Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 10,073 recruiting studies in this area right now.
By phase
- Not applicable8,041
- Phase 2490
- Phase 4483
- Phase 3452
- Phase 1359
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke855
- Heart Failure565
- Hypertension403
- Cardiovascular Diseases389
- Coronary Artery Disease375
- Multiple Myeloma330
- Atrial Fibrillation273
- Ischemic Stroke200
- Atrial Fibrillation (AF)146
- Acute Ischemic Stroke141
- Pulmonary Hypertension104
- Myocardial Infarction98
- Congenital Heart Disease87
- Peripheral Arterial Disease85
- Stroke, Ischemic84
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis78
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris92
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital54
- Massachusetts General Hospital51
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Insel Gruppe AG, University Hospital Bern50
- Johns Hopkins University47
Where studies are running
- California467
- Alabama198
- Massachusetts181
- Arizona176
- New York166
- Florida146
- Maryland120
- Texas120
- Illinois119
- Minnesota119
Recruiting studies10,070 total
- NCT04893278Enrolling by invitation
Virtual reality during an EP heart procedure
This trial tests whether a virtual reality experience in a heart testing lab (during an electrophysiology procedure) is safe and workable for patients. It may help the care team learn if virtual reality can make the lab experience easier for some people.
Jacksonville, FloridaAges 18 years+ - NCT04848506Enrolling by invitationPhase 2/Phase 3
Long-term safety follow-up with aficamten for adults with HCM
This study checks how safe and well-tolerated aficamten is over the long run in adults with hypertrophic cardiomyopathy (HCM). You may be eligible if you finished a prior Cytokinetics aficamten study and your heart pumping strength is in the required range.
Birmingham, AlabamaAges 18–85 - NCT04680130Enrolling by invitation
Study of brain, genetics, and clinical symptoms in neurodegenerative illness
This study looks at how your symptoms, brain imaging (MRI), and genetic factors relate to neurodegenerative conditions. It may help researchers better understand what causes these illnesses and how to classify them.
Rochester, MinnesotaAges 21 years+ - NCT04676100Enrolling by invitation
International registry for cardiac rehabilitation programs
This study collects information about cardiac rehabilitation (CR) programs in lower-resource areas. It helps improve how CR is delivered and understood, especially where healthcare resources and awareness are limited.
DohaAges 18 years+ - NCT04617639Enrolling by invitation
Exercise program after a heart attack in Norway
This trial tests whether a structured physical exercise plan can help people recover and stay healthier after a heart attack. It is designed for people who can safely be active and are not already doing as much exercise as the program requires.
TrondheimAges 18–79 - NCT04534556Enrolling by invitation
Wireless nerve stimulation to improve stroke recovery
This study tests a wireless nerve stimulation device placed near the vagus nerve to help people recover after a stroke. It focuses on people with specific remaining arm/hand movement and recovery levels at least 12 months after stroke.
Dallas, TexasAges 22–79 - NCT04520347Enrolling by invitation
Registry for heart rhythm ablation in VT or PVC
This study is a “registry,” meaning it collects information about people undergoing a procedure to treat abnormal heart rhythms like ventricular tachycardia (VT) or premature ventricular contractions (PVCs). It may help researchers better understand which patients benefit from the procedure and how it is done over time.
Phoenix, ArizonaAges Any age - NCT04451044Enrolling by invitation
Guided heart stent planning using an inside pressure sensor
This study tests whether using a tiny pressure sensor in heart arteries during a procedure can better guide where to place a stent. It may help doctors choose the safest and most effective stent plan by more accurately measuring artery narrowing.
Birmingham, AlabamaAges 18 years+ - NCT04444362Enrolling by invitation
Probacine to protect organs after cardiovascular surgery
This study tests whether a medicine called Probacine can help protect your gut and organs after cardiovascular surgery. If you qualify, you may be asked to take part and follow the study plan to see if complications are reduced.
Beijing, Beijing MunicipalityAges 18–90 - NCT04404465Enrolling by invitation
Test blood/heart signals to understand atrial fibrillation changes
This study looks at early changes in the heart related to atrial fibrillation (AF) using health data and biomarkers. It aims to find better ways to predict or understand AF, especially around procedures like ablation or cardioversion.
San Francisco, CaliforniaAges 18 years+ - NCT04279496Enrolling by invitation
CT heart scan registry to track outcomes over time
This is a research registry that follows people who are already getting a CT scan of their heart arteries for medical reasons. It aims to better understand how these scans relate to future heart outcomes, while collecting follow-up health information.
Charlottesville, VirginiaAges 18 years+ - NCT04269447Enrolling by invitation
Collecting samples from people with abdominal aortic aneurysm
This study sets up a long-term biobank by collecting health information and tissue/blood samples from people with an abdominal aortic aneurysm. It may help doctors better understand what causes aneurysms and how to detect or treat them in the future.
Solna, Stockholm CountyAges 50–80 - NCT04240119Enrolling by invitation
Study blood vessel growth markers in certain brain artery narrowing
This study looks at “angiogenic markers,” which are blood measures that may reflect how blood vessels grow, in people with significant narrowing of a brain artery. It aims to better understand these changes and how they relate to cerebrovascular disease.
Ages 18 years+ - NCT04190758Enrolling by invitation
Early arthritis study for RA, psoriatic arthritis, and psoriasis
This study looks at people with early arthritis related to rheumatoid arthritis, psoriatic arthritis, or psoriasis. Researchers want to understand how these early conditions behave and may help guide better treatment decisions.
GothenburgAges 18–80 - NCT04189822Enrolling by invitation
Heart rhythm genetic registry and blood sample bio bank
This study is building a Canadian database and tissue/blood bank for people and families with inherited heart rhythm conditions (and some inherited heart muscle diseases). It collects consented health and genetic information to help researchers better understand who is at risk and how these conditions work.
Vancouver, British ColumbiaAges Any age - NCT04178915Enrolling by invitation
Blood marker study to predict severe bacterial lung infection
This study looks at specific immune cells and how fats are transported in the blood to predict which people will have a severe bacterial infection (like pneumonia or sepsis). Your results may help doctors identify higher-risk patients earlier.
MinskAges 18–60 - NCT04148625Enrolling by invitation
Sub-xiphoid hybrid maze for persistent atrial fibrillation after failed ablation
This trial studies a hybrid heart procedure to treat persistent atrial fibrillation in people whose previous catheter ablation did not work. It aims to improve heart rhythm and reduce ongoing symptoms by using a planned combination of techniques and careful follow-up.
Ages 18–80 - NCT04141605Enrolling by invitation
Heart transplant candidates matched for better heart preservation
This study creates a worldwide registry and information database to help improve how donor hearts are preserved for transplant. If you are a heart transplant candidate, your details may be recorded to see what matching and preservation approaches work best.
Stanford, CaliforniaAges Any age - NCT04093297Enrolling by invitation
Band vs ring surgery for tricuspid valve leakage
This trial compares two surgical options (a band versus a ring) to treat tricuspid valve regurgitation, which means blood leaks backward through the tricuspid valve. It may help your heart work more efficiently and reduce symptoms by testing which device works better for people with the right valve problem.
Nanjing, JiangsuAges 18–70 - NCT04008173Enrolling by invitation
Survey study of acute heart attack symptoms
This study collects information about symptoms and experiences during acute coronary syndromes, which are sudden, serious heart events like heart attacks or unstable angina. It may help researchers understand patterns of care and symptoms to improve future treatment and support.
Bologna, BolognaAges 18 years+ - NCT03984591Enrolling by invitationPhase 4
Compare spironolactone vs eplerenone for heart failure patients
This study uses Denmark’s heart failure registry to compare two common tablet medicines—spironolactone and eplerenone—for people with symptomatic systolic heart failure. It aims to see which one leads to better health outcomes over time.
CopenhagenAges Any age - NCT03958773Enrolling by invitation
Transcatheter treatment for severe leaking mitral valve
This study tests a new catheter-based system to treat severe mitral valve leaking when open-heart surgery is considered high risk. It may help improve blood flow and symptoms by repairing the valve without open surgery, using ultrasound guidance and follow-up visits to track safety and results.
KaunasAges 18 years+ - NCT03836482Recruiting
SCD test for people with heart and kidney failure awaiting LVAD
This study looks at whether a treatment called SCD is safe and workable in people who have worsening heart failure along with kidney problems, and who are waiting to get an LVAD (a mechanical heart pump). It is mainly a feasibility study, meaning the researchers want to see if this approach can be used in real hospital care and monitor effects on key health measures.
Ann Arbor, MichiganAges 18 years+ - NCT03836300Enrolling by invitation
Parent-infant coaching for families with young diagnoses
This study tests a parent-and-infant coaching program for babies and caregivers. It aims to see whether the program helps after an early diagnosis when English is used at home.
Research Triangle Park, North CarolinaAges Up to 99 years
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 10,073 recruiting cardiology studies from the U.S. registry right now, out of 15,588 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Mental health
- Digestive system
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- Immune system & allergy
- Women’s health & pregnancy
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.