Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07529093Recruiting
Mobilization and Movement Training for Sacroiliac Joint Pain
This trial tests whether a combination of hands-on joint mobilization techniques and specific movement control exercises can reduce pain and improve function in people with sacroiliac joint dysfunction (pain in the lower back/buttock area where the spine connects to the pelvis). You would receive these treatments over several weeks and be measured on pain relief, movement, walking, and daily activities.
Lahore, Punjab ProvinceAges 45–64 - NCT07021105Enrolling by invitation
Comparing nerve blocks for pain after gynecological surgery
This study tests two different types of nerve blocks (called 'plain blocks') to see which one works better for controlling pain after major gynecological surgery. You would receive one of the blocks before surgery, and then use a pump you control to get extra pain medicine as needed.
Adana, SarıçamAges 18–69 - NCT07659236Recruiting
Plasma-activated water for fibromyalgia pain
This study tests whether a special water called 'plasma-activated water' can help reduce pain in people with fibromyalgia. If you have widespread pain for at least 3 months and meet the age and health requirements, you may be able to join.
TaipeiAges 20–75 - NCT06604156Recruiting
Anesthesia based on pain monitoring for painless GI endoscopy
This study tests a new way to give anesthesia during painless upper and lower GI exams by using a special monitor that tracks your body's response to pain. The goal is to make the procedure more comfortable and safer for you.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT07021287Recruiting
Cold therapy after knee replacement surgery
This study compares different cold therapy programs to see which works best for pain and swelling after total knee replacement. Everyone in the study receives cold therapy, and the researchers will track recovery outcomes.
Yiwu, ZhejiangAges 18 years+ - NCT06474429Recruiting
Movement test for chronic low back pain recovery
This study tests whether a simple movement screening test can help physical therapists decide when someone with chronic lower back pain is ready to stop treatment. If you join, you will do a few basic movements to see how your back is doing.
Plano, TexasAges 18–49 - NCT07658326Recruiting
Stress and rotator cuff surgery study
This study looks at how stress before surgery might affect recovery in people having rotator cuff surgery. You may be able to join if this is your first surgery for a torn rotator cuff and you don't have certain other health problems.
CornebarrieuAges 18 years+ - NCT07190339Recruiting
Nerve block for hip osteoarthritis pain
This trial tests whether blocking specific nerves in the hip and groin area can reduce pain from hip osteoarthritis when standard treatments like painkillers or physical therapy haven't worked.
AnkaraAges 18–75 - NCT07655804RecruitingPhase 3
Calcitonin injection for shingles pain in older adults
This trial tests whether a medication called calcitonin (given as a shot under the skin) can help reduce pain in people with a recent shingles outbreak. It is for adults 50 and older who have moderate to severe pain from their rash.
Tanta, Gharbia GovernorateAges 50 years+ - NCT07509593Recruiting
Comparing two types of tailbone pain treatment
This study compares two types of a targeted procedure (radiofrequency ablation) to treat long-lasting tailbone pain. It is designed for people who have already gotten good relief from a nerve block injection but whose pain has come back.
Istanbul, PENDİKAges 18–75 - NCT07473206Recruiting
Laughing gas for pain during office hysteroscopy
This study tests whether using laughing gas (nitrous oxide) plus a calming video on a screen can reduce pain and anxiety during a quick procedure to look inside the uterus (hysteroscopy). If you are having this procedure, the trial may help you feel more comfortable.
BiellaAges 25–60 - NCT07511764Recruiting
Comparing two airway devices for children's hernia surgery
This trial compares a laryngeal mask airway with a breathing tube in children having laparoscopic hernia repair. It aims to see which method works better.
Diyarbakır, Eyalet/YerleşkeAges 1–10 - NCT04609735Recruiting
Compare manual therapy, exercise, and ultrasound for golfer’s elbow
This study compares two treatment plans for golfer’s elbow—manual therapy plus exercise, and whether adding ultrasound helps more. It aims to reduce elbow and inner-forearm pain and improve how well you can use your arm.
Fort Wayne, IndianaAges 18–60 - NCT07510347Recruiting
Pain relief study for sleeve gastrectomy patients
This study tests if giving pain medicine in a different area of the abdomen can reduce pain after weight-loss surgery. It may help you feel more comfortable after your sleeve gastrectomy.
Shibīn al Kawm, MenofiaAges 20–60 - NCT06649383RecruitingPhase 4
Virtual reality for relaxation during surgery
This trial tests if virtual reality (VR) can help people over 65 relax or manage pain without medication during surgery with local or regional anesthesia.
Alingsås, Västra Götaland CountyAges 65 years+ - NCT06466408Recruiting
Enzyme supplement and exercise in older adults
This trial is testing if taking a fruit and vegetable enzyme supplement can help older adults recover better after short, intense exercise using video games. You would exercise and take the supplement to see how it affects your muscles, breathing, and blood.
TainanAges 65 years+ - NCT07515027Recruiting
Acupuncture plus anti-nausea medication after lung cancer surgery
This trial tests whether combining acupuncture with a standard anti-nausea medication can better prevent nausea and vomiting after minimally invasive lung cancer surgery. Many patients undergoing this surgery experience these side effects, especially when taking pain medication afterward.
ShanghaiAges 18 years+ - NCT06025201Recruiting
Brain activity markers for chronic low back pain
This study uses a safe, non-invasive cap with sensors (EEG) to measure your brain activity and look for patterns linked to chronic low back pain. It aims to better understand pain so doctors can improve treatments.
Palo Alto, CaliforniaAges 18–80 - NCT06138236RecruitingEarly Phase 1
Comparing shockwave therapy and collagen for plantar fasciitis
This study tests whether shockwave therapy or collagen supplements work better for reducing heel pain from plantar fasciitis. If you have heel pain and haven't had foot surgery, you may be able to join.
BariAges 18–80 - NCT07501468Recruiting
Comparing two breathing devices for shoulder surgery
This trial tests two types of breathing tubes (SafeLM and I-gel) to see which works better for people having shoulder surgery while sitting up. It aims to find a safer way to keep your airway open during the procedure.
Ankara, AnkaraAges 18–80 - NCT07477860RecruitingPhase 1
Achilles tendon pain treatment trial
This trial tests a minimally invasive treatment for chronic Achilles tendon pain that hasn't improved with at least 3 months of rest, therapy, or other non-surgical care. It aims to help people who want to avoid surgery.
Libertyville, IllinoisAges 25–80 - NCT06461767Recruiting
rTMS for chronic migraine without recent prevention
This study tests whether repetitive transcranial magnetic stimulation (rTMS) — a noninvasive treatment using magnetic pulses on the head — can help prevent and treat chronic migraine pain. It may be an option for people who have never tried or are currently off migraine prevention medicines.
SohagAges Any age - NCT07523854Recruiting
Knee Strength Recovery After ACL Surgery: Comparing Graft Types
This study compares how well the knee recovers its strength after ACL (anterior cruciate ligament) reconstruction surgery using two different graft options. By tracking your progress over time, researchers hope to understand which graft type helps you regain the most strength.
AnkaraAges 13–45 - NCT07509866Recruiting
Comparing pain relief options for knee replacement surgery
This trial tests two different numbing medicines for knee replacement surgery. It compares a long-acting numbing medicine (liposomal bupivacaine) with a standard one (ropivacaine) mixed with other drugs to see which provides better pain control. The goal is to find a way to reduce pain and improve recovery.
Wuhan, HubeiAges 18–80
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.