Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,756 recruiting studies in this area right now.
By phase
- Not applicable3,101
- Phase 4252
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Tanta University29
- Mayo Clinic28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas52
- Ohio48
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,755 total
- NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07712354Recruiting
Acupuncture and magnetic therapy for neck pain that travels to the arm
This study tests if high-frequency electroacupuncture (needles with mild electric current) at specific points on the neck, combined with electromagnetic field therapy, can help relieve pain from cervical spondylotic radiculopathy. It may be an option if you have neck pain that travels to your shoulder or arm and are not using strong painkillers.
Ho Chi Minh CityAges 30 years+ - NCT06386224Recruiting
Online pain self-management for pancreatitis pain
This study tests an online pain-management program for adults with chronic or recurrent acute pancreatitis. The program is done on your own device (or a loaner iPad) and is designed to help you learn skills to cope with pain and improve daily life.
Seattle, WashingtonAges 18 years+ - NCT07693270Recruiting
Study looking for markers of pain and opioid response after injury or surgery
This study is looking for biological markers (like blood tests) that can predict how people will respond to pain and opioids after a traumatic injury or surgery. The goal is to help doctors tailor pain treatment to each person.
La Jolla, CaliforniaAges 18 years+ - NCT06171659Recruiting
PET/MRI scan to find pain sources after joint surgery
This study uses a special type of scan called PET/MRI to look for areas in the body that may be causing ongoing pain after joint replacement or arthroscopy. It aims to better understand why some people have pain that lasts months after surgery.
Madison, WisconsinAges 18–85 - NCT07506018Recruiting
MucoLock for mouth pain caused by stomatitis
This study tests a new mouth rinse, MucoLock, to see if it can help people with severe mouth pain (stomatitis). If you have burning or painful mouth sores that rate very high on a pain scale, this trial may offer a new treatment option.
Miami, FloridaAges 18 years+ - NCT07707609Recruiting
Pain and brain changes in chronic pancreatitis
This study looks at how chronic pancreatitis pain affects the nervous system and mental health. It aims to understand pain better and may help develop new ways to manage it.
Hyderabad, TelanganaAges 18–60 - NCT07709598RecruitingPhase 2/Phase 3
HL-1186 for pain after abdominal surgery
This study tests a new painkiller called HL-1186 for people having abdominal surgery. If you qualify and enroll, you will receive the drug after surgery to see if it safely helps reduce your pain better than a placebo (a pill with no medicine).
Chengdu, SichuanAges 18–75 - NCT05906511RecruitingEarly Phase 1
Study how THC levels change in older adults
This early study measures how a THC dose (by mouth or vaporized form) moves through the body and how it affects the body’s responses. It mainly looks at safety and how THC behaves in older adults, including people who have used cannabis before.
West Haven, ConnecticutAges 65 years+ - NCT06186141RecruitingPhase 4
Comparing morphine and oxycodone for kids' pain after surgery
This study compares two common pain medicines—morphine and oxycodone—given through a PCA pump after surgery in children. The goal is to see which one causes less nausea and vomiting, so your child can recover more comfortably.
Melbourne, VictoriaAges 6–18 - NCT07140432Recruiting
Bone scan to find non-healing after neck fusion surgery
This study is testing whether a special bone scan (tomoscintigraphy) can better detect non-healing (pseudarthrosis) after cervical spine fusion surgery. The goal is to see if it gives more accurate information than standard X-rays to help guide treatment decisions.
Bourg-en-BresseAges 21–99 - NCT04025359RecruitingEarly Phase 1
Test dronabinol for pain responses in people on opioid treatment
This early-stage study tests whether dronabinol (a form of THC) changes pain perception in people with opioid use disorder who are already stable on methadone or buprenorphine. It may help researchers understand whether this treatment affects pain and drug-related outcomes in a safer, controlled way.
West Haven, ConnecticutAges 18–70 - NCT05946629Recruiting
Drug-coated stent trial for narrowed heart arteries
This trial studies a drug-coated balloon (plus standard heart medicines) to treat a specific type of blockage in the heart arteries in people who need an intervention. It may help keep the artery open and prevent the narrowing from coming back, depending on how well you match the detailed heart and medication requirements.
Jonesboro, ArkansasAges 18 years+ - NCT05634031Recruiting
Study of heart vessel dysfunction seen on heart imaging
This study looks at coronary microvascular dysfunction (small blood vessel problems in the heart) using heart imaging. It may help researchers understand causes of chest tightness with activity and shortness of breath when the main heart arteries are not blocked.
New York, New YorkAges 18 years+ - NCT07543692Recruiting
Ultrasound-guided injection therapy for spine pain
This study tests whether using ultrasound imaging to guide a special injection treatment (pharmacopuncture) is safe and effective for people with spine-related neck or lower back pain that radiates into the arms or legs. The treatment is already being offered as routine care, and this study tracks how well it works.
Daejeon, DaejeonAges 19–69 - NCT07706348RecruitingPhase 1/Phase 2
Pain relief with ondansetron and lidocaine after abdominal cancer surgery
This trial tests if rinsing the belly with ondansetron (a nausea medicine) and lidocaine (a numbing medicine) during surgery can reduce pain afterward. It is for people having major lower abdominal cancer surgery who are otherwise healthy.
AsyutAges 20–70 - NCT07688044Recruiting
How food and bacteria cause belly pain in IBS
This study looks at how certain foods and gut bacteria might trigger abdominal pain in people with Irritable Bowel Syndrome (IBS). If you have IBS and frequent belly pain, you may help researchers understand the link between diet, bacteria, and pain.
Kingston, OntarioAges 18–70 - NCT07704554Recruiting
Dural puncture epidural for labor pain relief
This study compares a modified epidural technique (dural puncture epidural) to the standard method for managing labor pain. It aims to see if the new approach is safer or works better for women in labor.
Columbus, OhioAges 18 years+ - NCT07519109RecruitingPhase 1
SYH9089 for pain after abdominal surgery
This study tests an injected medicine (SYH9089) to see if it safely controls pain after abdominal surgery. It may help you recover with less discomfort.
Changsha, HunanAges 18–75 - NCT07704931Enrolling by invitation
Can spinal cord stimulation repair small nerve fibers?
This study tests whether a special type of spinal cord stimulation (which uses mild electrical pulses to block pain) can help repair damaged small nerve fibers in people with small fiber neuropathy. If you have chronic nerve pain and meet the criteria, you may be able to join.
Grand Island, NebraskaAges 19 years+ - NCT07481864Recruiting
Early mental exercise after shoulder tendon repair
This study tests if a gentle, early mental exercise program helps improve shoulder recovery after a specific type of rotator cuff repair. It might be a good fit if you had surgery on two front shoulder tendons and are otherwise healthy.
Istanbul, TurkeyAges 30–65 - NCT07449325Recruiting
Heart sinus reducer for chest pain from small vessel disease
This trial tests a device placed in a heart vein (the coronary sinus) to improve blood flow and reduce chest pain in people with coronary microvascular dysfunction (small blood vessel disease). It aims to help those who still have symptoms despite taking heart medications.
New Haven, ConnecticutAges 18 years+ - NCT07372430Recruiting
Nerve block comparison for buttock nerve pain
This study compares two ways of giving a numbing injection (nerve block) to treat a condition where a nerve in the low back gets pinched, causing long-term buttock or low back pain. It aims to see which method works better.
IstanbulAges 18–75 - NCT03231241Recruiting
Study of worsening headaches using scans and blood testing
This study looks at why headaches can become long-lasting (“chronified”) by combining answers from online questionnaires, brain imaging, and blood protein tests. Your participation may help researchers find biological clues that could improve how headache problems are understood and treated.
Stanford, CaliforniaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,756 recruiting pain medicine studies from the U.S. registry right now, out of 6,776 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.