Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,976 recruiting studies in this area right now.
By phase
- Not applicable7,959
- Phase 2483
- Phase 4479
- Phase 3447
- Phase 1361
- Phase 1/Phase 2161
- Phase 2/Phase 386
Top conditions
- Stroke841
- Heart Failure567
- Hypertension401
- Cardiovascular Diseases390
- Coronary Artery Disease372
- Multiple Myeloma334
- Atrial Fibrillation268
- Ischemic Stroke201
- Atrial Fibrillation (AF)140
- Acute Ischemic Stroke137
- Myocardial Infarction102
- Pulmonary Hypertension100
- Congenital Heart Disease85
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California460
- Alabama197
- Massachusetts183
- Arizona174
- New York161
- Florida145
- Maryland120
- Illinois119
- Minnesota119
- Texas118
Recruiting studies9,973 total
- NCT07585968Recruiting
New Catheter Treatment for Dangerous Heart Rhythms
This trial tests a new catheter-based procedure to treat life-threatening irregular heartbeats (ventricular tachycardia) that keep coming back despite medication. If you've had a heart attack and your implanted defibrillator hasn't fully controlled these arrhythmias, this procedure might help prevent future episodes.
Columbus, OhioAges 18–85 - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Fairhope, AlabamaAges 40–85 - NCT06321575Recruiting
New device for clearing leg artery blockages
This trial tests a new device called the Golazo® Atherectomy System that removes plaque from leg arteries to improve blood flow. It may help people with leg pain when walking or small wounds caused by blocked arteries.
Scottsdale, ArizonaAges 18 years+ - NCT02089607Recruiting
Fenestrated or branched stent for large aortic tears or bulges
This study tests a special type of stent-graft (a tube with branch openings) to treat large or rapidly growing aneurysms and certain aortic dissections in the chest/abdomen or aortic arch. It aims to prevent the aneurysm from rupturing and to safely restore blood flow to key branch arteries.
Rochester, MinnesotaAges 18 years+ - NCT07242391Recruiting
Menopausal hormone therapy and heart function study
This study looks at how menopausal hormone therapy might affect the heart's pumping ability. It may help women who are naturally entering menopause understand if hormone therapy can protect their heart health.
Rochester, MinnesotaAges 45–60 - NCT06782230Recruiting
A biobank for rare disease samples and data
This study creates a collection of biological samples and health information from people with rare diseases and their family members. It aims to build a shared resource that can help future research on rare conditions.
San Donato Milanese, MilanAges Any age - NCT07691502Recruiting
Using CT scans before angioplasty to plan treatment
This trial tests if using a special heart CT scan (CCTA with FFRCT) before a planned angioplasty can help doctors better plan where to place stents. You may be eligible if you have a narrowing in one or two heart arteries that haven't been treated before.
Minneapolis, MinnesotaAges 22 years+ - NCT01855633Recruiting
Brain stimulation therapy for arm or leg weakness after stroke
This trial studies whether repeated magnetic pulses to the brain can improve movement in people with weakness after a stroke. It may help if your stroke happened more than 2 weeks ago and you can safely receive the magnetic treatment.
Hwaseong-si, Gyeonggi-doAges 18 years+ - NCT05568966Recruiting
Blood sample collection for new diagnostic tests
This study collects small blood samples to help test and improve new diagnostic devices. You may be eligible if you’re an adult with certain symptoms that match one of several health “groups,” and if you can consent and read English.
Airdrie, ScotlandAges 18 years+ - NCT06143332Recruiting
Aerobic exercise after a heart attack: which type works best?
This study compares two types of aerobic exercise (steady vs. interval) to see which one improves heart health more for people who have recently had a heart attack or procedure. If you've completed a stress test and been cleared for exercise, you may be able to join.
London, OntarioAges 18 years+ - NCT07324720Recruiting
Comparing ischemia vs plaque risk for high-risk artery disease
This trial compares two ways to decide which heart artery blockages need treatment: one looks at blood flow, the other at plaque buildup and risk. It's for people with high-risk blockages to see which approach leads to better outcomes.
Seoul, Main BuildingAges 19 years+ - NCT05288790RecruitingPhase 2
Study how gut chemicals and alcohol affect heart risk in HIV
This Phase 2 study looks at how “microbiome metabolites” (chemicals from gut bacteria) and alcohol may affect heart and blood vessel risk in people living with HIV. If you qualify, you may be asked to follow a study plan to see how these factors change health markers related to cardiovascular disease.
Nashville, TennesseeAges 18–89 - NCT06192342Recruiting
Breathing machine settings for brain injury patients
This study looks at how different breathing machine settings affect people with new brain or spinal cord injuries who need help breathing. It only includes people with healthy lungs to see which ventilator settings work best.
Ciudad Autonoma de Buenos Aires, Buenos AiresAges 16 years+ - NCT07427927Enrolling by invitation
Hemorrhoid surgery patient groups study
This study looks at people who have had surgery for hemorrhoids to find common patterns or groups among them. It may help improve care by better understanding different types of hemorrhoid disease.
San Donato Milanese, MilanAges 18 years+ - NCT07314138Recruiting
Comparing two minimally invasive heart bypass surgeries for three-vessel disease
This trial compares two types of heart bypass surgery for people with blockages in three main heart arteries. It tests a hybrid approach that combines a small incision bypass with a stent, versus a standard off-pump bypass. This may mean less recovery time for some patients.
Leuven, Vlaams BrabantAges 18–85 - NCT07655479Recruiting
Switching to a stronger heart pump after heart attack
This trial tests whether switching to a more powerful heart pump (Impella 5.5) within 24 hours of a heart attack helps people whose hearts are still struggling despite a standard pump. It may be an option for patients who had a heart attack, received an Impella CP pump, but still need strong medication to keep blood flowing.
Düsseldorf, North Rhine-WestphaliaAges 18–77 - NCT07787793Recruiting
Effects of non-invasive brain stimulation on hand movement after stroke
This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help improve hand movement in people who have had a stroke and have severe arm weakness. It uses a special device to stimulate the brain and may help with motor recovery.
Palma, Balearic IslandsAges 18 years+ - NCT07154927Recruiting
Using ultrasound to guide heart catheterization for pulmonary hypertension
This trial tests if using ultrasound to guide a catheter into the lung's blood vessels is a good way to diagnose pulmonary hypertension. It may help find a safer, more accurate method for diagnosis.
Asyut, Select A StateAges Any age - NCT07787091RecruitingPhase 1/Phase 2
First study of ARD001 in healthy people and those with hemophilia A
This study tests a new medicine, ARD001, for the first time in humans. It aims to see if the drug is safe and how the body handles it, and it is also being studied in people with hemophilia A to find a safe dose for future trials.
SingaporeAges 21–45 - NCT07786779RecruitingPhase 1
Safety study of an injectable drug in healthy adults
This study tests a new injectable medication to see if it is safe and how the body processes it. It is looking for healthy adults to participate and will monitor for side effects and study how the drug works.
Beijing, Beijing MunicipalityAges 18–55 - NCT07310992Recruiting
Meditation added to heart rehab
This study tests whether adding meditation to a standard cardiac rehabilitation program helps people with heart disease feel better and improve their recovery. If you have a heart condition and are starting rehab, you may be able to join.
São Paulo, São PauloAges 18 years+ - NCT07786649Recruiting
Non-invasive brain stimulation for stroke recovery
This trial tests different types of non-invasive brain stimulation to see which one helps people recover better from stroke-related problems like arm weakness, leg weakness, neglect, or speaking difficulty.
SingaporeAges 21–80 - NCT07038356RecruitingPhase 3
Continuing empagliflozin during heart failure hospitalizations
This study tests whether continuing empagliflozin (a heart failure medicine) during a hospital stay for heart failure is beneficial compared to stopping it. Participation may help improve recovery and reduce complications.
Jena, ThuringiaAges 18 years+ - NCT06940297RecruitingPhase 2
Dasatinib and quercetin with CAR-T therapy for relapsed or refractory multiple myeloma
This trial tests whether adding two drugs, dasatinib and quercetin, to CAR-T therapy can help people with multiple myeloma that has come back or not responded to past treatments. It aims to make the CAR-T cells work better and reduce side effects.
Rochester, MinnesotaAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,976 recruiting cardiology studies from the U.S. registry right now, out of 15,179 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.