Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06343714RecruitingPhase 1
Testing a new drug for knee osteoarthritis pain
This study tests a new antibody drug (FB1003) for people with knee osteoarthritis pain. It will check if the drug is safe and helps reduce pain. You may be eligible if you have moderate to severe knee pain and are willing to temporarily stop your usual pain medications.
Brisbane, QueenslandAges 18–75 - NCT06779812Recruiting
Auriculotherapy for pain after carpal tunnel surgery
This trial tests whether auriculotherapy (needles or pressure on specific points in the ear) can help reduce pain after endoscopic carpal tunnel surgery. If you have carpal tunnel syndrome and are scheduled for this surgery, you may be able to join.
ParisAges 20 years+ - NCT07744438Recruiting
Comparing two radiofrequency treatments for neck-related arm pain
This trial compares two doses of a procedure called pulsed radiofrequency, which uses energy to calm the nerve root in the neck that is causing pain that travels down the arm. It may help if you have had this type of pain for at least 3 months and standard treatments haven't worked.
AnkaraAges 18–65 - NCT06886815Recruiting
Nerve block for Achilles tendon repair surgery
This trial tests if a nerve block in the back of the knee improves pain control after surgery to repair a torn Achilles tendon. It may help you recover more comfortably as a day surgery patient.
Toronto, OntarioAges 18–65 - NCT06041321Recruiting
Testing a new sleeve for knee surgery recovery
This trial tests a special sleeve designed to help reduce pain and improve recovery after knee surgery for a torn meniscus. It may be a good option if you are having this type of knee surgery and are in generally good health.
Woodbury, New YorkAges 18–89 - NCT06737237Enrolling by invitation
Nerve block vs. local numbing for collarbone surgery
This trial compares two ways to numb the area during collarbone surgery: a nerve block (cervical plexus block) or local anesthetic injections. The goal is to see which provides better pain relief and recovery.
Marine Corps Base Camp Lejeune, North CarolinaAges 18–64 - NCT07470307Recruiting
Exercise for chronic low back pain: Pilates vs. strength training
This trial compares dynamic lumbar strengthening exercises to Pilates, both combined with myofascial release, for people with ongoing low back pain. It aims to find which approach works better for reducing pain and improving function.
Lahore, Punjab ProvinceAges 25–35 - NCT07741227Recruiting
Electric acupuncture for chronic neck pain
This study tests whether electric acupuncture can reduce stiffness and pain in the neck muscles. It may be a treatment option if you have had neck pain for at least 3 months and would like to try a non-drug approach.
Hong KongAges 18–65 - NCT06888895Recruiting
Stretching for tight hamstrings in low back pain
This study compares two types of hamstring stretching techniques (passive vs. active-passive) to see which one improves flexibility more in people with chronic low back pain. It may help you if your hamstrings feel tight and your pain has lasted at least 3 months.
Cébazat, FranceAges 18–65 - NCT06913088Recruiting
Ultrasound bubbles bandage for hand arthritis
This trial tests a special bandage that uses ultrasound and tiny bubbles to treat arthritis pain and stiffness in your hands. If you have hand arthritis with at least three painful finger or wrist joints, you may be able to join.
Taichung, TaichungAges 20 years+ - NCT07058376Enrolling by invitation
Herbal medicine for chronic low back pain
This trial tests whether a herbal medicine strategy can safely and effectively reduce chronic low back pain lasting over 3 months. It may be an option if your pain has been moderate to severe and you are looking for alternative treatments.
Seoul, Gangnam-GuAges 19–69 - NCT06908200Recruiting
Radiofrequency for chronic pelvic pain with myofascial syndrome
This trial compares radiofrequency treatment, myofascial therapy, and no treatment to see which is most effective for women with chronic pelvic pain caused by tight or tender pelvic floor muscles. It aims to help reduce pain and improve quality of life.
BarcelonaAges 18 years+ - NCT07740525Recruiting
Reducing anxiety in children during dental fillings
This trial tests whether using videos or having a parent present can help reduce anxiety in children during dental fillings. The goal is to make the dental visit less stressful for your child.
Islamabad, FederalAges 4–11 - NCT06892041Recruiting
MRI study for jaw muscle pain
This trial uses a special MRI scan to measure jaw muscle pain. It aims to better understand this condition and may help improve future treatments.
New York, New YorkAges 18–65 - NCT07418632Recruiting
Motion training for neck pain using smart classification
This study tests a special motion-training program for people with neck pain. It uses a computer to classify and guide your movements, which may help reduce pain better than usual care.
LjubljanaAges 18–65 - NCT05854914Recruiting
Smartphone hypnosis to reduce pain after emergency appendix surgery
This study tests whether guided hypnosis on a smartphone can lower pain after emergency surgery for a complicated appendicitis. If you qualify, you’ll use the app during your recovery and also answer quick questions about your pain and anxiety.
NiceAges 18 years+ - NCT06902233Recruiting
Brain stimulation for chronic low back pain
This trial tests if a non-invasive brain stimulation technique can help people with long-lasting low back pain. It uses mild electrical currents to adjust brain activity and may reduce pain and improve daily function.
Dunedin, OtagoAges 18–75 - NCT06758986Enrolling by invitation
Gender and shoulder pain study
This study looks at whether gender affects shoulder pain from subacromial impingement. It may help tailor future treatments.
Kırşehir, MerkezAges 18–65 - NCT07467291Recruiting
Comparing Nerve Blocks for Pain After Lung Surgery
This study compares two types of nerve blocks—SPSIP and SAP—to see which one works better for pain after a type of lung surgery called VATS. If you are having this surgery and match the criteria below, you may be able to join this trial to help doctors find the best pain relief method.
ElâzığAges 18–65 - NCT07146724Enrolling by invitation
Pilates for tight hamstrings in young adults
This study tests if Pilates-based exercises can help loosen tight hamstring muscles in young adults. You would follow an 8-week program and we would measure how your flexibility improves.
Yalova, YalovaAges 18–35 - NCT06689072Enrolling by invitation
High-frequency brain stimulation for opioid use disorder
This study tests whether a treatment called repetitive transcranial magnetic stimulation (rTMS) can help people with opioid use disorder. It involves a non-invasive procedure that uses magnetic pulses to stimulate certain parts of the brain.
Asyut, Asyut GovernorateAges 18–45 - NCT06888804Recruiting
Nerve block for chronic heel fracture pain
This study tests a non-surgical treatment (pulsed radiofrequency, or PRF) applied to a nerve in the ankle to see if it can reduce long-term pain after a heel bone (calcaneus) fracture. It may be an option if you have had pain for more than 3 months and other treatments haven't worked.
AnkaraAges 18–80 - NCT07308951Recruiting
Electrical acupoint stimulation for chronic cancer pain relief
This trial tests if a small, patient-controlled device that sends mild electrical pulses to acupoints (like acupuncture without needles) can improve quality of life for people with ongoing cancer pain. It may offer a drug-free way to manage pain at home.
Zhejiang, HangzhouAges 18–80 - NCT05657964Recruiting
Study of a back pain exercise program for chronic low back pain
This trial tests whether a structured exercise/education program can help people with chronic lower back pain. You may qualify if your pain and disability scores are high enough and you can complete study activities in English.
Redwood City, CaliforniaAges 18–65
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.