Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT07518953Recruiting
Can Music Help With Pain During a Nail Biopsy?
This study tests whether listening to music during a nail biopsy—a small procedure to remove a sample of nail tissue—can reduce pain and anxiety. You would listen to music during the procedure and answer a few questions about how you felt.
New York, New YorkAges 18 years+ - NCT07523802Recruiting
Managing pain after gum graft surgery with two methods
This trial tests two different ways to protect and manage pain in the mouth after a gum graft surgery. You would compare a product called Ora-Aid with a custom acrylic stent (a protective cover) to see which helps with healing and reduces discomfort better.
CairoAges 18 years+ - NCT07524673Recruiting
Comparing two nerve blocks for chest surgery pain
This study tests two different numbing techniques (nerve blocks) to see which one works better for pain relief after minimally invasive chest surgery. Both methods inject medicine near nerves to reduce post-surgery pain.
Sivas, MerkezAges 18 years+ - NCT07524231Recruiting
Laughter Yoga Effects on Health and Well-being
This study tests whether laughter yoga—guided exercises that combine laughter with breathing—can improve health outcomes. Researchers will measure how it affects participants' physical and mental well-being over time.
ElâzığAges 18 years+ - NCT07518732Enrolling by invitation
Thoracic Spine Treatment: Massage and Manipulation Study
This study tests whether hands-on treatments—spinal manipulation and massage—can reduce back pain, improve flexibility, and help with sleep in older adults with long-standing mid-back problems. You would receive these treatments over time and answer questions about your pain and sleep.
IstanbulAges 18–65 - NCT07522736Recruiting
Spinal anesthesia with dexmedetomidine for knee surgery
This trial tests adding dexmedetomidine (a calming medication) to bupivacaine (numbing medication) injected into the spine during knee surgery. The goal is to improve pain relief and recovery after surgery.
CairoAges 18–65 - NCT07520487Recruiting
Ketamine Plus Spinal Anesthesia for Older Adults Undergoing Leg Surgery
This study tests whether adding ketamine (a type of anesthetic medication) to spinal anesthesia—numbing medication injected near the spine—can make the numbness last longer for older adults having leg surgery. The goal is to see if this combination improves pain control after surgery.
Cairo, Giza GovernorateAges 65 years+ - NCT07523906Recruiting
Exercise therapy for chronic lower back pain in young adults
This study compares two types of exercise programs for chronic mechanical lower back pain: lumbar stabilization exercises (focused on core strength) versus muscular chain therapy (full-body movement patterns). You'll participate in one of these exercise programs to see which helps reduce your pain more effectively.
IslamabadAges 18–30 - NCT07517679RecruitingPhase 4
Methadone for Pain After Spine Surgery
This study tests whether methadone, an opioid medication, can safely manage pain after elective spine surgery. Researchers want to see if it works well and is safe for patients staying overnight in the hospital after their procedure.
Lexington, KentuckyAges 18–120 - NCT07519863RecruitingPhase 2
Comparing sedation medicines for burned children during procedures
This study tests two different sedation medicine combinations to see which one reduces confusion and agitation (called delirium) when children with burn injuries need procedures done. The goal is to find the safest, most comfortable option for your child during treatment.
CairoAges 3–16 - NCT07524387Recruiting
Nerve blocks for better leg strength after knee replacement
This study compares two types of numbing injections (nerve blocks) used during knee replacement surgery to see which one helps your thigh muscle recover strength faster. Both are standard care options; the trial tests which works better for early movement after surgery.
Ichinomiya, Aichi-kenAges 20 years+ - NCT07516327Recruiting
Cold and Compression Therapy After Rotator Cuff Surgery
This study tests whether using cold therapy and compression after rotator cuff repair surgery helps reduce pain and swelling during recovery. You would receive this special treatment as part of your regular physical therapy at a specific Ochsner location.
Kenner, LouisianaAges 35 years+ - NCT07523399Recruiting
Joint Health and Balance in Adults with Hemophilia A
This study looks at how hemophilia A affects joint health, balance, and quality of life in adults. Researchers will assess your joints and balance to understand the relationship between joint damage and everyday function.
VanAges 18–65 - NCT07522398Recruiting
Power Training Study for Adults Over 65
This study tests whether short, intense strength exercises can help older adults build muscle and stay stronger. You'll do exercises designed to build power (the ability to move quickly and forcefully) over several weeks, and researchers will measure changes in your strength and daily function.
Diepenbeek, FlandersAges 65–85 - NCT07524075Recruiting
Muscle Energy Technique for Neck Pain and Movement
This study tests whether a hands-on physical therapy technique called muscle energy technique can reduce neck pain and improve how far you can move your neck. If you have neck pain that's lasted at least 4 weeks with no clear medical cause, this trial may help you.
Istanbul, AtaşehirAges 18–65 - NCT07517809Recruiting
Comparing two nerve-block techniques for arm surgery
This trial compares two different ultrasound-guided methods of numbing the nerves in your upper arm and shoulder for surgery on your hand, wrist, or forearm. The goal is to see which technique works better and is safer for patients.
CairoAges 21–65 - NCT06757023Recruiting
Acupuncture for better sleep after breast cancer surgery
This study tests if thumbtack needle therapy (a type of acupuncture) can improve sleep and recovery in women after breast cancer surgery. If you're between 18 and 55 and having breast cancer surgery with general anesthesia, you may be eligible.
Xiamen, FujianAges 18–55 - NCT06758349Recruiting
Posture check for orchestra musicians
This study looks at the posture of professional orchestra musicians. It aims to help understand how their bodies are affected by playing and identify ways to prevent pain or injury.
Milan, MIAges 18 years+ - NCT06141187Recruiting
Vertebroplasty vs. sham for spine fractures due to osteoporosis
This trial tests if a procedure called vertebroplasty (injecting bone cement into a fractured spine bone) relieves pain better than a sham (fake) procedure. It is for people with painful spine fractures caused by osteoporosis (weak bones) that started within the last three months.
Middelfart, FynAges 50 years+ - NCT06759337Recruiting
Stress ball or hand holding during IUI for pain and anxiety
This trial tests if using a stress ball or having your hand held during intrauterine insemination (IUI) can reduce pain, anxiety, and discomfort. It compares these two simple comfort techniques to standard care.
Kayseri, MelikgaziAges 18–50 - NCT06761300Recruiting
Psychology and spinal cord stimulation for chronic pain
This trial studies how psychological assessment can help people with long-term pain who are getting Spinal Cord Stimulation (SCS)—a treatment that uses mild electrical pulses to block pain signals. You may join if you've had chronic pain for at least 6 months, are eligible for SCS, and speak Italian.
Milan, ItalyAges 18 years+ - NCT07515885Recruiting
Electroacupuncture for Shingles Pain Relief
This study tests whether electroacupuncture (a form of acupuncture with mild electrical stimulation) can reduce pain from shingles (herpes zoster), a viral infection that causes painful skin rashes. Researchers will also measure certain markers in your blood to understand how the treatment works.
Hangzhou, ZhejiangAges 20–80 - NCT07508410Recruiting
Mulligan vs Myofascial Release for Neck-Related Headaches
This study compares two hands-on therapy techniques—Mulligan mobilization and myofascial release—to see which works better for headaches that start from the neck. If you have neck pain on one side and headaches that get worse with movement, this trial may help you find relief.
KonyaAges 18–65 - NCT07510789Recruiting
Low back pain impact in ankylosing spondylitis
This study looks at how different types of low back pain in people with ankylosing spondylitis affect their daily functioning and overall well-being. It aims to better understand these pain patterns so doctors can provide more personalized care.
Konya, SelçukluAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.