Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,973 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2481
- Phase 4480
- Phase 3447
- Phase 1360
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke843
- Heart Failure565
- Hypertension399
- Cardiovascular Diseases390
- Coronary Artery Disease373
- Multiple Myeloma333
- Atrial Fibrillation268
- Ischemic Stroke200
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke138
- Myocardial Infarction101
- Pulmonary Hypertension100
- Stroke, Ischemic86
- Congenital Heart Disease85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama197
- Massachusetts183
- Arizona173
- New York161
- Florida145
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,970 total
- NCT04094428Recruiting
Study of ICU outcomes, deaths, and care costs
This study looks at what happens to people in intensive care, including deaths and hospital resource use. It may help hospitals plan better care and understand the costs of staying in the ICU.
UlmAges Any age - NCT03847025Recruiting
Lead extraction registry for pacemaker and defibrillator patients
This registry collects information from people who are having pacemaker or defibrillator leads removed. It helps doctors and researchers understand how these procedures are done and what happens afterward.
Portland, OregonAges Any age - NCT03806972Recruiting
Study outcomes after emergency heart failure admission
This study follows people admitted to the emergency department for acute heart failure to understand their short- and long-term outcomes. It may help doctors predict who needs more support and improve follow-up after discharge.
Monastir, Monastir GovernorateAges 18–80 - NCT03275584RecruitingPhase 4
Safety of an ammonia heart scan at CHUM
This trial checks how safe a specific heart scan is when used to look at blood flow to the heart. It is done as part of routine (clinically needed) testing at CHUM, using a special radioactive ammonia tracer.
Montreal, QuebecAges 18 years+ - NCT03113435Recruiting
Oxygen plan during major belly surgery for adults
This study tests a more guided oxygen plan during long major abdominal operations to help manage how much oxygen your body uses. It compares the new oxygen approach to the current standard method during surgery.
RomaAges 18 years+ - NCT02766166Recruiting
Study of health status scores in monitored hospital patients
This study looks at how a “health score” measures a patient’s condition and outcomes while they are in the hospital with heart monitoring. It may help doctors better assess risk and track how patients do over time.
Indianapolis, IndianaAges 18 years+ - NCT04715022RecruitingTeam says not enrollingPhase 1/Phase 2
Vitamin C study for insulin resistance in obesity
This early-stage study tests whether vitamin C (and possibly how your body uses it) affects blood vessel function in people with obesity and insulin resistance. You may be asked to stop certain supplements before starting so researchers can measure the effect more clearly.
Kansas City, KansasAges 35–65 - NCT07750873RecruitingPhase 2
Study of an investigational medicine for heart failure with reduced pumping function
This trial tests an investigational medicine called CRD-4730 (taken as a pill) to see if it can improve heart function and symptoms in people with heart failure and a reduced pumping ability. It may help you feel better and slow the progression of your condition.
Pasadena, CaliforniaAges 18–85 - NCT07749183Recruiting
Light-based detection of atrial fibrillation in heart failure
This study tests a new device that uses light to detect irregular heartbeats (atrial fibrillation) in people with heart failure. If you join, you'll wear a small sensor that may help catch early signs of this condition.
BratislavaAges 18 years+ - NCT06404242Recruiting
Plaque features predict repeat stroke after middle cerebral artery blockage
This study looks at people who recently had a stroke caused by hardening of the arteries in the middle cerebral artery, a major blood vessel in the brain. The researchers use special MRI scans to see if the plaque (the fatty buildup) can predict whether another stroke might happen.
Ho Chi Minh City, Ho Chi Minh CityAges 45–100 - NCT07748858Recruiting
Heart care support for older African American patients
This study aims to improve care for older African American patients with heart conditions and other health problems. It tests ways to provide more patient-centered support.
Birmingham, AlabamaAges 50–99 - NCT07749170Recruiting
Stroke treatment for blockages in smaller brain arteries
This study looks at how well a special catheter system works to remove blood clots from smaller arteries in the brain after a stroke. It aims to see if this treatment helps people recover better.
Knoxville, TennesseeAges 18 years+ - NCT07463807RecruitingPhase 1/Phase 2
Comparing two drug combinations for multiple myeloma that returned quickly
This study tests a new combination of two drugs, teclistamab and pomalidomide, against the usual treatment of three drugs for multiple myeloma that has come back shortly after a standard treatment. The goal is to see if the new combination works better or is safer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07222852RecruitingPhase 3
Heart Protection After Preeclampsia With Enalapril
This trial tests whether the blood pressure medicine enalapril can help protect the hearts of people who had preeclampsia (a pregnancy-related high blood pressure condition) after they give birth. It is for those already in a hospital hypertension monitoring program.
Providence, Rhode IslandAges 18 years+ - NCT05879211Enrolling by invitation
Care learning lab for Duke Health patients
This trial is a “learning laboratory” that studies how best to provide goal-focused care. It may help improve care experiences for Duke Health patients, based on what the study learns.
Durham, North CarolinaAges 18 years+ - NCT06483100RecruitingPhase 2
Elranatamab after stem cell transplant for multiple myeloma
This trial tests a drug called elranatamab to keep multiple myeloma from coming back after an autologous stem cell transplant. It is for people who still have small amounts of cancer cells detectable after transplant.
St Louis, MissouriAges 18 years+ - NCT05812755RecruitingPhase 4
Study drug effects on blood vessels and organs in heart surgery
This Phase 4 trial studies vericiguat-like stimulation (a type of medicine that affects blood-vessel signaling) around the time of planned open-heart surgery. It aims to see whether this can change blood-vessel “reactivity” and reduce injury to organs during and after surgery.
Nashville, TennesseeAges 18 years+ - NCT05700617RecruitingEarly Phase 1
Testing cardiac pumping strength in cardiogenic shock
This early study looks at how well the heart is pumping in people with cardiogenic shock, using measurements taken during a right-heart catheter (a small pressure-monitoring test). It may help doctors better assess heart function and guide next-step treatments like LVAD, heart transplant, or valve surgery.
Chicago, IllinoisAges 18 years+ - NCT07094256Recruiting
New device for heart rhythm procedure in young people
This trial is testing a new device used during a procedure that checks or treats heart rhythm problems in children and young adults. It may help doctors do the procedure more safely or effectively.
Washington D.C., District of ColumbiaAges Up to 21 years - NCT04077307RecruitingPhase 1
Karonudib for leukemia that has come back or not responded
This Phase 1 trial studies Karonudib, a new treatment, for people with leukemia (and a few related blood cancers) that has come back or didn’t respond to standard care. The goal is to see if the treatment is safe and to learn how it may work in this hard-to-treat setting.
AarhusAges 18–75 - NCT07230340Enrolling by invitationPhase 4
Placenta tissue for nonhealing leg ulcers
This study tests a special dehydrated human placenta tissue dressing for leg ulcers that won't heal. You will get either standard wound care plus this dressing, or standard care alone; later you may have the chance to receive the dressing.
Rocky Mount, North CarolinaAges 18 years+ - NCT07002294Recruiting
Specialist care after cardiac arrest recovery trial
This trial tests whether care from a specialist team helps people recover better after a cardiac arrest outside the hospital. If you were revived and brought to the emergency department with a pulse, you might be eligible.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07284758RecruitingPhase 2
Cemsidomide and dexamethasone for relapsed/refractory multiple myeloma
This clinical trial tests a new combination of two medicines (cemsidomide and dexamethasone) for people with multiple myeloma that has come back or stopped responding after at least three prior treatments. The goal is to see if this new drug can help control the cancer when other options have stopped working.
Huntsville, AlabamaAges 18 years+ - NCT04298723Recruiting
Left atrial appendage closure vs blood thinners after brain bleed
This trial compares a procedure that blocks a heart blood-choke point (the left atrial appendage) versus taking blood thinners by mouth. It is for people with atrial fibrillation who have had a brain bleed and may be safer avoiding long-term blood thinners.
Mannheim, Baden-WurttembergAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,973 recruiting cardiology studies from the U.S. registry right now, out of 15,205 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.