Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT04754217Recruiting
Follow-up study after valve graft replacement
This study looks at outcomes after certain heart valve surgeries using a valved graft. It may help doctors understand how well these grafts work over time in people who have had valve replacement surgery.
Birmingham, AlabamaAges 18 years+ - NCT04755153Recruiting
Community health program to lower heart disease risk
This trial tests a community-based health intervention in Chicago to help reduce the risk of cardiovascular (heart and blood vessel) disease. It may help people by offering structured support through local clinics or churches.
Chicago, IllinoisAges 18–89 - NCT04755764Recruiting
Compare blood-pressure medicines in early pregnancy
This trial tests how three common blood-pressure medicines (labetalol, atenolol, and nifedipine) affect blood flow in early pregnancy. It may help doctors choose the safest, most effective option for pregnant people with high blood pressure.
Huntington, West VirginiaAges 18–45 - NCT04755699RecruitingEarly Phase 1
Electrical stimulation study for hand or limb movement recovery
This early-stage study tests whether regular, skin-based electrical stimulation can help people with paralysis or weakness regain movement. You would attend frequent clinic sessions for months, while the team checks your ability to follow instructions and your safety.
Manhasset, New YorkAges 18–75 - NCT04755842Recruiting
Study of severe tricuspid valve leakage in Hamburg
This study focuses on people with severe “tricuspid regurgitation,” which means a valve in the right side of the heart leaks backward. It collects information (including interviews) to better understand this condition and what to do next.
HamburgAges 18 years+ - NCT04756076Recruiting
Study heavy metal levels in pulmonary hypertension patients
This study looks at whether heavy metals in the body—and an imbalance of important minerals—are different in people with pulmonary arterial hypertension. It may help researchers understand possible causes and targets for future treatments.
Louisville, KentuckyAges 18 years+ - NCT04759326Recruiting
Hippotherapy after stroke to improve movement and function
This trial studies whether therapy using a horse (hippotherapy) can help adults who still have stroke-related physical difficulties more than 3 months after their stroke. It aims to improve daily function and movement when standard recovery has not been enough.
La CanourgueAges 18 years+ - NCT04760977Recruiting
HEMS care for bleeding trauma with low blood pressure
This trial studies how emergency helicopter (HEMS) teams manage trauma patients who have signs of shock from blood loss, especially when bleeding is suspected or ongoing. It may help teams choose the best pre-hospital approach to stabilize you sooner.
AlessandriaAges 18 years+ - NCT04761120Recruiting
Follow-up study for specific heart valve repair ring implants
This study follows people who are going to get certain types of heart valve repair rings or bands. It aims to track safety and outcomes after the Abbott device is implanted in routine care over follow-up visits.
Durham, North CarolinaAges 18 years+ - NCT04761991Recruiting
CMR vs CT scan for coronary artery disease
This study compares two heart-imaging tests—cardiac MRI (CMR) and CT—to see which better helps evaluate coronary artery disease in people with chest pain. You may be asked to have one of these scans as part of your heart work-up.
Leicester, LeicsAges 18 years+ - NCT04766866Recruiting
Check two blood markers to help prevent preeclampsia
This trial tests whether measuring two pregnancy blood markers (sFlt1 and PlGF) and planning delivery timing can help prevent preeclampsia as you reach term. It may help reduce risk for mother and baby by guiding when to deliver based on test results.
LiègeAges 18 years+ - NCT04768322Recruiting
LVAD versus standard heart failure medicines in advanced patients
This trial compares an LVAD device (a pump placed in the chest) plus medicines versus medicines alone for people with advanced, end-stage heart failure. It aims to see which approach works better to help patients live and stay out of the hospital.
BesançonAges 18 years+ - NCT04769362RecruitingPhase 4
Checking long-term beta-blocker use after a heart attack
This study looks at people who have already been on a beta-blocker for at least a year after a heart attack. It aims to understand how long-term beta-blocker treatment affects heart health and outcomes.
SeoulAges 19 years+ - NCT04771572RecruitingPhase 1
Oral drug LP-118 for relapsed blood cancers
This Phase 1 study tests an oral (by mouth) drug called LP-118 in people whose blood cancers have returned or did not respond to prior treatment. The goal is to find a safe dose and see whether it can shrink or control the cancer.
Chicago, IllinoisAges 13 years+ - NCT04772963Recruiting
Genetics study for brain blood vessel malformations
This study looks at genetic (inherited DNA) factors in people with certain abnormal blood vessel connections in the brain or spinal cord. It may help researchers understand why these malformations happen and how they might behave over time.
ParisAges Any age - NCT04772768Recruiting
Checking problems in vein bypass grafts in people with recurring chest pain
This study looks at how vein bypass grafts are working over time in people who had heart bypass surgery and now have recurring angina (chest discomfort). It may help doctors better understand why symptoms come back and how the heart and grafts change.
AmsterdamAges 18–90 - NCT04774159RecruitingPhase 3
Low-dose colchicine to lower risk in leg artery disease
This trial tests whether low-dose colchicine can reduce “residual” risk—future heart and blood-vessel problems—in people with peripheral artery disease (PAD). It targets PAD symptoms and complications like poor blood flow in the legs, even after certain procedures.
New Haven, ConnecticutAges 18 years+ - NCT04775108Recruiting
Testing a new heart procedure for severe leaking mitral valve
This trial studies a new transcatheter (through the heart without open surgery) mitral valve treatment for people with severe mitral valve leaking who are too high-risk for standard surgery. It may help reduce valve leakage and improve symptoms, but it’s an early “first-in-human” device study.
InnsbruckAges 60 years+ - NCT04775914Recruiting
Test a heart procedure guide during emergency STEMI treatment
This trial studies whether adding a special heart “reset” step (ischemic postconditioning) and using an imaging guide during the emergency procedure can improve outcomes for people having a STEMI heart attack. It’s meant to optimize treatment when a blocked heart artery is being opened.
Copenhagen, Capital RegionAges 18 years+ - NCT04775745RecruitingPhase 1
Oral drug test for relapsed or refractory B-cell blood cancers
This Phase 1 trial studies LP-168 taken by mouth in people whose B-cell cancers have come back or did not respond to treatment. The study aims to find how the drug works, the right dose, and what side effects to expect.
Durham, North CarolinaAges 18 years+ - NCT04776330RecruitingPhase 1/Phase 2
BCMA-targeted CAR-T for relapsed or refractory multiple myeloma
This trial tests a lab-made immune cell therapy (CAR-T) designed to attack a protein called BCMA on myeloma cells. It’s for adults whose multiple myeloma or related plasma cell disease has come back or didn’t respond to prior treatment, aiming to improve cancer control.
Kunming, YunnanAges 18–75 - NCT04776759Recruiting
Study of first atrial fibrillation in young adults
This study records and follows people under 35 who have their first episode of an irregular heartbeat. It aims to better understand this condition early on and how it shows up in real life.
Caen, NormandyAges Up to 35 years - NCT04776642Recruiting
Biobank for heart rhythm disorders and conduction problems
This study builds a biobank (a secure collection of medical information and body samples) for people with certain heart rhythm problems. You may be able to contribute to research that helps improve understanding and treatment of these conditions.
AmsterdamAges 18 years+ - NCT04779008Recruiting
Remote arm treatment to help blood flow after heart bypass
This trial studies whether a simple, at-home type of treatment using brief arm blood-flow changes can improve blood flow to the heart and outcomes after CABG (heart bypass surgery). It may help some people recover better by protecting the heart around the time of surgery.
Zhengzhou, HenanAges 18–80
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.