Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,981 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2482
- Phase 4481
- Phase 3449
- Phase 1361
- Phase 1/Phase 2164
- Phase 2/Phase 387
Top conditions
- Stroke841
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke201
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke138
- Myocardial Infarction100
- Pulmonary Hypertension100
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas117
Recruiting studies9,978 total
- NCT06922240RecruitingPhase 3
Stopping riociguat to see how the heart responds in CTEPH
This trial is for people with a type of long-term blood clot in the lungs (CTEPH) who have been taking riociguat for at least 12 weeks. It will see what happens when the medication is stopped, focusing on how the right side of the heart is doing.
Beijing, ChinaAges 18 years+ - NCT05766943Recruiting
Testing a new device feature to reduce signal noise in S-ICD patients
This study tests whether a smart feature (Smart Pass) can reduce unwanted electrical signal interference in people with an implanted S-ICD. It may help the device work more smoothly and reduce potential noise-related problems.
Charleston, South CarolinaAges 18 years+ - NCT06635863Enrolling by invitationPhase 4
Steroids versus standard heart medications for heart inflammation
This study compares two treatment strategies for people with unexplained heart failure and irregular heartbeats caused by inflammation: one group gets standard heart medications plus an immune-suppressing steroid (prednisone), and the other gets standard medications alone. Doctors want to see whether adding steroids helps improve heart function and control dangerous heart rhythms.
Phoenix, ArizonaAges 18 years+ - NCT07235865Recruiting
Blood test to find and monitor heart masses
This trial uses a blood test (liquid biopsy) to help find and monitor heart masses without surgery. It may help diagnose what the mass is and how it changes over time.
Milan, ItaliaAges 12 years+ - NCT05300451Enrolling by invitationPhase 2
Daratumumab to help lower rejection risk before heart transplant
This Phase 2 trial tests daratumumab to reduce your body’s immune reaction (HLA antibodies) before a heart or heart-and-kidney transplant. It may help lower the risk of immediate, severe rejection in people who already have high antibody levels.
Rochester, MinnesotaAges 18–80 - NCT06737614Recruiting
Blood pressure and heart function in ICU patients
This study looks at the relationship between blood pressure and the amount of blood the heart pumps in critically ill patients. It may help doctors better understand and manage your condition in the ICU.
São PauloAges 18 years+ - NCT06527443Recruiting
Arterial stiffness in adults with sepsis
This study measures how stiff your arteries are during sepsis, which may help doctors understand your condition better. You need to be an adult in the ICU with sepsis and be tested within 24 hours.
AsyutAges 18 years+ - NCT05828719Recruiting
Compare heart stent treatment vs medicines for weak heart function
This study looks at whether opening blocked heart arteries with a stent (a PCI procedure) works better than staying on heart medicines for people with weakened pumping function and certain types of heart failure. It may help patients by testing which approach best improves outcomes over time.
SeoulAges 19 years+ - NCT06608953Enrolling by invitation
EECP for artery stiffness in dialysis patients
This study tests whether a non‑invasive treatment called enhanced external counterpulsation (EECP) can help reduce stiffness in the arteries of people on chronic hemodialysis. It may improve heart health and make dialysis more effective.
Bangkok, BangkokAges 18 years+ - NCT07353892Recruiting
Robotic exoskeleton therapy for heart or lung surgery recovery
This trial tests whether using a robotic exoskeleton during physical therapy helps people recover more quickly after heart or lung surgery. The device supports your body as you practice standing and walking, even if you need a lot of help from your therapist.
Dallas, TexasAges 18 years+ - NCT06839404Recruiting
Fluid bolus effect on heart and blood flow
This study looks at how a standard IV fluid bolus affects blood flow and heart function in ICU patients. It aims to better understand the body's response to this common treatment.
Le Kremlin-BicêtreAges 18 years+ - NCT04014348Recruiting
Study links neighborhood stress to heart health in women
This study looks at whether stressful neighborhood conditions are connected to heart-health blood markers and everyday health behaviors. It mainly enrolls healthy women in Washington, DC to help researchers understand how environment may affect cardiovascular risk.
Bethesda, MarylandAges 19–45 - NCT06836986Recruiting
Norepinephrine vs. phenylephrine for blood pressure in C-section
This trial compares two medications, norepinephrine and phenylephrine, to see which works better at preventing low blood pressure during emergency C-sections under spinal anesthesia.
Karachi, SindhAges 18–40 - NCT07015554Enrolling by invitation
IGF1 levels in women with heart failure
This study looks at a hormone called IGF1 in women with a specific type of heart failure (where the heart pumps normally but is stiff). It may help understand if this hormone is linked to the condition.
Shenzhen, GuangdongAges 18 years+ - NCT07223645Recruiting
Handgrip exercise and brain blood flow in young adults
This study tests whether a simple handgrip exercise program can improve blood flow regulation to the brain in young adults who are not very active. Participants will do handgrip exercises at home using a mobile app to track their progress.
Tallahassee, FloridaAges 18–35 - NCT06920173RecruitingPhase 2
Low-dose vasopressors for shock in the ICU
This study tests whether giving low-dose blood pressure medicines through a standard IV (instead of a larger central line) is safe and effective for patients with shock in the intensive care unit.
Kingston, OntarioAges 18 years+ - NCT04924998Recruiting
Study for AL-CM treatment in adults at one hospital
This study is looking at a treatment approach for people diagnosed with AL-CM at a specific hospital. It may help researchers understand whether the treatment is safe and effective for patients like you.
Hangzhou, ZhejiangAges 18–80 - NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Little Rock, ArkansasAges 50 years+ - NCT05301192RecruitingEarly Phase 1
Study angiotensin-1-7 effects on hearts and blood vessels in older adults
This early-phase study tests how angiotensin-(1-7) affects blood vessels and the heart in people ages 65–80. It may help researchers understand how to improve cardiovascular function as we age.
Hershey, PennsylvaniaAges 65–80 - NCT07216573Recruiting
The continuity study: blood pressure monitoring during surgery
This trial tests a device that monitors blood pressure continuously during surgery using a finger cuff, instead of the standard arm cuff that gives readings every few minutes. You may be able to join if you are having surgery and are at higher risk of complications during anesthesia.
Rochester, New YorkAges 18 years+ - NCT05776082Recruiting
Study how healthy pregnancy heart risk affects outcomes
This study looks at how cardiovascular (heart and blood vessel) health during pregnancy is linked to pregnancy outcomes. It may help doctors better predict and improve outcomes by using information from routine prenatal care.
Hangzhou, ZhejiangAges 20–49 - NCT05663216Recruiting
Study of fluid leaks in serious whole-body inflammation
This trial looks at what causes blood vessels to “leak” fluid during a dangerous whole-body inflammation response. It may help doctors understand why some people develop fluid buildup and aim for better monitoring and care in the ICU.
ParisAges 18 years+ - NCT07211282Recruiting
Activity tracking for late-stage cardiac rehab
This trial uses a smartphone app to monitor and guide your physical activity during the final phase of cardiac rehab. It aims to help you safely stay active and improve your recovery.
Edegem, AntwerpAges 18 years+ - NCT07211347RecruitingPhase 4
Nerve block for electrical storm
This trial tests whether injecting numbing medicine around neck nerves (stellate ganglion block) can calm dangerous heart rhythms called electrical storm. It's for people with heart disease whose abnormal rhythms keep happening despite usual medications.
São Paulo, São PauloAges 18 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,981 recruiting cardiology studies from the U.S. registry right now, out of 15,236 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.