Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07289737Recruiting
Comparing two spine surgeries for a slipped backbone
This study compares two types of spine surgery for a common condition where a lower back bone slips forward. It aims to see which surgery works better to relieve pain and improve function.
Yiwu, ZhejiangAges 50–90 - NCT06805942Recruiting
Embolization for heel pain from plantar fasciitis
This study tests a minimally invasive procedure called embolization to reduce heel pain caused by plantar fasciitis. It blocks tiny blood vessels in the painful area, which may relieve pain and help you walk more comfortably.
Falls Church, VirginiaAges 22–100 - NCT06910696Enrolling by invitation
Comparing two nerve blocks for lumbar disc surgery pain
This trial tests two types of nerve blocks to see which one works better for pain control after lumbar disc surgery. It may help reduce pain and the need for strong pain medicines after your operation.
ZagazigAges 21–64 - NCT07283276Recruiting
Core training vs cognitive training for ankle instability
This study tests whether special core exercises or mental training can help improve your balance and control after repeated ankle sprains. If you have chronic ankle instability, this could help you find which type of training works best.
CairoAges 18–30 - NCT07289776RecruitingPhase 1
Testing a new medicine in healthy volunteers
This first-in-human trial tests a new medicine called GRT7041 in healthy people to see how safe it is and how it works in the body. It helps doctors understand the right dose and any side effects before testing in patients.
ChristchurchAges 18–60 - NCT07284615Recruiting
Nerve Block vs. Wound Injection for Hip Replacement Pain
This trial compares two pain-relief methods after hip replacement surgery: a nerve block (numbing the hip area) versus a numbing injection into the wound. The goal is to see which provides better pain control.
Cinisello Balsamo, MilanoAges 18 years+ - NCT07480304Enrolling by invitation
Dexmedetomidine mist for stable breathing tube placement
This trial tests if a medication called dexmedetomidine (given as a mist through a nebulizer) can help keep your heart rate and blood pressure steady when a breathing tube is placed for surgery. It may be an option for people having planned surgery who want a smoother experience.
Karachi, SindhAges 18–65 - NCT07283003Recruiting
Pain after ureter stone removal surgery study
This study looks at pain levels after a procedure to remove stones from the ureter (the tube connecting your kidney to your bladder). It may help find better ways to manage pain after surgery.
BadenAges 18 years+ - NCT07282522Recruiting
Sensory and function in cervical disc herniation
This study looks at how cervical disc herniation affects sensation and daily function. If you have had neck pain for at least 3 months and have been diagnosed with cervical disc herniation, researchers want to compare your results to people without neck pain.
Iğdır, IğdirAges 18–65 - NCT07347054Recruiting
Trigger point injection for shoulder arthritis pain
This study tests whether injecting a medication into painful knots in the shoulder muscle can reduce pain from shoulder arthritis. It may be a good option if you have had shoulder pain for at least 3 months and other treatments haven't worked well enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT05575661Recruiting
Study links low blood pressure after meals and after anesthesia
This study looks at whether people who have low blood pressure after eating are also more likely to have low blood pressure after starting general anesthesia. It may help doctors better predict and manage blood pressure drops during non-heart surgeries in older adults.
Beijing, Beijing MunicipalityAges 65 years+ - NCT07277517Recruiting
Pain education plus physical therapy for new back pain
This study tests whether adding Pain Neuroscience Education (learning how your brain and nerves process pain) to standard physical therapy can help people with new low back pain feel better and move more easily. It's for adults whose pain started within the past 6 weeks and who do not have a serious spine condition.
TehranAges 18 years+ - NCT07276646Recruiting
Pain relief after gallbladder surgery: two nerve blocks compared
This trial compares two anesthetic nerve blocks to see which one reduces the need for opioid pain medicine after gallbladder removal. If you are having laparoscopic gallbladder surgery, this study may help you recover with less pain and fewer opioid side effects.
ZagazigAges 21–64 - NCT07177027Recruiting
Breathing exercises and music for first-time mothers in labor
This study tests whether combining breathing exercises with listening to music during labor can help first-time mothers feel less pain, have more positive expectations, and feel more satisfied with their birth experience. If you join, you will practice breathing techniques and listen to music while in labor.
Uşak, UşakAges 18–35 - NCT07178262RecruitingPhase 4
Nerve block to reduce pain medicine after hysterectomy
This study tests whether a nerve block (an injection near the spine) can help reduce the amount of strong pain medicine you need after a hysterectomy. The goal is to see if it leads to fewer side effects and a smoother recovery.
Islamabad, FederalAges 16–80 - NCT06962046Recruiting
Can virtual reality improve knee replacement surgery results?
This trial tests if using virtual reality (VR) during knee replacement surgery can help improve your recovery. You wear a VR headset during the procedure to relax and distract you, which may lead to better outcomes.
BelfastAges 18–100 - NCT07273136Recruiting
Belly nerve block vs. epidural for pain after cancer surgery
This study compares two ways to manage pain after major abdominal cancer surgery: a numbing injection around the belly muscles (subcostal and lateral TAP block) versus an epidural (a thin tube placed in your back). The goal is to see which provides better pain relief.
AsyutAges 18 years+ - NCT06815510Recruiting
Complications after surgery in the recovery room
This study looks at how often complications happen in the recovery room after surgery. It aims to find out what factors might be linked to these complications, which could help improve care for future patients.
HararAges 18 years+ - NCT07272577Recruiting
Nerve block for pain after laparoscopic abdominal surgery
This study tests a nerve block (erector spinae plane block) to see if it helps reduce pain after laparoscopic abdominal surgery. If you're having keyhole surgery, you may receive the block along with standard anesthesia.
AsyutAges 18 years+ - NCT06480539RecruitingPhase 4
Dexmedetomidine for Better Sleep After Lung Surgery in Older Adults
This study tests whether giving a medicine called dexmedetomidine at night can help older adults sleep better and feel less tired after lung surgery. If you are 60 or older and having lung surgery through small cuts (thoracoscopy), you may be able to join.
Genk, LimburgAges 60 years+ - NCT06949059RecruitingPhase 1/Phase 2
Hydromorphone for acute chest pain relief
This trial tests a quick-acting pain medicine (hydromorphone) given through a vein to treat severe chest pain. It may be an option for people experiencing acute pain who haven't been helped by other medicines.
Nanjing, JiangsuAges 18–64 - NCT07128043Enrolling by invitation
Cassava wax baths for trigger finger pain and function
This study tests whether warm baths made from cassava (tapioca) wax can reduce pain, improve hand function, and help with the catching or locking feeling in people with trigger finger. If you have trigger finger and no other major hand problems, this treatment may offer a gentle, non-surgical option.
Chiang Rai, Tha SutAges 40–70 - NCT05605639RecruitingPhase 4
Study tests a targeted injection for neck pain
This trial studies whether an injection near the phrenic nerve can help people with neck pain. It is only for certain types of neck/diaphragm-related problems and excludes people with nerve, injury, cancer, infection, or autoimmune causes.
Dos Hermanas, SevilleAges 18–64 - NCT07227389Recruiting
Opioid Timing and Breathing Risk After Surgery
This study looks at when opioids are given during surgery and how it affects breathing problems after surgery. It might help understand how to make pain control safer.
Detroit, MichiganAges 18–85
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.