Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06871605Recruiting
Nerve blocks for chronic groin pain after hernia surgery
This study compares two types of nerve blocks (injections near the nerves) to treat chronic groin pain after hernia surgery. The goal is to find which block provides better pain relief.
AnkaraAges 18 years+ - NCT06279650Recruiting
Self-hypnosis for chronic pain: follow-up interviews
This study asks people who took a self-hypnosis course for chronic pain about their experience. They will share their thoughts in an interview to help improve the program.
Montreal, QuebecAges 18 years+ - NCT07410780Recruiting
Pain after root canal with two different sealers
This trial compares two types of root canal filling materials—bioceramic and calcium hydroxide—to see which one causes less pain after the procedure. If you have a tooth with a live but inflamed nerve, you may be able to join.
Rawalpindi, Punjab ProvinceAges 18–40 - NCT06859892RecruitingPhase 4
Drug combo study for better sleep after major surgery
This study tests whether a combination of two medicines, dexmedetomidine and esketamine, can help improve sleep problems after major non-heart surgery. You may be eligible if you are having planned surgery lasting at least one hour and will use a pain pump after surgery.
BeijingAges 18 years+ - NCT07681336Recruiting
Ear nerve stimulation for chronic low back pain
This trial tests if stimulating the vagus nerve through the ear can reduce chronic low back pain in people who haven't gotten enough relief from painkillers. It aims to see if this non-invasive treatment can help manage pain without medication.
Ghent, Oost-VlaanderenAges 30–60 - NCT06836934Enrolling by invitation
Knee brace vs. wedge for osteoarthritis
This study compares two non-surgical options—a soft knee brace vs. a lateral wedge shoe insert—to see which better relieves pain and improves function in people with knee osteoarthritis. If you're between 40 and 60 and have pain on one side of your knee, this study may help you find better relief.
Giza, Giza GovernorateAges 40–60 - NCT06835608Recruiting
Schroth exercise for kyphosis and chronic neck pain
This study tests whether an exercise program called Schroth (which strengthens back muscles) can improve your posture, reduce neck pain, and make daily activities easier. It is for people with a hunched upper back (kyphosis) and long-lasting neck pain.
Ankara, ÇankayaAges 20–50 - NCT07682051Enrolling by invitation
Resistance training for patellar tendon pain
This study tests whether resistance training can improve the health of the patellar tendon in people with patellar tendinopathy (pain at the knee cap). It may help you recover strength and reduce pain over time.
Graz, StyriaAges 18–50 - NCT06828016Recruiting
Foot Reflexology for Chronic Low Back Pain
This study tests whether foot reflexology—a gentle massage of the feet—can help relieve chronic low back pain that has lasted more than 12 weeks. It is a safe, non-drug approach that may be a good option for people looking for a natural way to manage their pain.
New Taipei CityAges 18–100 - NCT06245317Recruiting
New ventilation method for children having laparoscopic surgery
This trial compares a special ventilation method (PCV-VG) to standard care during laparoscopic surgery in children. It aims to see if it helps them breathe better during the procedure.
Asyut, Asyut GovernorateAges 1–8 - NCT07030582Recruiting
Online therapy for back pain and recovery after spinal fusion
This trial tests if internet-based cognitive behavioral therapy can help people recover better after lumbar fusion surgery by reducing pain, strengthening back muscles, and improving outlook on recovery. You can participate from home using WiFi.
Nantong, JiangsuAges 18–55 - NCT06821607Recruiting
Telerehab for chronic low back pain
This study tests if online rehabilitation therapy can help people with ongoing low back pain. You would connect with a specialist from home.
Baltimore, MarylandAges 18–64 - NCT03976154Recruiting
Testing a fixation method to reduce thoracic epidural movement
This trial studies whether a new way of securing a thoracic epidural line keeps it from shifting during surgery. You might benefit if your surgical care includes a thoracic epidural and you can safely receive this type of anesthesia.
Salt Lake City, UtahAges 18 years+ - NCT06815809Recruiting
Floor training to reduce fear of falling
This study tests a simple program where you learn to safely get down to and up from the floor to help manage fear of falling. It is for healthy adults who want to feel more confident handling a fall.
Karlstad, Värmland CountyAges 18–64 - NCT05893030Recruiting
Monitoring pain and sleep medicines to prevent complications after surgery
This study looks at whether closely monitoring opioid and sleep medicines during and after surgery can lower organ problems and death in older adults at high risk. If you qualify, your team will track how these medicines are given to help keep you safer in the postoperative period.
AmiensAges 75 years+ - NCT06810882Recruiting
Two ways to give nausea medicine for weight loss surgery
This study compares giving ondansetron (a nausea medicine) through a vein versus injecting it near a nerve to prevent nausea and vomiting after weight loss surgery. It may help identify which method works best for patients undergoing laparoscopic sleeve gastrectomy.
Tanta, Gharbia GovernorateAges 18–65 - NCT06685575Enrolling by invitation
Comparing two types of back surgery for leg pain
This trial compares a newer, less invasive surgery (endoscopic foraminotomy) to a traditional back surgery for people with leg pain caused by a narrowed spine canal. The goal is to see which approach provides better relief and recovery.
Chon Buri, Changwat Chon BuriAges 30–80 - NCT06807866RecruitingPhase 4
Duloxetine for pain after hip replacement surgery
This trial tests if duloxetine, a medication that helps with nerve pain, can reduce pain after hip replacement surgery. It may help patients who are having a first-time total hip replacement.
Miami, FloridaAges 18 years+ - NCT07401758Recruiting
Shockwave therapy for knee tendon pain
This study tests whether a noninvasive treatment called shockwave therapy can help reduce pain and improve function in people with patellar tendinitis, a common overuse injury of the knee tendon. It may be a good option for you if you have moderate knee pain and are otherwise healthy.
Guangzhou, GuangdongAges 18–45 - NCT06806202RecruitingPhase 2
Warm vs. standard numbing medicine for tooth injections
This trial tests if warming the numbing medicine before injecting it into the jaw makes the numbing work better for people with a painful tooth infection. If you have a bad toothache in a lower molar and need a dental procedure, this study might help make the numbing more effective.
Rawalpindi, Punjab ProvinceAges 18–50 - NCT06801574Recruiting
Comparing pain relief methods for back surgery
This trial compares three different ways to manage pain during and after back surgery (lumbar fixation). The goal is to find which approach provides better pain relief and recovery.
ErzurumAges 18–65 - NCT07065266Enrolling by invitation
Pain survey for ACL knee surgery patients
This trial is testing a simplified pain questionnaire for people who are having ACL knee surgery. The goal is to see if this shorter questionnaire can effectively measure pain levels after surgery.
Redwood City, CaliforniaAges 18 years+ - NCT07409688RecruitingPhase 4
Pain relief after gallbladder surgery: comparing two ways to give local anesthetic
This trial compares two methods of giving local anesthetic during laparoscopic gallbladder removal to see which provides better pain relief. It may help patients recover with less pain after surgery.
Rawalpindi, Punjab ProvinceAges 15–60 - NCT06776887Recruiting
Virtual reality exercises for burn recovery on legs
This trial tests whether virtual reality exercises can help people with leg burns improve balance and reduce depression and anxiety. It is for people who had a large thermal burn on their lower body at least 3 months ago.
GizaAges 35–55
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.