Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT06765486Recruiting
Exercise and pain relief: arm vs leg training
This trial compares how resistance training of the arms versus legs affects your body's natural ability to reduce pain. It may help understand which type of exercise is best for managing pain.
MadridAges 18–64 - NCT07703332Recruiting
Stretching methods for arm pain from overuse
This study tests two different stretching techniques to see which one better relieves arm pain and improves movement in people with overuse injuries. It may help you if you have long-lasting discomfort from repetitive activities like typing or manual work.
Faisalabad, Punjab ProvinceAges 20–50 - NCT05757960Enrolling by invitation
Physiotherapy program for jaw pain in hEDS
This study tests a tailored physical therapy (physiotherapy) approach for jaw pain caused by temporomandibular disorder (TMD) in people with hypermobile Ehlers-Danlos syndrome (hEDS). It may help reduce jaw muscle and joint pain and improve function.
MünsterAges 18 years+ - NCT06625060RecruitingPhase 2
Study of IPN10200 for preventing migraine in adults
This trial tests a new medicine called IPN10200 to see if it can prevent episodic or chronic migraine. It is for adults who have had migraine for at least a year and have tried at least one preventive treatment before.
Birmingham, AlabamaAges 18–80 - NCT05830630Recruiting
Methylene blue given during leg amputation surgery
This trial studies whether infusing methylene blue during above- or below-knee leg amputation can improve outcomes for people with poor blood flow to the legs. It targets patients having surgery under general anesthesia, while excluding those with certain allergies or blood clotting problems.
Tanta, Gharbia GovernorateAges 18 years+ - NCT06732765Recruiting
Eloda with or without muscle energy for back pain relief
This trial tests whether adding a muscle relaxation technique to Eloda treatment helps people with lower back pain caused by a tight muscle near the hip. It aims to find a more effective way to reduce pain and improve movement.
Sialkot, Punjab ProvinceAges 18–45 - NCT06729437Recruiting
Transcranial brain stimulation for patellar tendon pain
This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve knee function and reduce pain in people with long-term patellar tendinopathy (jumper's knee). It may help by calming pain signals in the brain.
Valencia, ValenciaAges 18–50 - NCT06929559Recruiting
How the body responds to walking when expecting pain
This study looks at how your muscles and walking pattern change when you expect a mild pain. It may help researchers understand how the body adapts to pain anticipation in healthy people.
AmiensAges 18–35 - NCT06080464Recruiting
Doctor satisfaction with VERABAND™ for chronic low back pain
This study tests how satisfied doctors are with a wearable device called VERABAND™ that monitors movement in people with chronic low back pain. If your pain limits your ability to move, you may be able to help researchers understand if this device is useful during your regular non-surgical treatment.
La Jolla, CaliforniaAges 18–85 - NCT06706375Recruiting
Comparing two types of penile nerve blocks for child circumcision
This study tests two ways of numbing the penis before circumcision in children. The goal is to see which method works better and causes less discomfort.
Lausanne, Canton of VaudAges Up to 17 years - NCT07618832Recruiting
Mind-Based Pain Relief Training for Menstrual Cramps
This study tests whether a mental training technique called graded motor imagery—where you imagine moving your body in specific ways—can reduce severe menstrual pain. The trial is for women with confirmed primary dysmenorrhea (painful periods without underlying disease) who have altered pain sensitivity.
Lahore, Punjab ProvinceAges 18–30 - NCT06708169Recruiting
Education before C-section to prevent shivering
This trial tests if teaching mothers about what to expect during a planned C-section can reduce the chance of shivering during surgery. It may help you feel more prepared and comfortable.
Seoul, Jongno-guAges 19 years+ - NCT06707870Recruiting
Neck exercises for chronic pain relief
This trial compares two different treatments for long-lasting neck pain: a special exercise that helps with neck posture (cervical retraction) and a gentle manual therapy technique (facet oscillatory mobilization). It aims to find which method is better at reducing pain and improving neck movement.
Peshawar, KPKAges 35–50 - NCT06706479Enrolling by invitation
Brain stimulation for balance in older adults with back pain
This study tests whether a gentle, non-invasive electrical brain stimulation technique (called high-definition tDCS) can improve balance in older adults with chronic low back pain. Participants receive either real or sham stimulation during balance training sessions.
Hong Kong, Hong KongAges 60–85 - NCT07547215Recruiting
TRAQ Minimally Invasive Sacroiliac Joint Fusion Study
This study tests a minimally invasive surgical procedure called TRAQ to treat chronic sacroiliac joint (SIJ) pain—a type of lower back and buttock pain. The procedure may help if you've had pain for at least 6 months that didn't improve with non-surgical treatments and have already benefited from diagnostic joint injections.
Tucson, ArizonaAges 21 years+ - NCT06175884Recruiting
Communication skills for chronic muscle and joint pain
This trial tests how a physical therapist's communication style affects pain and function in people with long-term muscle or joint pain. Participants will fill out questionnaires and watch a video to see if better communication improves outcomes.
LamiaAges 18–65 - NCT06663644Recruiting
Muscle energy technique for short-term low back pain
This study will test whether a gentle hands-on technique called muscle energy can help relieve short-term lower back pain caused by poor posture. If you are an adult between 18 and 40 with new back pain and no other major health issues, this trial may be a good fit.
Gilgit, Gilgit-BaltistanAges 18–40 - NCT06697860Recruiting
Shockwave vs. massage for chronic heel pain
This study compares two treatments for chronic heel pain (plantar fasciitis): radial shockwave therapy and Graston technique (a special scraping massage). It aims to see which works better to reduce pain and improve function in adults aged 20–45 who have had symptoms for more than 3 months.
Lahore, Punjab ProvinceAges 5 months–10 months - NCT06690307RecruitingPhase 4
Comparing two pain medicines after laparoscopic hysterectomy
This study compares two pain medicines, oxycodone and sufentanil, given through a pump you control after a laparoscopic hysterectomy. The goal is to see which one provides better pain relief with fewer side effects.
Nantong, JiangsuAges 18–65 - NCT06685120Recruiting
PRP and hyaluronic acid for knee osteoarthritis
This study tests a combination of platelet-rich plasma (PRP) and hyaluronic acid injections for knee osteoarthritis. It aims to see if these injections together can reduce pain and improve function better than standard treatments.
BolognaAges 40–75 - NCT07150143Recruiting
Massage and exercises for chronic neck pain
This trial tests whether adding a special type of massage (connective tissue massage) and other physical therapies to standard neck stabilization exercises helps people with long-term neck pain feel better.
Ataşehir, IstanbulAges 18–65 - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT06679491Recruiting
How your menstrual cycle affects strength training
This study looks at how resistance training timed to your menstrual cycle affects muscle performance in women who have a natural cycle or take the pill.
Le Tampon, FranceAges 18 years+ - NCT06676098Recruiting
Best spot for a guided numbing shot for root canals
This study compares different injection spots for a new device that helps numb lower back teeth before root canal treatment. If you need a root canal on a lower molar or premolar, you may be able to help find the best spot for the numbing shot.
Boston, MassachusettsAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.