Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05132439RecruitingPhase 3
Metformin to improve walking in leg artery blockage
This Phase 3 study tests whether metformin can help people with intermittent claudication (leg pain when walking) walk farther. It compares how well metformin works on walking ability alongside standard (already recommended) heart and blood-vessel medicines.
Pittsburgh, PennsylvaniaAges 35–89 - NCT05132517Recruiting
Magnesium to support thinking after stroke
This trial studies whether magnesium can help improve or protect thinking skills after a stroke. It may be offered to people who did not already have memory or thinking problems before their stroke.
Hessisch Oldendorf, Lower SaxonyAges 18 years+ - NCT05133843Recruiting
Test heart blood-flow measurements before and after TAVI
This study checks whether special heart tests can better understand “in-between” blocked heart arteries before and after TAVI (a valve replacement done through a catheter). It may help doctors choose the safest, most accurate treatment when coronary artery disease is unclear.
LeipzigAges 18 years+ - NCT05134311Recruiting
3D ultrasound check for blood-flow problems in wound care
This study tests whether a 3D ultrasound scan can better assess blood-flow problems that may affect healing in the wound clinic. If you’re already scheduled for an ultrasound evaluation at the wound center, the trial may use an additional 3D ultrasound approach to help doctors understand your circulation.
Lake Success, New YorkAges 18 years+ - NCT05135403Recruiting
Registry study for the ASSURE wearable heart defibrillator
This study collects information from adults who have been prescribed the ASSURE wearable defibrillator. The goal is to understand how the device performs in real-world patients after it is approved.
Seattle, WashingtonAges 18 years+ - NCT05139589Recruiting
Collecting data from adults with heart valve infection
This study collects information about adults who are treated in Amsterdam UMC for infective endocarditis (a serious infection of the heart valves). The goal is to better understand this condition—especially for people undergoing heart valve surgery—by comparing them to similar surgery patients who do not have an infection.
Amsterdam, North HollandAges 18 years+ - NCT05140434Recruiting
Check whether exercise heart tests help diagnose artery blockage
This study looks at whether an “exercise heart test” can better diagnose blockage in the heart’s coronary arteries. Participants may also have a heart scan or imaging test for comparison, within a short time window.
Corbeil-Essonnes, FranceAges 18 years+ - NCT05140148RecruitingPhase 2
Amantadine to help recovery after stroke
This Phase 2 study tests whether the medicine amantadine can improve recovery after a recent stroke. It may help some people regain function during early rehabilitation.
Philadelphia, PennsylvaniaAges 18–85 - NCT05142124Recruiting
Registry of out-of-hospital cardiac arrest cases
This study collects information about people who had a cardiac arrest outside the hospital, where it is thought to be from a heart or blood-vessel cause. It helps researchers understand what happens and may improve future care, even though it is mainly about collecting data.
Berlin, State of BerlinAges 18 years+ - NCT05144503Recruiting
Test of a new catheter procedure for irregular heart rhythm
This study checks how safe and effective a special catheter procedure (SpherePVI) is for treating paroxysmal (comes and goes) or persistent atrial fibrillation. You may be considered if your atrial fibrillation keeps returning and you’ve already tried at least one medication but it didn’t work or you couldn’t tolerate it.
VilniusAges 18–75 - NCT05145517Recruiting
Follow-up study for people who received a JOTEC vascular graft
This study tracks people 18 and older who were treated with a JOTEC vascular graft. It checks how well the graft and follow-up care work over time for certain blood vessel problems.
Münster, North Rhine-WestphaliaAges 18 years+ - NCT05145400RecruitingPhase 2
Drug treatment for frail or older newly diagnosed multiple myeloma
This Phase 2 study tests whether “isa-Rd” can safely and effectively treat people who have newly diagnosed multiple myeloma and are frail or much older. It may help those who are at higher risk of side effects from stronger, full-intensity chemotherapy.
Chapel Hill, North CarolinaAges 18 years+ - NCT05146336Recruiting
CytoSorb registry for critically ill patients needing blood treatment
This registry collects information about critically ill patients who receive the CytoSorb 300 mL blood treatment. It may help doctors better understand when the treatment works best and when it should not be used.
KlagenfurtAges Any age - NCT05146180Recruiting
Scan to help diagnose infection on a replaced heart valve
This study tests a special type of PET/CT scan to better detect infections on a prosthetic (replaced) heart valve. It may help doctors confirm whether infection is present, based on imaging results.
RouenAges 18 years+ - NCT05147701RecruitingPhase 1
Testing stem cell treatment for NAION safety
This Phase 1 study tests whether lab-made stem cells taken from donated umbilical cord are safe for people with NAION. It mainly looks for side effects and safety rather than proving the treatment works.
St John'sAges Any age - NCT05150704RecruitingPhase 3
Steroid treatment for suspected acute myocarditis in hospital
This study tests whether steroid medicine helps people hospitalized with suspected acute myocarditis (inflammation of the heart). Participants are randomly assigned to receive steroids or a placebo, and the trial looks at outcomes after the acute episode starts.
San Diego, CaliforniaAges 18–69 - NCT05155137RecruitingPhase 3
Daily pill and home risk check to prevent stroke and memory loss
This Phase 3 trial tests whether a daily “polypill” plus a simple home risk-check plan can lower the chance of stroke and future thinking/memory problems. It is aimed at adults at moderate risk but who have not had stroke or heart disease before.
Porto Alegre, Rio Grande do SulAges 50–75 - NCT05156736Recruiting
Study of early heart artery disease in South Asians
This study looks at early buildup of plaque in heart arteries in young adults from Pakistan. It may help doctors understand why this happens earlier and guide better prevention and screening.
Karachi, SindhAges 35–65 - NCT05156385Recruiting
Study of sexual problems in women with treated high blood pressure
This study looks at sexual dysfunction (sexual problems) in women who are being treated for high blood pressure. It may help researchers understand what causes these issues and what could improve them.
Toulouse, CHU de ToulouseAges 18 years+ - NCT05156983RecruitingPhase 3
Reversal drug for urgent surgery in people on Factor Xa blood thinners
This Phase 3 study tests TAK-330, a reversal (blocking) medicine, to reduce bleeding risk during urgent surgery for adults taking Factor Xa inhibitors like rivaroxaban, apixaban, or edoxaban. It’s for situations where surgery can’t wait and doctors need a fast way to restore normal clotting.
Arkansas City, ArkansasAges 18 years+ - NCT05158101RecruitingPhase 1
Nasal stem cell exosome treatment safety for stroke
This early-stage study (Phase 1) tests whether a tiny dose given through the nose is safe for people who have had a stroke. It uses exosomes made from adult umbilical cord stem cells, mainly to look for side effects and dosing safety.
St John'sAges Any age - NCT05158738Recruiting
Study of inherited heart conditions in children
This trial studies children with inherited (genetic) heart conditions that started before age 16. It may help improve how doctors identify the genetic cause and understand which families are affected.
LondonAges Any age - NCT05161377Recruiting
Test treatment planning for a middle brain artery aneurysm
This study looks at treatment options for aneurysms in a specific brain artery (the middle cerebral artery). It may help by guiding safer, more appropriate surgical or catheter-based treatment for aneurysms that fit certain health and imaging criteria.
EdmontonAges 18 years+ - NCT05164107Recruiting
Test a new pulsed-field catheter procedure for atrial fibrillation
This trial tests a new pulsed-field device used during an atrial fibrillation (AF) catheter ablation, aiming to improve safety and effectiveness. It’s for people who have AF and are planning an AF ablation procedure.
PragueAges 18–75
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.