Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06963177RecruitingPhase 2
Study of GenSci048 for endometriosis pain
This trial tests a new drug called GenSci048 to see if it can reduce moderate to severe pain caused by endometriosis. It might be an option if you have regular periods and are willing to switch to only the pain relievers allowed in the study.
Beijing, Beijing MunicipalityAges 18–49 - NCT06957912Recruiting
Ear nerve stimulation for recovery after major surgery
This trial tests if stimulating a nerve in your ear (vagus nerve) before and after noncardiac surgery can improve your recovery. It's for adults aged 18 to 84 having planned or time-sensitive surgery lasting at least 2 hours.
Beijing, Beijing MunicipalityAges 18–85 - NCT05840562RecruitingPhase 3
Capsaicin skin patch vs duloxetine for nerve pain after chemo
This Phase 3 trial tests whether a capsaicin patch works better than duloxetine tablets to reduce painful nerve pain after chemotherapy. It aims to help people whose “gloves and socks” nerve pain has lasted after chemo.
AngersAges 18 years+ - NCT06959680Recruiting
Kinesiotaping for posture and balance in hyperkyphosis
This study tests whether kinesiotaping (a special elastic tape placed on the back) can improve posture and balance in people with an exaggerated upper back curve (hyperkyphosis). It may help you if you have poor posture or back pain and meet the age and curve requirements.
IstanbulAges 18–45 - NCT06956950RecruitingPhase 2/Phase 3
Magnesium Added to Numbing Medicine for Hip Replacement Pain
This study tests whether adding magnesium sulfate to a numbing medicine (bupivacaine) can provide better pain relief after hip replacement surgery. The medicine is given as a shot in the back near the hip muscles.
Tanta, El-GharbiaAges 18 years+ - NCT06954935Recruiting
Eye massage for nausea after gallbladder surgery
This study tests if a gentle massage around the eyes can help reduce nausea and vomiting after laparoscopic gallbladder removal. If you often feel sick after surgery, this might offer a drug-free way to feel better.
GaziantepAges 18–70 - NCT06942806Recruiting
Spinal cord stimulation for shingles nerve pain
This trial tests a treatment called high-frequency short-time spinal cord stimulation for pain caused by shingles (herpes zoster). It's for people whose pain hasn't improved with other treatments or who can't take pain medicines due to side effects or other health issues.
Zunyi, GuizhouAges 40–85 - NCT06942689RecruitingPhase 4
Finding the best dose of numbing medicine for knee surgery pain
This trial tests different amounts of a long-lasting numbing medicine (liposomal bupivacaine) injected near the nerve in your thigh to see which volume works best for controlling pain after knee surgery. If you qualify, you may receive better pain relief and need fewer opioids.
Nanjing, JiangsuAges 18–85 - NCT05842928Recruiting
Deprescribing risky medicines in older adults with many medications
This study tests a patient-centered plan to safely reduce certain medicines that may cause side effects in older people who take many drugs. It aims to improve safety and comfort by lowering unnecessary use while keeping you well.
BielefeldAges 65 years+ - NCT05734625RecruitingPhase 2
Nerve block injections for episodic migraine pain relief
This Phase 2 trial tests whether nerve block injections can reduce pain from episodic migraines. It may help some people who get frequent migraine attacks but are not also using certain migraine preventions or strong pain medicines.
Rochester, MinnesotaAges 18 years+ - NCT06814808Enrolling by invitation
Comparing three treatments for chronic neck pain
This study compares three different treatments for chronic neck pain caused by trigger points (tender knots in muscles). It aims to find which approach works best for pain relief and improved function.
Istanbul, ZeytinburnuAges 18–65 - NCT06944730Recruiting
Trunk muscle training for better movement and balance in low back pain
This study tests whether trunk muscle training can improve the quality of your movements and balance if you have chronic low back pain. It is designed for people with moderate pain and no other major health issues.
Hong KongAges 18–55 - NCT05766397Enrolling by invitationPhase 4
Tested inhaled methoxyflurane for workplace exposure safety
This study looks at how inhaled methoxyflurane affects people after a possible occupational exposure, with a focus on safety. You may be able to join if you’re an adult and don’t have certain heart, lung, liver, or kidney problems or specific risk factors.
Ottawa, OntarioAges 18 years+ - NCT06942611Recruiting
Electrical brain stimulation for chronic pain from nerve inflammation
This study tests a noninvasive brain stimulation technique (transcranial electrical stimulation) to see if it can reduce chronic pain in people with conditions like multiple sclerosis or neuromyelitis optica. It aims to offer a new, drug-free option for pain relief without major side effects.
BeijingAges 18–65 - NCT06940063Recruiting
Music therapy for chronic low back pain
This trial tests whether an active music-based program can help reduce chronic low back pain. It is for adults aged 18 to 65 whose pain has lasted at least 3 months and has been present on most days.
Denton, TexasAges 18–65 - NCT06008899Recruiting
Ultrasound-guided pulsed radiofrequency for cancer anal pain
This trial tests a treatment called pulsed radiofrequency applied through a small needle near the tailbone (caudal epidural) to see if it can help relieve cancer-related anal or perineal pain. It may be an option if you have this type of pain and are in reasonably good health aside from your cancer.
AsyutAges 18–60 - NCT06882733Recruiting
TENS therapy for leg blood flow in healthy adults
This trial tests whether a gentle electrical stimulation (TENS) applied to the leg muscles and nerve clusters can improve blood flow behind the knee. It looks at immediate effects and might help understand better ways to support circulation.
Kaohsiung City, TaiwanAges 18 years+ - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT06933953Recruiting
French foot health questionnaire study
This study tests a French version of a foot health questionnaire. It aims to make sure the questions are clear and accurate for people receiving foot care.
AlençonAges 18 years+ - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Sun City, ArizonaAges 22–80 - NCT05688943Enrolling by invitation
Spinal versus general anesthesia for vNOTES sterilization
This study compares two ways of giving anesthesia—spinal anesthesia versus general anesthesia—during a minimally invasive sterilization procedure called vNOTES. The goal is to see which option is safer and works better for people having planned (non-emergency) tubal or related surgery.
Kansas City, KansasAges 21 years+ - NCT06930183Recruiting
Awake vs. asleep for lung surgery recovery
This trial compares being awake with numbing medicine in your back (epidural) versus being fully asleep (general anesthesia) for lung surgery. It aims to see which approach leads to a smoother recovery with fewer complications.
CairoAges 18–75 - NCT07285018RecruitingPhase 2
Study of a new drug for diabetic nerve pain in legs
This trial tests an investigational drug for people with pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It may help reduce pain in your lower legs if other treatments haven't worked well.
Birmingham, AlabamaAges 18 years+ - NCT06925152RecruitingPhase 4
Nerve block for C-section pain in complex surgery history
This study tests a targeted numbing injection (a nerve block) in the belly wall during C-sections to improve pain control and recovery for people who have had multiple or complex abdominal surgeries. It aims to see if this approach reduces the need for strong pain medicines.
Memphis, TennesseeAges 18–50
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.