Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,973 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2481
- Phase 4480
- Phase 3447
- Phase 1360
- Phase 1/Phase 2162
- Phase 2/Phase 386
Top conditions
- Stroke843
- Heart Failure565
- Hypertension399
- Cardiovascular Diseases390
- Coronary Artery Disease373
- Multiple Myeloma333
- Atrial Fibrillation268
- Ischemic Stroke200
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke138
- Myocardial Infarction101
- Pulmonary Hypertension100
- Stroke, Ischemic86
- Congenital Heart Disease85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California461
- Alabama197
- Massachusetts183
- Arizona173
- New York161
- Florida145
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,970 total
- NCT01427179Recruiting
Studying genes in families affected by SCAD
This study looks at genetic (inherited) causes of spontaneous coronary artery dissection (SCAD) in families. It may help researchers understand why SCAD happens and how it could be prevented or identified earlier in others.
Rochester, MinnesotaAges 18 years+ - NCT03053141Recruiting
RHAPSODY mapping study during catheter procedures for heart rhythm
This study tests how heart electrical signals are mapped and recorded during a standard catheter procedure for atrial or ventricular rhythm problems. It may help researchers improve the way doctors analyze rhythm data, using a specific mapping system.
Birmingham, AlabamaAges 18 years+ - NCT05593627RecruitingPhase 4
Lithium to improve sleep and thinking after heart surgery
This trial tests whether lithium carbonate can improve sleep and thinking (cognitive function) after heart valve surgery that uses a heart-lung machine. It may help some people who have trouble sleeping or thinking after surgery, but it excludes people with significant sleep or thinking problems before surgery.
Shenyang, LiaoningAges 18–65 - NCT03253705Recruiting
Donate small blood samples to study heart and inflammation health
This study collects small blood samples (and sometimes samples during treatment) to help researchers understand diseases involving the heart, inflammation, and blood vessel function. It may help improve future tests and treatments by giving scientists usable human data.
Bethesda, MarylandAges 18–100 - NCT06964685Recruiting
Impella heart pump in heart attack with shock
This study looks at how well the Impella CP heart pump works for people who have a severe heart attack that causes their heart to pump too weakly to keep blood flowing to their body. It's a registry that follows your care to improve best practices.
Jonesboro, ArkansasAges 18 years+ - NCT03538639Recruiting
Study blood and tissue samples for vascular disease discovery
This study collects blood (and sometimes tissue samples) from people who may have vascular (blood vessel) problems and from certain pregnant participants. Researchers use the samples to better understand vascular disease and to help guide future research.
Bethesda, MarylandAges 2–100 - NCT03102125RecruitingPhase 4
Testing causes of heart transplant graft problems with scans
This study looks at why heart transplant “grafts” can start to malfunction again after transplant. If you qualify, you may undergo MRI and related heart testing to help researchers find ways to detect or understand graft dysfunction.
La Jolla, CaliforniaAges 18 years+ - NCT02851758Recruiting
Autologous mitochondria treatment for critically ill heart children on ECMO
This trial looks at giving a child their own mitochondria to help protect the heart from injury caused by reduced blood flow. It is for children with serious heart problems who are on a heart-lung machine and may have signs of ischemia (reduced blood flow damage).
Boston, MassachusettsAges Up to 17 years - NCT03492528Recruiting
Heart care study for people starting cancer treatment
This study follows adults who are referred to a heart (cardio-oncology) specialist before starting cancer treatment. It may help doctors better understand heart outcomes in people with cancer and improve how heart risks are managed early.
MarseilleAges 18 years+ - NCT05303363Recruiting
Checking brain blood flow during a breathing heart-lung machine
This study monitors how much blood is reaching the brain in adults who need a specific type of life-support called VV-ECMO. The goal is to better understand brain blood flow and how monitoring may help manage care during ECMO.
Amsterdam-ZuidoostAges 18–100 - NCT05289063RecruitingPhase 1
Study new sleep apnea and blood vessel function
This Phase 1 study looks at how blood vessel function is affected by obstructive sleep apnea in adults who are newly diagnosed and have not used CPAP. It may help researchers understand the early effects of sleep apnea and guide future treatments.
New York, New YorkAges 18 years+ - NCT02352818Recruiting
Chronic heart artery blockage registry for treatment outcomes
This study is a registry that collects information about people who try to reopen a long-term blocked heart artery. It doesn’t test a new treatment—your doctors use standard care, and the registry helps learn what happens over time.
LeuvenAges 18 years+ - NCT05525325Recruiting
Sedation method during clot removal for posterior stroke
This study compares different ways of giving sedation during a procedure to remove blood clots in strokes caused by blocked vertebral or basilar arteries. The goal is to see which sedation approach is safest and works best for patients undergoing endovascular treatment.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT01889459Recruiting
Registry after stent procedure for blocked heart arteries
This study follows people who had a stent placed for a long-standing blockage in a heart artery (called a CTO). It’s mainly a “registry” to understand outcomes after these procedures and help improve care in the future.
KurashikiAges 20 years+ - NCT05517291Recruiting
Compare two stent types for blocked thigh artery disease
This trial compares a special drug-coated balloon/stent strategy versus a standard stent approach for people with blocked thigh artery segments. It aims to improve how long the artery stays open and reduces repeat procedures.
BeijingAges 18–85 - NCT06199180Recruiting
Comparing two ablation methods for repeat atrial fibrillation treatment
This trial tests a newer type of energy (pulsed field ablation) against the standard heat-based method (radiofrequency) for people who have already had one ablation and now have atrial fibrillation again. The goal is to see which works better for keeping your heart in a normal rhythm.
GroningenAges 18–80 - NCT03667196Recruiting
Test opening blocked heart arteries using two different procedures
This trial studies whether two ways of threading a device to open a long-term blocked coronary artery are both safe and effective. You may qualify if you have a chronic total blockage and heart-related symptoms, and you can follow the study follow-up plan.
AnyangAges 19 years+ - NCT02814396Recruiting
ECG analysis system for heart conditions
This trial uses a new ECG analysis system to better detect heart rhythm problems or other heart diseases. It may help doctors diagnose and treat heart conditions more accurately.
TaipeiAges 20 years+ - NCT07016815Recruiting
Remote monitoring to adjust heart failure medications
This trial tests whether checking in remotely (telemonitoring) helps doctors adjust heart failure medications more effectively. It is for people newly diagnosed with heart failure who have reduced pumping strength and signs of fluid buildup.
Hong Kong, Hong KongAges 19 years+ - NCT03496792Recruiting
Study of blood pressure changes when standing up
This study checks how your blood pressure changes when you go from lying down to standing. It may help researchers understand why some people get “orthostatic hypertension” (higher blood pressure when standing) and how that reflex works.
Hershey, PennsylvaniaAges 18 years+ - NCT06082050RecruitingEarly Phase 1
YOLT-201 for transthyretin heart disease
This trial tests a new intravenous medicine called YOLT-201 for people with a heart condition caused by buildup of a protein called transthyretin (ATTR-CM). The goal is to see if it can slow or improve the disease.
Hangzhou, ZhejiangAges 18–80 - NCT03179774Recruiting
Procedure trial for blocked carotid artery to improve brain blood flow
This trial studies an endovascular procedure to reopen a chronically blocked carotid artery and improve blood flow to the brain. It also compares outcomes against standard care in part of the study, for people who show abnormal brain circulation on brain scans.
TaipeiAges 20 years+ - NCT03475498Recruiting
ECG and heart ultrasound before and after pacemaker implantation
This study looks at how heart test results—electrical tracing (ECG) and heart ultrasound (echocardiogram)—change after a device is implanted. It may help doctors better predict who develops PICM (a certain pacing-related heart weakening) and how that affects outcomes.
ChungjuAges 20 years+ - NCT03292861Enrolling by invitationPhase 2
Thymoglobulin after first heart transplant: safety and effect
This trial tests whether Thymoglobulin® is safe and how well it works in people getting their first heart transplant. It may help doctors fine-tune medicines used to prevent the body from rejecting the new heart.
Los Angeles, CaliforniaAges 18–70
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,973 recruiting cardiology studies from the U.S. registry right now, out of 15,205 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.