Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT04782232Recruiting
Study of a new blood tube for heart pump patients
This registry study checks whether a new venous blood tube used with a heart pump is safe and practical for people whose right heart is failing and who may need a heart transplant. If you qualify, your care team would monitor how the device works over time.
MunichAges Any age - NCT04782830Recruiting
Wearable sensor study for low blood pressure on standing
This study uses an accelerometer (a wearable motion sensor) to measure symptoms and blood pressure changes when you stand up. It may help doctors better track how neurogenic orthostatic hypotension affects you and how well current treatments are working.
Nashville, TennesseeAges 40–80 - NCT04783701Recruiting
CT scan timing to check bypass grafts after heart attack
This study looks at whether a special CT heart scan (CT angiography) can show how well bypass grafts are working in people who had a CABG after an acute coronary syndrome. It compares people managed with two anti-platelet medicines versus one aspirin, aiming to understand how well grafts stay open and guide care.
BergenAges 18 years+ - NCT04785976Recruiting
Study of long-term outcomes after a ruptured brain aneurysm bleed
This trial is a long-term follow-up study of people who come to the emergency room with a ruptured brain aneurysm (bleeding in the space around the brain). It helps doctors understand what outcomes are most common and what may affect recovery over time.
Beijing, Beijing MunicipalityAges Any age - NCT04789616RecruitingPhase 2
Maraviroc plus stroke rehab to improve recovery
This study tests whether maraviroc (or a placebo) given soon after an ischemic stroke can improve how well people recover with inpatient rehabilitation. It may help some stroke survivors regain arm and/or leg function faster with the usual rehab therapies.
Calgary, AlbertaAges 18 years+ - NCT04790240RecruitingPhase 1/Phase 2
Herbal treatment aimed to reduce COVID-19 inflammation
This early-stage trial studies whether certain medical herbs can lower inflammation in people with recent COVID-19 and help the immune system better fight the virus. You may be able to join whether or not you take standard COVID medicines, but you would need to complete the herb plan and provide specific lab and scan results.
Rockville, MarylandAges Any age - NCT04791449Recruiting
Exercise program for healing diabetic foot ulcers
This study tests whether an exercise program can help wounds (ulcers) heal faster in people with diabetic foot ulcers. It mainly looks for adults with type 2 diabetes and enough blood flow to the foot, and checks safety and healing progress.
Albuquerque, New MexicoAges 20–80 - NCT04792281Recruiting
FDG-PET/CT scan to guide treatment for heart valve infection
This study tests whether an FDG-PET/CT scan (a special imaging test) can help doctors choose the best treatment plan for people with a suspected native heart valve infection. It may help reduce uncertainty by showing where the infection activity is.
Montreal, QuebecAges 18 years+ - NCT04793581Recruiting
Testing a small-vessel device for foot circulation problems
This trial checks how well a device called the Pantheris Small Vessel System works to treat blocked small blood vessels in the foot/leg. It may help people improve circulation, but you must meet specific health and follow-up requirements.
Grand Rapids, MichiganAges 18 years+ - NCT04794530RecruitingPhase 3
Cocoa extract trial for walking problems in blocked leg arteries
This Phase 3 study tests whether cocoa extract (cocoa flavanols) can improve walking ability and circulation in people with peripheral artery disease (PAD). It may help people who have PAD-related walking limits and can safely avoid competing cocoa sources and caffeine.
Chicago, IllinoisAges 55 years+ - NCT04795882RecruitingPhase 1
Study of modular CAR T therapy for multiple myeloma
This early-phase study tests a personalized type of immune therapy called modular CAR T for people with relapsed or treatment-resistant multiple myeloma. It aims to see whether the therapy can reduce the myeloma, including in cases where standard treatments have not worked.
London, County (Optional)Ages 18 years+ - NCT04796714RecruitingPhase 4
Aspirin and clopidogrel after left heart appendix closure
This trial studies a “double anti-platelet” medicine plan (aspirin plus clopidogrel) after closing the left atrial appendage, a procedure used to reduce stroke risk in some heart rhythm conditions. It aims to find a safer, better medicine strategy for people who cannot take standard blood thinners.
PessacAges 18 years+ - NCT04797572Recruiting
Testing a tool to measure the aortic valve during surgery
This trial evaluates a measuring tool used during aortic valve surgery. It may help surgeons size the valve opening more accurately when treating valve leakage or a dilated (enlarged) ascending aorta.
BrusselsAges 18–80 - NCT04798950Recruiting
Bronchial Dilation Study in Polynesian Patients
This is a retrospective study (looking back at medical records) examining bronchial dilation—a condition where airways in the lungs become abnormally enlarged—in Polynesian patients. Researchers want to understand this condition better by reviewing past medical records from 2010–2020.
PapeeteAges 18 years+ - NCT04800913Recruiting
Imaging tests during left atrial appendage closure
This study looks at how different imaging tests can help guide a procedure that closes off the left atrial appendage to reduce stroke risk. It may help doctors choose the safest approach during the procedure.
BudapestAges 18 years+ - NCT04804683Recruiting
FMD and SCAD registry study in Europe and beyond
This trial is a registry, meaning it collects detailed medical information to better understand fibromuscular dysplasia (FMD) and a specific type of heart-vessel dissection (SCAD) linked to FMD. It may help researchers learn who is at risk and guide better care in the future.
BrusselsAges Any age - NCT04804384Recruiting
Testing a brain-controlled hand device after a stroke
This study tests whether a “closed-loop” neuroprosthesis (a hand-control device that responds to your movement) can improve hand grasping after a stroke. It may help people who cannot open or grab objects on their own, and who can safely participate during a short hospital stay.
ToulouseAges 18 years+ - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT04808401Recruiting
Testing how different oxygen levels affect surgery outcomes
This trial studies whether giving higher or lower oxygen during general anesthesia changes heart and lung outcomes after planned (non-emergency) non-heart surgery. It may help doctors choose safer oxygen settings during surgery for people at higher risk for heart problems.
BernAges 18 years+ - NCT04808596Recruiting
Pulmonary hypertension registry and blood sample study
This study builds a registry and collection system for people with pulmonary hypertension, confirmed by a specific heart test. By joining, you help researchers learn more about the condition and may support future studies.
Kansas City, KansasAges 18 years+ - NCT04809506Recruiting
Blood and genetic tests to predict future heart problems
This study looks for new body markers (including possible genetic traits) to better predict who is likely to have future cardiovascular events. Your results could help doctors estimate risk and choose prevention strategies more accurately.
ToulouseAges 18–99 - NCT04813159Recruiting
Remote heart preconditioning for people with blocked-heart-attack
This study tests whether a remote, arm-based treatment done around the time of a heart attack can improve outcomes in people with STEMI (a serious heart-attack type). Some participants receive the real treatment and some receive a sham version, while others may be followed observationally depending on how long ago symptoms started.
Mombasa, Mombasa CountyAges 18 years+ - NCT04814212Recruiting
Testing a drug-coated balloon for people with bleeding risk
This trial looks at whether a “drug-coated balloon” used during a heart procedure (PCI) is safer or better for people who are at higher risk of bleeding while on blood thinners. It may help reduce complications around the time of the procedure in people like you.
Jyväskylä, Central FinlandAges 18 years+ - NCT04814420Recruiting
Study heart scarring in sleep apnea, with or without atrial fibrillation
This pilot study looks at whether obstructive sleep apnea leads to heart scarring (called atrial fibrosis), especially in people with and without an irregular heart rhythm (atrial fibrillation). It may help researchers understand who is at higher risk and why, using sleep testing and heart imaging.
New Orleans, LouisianaAges 18–75
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.