Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07322445Recruiting
Study of neck and shoulder pain with special MRI
This study uses special MRI scans to look at muscles and nerves in people with long-term neck or shoulder pain caused by trigger points (tender spots in muscles). The goal is to understand what happens in the body with this type of pain—so doctors can find better ways to treat it.
St Louis, MissouriAges 18–80 - NCT06492213Recruiting
Combining PRP with Radiofrequency for Face Nerve Pain
This study tests whether adding platelet-rich plasma (a concentrate from your own blood that may help healing) to a standard pulsed radiofrequency procedure reduces pain from infraorbital neuralgia more effectively than radiofrequency alone. It involves two treatments and follow-up for several months.
Beijing, Beijing MunicipalityAges 18–75 - NCT07370129Enrolling by invitation
Numbing injection for pain after tonsil surgery
This study tests a numbing injection near a nerve in your nose to see if it can reduce pain and help you recover faster after tonsillectomy. It is a non-drug approach that may offer an alternative to strong pain medicines.
Ankara, AnkaraAges 12 years+ - NCT07090122Recruiting
Spinal tumor treatment: ablation plus radiation vs radiation alone
This study compares two treatments for cancer that has spread to the spine. One group receives radiofrequency ablation (a heat-based treatment to destroy tumor cells) plus bone strengthening, followed by radiation. The other group receives radiation alone. The goal is to see which approach better controls pain and prevents spine problems.
Minneapolis, MinnesotaAges 18 years+ - NCT06920095Enrolling by invitation
Relaxation exercises for better sleep and less pain in lymphoma
This trial tests if progressive muscle relaxation exercises can help lymphoma patients sleep better, feel less tired, and have less pain. You will be guided through simple exercises using your phone.
Küçükçekmece, IstanbulAges 18 years+ - NCT06931951Recruiting
Acupuncture with medicine for knee pain after a car accident
This trial tests a type of acupuncture that injects medicine into specific points (pharmacopuncture) to treat severe knee pain from a recent traffic accident. It looks at whether this treatment is safe and effective for people who are already in the hospital for their injury.
DaejeonAges 19–69 - NCT06529432RecruitingPhase 2
Study of a long-acting painkiller for lung surgery recovery
This trial tests a long-acting pain medication (bupivacaine liposome injection) to control pain after lung surgery done through a small cut. It may help you feel more comfortable and reduce the need for other pain medicines.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07571889Recruiting
Numbing spray to reduce Botox injection pain for chronic migraine
This study tests whether a numbing spray applied inside the nose before Botox injections can reduce injection pain in people with chronic migraine. The goal is to make the treatment more comfortable without affecting how well it works.
East Providence, Rhode IslandAges 18 years+ - NCT06904703Recruiting
Nerve blocks for older adults having hip replacement surgery
This trial tests two types of nerve blocks to see which one works better for pain control in older adults undergoing total hip replacement. A nerve block is a shot of anesthetic near a nerve to numb a specific area, and the goal is to help you feel less pain after surgery.
TantaAges 75 years+ - NCT06574269RecruitingPhase 2
Study on TLC590 for pain after surgery
This trial tests a new pain medicine, TLC590, for people having one of several common surgeries, like bunion removal, hernia repair, breast augmentation, knee replacement, or tummy tuck. The goal is to see if it helps manage pain after the procedure.
Bellaire, TexasAges 18–70 - NCT07301476Recruiting
Testing numbing medicine spread in a knee block
This trial checks how a numbing medicine moves during a common knee block for surgery. It may help doctors improve pain control after knee operations.
Boulogne-BillancourtAges 18 years+ - NCT07297459Enrolling by invitation
Surgery options for a jaw joint problem
This trial compares two types of surgery to treat a common jaw joint problem where the disc slips out of place. It looks at which procedure works better for reducing pain and improving function.
StockholmAges 18 years+ - NCT07161375Recruiting
Using heat camera to predict nerve block success in child hernia surgery
This study tests if a special heat-sensing camera can predict whether a nerve block will work for children having hernia surgery. If successful, this could help doctors know right away if the block is effective.
CairoAges 3 months–6 years - NCT05728775RecruitingPhase 4
Comparing two anesthetics after major non-heart surgery
This trial compares the anesthesia medicines remimazolam and propofol during major surgery to see how patients do afterward. It may help guide which anesthetic is safer or leads to better recovery in higher-risk patients.
Hefei, AnhuiAges 45 years+ - NCT06948253Enrolling by invitation
Pain relief methods for kids having umbilical hernia surgery
This study compares three types of ultrasound-guided nerve blocks to see which one provides the best pain relief for children after umbilical hernia repair. The goal is to find a safe and effective way to manage pain in young patients.
TantaAges 2–7 - NCT06802419Recruiting
Comparing two types of knee nerve blocks for pain relief after knee surgery
This study compares two types of nerve blocks—one that numbs the front of the thigh and one that adds extra numbing behind the knee—to see which provides better pain relief after arthroscopic knee surgery (like ACL or PCL repair). The goal is to help patients have less pain and recover more comfortably.
CairoAges 21–65 - NCT07294651Recruiting
Needle treatment for chronic neck pain
This trial is testing a procedure called percutaneous electrolysis, where a tiny needle is used to treat painful trigger points in the upper neck muscles. It may help people with long-lasting neck pain.
SivasAges 18–70 - NCT07293975Recruiting
Pain relief during brace removal with TENS or vibration
This study tests two drug-free methods—gentle electrical stimulation (TENS) and high-frequency vibration—to see if they can reduce pain when braces are removed.
BaghdadAges 15–35 - NCT06803485RecruitingPhase 4
Comparing two antidepressants for pain-related somatic symptom disorder
This trial tests whether venlafaxine or dosulepin works better for people whose main problem is pain from a condition called somatic symptom disorder. You may join if you are 18–65, have not recently taken similar medication, and do not have other serious health issues.
Bhubaneswar, OdishaAges 18–65 - NCT07588165Recruiting
Measuring Pain During Emergency Breathing Tube Placement
This study tests a pain-monitoring device during emergency anesthesia for stomach or abdominal surgery. Researchers want to see how well the device (called ANI) detects pain when doctors quickly put a breathing tube in your airway.
MonacoAges 18 years+ - NCT06969859Recruiting
Pulsed electromagnetic field therapy for Achilles tendon pain
This study tests if pulsed electromagnetic field (PEMF) therapy can help people with mid-portion Achilles tendinopathy (pain and swelling in the middle of the Achilles tendon). It aims to see if this non-invasive treatment can reduce pain and improve function.
Shatin, New TerritoriesAges 18 years+ - NCT07289321Enrolling by invitation
Pain relief study for robotic prostate surgery
This trial tests if adding tramadol and magnesium to a local anesthetic (ropivacaine) improves pain control after robotic prostate removal. It may help reduce the need for strong painkillers after surgery.
Athens, AtticaAges 40–80 - NCT06805396RecruitingPhase 2
Adding palliative care support during radiation for bone cancer pain
This study tests whether adding a palliative care team early while you receive radiation for bone metastases can improve your quality of life and reduce symptoms.
AmersfoortAges Any age - NCT06969625Recruiting
Shoulder Block for Pain Relief After Rotator Cuff Surgery
This study tests a special numbing injection (shoulder block) to see how well it controls pain after arthroscopic rotator cuff repair. If you are having this type of shoulder surgery and are generally healthy, this trial may help you recover with less pain.
Zagazig, Al SharqiaAges 21–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.