and how they affect health over time.
RomeAges 18–80 - NCT04040777Recruiting
Cardiometabolic risk registry for adults
This study is a health registry that collects information about risk factors for heart and metabolic problems in adults. It may help doctors better understand who is at higher risk and guide future prevention strategies.
Pilar, Buenos AiresAges 18 years+ - NCT04043598Recruiting
Fluids choice after brain bleed to improve brain outcomes
This trial studies whether giving a specific type of IV fluid (a salt-water fluid in the vein) after a type of brain bleed can improve neurological recovery. It focuses on adults with a non-traumatic subarachnoid hemorrhage (a bleeding in the space around the brain) given soon after diagnosis.
Sankt Gallen, Canton of St. GallenAges 16 years+ - NCT04046237Recruiting
Treating gum disease to study heart artery inflammation after a heart attack
This study tests whether treating severe gum disease in people who recently had a heart attack can reduce inflammation in the artery plaque. It may help researchers understand if gum treatment could benefit heart health after a heart attack.
ParisAges 30–70 - NCT04045665RecruitingPhase 3
Blood thinner vs usual care for new heart rhythm after bypass surgery
This trial tests whether using a blood thinner in people with new, temporary atrial fibrillation after CABG (heart bypass surgery) can reduce harmful outcomes compared with standard treatment. It may help prevent stroke or other complications if your rhythm problem fits the trial’s timing and risk profile.
Little Rock, ArkansasAges 18 years+ - NCT04049591Recruiting
Higher vs lower heparin dose during planned heart stent procedure
This trial compares a higher versus lower dose of heparin (a blood thinner) during a planned PCI, which is a heart procedure to open blocked arteries using a stent. It may help hospitals and patients know which dosing approach is safest and works well during the procedure.
Hamilton, OntarioAges 18 years+ - NCT04053478Recruiting
Testing common blood-pressure drugs on uterine and umbilical muscle
This study tests how several medicines used for blood pressure affect muscle “tightening” in tissue taken during planned C-sections. It’s an in-vitro (lab) study, so it mainly helps doctors understand how to prevent weak uterine contractions (uterine atony) during delivery.
Toronto, OntarioAges 19–40 - NCT04054609Recruiting
FAZA PET/MRI scan before and after leg revascularization
This study uses a special combined scan (PET/MRI) to look at blood flow and tissue changes in people with severely reduced blood supply to the legs. The scan is done before and after a procedure to reopen blocked blood vessels, to understand how well treatment works.
Toronto, OntarioAges 18 years+ - NCT04055428RecruitingPhase 2
Testing a hormone supplement to improve heart and metabolic health
This study tests whether adding a natriuretic peptide medicine improves heart health and metabolism in Black adults. It may help with blood pressure and related health markers, but you must meet specific health and safety criteria.
Birmingham, AlabamaAges 18 years+ - NCT04059276Recruiting
Brain scan study of stroke-related changes
This study uses brain magnetic resonance imaging (MRI) scans to look at changes in the brain after a stroke. It may help researchers better understand what happens in the brain over time and improve future care.
ZurichAges 18–80 - NCT04061512RecruitingPhase 2/Phase 3
Rituximab plus ibrutinib versus standard steroids plus rituximab
This trial compares two starting treatment plans for Waldenström’s macroglobulinaemia, testing whether one works better or causes fewer problems. It studies rituximab plus ibrutinib versus a standard mix of rituximab, cyclophosphamide, and dexamethasone (steroids).
BathAges 18 years+ - NCT04062500Recruiting
Heart failure patient follow-up study to track health and deaths
This study follows people with heart failure over time to record outcomes like illness course and death, and to understand how treatments affect results. If you have heart failure and can join regular check-ins, your information may help improve future care.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT04064177Recruiting
Noninvasive heart monitoring for newborns
This study tests a noninvasive way to continuously measure heart output (how well the heart is pumping) in newborn babies. It may help clinicians monitor babies more safely and adjust care sooner.
LondonAges 1 hour–9 months - NCT04067700Recruiting
Testing a heart scan for reduced blood flow
This study looks at how a special heart imaging test (PET/CT) can show areas with reduced blood flow. It may help doctors understand your heart’s circulation better and guide future care.
KuopioAges 18 years+ - NCT04068597RecruitingPhase 1/Phase 2
Testing inobrodib for blood cancers that came back
This is an early-stage study of inobrodib (CCS1477) for blood cancers like lymphoma, multiple myeloma, or acute myeloid leukemia that have returned or did not respond to standard treatment. It aims to see whether the drug is safe and can help control the cancer.
Atlanta, GeorgiaAges 18 years+ - NCT04071015Recruiting
Tests a new blood pressure monitor after heart surgery
This study checks whether a non-invasive blood pressure device can measure blood pressure accurately in ICU patients right after cardiac surgery. It compares the new device to standard invasive monitoring through an arterial line or catheter.
Ramat GanAges 18 years+ - NCT04071327Recruiting
Pulmonary hypertension registry for patient experiences
This trial is a registry that collects health information from people with pulmonary hypertension to better understand the disease and improve care. You may be asked to share details about your diagnosis and visits, especially soon after you start seeing a specialized PH care center.
Phoenix, ArizonaAges birth+ - NCT04073420Recruiting
Cardiac surgery registry to track Medtronic device outcomes
This registry collects real-world information from people who have had—or plan to have—an eligible Medtronic cardiac surgery device. It aims to better understand how these treatments do over time and help guide future care.
Marietta, GeorgiaAges Any age - NCT04073797Recruiting
PET scan study of inflammation and cholesterol-lowering treatment
This study uses PET/CT and related scans to measure inflammation in artery plaque and how cholesterol-lowering treatment changes it. It may help researchers understand which treatments reduce artery inflammation for people with heart or blood-vessel disease and high LDL (“bad”) cholesterol.
CambridgeAges 18–99 - NCT04074135RecruitingPhase 2
Study of pancreatic tumors in people with VHL
This trial studies the natural course and management of pancreatic neuroendocrine tumors in people with von Hippel–Lindau (VHL) disease. It may help doctors better predict how these pancreatic findings change over time and how to manage them.
Bethesda, MarylandAges 12 years+ - NCT04076150Recruiting
Testing a new valve placed through a blood vessel
This study checks whether an “investigational” transcatheter aortic valve is safe and works well for people with severe, calcified aortic stenosis (a stiff, narrowed heart valve). It may help improve valve function and symptoms, but you must meet specific heart, scan, and health-status requirements.
KrakowAges 70 years+ - NCT04075084Recruiting
Watching outcomes of routine home monitoring after a heart monitor implant
This registry study follows people who get a BIOTRONIK implantable heart monitor and use home monitoring. It looks at how routine care and at-home check-ins work in real life, which may help improve support and tracking over time.
AdelaideAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,982 recruiting cardiology studies from the U.S. registry right now, out of 15,268 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.