Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05509166Recruiting
Therapy for sexual-minority women dealing with anxiety or depression and drinking
This trial tests a type of supportive psychotherapy to help sexual-minority women improve mental well-being and reduce drinking. It may help if you’re experiencing depression or anxiety and have been drinking heavily, and you’re not already in certain kinds of treatment.
New York, New YorkAges 18 years+ - NCT05543083Recruiting
Therapy plus exercise for teens at risk of type 2 diabetes
This trial tests whether a combination of coaching (cognitive-behavioral therapy) and exercise can improve mood and help teens who are at higher risk for type 2 diabetes. It may be especially helpful if you’re dealing with depression symptoms and a family history of type 2 diabetes.
Aurora, ColoradoAges 12–17 - NCT05525702Recruiting
VR sessions to lower confusion in ICU patients
This trial tests whether virtual reality (VR) activities can reduce delirium—new, sudden confusion—in people staying in the ICU. It may help patients feel clearer and more oriented during a longer ICU stay.
Beijing, Beijing MunicipalityAges 18–90 - NCT05537610Recruiting
Test a behavior strategy for frequent self-injury
This study looks at how to reduce serious problem behaviors (including self-injury) in children who have it many times per day even after previous treatment. It may help if your child’s behavior is driven by social attention or other positive effects and they can stay on the same supports, school plan, and medicines during the study.
Somerset, New JerseyAges 3–17 - NCT05534243Recruiting
A breathing and brain-signal study for adults on ventilators
This study looks at brain activity during care for adults who are on a breathing machine through a tube in the windpipe. It may help doctors understand how to monitor recovery and guide care after intubation.
Iowa City, IowaAges 18 years+ - NCT05514899RecruitingPhase 2
Cannabidiol and THC study for gut health and brain inflammation in HIV
This Phase 2 study tests whether cannabidiol (CBD) and tetrahydrocannabinol (THC) change the gut microbiome and brain-related inflammation in people with HIV. It may help researchers understand new ways to reduce inflammation, but you would need strict cannabis and CBD/THC avoidance during the study.
San Diego, CaliforniaAges 21–70 - NCT05540704Recruiting
Therapy support for eating problems in type 1 diabetes
This study compares three groups: Acceptance and Commitment Therapy, standard supportive diabetes counseling, or a waitlist. It aims to reduce binge eating and harmful weight-control behaviors, including insulin withholding, in people with type 1 diabetes.
Durham, North CarolinaAges 16–50 - NCT05548244Recruiting
Testing behavioral activation for teens with depression
This study looks at how a therapy approach called behavioral activation may affect depression in teens. It also uses brief daily check-ins on a phone to understand what changes during treatment.
Atlanta, GeorgiaAges 15–17 - NCT05541029Recruiting
Music listening for children on breathing machines
This study tests whether listening to music can help children who are in the Pediatric Intensive Care Unit (PICU) and need a breathing machine. It looks at the “how it works” side—whether music changes things in the body or brain during intensive care.
Pittsburgh, PennsylvaniaAges 2 months–17 years - NCT03124303Recruiting
Testing ways to measure and prevent delirium after surgery
This study looks at interventions to help with “postoperative delirium,” a sudden confusion that can happen after surgery, and uses brain measures like EEG and optional MRI. It may help doctors identify who is at risk and learn what approaches are most helpful after surgery.
Madison, WisconsinAges 60 years+ - NCT05491538Recruiting
Work-focused social skills training for veterans with mental illness
This study tests a program to help veterans with serious mental illness improve social skills for work and find jobs near the VA. It aims to see if the program is acceptable and feasible for participants.
Minneapolis, MinnesotaAges 18 years+ - NCT02022943Recruiting
Join an Alzheimer's prevention registry website
This trial builds a registry so researchers can contact you about future Alzheimer’s studies. It mainly requires agreeing to the registry’s website terms and conditions.
Phoenix, ArizonaAges 18–110 - NCT05462106RecruitingPhase 1/Phase 2
ACI-24.060 study for early Alzheimer’s in adults and Down syndrome
This Phase 1/2 study tests an Alzheimer’s treatment called ACI-24.060 to see if it affects the disease in people with early Alzheimer’s changes. It includes two groups: older adults with early symptoms and people with Down syndrome who also show Alzheimer’s-related changes on brain scans.
Phoenix, ArizonaAges 35–85 - NCT04577911Recruiting
Brain study of social connection using MRI scans
This study looks at how social connection shows up in the brain using MRI, a type of scan. You may be able to take part if you can safely have an MRI and you’re not currently taking psychiatric medications.
New York, New YorkAges 18–65 - NCT05487911Recruiting
Brain stimulation for depression
This study uses a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to treat depression. It may help reduce depressive symptoms for people who have not found relief from other treatments.
Houston, TexasAges 18–64 - NCT05464888Recruiting
Animal-assisted therapy for kids’ dental visits
This study tests whether working with a trained animal can make dental checkups and cleanings easier for children ages 4 to 8. It may help reduce fear and improve how kids tolerate routine dental care.
Chapel Hill, North CarolinaAges 4–8 - NCT05471960Recruiting
Brain training study in people with REM sleep behavior disorder
This study looks at how the brain changes (“neuroplasticity”) in people diagnosed with isolated REM sleep behavior disorder (iRBD) using brain stimulation and other testing. Results may help researchers understand brain differences in iRBD and guide future treatments.
Minneapolis, MinnesotaAges 21–75 - NCT05460468Recruiting
Brain stimulation study to improve memory in aging
This study tests a brain-stimulation approach to help improve memory as people age. You may be able to take part if you can consent and meet safety and medical criteria, especially related to brain/nerve health and seizure risk.
Durham, North CarolinaAges 18–75 - NCT05486234Recruiting
Study to reduce cannabis and alcohol use with teen and caregiver
This study looks at ways to help teens cut down on cannabis and alcohol use. You may qualify if you’ve been using both in the last three months and your caregiver is able to join and consent.
Charleston, South CarolinaAges 13–17 - NCT05494398Enrolling by invitationPhase 2/Phase 3
Testing N-acetylcysteine for autism symptoms
This study looks at whether N-acetylcysteine (NAC), a supplement/medication, can help autism-related symptoms by trying to target brain chemistry. You may be able to join if you previously took part in a related NAC study and can keep your usual medications steady.
Stanford, CaliforniaAges 3–13 - NCT05499182Recruiting
Teen depression treatment study for Latino teens
This study is testing a treatment approach for depression in Latino teens, including therapy and/or antidepressant care. It may help by improving how depression is identified and treated for this specific community.
Nashville, TennesseeAges 13 years+ - NCT05491551Recruiting
Alcohol training program to help you cut back or quit
This study tests a structured training program for young adults who’ve been drinking heavily, to help them reduce drinking or quit. You’ll be asked to complete daily short check-ins and follow study instructions, and you may be randomly assigned to different parts of the program.
Berkeley, CaliforniaAges 18–26 - NCT05501834Enrolling by invitation
Anxiety study for kids getting arm pins removed
This study tests if a child life specialist can help reduce anxiety when children have pins removed from their arm after a fracture. If your child is between 3 and 10, had a specific arm fracture treated with pins at Boston Children's Hospital, and speaks English, they may be eligible.
Boston, MassachusettsAges 3–10 - NCT05501678RecruitingPhase 2
Diphenhydramine to help sleep in autistic children
This Phase 2 study tests whether diphenhydramine improves sleep in children with autism who have significant sleep problems. It requires sleep monitoring (watch data and sleep testing) and checking for side effects to see if the treatment is safe and helpful.
Stanford, CaliforniaAges 8–17
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.