Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05100940Recruiting
Study after a heart procedure complication
This trial looks at what happens after complications during or after a heart procedure called coronary angiography or PCI. It may help improve care and outcomes for people who experience a problem during treatment.
Minneapolis, MinnesotaAges 18 years+ - NCT05100992Recruiting
Bifurcation heart procedure registry for adults
This study is a real-world registry that follows adults who are getting a specific type of heart stent procedure in a forked artery. It helps doctors learn what happens before and after the procedure and improve care.
Minneapolis, MinnesotaAges 18 years+ - NCT05102448RecruitingPhase 4
Tofacitinib vs methotrexate for active Takayasu’s arteritis
This trial compares two medicines—tofacitinib and methotrexate—to see which works better for controlling active Takayasu’s arteritis. It also looks at safety in people with this condition who need treatment right now.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT05103670Recruiting
PET/CT lung scan to assess recovery after pulmonary embolism
This study uses a special scan (PET/CT) and an inhaled/linked tracer to measure how well air and blood flow work in different lung areas after a pulmonary embolism. It’s meant to better understand regional lung function and how rehabilitation may help some people recover.
BrestAges 18–99 - NCT05103566Recruiting
Noninvasive vagus nerve stimulation for ruptured brain aneurysm bleed
This trial studies whether a noninvasive device that stimulates the vagus nerve can be safely given soon after a ruptured aneurysm bleed to improve outcomes. It may help calm the brain’s stress response after this type of stroke-like emergency.
Boston, MassachusettsAges 18–85 - NCT05105633RecruitingPhase 2/Phase 3
Tenecteplase for basilar stroke within an extended time window
This trial tests whether giving a clot-busting medicine (tenecteplase) can help people with a specific type of stroke caused by a basilar artery blockage, even if treatment starts later than usual. It aims to improve brain recovery and function by reopening the blocked artery.
Bankstown, New South WalesAges 18 years+ - NCT05106140Recruiting
Robots help measure arm learning after a new stroke
This study uses robotic devices to understand how your arm learns movement after a recent stroke. It may help researchers improve stroke rehabilitation by figuring out what kinds of practice work best.
Calgary, AlbertaAges 18 years+ - NCT05106036Recruiting
Lowering BP targets to prevent memory and thinking decline
This study tests whether setting a lower blood pressure goal can help prevent future memory and thinking problems in older adults. It compares a more intensive blood pressure plan with usual care to see if it better protects the brain over time.
Dallas, TexasAges 70 years+ - NCT05106270Recruiting
Atrial pressure changes around a heart procedure for atrial fibrillation
This trial studies how changing pressure in the heart’s upper chamber before and after a combined heart procedure affects outcomes in people with atrial fibrillation. It may help guide safer, more effective care for patients who need left atrial appendage closure (a way to reduce stroke risk).
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05111288Recruiting
Testing a pulse field therapy for reduced heart ischemia
This trial studies whether pulse electromagnetic field therapy can improve signs of reduced blood flow to the heart (ischemia) in people who cannot or will not get a coronary procedure during the study. If you already take standard heart medicines, you may be eligible to add this therapy and undergo exercise testing and heart imaging.
Scottsdale, ArizonaAges 18 years+ - NCT05112705Recruiting
Finding deep vein clots early in ICU patients
This study focuses on diagnosing deep-vein thrombosis (DVT, blood clots in the leg) early in people who are very ill in the ICU. It aims to test an approach to better detect clots sooner, which could help prevent complications.
Riyadh, Riyadh RegionAges 18 years+ - NCT05113043Recruiting
Study links gut changes with stroke in younger adults
This study looks at whether differences in gut bacteria (microecology) are linked to stroke in adults ages 18–45. You may be asked to provide stool (fecal) samples soon after admission to help researchers understand possible connections.
ShanghaiAges 18–45 - NCT05114850Recruiting
Follow-up study for people treated with TricValve
This study looks back at patients who were successfully treated with TricValve bicaval valve devices and then follows up with their outcomes. You might join if you (or your legal guardian) agree to be included.
Sankt Pölten, Lower AustriaAges 18 years+ - NCT05115214Recruiting
Device test for treating irregular heartbeat with AF ablation
This trial studies a heart procedure using the Affera SpherePVI system to treat paroxysmal (comes and goes) or persistent atrial fibrillation. It’s for people who still have symptoms despite at least one anti-arrhythmia medicine, and who are good candidates for catheter ablation.
PragueAges 18–75 - NCT05116384Recruiting
Renal nerve ablation plus AF ablation for persistent AF
This study tests whether treating kidney-related nerves along with the usual AF (irregular heartbeat) catheter procedure works better than the usual procedure alone. It may help some people with persistent AF, but you must meet specific heart and kidney safety requirements.
Short Hills, New JerseyAges 18 years+ - NCT05117424Recruiting
Study of metabolism and plaque changes in heart disease
This trial looks at how treating or managing conditions like diabetes, prediabetes, obesity, kidney disease, or high cholesterol affects artery plaque over time. It may help researchers find ways to slow plaque buildup and related heart risks.
ShanghaiAges 18–80 - NCT05118997Recruiting
Irrigation procedure to help clear brain bleeding
This trial tests a method to actively flush (irrigate) and help remove an active brain bleed inside the brain. It may help some adults recover better by improving how the blood is cleared after bleeding starts.
HelsinkiAges 18 years+ - NCT05122962Recruiting
MRI study of heart rhythm and exercise capacity after congenital surgery
This study looks at how blood flow and heart rhythm may affect exercise ability in people born with certain heart defects that have been repaired or treated. It uses a specialized heart MRI and ultrasound measurements to better understand these problems and their causes.
Rochester, MinnesotaAges 18 years+ - NCT05124249Recruiting
Imaging tests to evaluate clogged heart arteries
This study looks at how well special heart imaging and pressure-based tests can evaluate coronary artery disease (clogged heart arteries). If you had testing for suspected heart artery disease, the study may help doctors compare how these measurements work.
GwangjuAges 18 years+ - NCT05127720Recruiting
Pacemaker monitoring to study sleep apnea long term
This study uses a pacemaker to track information over time related to sleep apnea. It also includes CT scans to help the researchers better understand what’s happening in and around the heart during sleep.
Innsbruck, TyrolAges 18 years+ - NCT05129345Recruiting
HIV care program for heart health goals in the Southeast US
This trial tests an approach to help people living with HIV reach heart- and metabolism-related health goals, such as blood pressure, cholesterol, and blood sugar. It involves clinics and community partners and may offer education, support, and care coordination to remove barriers to treatment.
Charlotte, North CarolinaAges 18 years+ - NCT05131022RecruitingPhase 1
Study of NX-5948 for relapsed B-cell blood cancers
This Phase 1 study tests NX-5948 in adults whose B-cell cancers have come back or did not respond to prior treatment. It aims to find a safe dose and see how well the treatment works in different types of B-cell malignancies.
Duarte, CaliforniaAges 18 years+ - NCT05132179Recruiting
Testing two antiseptic creams for diabetic foot ulcers
This study compares two topical (applied on the skin) antimicrobial agents—Dakin’s and Prontosan—to help heal diabetic foot ulcers. You may be eligible if you have a diabetic foot ulcer that has been present for at least 3 weeks and is large enough.
Uddevalla, TrollhattanAges 18–100 - NCT05132387Recruiting
Out-of-hospital cardiac arrest registry using automatic CPR
This study records information about people who suffer an out-of-hospital cardiac arrest and receive automatic chest compressions. It focuses on specific heart rhythms and emergency timing, which may help improve future emergency treatment.
WroclawAges 18–60
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Mental health
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.