Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,981 recruiting studies in this area right now.
By phase
- Not applicable7,957
- Phase 2482
- Phase 4481
- Phase 3449
- Phase 1361
- Phase 1/Phase 2164
- Phase 2/Phase 387
Top conditions
- Stroke841
- Heart Failure566
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke201
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke138
- Myocardial Infarction100
- Pulmonary Hypertension100
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois118
- Texas117
Recruiting studies9,978 total
- NCT07424885Recruiting
Comparing two stent grafts for complex aneurysm repair
This study compares two types of stent grafts used during a minimally invasive aneurysm repair (FEVAR). It is for people with complex aneurysms (near the kidneys or in the chest/belly area) who need surgery soon.
Vienna, State of ViennaAges 18 years+ - NCT07266116RecruitingPhase 1/Phase 2
TQB2934 injection for light chain amyloidosis
This trial tests a new injectable drug called TQB2934 for people with systemic light chain amyloidosis. It aims to see if the drug is safe and effective for those whose disease has come back or gotten worse after previous treatment.
Beijing, Beijing MunicipalityAges 18–80 - NCT07096219Enrolling by invitation
Catheter Ablation for Leaky Mitral Valve in Persistent Atrial Fibrillation
This trial tests if catheter ablation—a procedure to fix heart rhythm—can help people with a leaky mitral valve that is caused by atrial fibrillation (functional mitral regurgitation). If you have persistent atrial fibrillation and moderate leaky valve, you may benefit from this treatment.
Guangzhou, GuangdongAges 18–75 - NCT06840756RecruitingPhase 4
Does donor-patient sex matching improve blood transfusion outcomes?
This trial tests whether giving ICU patients blood from a donor of the same sex (male-to-male or female-to-female) leads to better recovery compared to mismatched transfusions. The goal is to see if matching donor and patient sex makes a difference in how well patients do.
Hamilton, OntarioAges 18 years+ - NCT07265349RecruitingPhase 1/Phase 2
Stem cells plus bypass surgery for chronic heart failure
This trial tests whether injecting stem cells from umbilical cord tissue into the heart muscle during bypass surgery can improve heart function in people with chronic heart failure. It is for patients who are already scheduled for bypass surgery and have a weakened heart pump (LVEF between 21% and 40%).
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06536231Recruiting
Remote ischemic conditioning in ICU patients
This study tests a simple, non-invasive treatment called remote ischemic conditioning (using a blood pressure cuff to briefly stop blood flow to one arm) to see how it affects heart and blood flow in critically ill patients in the ICU. If you are in the ICU, over 18, and have a special heart monitor, you may be able to join.
KaunasAges 18–85 - NCT07205393Recruiting
Heart rehab after valve replacement surgery
This trial tests a phase one cardiac rehabilitation program for people who have had their mitral or aortic heart valve replaced. It aims to see if the rehab helps recovery. You might qualify if you had planned (not emergency) valve surgery and are stable enough for light exercise.
QinaAges 40–55 - NCT06842940Recruiting
Predicting best lead placement during pacemaker or ICD surgery
This study tests whether a measurement called 'slew rate' can help doctors find the best spot to attach the leads (wires) from a pacemaker or ICD to your heart. It may lead to more stable and effective placement during your procedure.
FidenzaAges 18–100 - NCT05735002Recruiting
Check tests to find chronic bowel blood flow problems early
This study looks at ways to promote early diagnosis of chronic mesenteric ischemia, a condition where the intestines don’t get enough blood over time. If you’re being evaluated for this problem, the trial may help ensure the right diagnosis happens sooner.
Enschede, OverijsselAges 18 years+ - NCT06837870Enrolling by invitation
Closing the access site after leadless pacemaker implant
This trial compares two ways to close the access site after placing a leadless pacemaker—one uses a special device, the other a stitch. It aims to see which method is safer and works better.
Worcester, MassachusettsAges 18 years+ - NCT07200726Recruiting
Brain inflammation and thinking after heart surgery
This study looks at whether brain inflammation during heart surgery may affect memory and thinking. It includes people aged 60 and older who are having planned heart surgery.
Genk, LimburgAges 60 years+ - NCT06823583Recruiting
VAD guidance tool testing for patients and clinicians
This study tests a new tool that helps patients prepare for getting a ventricular assist device (VAD), a machine that helps the heart pump blood. Researchers want to see if the tool is easy to use and helpful for both patients and their doctors.
Lincoln, NebraskaAges 19 years+ - NCT07197970RecruitingPhase 3
Stent for blocked brain arteries
This trial tests whether a drug-coated stent can help people with severely narrowed brain arteries that have already caused a stroke or mini-stroke. It aims to improve blood flow and prevent future strokes.
Beijing, Beijing MunicipalityAges 18–80 - NCT05271214Recruiting
Testing conservative care for people with failing heart pumps
This trial is studying a non-surgical (conservative) treatment approach for people being considered for a left ventricular assist device (LVAD). It may help some patients who are too sick or unable to tolerate standard heart failure medicines, but it will only match people with specific heart function and health-test results.
Tel AvivAges 18–80 - NCT06845579Recruiting
Predicting blood pressure results after kidney nerve treatment
This study tests a treatment called renal denervation, which uses a special procedure to calm nerves near the kidneys that can raise blood pressure. It may help people whose high blood pressure is not well controlled despite taking several medications.
Mainz, Rheinland PflanzAges 18 years+ - NCT07354841Recruiting
Testing safety of heart-lung machine tubes
This study tests two types of tubes used during heart surgery to connect you to a heart-lung machine. It aims to see if they work safely and effectively.
Bari, BAAges 18 years+ - NCT06662500Recruiting
Shockwave balloon for hard heart blockages trial
This trial tests a new balloon catheter that uses sound waves to break up hard calcium blockages in heart arteries. It may be an option for people with stable chest pain or who have recovered from a recent heart attack, and who have a single, tough blockage.
La Jolla, CaliforniaAges 18 years+ - NCT07177612Enrolling by invitation
Testing the LILAC method for lipoprotein(a) education
This trial tests a new method called LILAC to help people learn about and manage high levels of lipoprotein(a), a type of fat in the blood. It is for anyone 16 or older who attends educational events or is part of a health group.
PerthAges 16 years+ - NCT04769206RecruitingPhase 1/Phase 2
Boost nerve signaling to improve blood vessel function
This study tests a treatment aimed at increasing “rest-and-digest” nerve activity to improve how blood vessels work, especially in people with vascular oxidative stress. It is designed for African American adults and looks at whether the intervention can improve blood vessel-related health markers.
Nashville, TennesseeAges 18–60 - NCT07184814Recruiting
Takayasu's arteritis with lung artery involvement study
This study looks at people with Takayasu's arteritis that also affects the lungs' blood vessels. Researchers want to understand the disease's behavior and outcomes over time.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07630402Recruiting
Heart Imaging Study for Women With Early Breast Cancer
This study helps doctors find the best way to monitor heart health in women with HER2-positive breast cancer who are receiving a type of targeted chemotherapy. The goal is to catch any heart problems early and keep you safe during treatment.
Rochester, New YorkAges 18–79 - NCT06043570Recruiting
Remote monitoring for pacemaker patients
This trial tests if remote monitoring of your pacemaker is as good as in-person checks. It may help you avoid frequent clinic visits.
SeoulAges 18–80 - NCT06414759RecruitingPhase 4
Combination diuretic therapy for heart failure fluid overload
This trial tests a combination of water pills (diuretics) to help remove extra fluid in people hospitalized with acute decompensated heart failure (sudden worsening of heart failure). It aims to find a safe and effective way to reduce swelling and fluid buildup.
Giza, GZAges 18–65 - NCT07168044Enrolling by invitation
Heart health program for older adults at dining sites
This program aims to reduce heart disease risk in older adults who eat at community dining sites. Participants will learn about heart health and get support to make healthier choices.
Lexington, KentuckyAges 60 years+
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,981 recruiting cardiology studies from the U.S. registry right now, out of 15,236 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.