Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,982 recruiting studies in this area right now.
By phase
- Not applicable7,962
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke844
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California465
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas118
Recruiting studies9,979 total
- NCT06529978Recruiting
CoreMap heart mapping for atrial fibrillation ablation
This study tests a new mapping system that helps doctors see the electrical signals in your heart more clearly during a standard ablation for persistent atrial fibrillation. It may improve the accuracy of the treatment.
Naples, FloridaAges 18–80 - NCT07692490Recruiting
Avoiding cooling after warm machine perfusion for liver transplant
This study tests whether a donor liver kept on a special warm machine can be transplanted safely without needing to cool it down first. It is for adults receiving their first liver transplant who have stable liver disease (not acute failure).
AnconaAges 18 years+ - NCT07315997Recruiting
Heart health study for people with rheumatoid arthritis
This study looks at whether calcium in the heart arteries and a blood test (troponin) can help predict heart disease risk in people with rheumatoid arthritis. It may help doctors better prevent heart attacks and strokes.
Boston, MassachusettsAges 35–79 - NCT07603076Recruiting
Vein Problems and Symptoms in Lipedema
This study looks at how vein function relates to lipedema (a condition causing painful fat buildup in legs). Researchers will use ultrasound to check your veins and ask about your symptoms to better understand how the two conditions connect.
Istanbul, UskudarAges 18–65 - NCT07588932RecruitingEarly Phase 1
Medication and Robot Training for Stroke Arm Recovery
This study tests whether three medications (Telmisartan, Cilostazol, and Metformin) combined with robotic arm training can help people improve arm movement and strength after a chronic stroke. You would participate in supervised training sessions using a robotic rehabilitation system.
Charlestown, MassachusettsAges 21–80 - NCT07536373RecruitingPhase 3
Colchicine to prevent amputation after leg artery treatment
This study tests whether a medication called colchicine can help prevent amputation in people with severe leg blood flow problems who just had surgery or a catheter procedure to restore blood flow. Colchicine is an anti-inflammatory drug that may help protect the leg tissue after treatment.
Taipei, TaipeiAges 18 years+ - NCT07587099Recruiting
Single vs. Dual Blood Thinners After Balloon Heart Treatment
This study compares whether patients who receive a special drug-coated balloon to open a blocked heart artery (without a stent) need to take one or two blood-thinning medications afterward. The goal is to find the safest and most effective approach for preventing future blockages.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07280013RecruitingPhase 1
Cemsidomide with elranatamab for multiple myeloma
This trial tests a new drug combination (cemsidomide and elranatamab) for people with multiple myeloma that has come back after previous treatments. The goal is to see if the combination is safe and works better than current options.
Gilbert, ArizonaAges 18 years+ - NCT07047326Recruiting
Urokinase for acute ischemic stroke within 6 hours
This trial tests whether the clot-busting drug urokinase can help people who have had an ischemic stroke (a stroke caused by a blood clot). The goal is to dissolve the clot and improve recovery, as long as treatment starts within 6 hours of the first symptoms.
Beijing, Beijing MunicipalityAges 18–80 - NCT07405359Recruiting
Comparing ablation methods for persistent atrial fibrillation
This trial tests a newer, possibly safer way to treat persistent atrial fibrillation using pulsed field ablation. It compares standard vein isolation alone to adding extra ablation spots to improve success.
San Francisco, CaliforniaAges 18 years+ - NCT06433011Recruiting
New clot-busting method for pulmonary embolism
This study tests a new way of delivering a clot-dissolving medicine for people with a serious but not immediately life-threatening pulmonary embolism. The goal is to see if giving the medicine as small bursts directly into the clot can help the heart recover faster.
Scottsdale, ArizonaAges Any age - NCT05869825Recruiting
Breathing support after extubation in babies after heart surgery
This trial compares two ways of helping babies breathe after their breathing tube is removed following heart surgery. It may help find which support method works better and is safer for the smallest patients.
Atlanta, GeorgiaAges Up to 1 year - NCT05034432RecruitingPhase 4
Test treatment for dangerous heart rhythm episodes in LVAD patients
This trial studies a procedure to fix abnormal heart rhythms (ventricular tachycardia or ventricular fibrillation) in people who have an LVAD and a defibrillator (ICD) or an alternative device. It may help prevent future dangerous rhythm episodes after LVAD treatment.
Phoenix, ArizonaAges 18 years+ - NCT04008121RecruitingEarly Phase 1
Testing an eye imaging drug during retinal blood-vessel photos
This early safety study tests how well and how safely an investigational dye (MB-102) works during a special eye imaging test of retinal and choroidal blood vessels. It compares it to the commonly used fluorescein dye and may help doctors refine future eye imaging approaches.
Ann Arbor, MichiganAges 18 years+ - NCT04011527Recruiting
Registry for heart stent procedure using rotational atherectomy
This study collects information from people who are having a heart procedure called rotational atherectomy to open blocked heart arteries. It helps doctors better understand how the procedure is used and its outcomes.
Bad SegebergAges 18–100 - NCT04012905RecruitingPhase 3
Compare two steroid taper schedules for giant cell arteritis
This Phase 3 study compares how two standard steroid dose-reduction (tapering) schedules work for people with giant cell arteritis. It aims to see which taper approach controls the disease while reducing problems from long-term steroid use.
CaenAges 50 years+ - NCT04014140Recruiting
iFR-guided bypass surgery planning during elective heart surgery
This trial studies whether using a pressure-measurement test called iFR during a pre-surgery heart scan can help guide coronary artery bypass surgery (CABG). It may improve how doctors choose which artery blockages to treat during planned surgery.
London, Greater LondonAges 25–80 - NCT04014803RecruitingPhase 4
Aspirin plus one blood thinner versus aspirin plus clopidogrel
This trial compares two common “blood thinner” combinations to prevent problems after a PCI procedure for complex blocked heart arteries. It may help your care team find which combination works better for people with higher-risk artery patterns.
SeoulAges 19–75 - NCT04016649Recruiting
Study measures how leg veins move and respond
This study measures the properties of human saphenous and popliteal veins. If you’re having certain lower-leg procedures, your care team may collect information to better understand vein function and support future treatment.
Limerick, LimerickAges 18 years+ - NCT04020263RecruitingPhase 3
Levosimendan early treatment vs placebo for cardiogenic shock
This study tests whether giving levosimendan early (a heart-strengthening medicine) improves outcomes compared with placebo, on top of standard inotropic support, in people with cardiogenic shock. It mainly looks at whether patients have fewer serious complications or deaths.
Strasbourg, Bas-RhinAges 18 years+ - NCT04025450RecruitingPhase 1/Phase 2
Tested stronger combo for high-risk myeloma patients
This early-phase study compares two drug combinations—chidamide plus VRD versus VRD alone—to see which works better for primary high-risk multiple myeloma. The goal is to improve response while closely monitoring side effects and heart/lung safety.
Suzhou, JiangsuAges 18–80 - NCT04027244Recruiting
Studying care plans for severe leg blood flow problems
This study looks at how best to manage severe leg ischaemia, a condition where blood flow to the leg is dangerously reduced. It mainly involves patients who are planning an intervention, and some participants may also do special heart imaging tests.
Leicester, LeicestershireAges 18–110 - NCT04029337Recruiting
Transcatheter mitral valve replacement for severe leakage
This study tests a new device that replaces a leaking mitral valve without open-heart surgery. It may help people who have severe mitral valve leakage but cannot safely have standard surgery or some other less invasive valve repairs.
Tucson, ArizonaAges 18 years+ - NCT04029844Recruiting
Transcatheter valve replacement for older adults with severe aortic stenosis
This study tests a new “through-a-vein” heart valve procedure for people age 75+ with severe aortic valve narrowing that causes symptoms. It aims to see if the new valve can be safely implanted and improve outcomes in higher-surgery-risk patients.
LilleAges 75 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,982 recruiting cardiology studies from the U.S. registry right now, out of 15,268 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.