Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,576 recruiting studies in this area right now.
By phase
- Not applicable2,951
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University60
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California152
- New York79
- Massachusetts65
- Florida64
- Texas50
- North Carolina41
- Illinois40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,576 total
- NCT07514013Recruiting
Olive Oil Extract for Knee Comfort and Function
This study tests whether a daily olive oil extract capsule can help improve knee comfort and function in adults with ongoing knee discomfort. Participants will track their symptoms and wear an activity monitor while taking the supplement.
San Francisco, CaliforniaAges 40–75 - NCT07507422Recruiting
Post-market study of Inceptiv spinal cord stimulation
This study follows people receiving Inceptiv, a spinal cord stimulator from Medtronic, to see how well it works over time. It is for adults with chronic back or limb pain who have not tried spinal cord stimulation before.
Phoenix, ArizonaAges 18 years+ - NCT07511816RecruitingPhase 2
Pain Relief Study After Wisdom Tooth Removal
This study tests a new pain medication (LY4515100) in people recovering from wisdom tooth extraction surgery. The goal is to see if it reduces pain better than current options after the procedure.
Salt Lake City, UtahAges 18–40 - NCT07507734Recruiting
Splint and exercise therapy for jaw joint pain
This trial tests whether a custom mouth splint combined with jaw exercises can reduce pain in the jaw joint (TMJ). It may help people who have had jaw joint pain for at least 3 months.
Istanbul, TuzlaAges 18–65 - NCT07511842Recruiting
Keeping Your Knee Still After Surgery to Reduce Pain
This study tests whether keeping your knee immobilized (held still) for 72 hours after knee replacement surgery helps reduce pain. Researchers will compare this approach to standard care to see if it makes recovery easier.
Sherbrooke, QuebecAges 18 years+ - NCT07510269Recruiting
Nerve blocks for pain control during mastectomy
This study tests two different numbing shots for the chest wall to see which one provides better pain relief during and after mastectomy surgery.
Bursa, NilüferAges 18–75 - NCT07510698Recruiting
Same-day awake mastectomy with immediate breast reconstruction
This study tests whether people can have a mastectomy while awake (using numbing medicine instead of general anesthesia) and go home the same day with immediate breast reconstruction. It may be an option if you're healthy enough and have support at home.
Rome, RomeAges 18–75 - NCT07511959Enrolling by invitation
Blood-derived treatment for chronic jaw pain
This trial tests whether a treatment made from your own blood (platelet-rich plasma exosomes) can help relieve long-term jaw joint pain and improve function. If you qualify, you would receive injections directly into your jaw area.
WroclawAges 18 years+ - NCT07513012Enrolling by invitation
Pain Relief Methods After Gallbladder Removal Surgery
This study compares two ways of numbing the abdomen during gallbladder removal surgery to see which one works better for pain relief. One method numbs one side of your belly, and the other numbs both sides.
Lahore, Punjab ProvinceAges 18–80 - NCT07513740Recruiting
Pain relief methods for hip fracture surgery
This trial compares two different nerve-block techniques (pain-relief injections) to see which one works better for patients having surgery to repair a broken hip. Both methods numb the area around the hip so you feel less pain during and after surgery.
Erzincan, Merkez/TürkiyeAges 18–75 - NCT07509671Recruiting
Can a diet help painful diabetic nerve pain?
This study tests whether a special diet can help reduce pain caused by nerve damage from Type 2 diabetes or prediabetes. You may qualify if you have painful diabetic neuropathy and are looking for a non-medication approach.
Hendersonville, North CarolinaAges 18 years+ - NCT07513350Recruiting
Exercise and anti-fibrotic treatment for frozen shoulder
This study tests whether exercise combined with an anti-fibrotic medication (a drug that reduces scar tissue) helps people with frozen shoulder regain shoulder movement. Frozen shoulder causes stiffness and pain that limits your ability to move your arm.
IstanbulAges 18 years+ - NCT07511985Recruiting
Managing Pain After Knee Replacement Surgery
This study looks at how "rebound pain" (increased pain when pain medication wears off) affects long-term pain after total knee replacement. Researchers want to understand this connection and potentially improve pain management strategies for knee surgery patients.
Konya, MeramAges 18 years+ - NCT07510347Recruiting
Pain relief study for sleeve gastrectomy patients
This study tests if giving pain medicine in a different area of the abdomen can reduce pain after weight-loss surgery. It may help you feel more comfortable after your sleeve gastrectomy.
Shibīn al Kawm, MenofiaAges 20–60 - NCT07511491Recruiting
Ondansetron lozenge vs IV for preventing shivering during C-section
This trial tests if an ondansetron lozenge (a tablet you dissolve in your mouth) works as well as ondansetron given through a vein to prevent shivering during cesarean section. Shivering is a common side effect of spinal anesthesia.
Tanta, El-GharbiaAges 18–40 - NCT07509593Recruiting
Comparing two types of tailbone pain treatment
This study compares two types of a targeted procedure (radiofrequency ablation) to treat long-lasting tailbone pain. It is designed for people who have already gotten good relief from a nerve block injection but whose pain has come back.
Istanbul, PENDİKAges 18–75 - NCT07511751Recruiting
Comparing treatments for myofascial pain syndrome
This trial compares three different treatments to find which works best for long-term back pain caused by myofascial pain syndrome, a condition where tight muscle knots cause pain. It is for people who have not found relief with standard treatments.
Adapazarı, SakaryaAges 18–65 - NCT07507799Recruiting
Comparing low vs standard dose block for gallbladder surgery
This trial tests two different amounts of a numbing medicine (local anesthetic) given during gallbladder removal surgery. The goal is to see if a lower dose works just as well for pain control.
El Fayoum Qesm, Faiyum GovernorateAges 18–65 - NCT07516171Recruiting
Digital education tool for pain relief decisions in labor
This study tests a digital educational tool that helps first-time mothers make informed decisions about pain relief during labor, specifically about epidurals. It aims to prepare you for conversations with your healthcare provider so you feel more confident and ready.
Toronto, OntarioAges 18–55 - NCT07515027Recruiting
Acupuncture plus anti-nausea medication after lung cancer surgery
This trial tests whether combining acupuncture with a standard anti-nausea medication can better prevent nausea and vomiting after minimally invasive lung cancer surgery. Many patients undergoing this surgery experience these side effects, especially when taking pain medication afterward.
ShanghaiAges 18 years+ - NCT07513974Recruiting
Pain sensitivity test to predict opioid needs in heart surgery
This study measures how sensitive you are to pain using a special device, then tracks how much pain medication you need during heart surgery. The goal is to see if pain sensitivity can predict opioid requirements and help doctors customize pain control for you.
Brussels, AnderlechtAges Any age - NCT07515144Enrolling by invitation
Nerve Stretching for Muscle Strength in Older Adults
This study tests whether a gentle nerve-stretching technique in the leg can help older adults with age-related muscle loss regain strength and muscle size. You'll attend sessions where a therapist guides your leg through specific movements designed to mobilize nerves and improve muscle function.
Seremban, Negeri SembilanAges 60 years+ - NCT07515287Enrolling by invitation
Pilates for Back Pain Recovery in Middle-Aged Women
This study tests whether Pilates exercises can help women aged 45–60 with chronic lower back disc problems improve their balance, leg strength, and body awareness. Pilates focuses on core stability and controlled movement, which may help restore function lost due to the disc herniation.
Kahramanmaraş, onikişubatAges 45–60 - NCT07514546Recruiting
Laughter yoga video for menstrual cramp relief
This study tests whether watching a video of guided laughter exercises can reduce the pain of menstrual cramps. Researchers believe laughter and breathing may help ease discomfort during your period.
Konya, KaratayAges 18–24
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,576 recruiting pain medicine studies from the U.S. registry right now, out of 6,474 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.